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Medical Forum / General / Laboratory / October 2008

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Non-diabetic w/ a fasting blood glucose of 37 mg/dL

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douglas - 20 Sep 2008 06:58 GMT
I'm a non-diabetic w/ a fasting blood glucose of 37 mg/dL, and
tremors, ataxia --which could be neurological as well--, restlessness,
and occasional dizziness. My FP says just eat more, but I drink enough
sugar through out the day to be hyperglycemic. Do I need a C-peptide
test?

Thanks!!!
Bob - 21 Sep 2008 02:52 GMT
>I'm a non-diabetic w/ a fasting blood glucose of 37 mg/dL, and
>tremors, ataxia --which could be neurological as well--, restlessness,
>and occasional dizziness. My FP says just eat more, but I drink enough
>sugar through out the day to be hyperglycemic.

Drinking "sugar through out the day" is not good for you. Drink less
sugar, and eat some real food. If you just add food, you will gain too
much weight. Cut the sugar drinks, eat food. You will magically be
fine! :-)

Try it, at least you will be better nourished.

bob
JEDilworth - 21 Sep 2008 07:22 GMT
If you had a glucose of 37 you'd probably be passed out. Then they would
take you to the ER and would perform glucose testing. They would
probably refer you to an endocrinologist. They might keep you overnight
if your electrolytes were out of whack also. They might do some scans if
tumors were suspected, although I'm not sure how they determine the
presence of tumors on islet cells of the pancreas.

Are you making up stuff again Douglas??? It's insulting to us if you
are....

Your FP would send you to an endocrinologist with a low glucose like
that and would not be stupid enough to tell you to eat more. You
obviously are getting too much insulin and have a BIG problem. You are
seeing a quack and need to find a better doctor.

http://labtestsonline.org/understanding/analytes/c_peptide/test.html

A C-peptide test is probably not something that is done STAT. I'm not
sure if it's a test that's even done in most chemistry labs - may be a
send-out to a reference lab. I haven't worked in there in 20 years;
doesn't sound like a test that's ordered very often, though, from my
foggy chemistry memory bank. From the URL above:

"C-peptide measurements also can be used in conjunction with insulin and
glucose levels to help diagnose the cause of documented hypoglycemia and
to monitor its treatment.  Symptoms of hypoglycemia may be caused by
excessive supplementation of insulin, alcohol consumption, inherited
liver enzyme deficiencies, liver or kidney disease, or insulinomas
(tumors of the islet cells in the pancreas that can produce uncontrolled
amounts of insulin and C-peptide)...
C-peptide levels may be done when there is documented acute or recurring
hypoglycemia.  Symptoms include sweating, palpitations, hunger,
confusion, blurred vision, fainting, seizures, and even loss of
consiousness, although these symptoms also can occur with other
conditions.  The C-peptide test may be used to help separate excessive
insulin production from excessive administration and to help diagnose
insulinomas."

Judy Dilworth, M.T. (ASCP)

Microbiology

> I'm a non-diabetic w/ a fasting blood glucose of 37 mg/dL, and
> tremors, ataxia --which could be neurological as well--, restlessness,
[quoted text clipped - 3 lines]
>
> Thanks!!!
Manky Badger - 21 Sep 2008 09:17 GMT
> Are you making up stuff again Douglas??? It's insulting to us if you
> are....

Agree entirely. When he originally posted "I'm a non-diabetic w/ a fasting
blood glucose of 37 mg/dL, and tremors, ataxia --which could be neurological
as well--, restlessness, and occasional dizziness", he's actually
contradicting an earlier post he maded in which he said he was sixteen years
old and trying to be cute.
JEDilworth - 21 Sep 2008 20:20 GMT
I think he's trying to put a case history in the first person. He's
pretending he's the doc with these abnormal results and he has a patient
with these symptoms.

Douglas, this is NOT a cute way to do this. If you want to make up a
hypothetical patient and/or case history, please state that it IS a
hypothetical patient and/or case history. Try to pick figures and lab
results that are clinically possible. We really are NOT as dumb as you
think.

Again, with a blood sugar this low you would probably NOT be sitting
around your living room casually calling your doc's office to make an
appointment. You'd be passed out and/or in the ER.

Judy Dilworth, M.T. (ASCP)
Microbiology

> Agree entirely. When he originally posted "I'm a non-diabetic w/ a
> fasting blood glucose of 37 mg/dL, and tremors, ataxia --which could
> be neurological as well--, restlessness, and occasional dizziness",
> he's actually contradicting an earlier post he maded in which he said
> he was sixteen years old and trying to be cute.
douglas - 22 Sep 2008 16:24 GMT
On Sep 21, 12:20 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> I think he's trying to put a case history in the first person. He's
> pretending he's the doc with these abnormal results and he has a patient
[quoted text clipped - 20 lines]
>
> - Show quoted text -

I'm serious about this one. My lab results have been repeated twice.
JEDilworth - 22 Sep 2008 18:33 GMT
Then you need to see an endocrinologist pronto. This is NOT normal.
Hypoglycemia can be a precursor to diabetes.

Judy Dilworth, M.T. (ASCP)
Microbiology

I'm serious about this one. My lab results have been repeated twice.
Manky Badger - 22 Sep 2008 19:36 GMT
> Then you need to see an endocrinologist pronto. This is NOT normal.
> Hypoglycemia can be a precursor to diabetes.
[quoted text clipped - 3 lines]
>
> I'm serious about this one. My lab results have been repeated twice.

It's another of his games - look at his original post.

He's trying to catch us out with the units. He was hoping we wouldn't know
the difference between mg/dL and mmol/l.

http://en.wikipedia.org/wiki/The_Boy_Who_Cried_Wolf
JEDilworth - 23 Sep 2008 05:10 GMT
I'm pretty sure we use mg/dl in the US, not mmol/l. That is a low
reading according to my faint memory of chemistry normals here in
Amerika.

Douglas, what's your game here?

Judy Dilworth, M.T. (ASCP)
Microbiology

> It's another of his games - look at his original post.
>
> He's trying to catch us out with the units. He was hoping we wouldn't
> know the difference between mg/dL and mmol/l.
>
> http://en.wikipedia.org/wiki/The_Boy_Who_Cried_Wolf
Manky Badger - 23 Sep 2008 13:48 GMT
> I'm pretty sure we use mg/dl in the US, not mmol/l. That is a low reading
> according to my faint memory of chemistry normals here in Amerika.

For me the "35" bit is through the roof. until I saw the units

> Douglas, what's your game here?

Silly beggers, I would guess.

> Judy Dilworth, M.T. (ASCP)
> Microbiology
[quoted text clipped - 5 lines]
>>
>> http://en.wikipedia.org/wiki/The_Boy_Who_Cried_Wolf
douglas - 24 Sep 2008 19:47 GMT
> > I'm pretty sure we use mg/dl in the US, not mmol/l. That is a low reading
> > according to my faint memory of chemistry normals here in Amerika.
[quoted text clipped - 16 lines]
>
> - Show quoted text -

I put the results in the units my lab report gave: 37 mg/dL, which is
about 2.06 mmol/L. The la repeated it twice, and I'm having the FBG
redrawn, along w/ a C-peptide , on Friday morning. What other tests do
you believe should be ordered, proinsulin, ketones, cortisol, etc.?
Manky Badger - 24 Sep 2008 23:08 GMT
I put the results in the units my lab report gave: 37 mg/dL, which is
about 2.06 mmol/L. The la repeated it twice, and I'm having the FBG
redrawn, along w/ a C-peptide , on Friday morning. What other tests do
you believe should be ordered, proinsulin, ketones, cortisol, etc.?
____________________________________________________________

What condition(s) are you suspecting?
That might give you a clue as to what tests could be requested to be of
diagnostic value.
There is a lot of difference between a path lab and a Star Trek tricorder.

http://en.wikipedia.org/wiki/The_Boy_Who_Cried_Wolf
douglas - 25 Sep 2008 01:45 GMT
> I put the results in the units my lab report gave: 37 mg/dL, which is
> about 2.06 mmol/L. The la repeated it twice, and I'm having the FBG
[quoted text clipped - 8 lines]
>
> http://en.wikipedia.org/wiki/The_Boy_Who_Cried_Wolf

Hyperinsulinemia, hormone deficencies, dietary deficencies, and
insulinoma.

Is a diagnostic fast necessary?
Robert - 25 Sep 2008 04:21 GMT
> > "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 19 lines]
>
> - Show quoted text -

Proinsulin levels are used to confirm an islet cell tumor as the cause
of hyperinsulinemia. Patients have a higher percentage of proinsulin
and even higher still in cases involving islet cell carcinoma. The
percentage of proinsulin may be elevated in hypokalemic patients.

Hyperinsulinemia by itself are generally obese individuals but tend to
have a normal
glucose level.

About 2-4% of insulinomas may be associated with multiple endocrine
adenomas I. There are a variety of tests for that including hormone
testing for hyperfunction of the pituitary.

First things first.
JEDilworth - 25 Sep 2008 05:49 GMT
If your previous glucose was a fasting, then, to compare apples to
apples I would say yes, as glucose levels fluctuate with food intake.
It's also best if you use the same laboratory for your repeat testing,
if possible, as instruments vary in small ways. If your fasting is
running this low, however, you probably should get someone else to drive
you to the lab.

However, this is something you need to check with the physician who
ordered the blood work - not people on the internet.

I do hope you see an endocrinologist. As I recall you are pretty young.
A coworker has somewhat the same problems with her blood sugar. She sees
an endocrinologist regularly and it has helped her immensely. They have
put her on medication to stop the low glucose swings. When she was
pregnant she developed gestational diabetes and was self-testing her
glucose levels 3-4 times a day. Obviously this won't happen to you, but
her concern was that she would stay diabetic post partum. She is in her
mid-30's now, and has had this condition since her early 20's. She is
not diabetic, but still has glucose problems and is still on
medications.

I must say, Douglas, that if this is legitimate then I wish you well.
Your previous mischief has set people on this list on guard. Please
learn from this and don't play us for fools any more.

Judy Dilworth, M.T. (ASCP)
Microbiology

"douglas" <Protoman2050@gmail.com> wrote in message
news:df8896ca-b232-4bd7-a2ec-
Is a diagnostic fast necessary?
douglas - 25 Sep 2008 22:08 GMT
On Sep 24, 9:49 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> If your previous glucose was a fasting, then, to compare apples to
> apples I would say yes, as glucose levels fluctuate with food intake.
[quoted text clipped - 28 lines]
> news:df8896ca-b232-4bd7-a2ec-
> Is a diagnostic fast necessary?

I did check w/ Dr Phan -- my FP--, my friend Dr Asbill --an
internist--, as well as my Mom --a RN--; they said to get them
redrawn, and that they are very low. I'm going in on Friday morning
for the labwork and a discussion. Wish me luck!

For future reference, in any hypothetical situations I post about,
I'll clearly indicate they are hypothetical.
douglas - 25 Sep 2008 22:10 GMT
On Sep 24, 9:49 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> If your previous glucose was a fasting, then, to compare apples to
> apples I would say yes, as glucose levels fluctuate with food intake.
[quoted text clipped - 28 lines]
> news:df8896ca-b232-4bd7-a2ec-
> Is a diagnostic fast necessary?

Could my body be in ketosis, using fatty acids for energy? Maybe
that's why I'm not passed out.
douglas - 24 Sep 2008 19:44 GMT
On Sep 22, 10:33 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Then you need to see an endocrinologist pronto. This is NOT normal.
> Hypoglycemia can be a precursor to diabetes.
[quoted text clipped - 3 lines]
>
> I'm serious about this one. My lab results have been repeated twice.

I've asked Dr Phan to consult the internist in his group, Dr Asbill.
Do you think a C-peptide and ketones need to be ordered?
Robert - 24 Sep 2008 23:51 GMT
> On Sep 22, 10:33 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
> wrote:
[quoted text clipped - 13 lines]
> I've asked Dr Phan to consult the internist in his group, Dr Asbill.
> Do you think a C-peptide and ketones need to be ordered?

Are you sure it isn't Dr Billass?

Read Judy's post above is it is pretty much complete and self
explanatory. C-peptide is used to determine exogenous injection of
insulin where it would be undetectable. It takes 3-6 weeks to form
insulin antibodies in response to exogenously administered insulin and
so that is another test one can do for fictitious hypoglycemia, Rare
cases of insulin autoimmune syndrome with hyperinsulinemia has been
reported. Are you injecting yourself with insulin?

Glucose and simultaneous insulin levels are needed in such cases in
search of inappropriate high insulin levels in relation to the glucose
level. An endocrinologist is needed to rule out an insulinoma. A
fasting glucose under 40 with symptoms would warrant that.

There can be other artifactual reasons such as delay in testing of
glucose levels not separated from the red cells in warm weather which
might cause lower glucose levels than expected.

The mechanism of ketogenesis is still not completely understood.
"Two steps are required for ketogenesis: (1) enhanced lipolysis with
an increased delivery of free fatty acids to the liver and (2) an
alteration in hepatic metabolism by which these free fatty acids are
converted preferentially into ketones instead of into triglycerides.
Decreased insulin activity, increased counter-regulatory hormone
levels (primarily glucagon, but also cortisol, catecholamines, and
growth hormone), and volume depletion all play a role in ketogenesis."

Type I diabetes and low levels of insulin can stimulate ketogenesis as
can alcoholic ketoacidosis which the above describes. The ketone
excess is to the point of acidosis when compared to simple fasting.
There is no clinical reason to do BHB testing.
douglas - 25 Sep 2008 01:43 GMT
> > On Sep 22, 10:33 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
> > wrote:
[quoted text clipped - 48 lines]
>
> - Show quoted text -

There is no way I can get extraneous insulin, since no-one I know is
diabetic. And why on earth would I do that?

The lab repeated their runs twice, b/c they suspected that, according
to the report. Same values both times.

I do not drink alcohol.
none - 25 Sep 2008 10:49 GMT
Douglas wrote:
>There is no way I can get extraneous insulin, since no-one I know is
diabetic. And why on earth would I do that?

Well, hypoglycaemia could be seen in a starving patient - and injecing
insulin has been attempted as a way to weight loss.
But I don't know you from anything else than your postings here - and since
I cannot judge your mental condition I can only say that it does happen that
some patients who show an almost nerdy interest in medicine do inflict
strange symptoms in order to appear sick and get the interest of
specialists - whre they can then get into a dialogue on their favorite
interest.

>The lab repeated their runs twice, b/c they suspected that, according
to the report. Same values both times.

If an odd result comes up and retesting is easy and relatively costless,
they would. Then at least they are sure the result is valid for the
particular blood tested. Which pre-analytical errors might influence it, is
hard to say -
However the measured blood glucose is very low and would - should - ring a
bell or two.

>I do not drink alcohol.
So much more for the rest of us - have to get that liver up and running
douglas - 25 Sep 2008 22:09 GMT
> Douglas wrote:
> >There is no way I can get extraneous insulin, since no-one I know is
[quoted text clipped - 24 lines]
>
> So much more for the rest of us - have to get that liver up and running

I'm interested in medicine, but not so much as to make me sick just
for that purpose.
Robert - 25 Sep 2008 23:49 GMT
> Douglas wrote:
> >There is no way I can get extraneous insulin, since no-one I know is
[quoted text clipped - 24 lines]
>
> So much more for the rest of us - have to get that liver up and running

Pre-analytical or specimen integrity issues can result in low glucose
values if the specimen is left in contact with red blood cells for
long periods of time before testing is done. A special tube containing
preservative anti-glycolytic chemicals are needed for long delays in
glucose testing or separation of serum from red cells. Heat also makes
the glycolysis in a blood sample worse and will drop the glucose blood
values.
Retesting only tests the same sample and eliminates precision error
although accuracy can not be validated by such testing.
douglas - 26 Sep 2008 00:21 GMT
> > Douglas wrote:
> > >There is no way I can get extraneous insulin, since no-one I know is
[quoted text clipped - 36 lines]
>
> - Show quoted text -

The lab thought that, too, apparently, b/c it was on my lab report.
They retested it, and got the same answer.
Robert - 26 Sep 2008 00:48 GMT
> > > Douglas wrote:
> > > >There is no way I can get extraneous insulin, since no-one I know is
[quoted text clipped - 41 lines]
>
> - Show quoted text -

One does not check specimen integrity by retesting it. One checks it
by re-submitting another sample. You can test the same sample a
hundred times but that does not mean there is nothing wrong with the
sample being tested.. It does not prove that something isn't wrong
with the specimen. That is only valid only for the detection of
analytical errors and not specimen integrity. If you don't get the
same result on repeat than there is a prescision error with the
instrument. If you get the same result that in and of itself does not
mean the instrument isn't giving low results on every specimen out
there. There has to be other ways to confirm accuracy.

Such a low result is a critical value result and would be called to
the caretarker for immediate action. Some institutions have a repeat
policy before reporting out such critical values. We do not based on
documented studies. We do have a comment based on the condition of the
specimen submitted that may yield altered results. Such a specimen
would be a red top tube uncentrigued and left out at high temperatures
for hours. The decrease in glucose has been calculated in the
literature and can be significant. The recommendation is centrifuation
immediately after collection in gel separation tubes. This minimizes
the reduction although it doesn't eliminate it. The preferred
submission of a sample for glucose testing is a gray-top tube
containing glycolytic inhibitors.

Specimen integrity such as delayed testing in an improperly preserved
sample may also give elevations of potassium as a result of cell
leakage vs insulin adminstration that results in low potassium levels.
The rest of the chemistry panel is also helpful for checking specimen
integrity and other endocrine abnormalities such as Addisons. One
looks at the total lab findings along with the clinical picture to put
it all together.
JEDilworth - 26 Sep 2008 03:49 GMT
Robert makes an excellent point about glucose testing. If glucose
specimens are going to be transported and not spun down, a sodium
fluoride (gray top) tube is essential. Otherwise, you will get the
problems he's talking about. The blood should be separated by
centrifugation and tested as soon as possible. Glucose is only stable
for a couple of hours in tubes other than a gray top. The serum/plasma
should NOT sit on the cells. This is basic good lab practice for any
blood work that requires centrifuged specimens. These are basics that
are taught to all medical technology students in their training.

I personally would recommend your going to an in-house draw station at a
hospital. The specimen will be transported to the laboratory pretty
quickly, whereas an offsite draw station depends on couriers for
transportation. Depending on the facilities at the draw station they may
or may not have a centrifuge to separate your specimen before
transportation. If you're having your blood drawn at a doc's office, you
are entirely dependent on their staff to know what they're doing with
laboratory specimens. If it's a very large clinic with their own
in-house lab, that's one thing and a good thing. If this is just a doc's
office in a building and the secretary/nurse/lab assistant is taking
care of your specimen, i.e. just popping the tubes into a bag and
sending them off to the lab by way of putting them in the drop box on
the office door, that COULD be your problem. Most reference labs supply
their clients with small centrifuges but that doesn't necessarily mean
that the doc's offices know how to use them. Hopefully your glucose
testing wasn't performed in a doctor's office. That's even scarier if
that was the case.

I marketed laboratory services to doctor's offices for two years in the
mid-80's. I know whereof I speak. We ran into all types of analytical
errors from doctor's offices who didn't know the first thing about
collecting laboratory specimens. The specimen provided to the lab for
analysis is everything. The lab has no control over pre-analytical
errors in collection. We dealt with offices putting blood specimens into
lock boxes when the outdoor temperatures were near zero. What do you
think happens to blood at that temperature? It freezes and lyses the
cells. Testing requiring whole blood (CBC's [complete blood counts]) are
pretty worthless when frozen. Many times the courier doesn't pick up
until hours after the docs offices close and put the specimens in the
drop box. One of our clinics was performing in-house chemistry testing
but they hadn't run controls in months and months. They didn't do any
routine maintenance on their equipment either. I was brought in as a
consult. I was horrified. They were actually charging MONEY for this
testing. It was pitiful.

I worked for a small draw station before I was a marketing rep. I did
very limited testing onsite and the rest was sent up to the main
laboratory. We were extremely careful with our pre-analytical processing
but it still had to travel distances. We kept specimens refrigerated
until our courier took them in a Styrofoam package in his cooler, but it
took about 4 hours to get to the lab by car. Specimens travel all over
the country every day via courier. That is why it is important to adhere
strictly to lab collection requirements.

We also got lab work from the docs in the building. We had a
pediatrician across the hall who had a young teen patient that they
suspected of being pregnant. They had their own urine pregnancy kit but
the results came up negative. They brought the urine over to me and I
ran it. The result was definitely positive. I went over to the office
and checked their kit. The date was right but they stored it at room
temperature. The kit was definitely supposed to be in the refrigerator.
I also do not think they ran controls so they didn't know that the kit
was not working. As a marketing rep I ran into quite a few similar
horror stories from doctor's offices.

If you repeatedly test an incorrectly collected specimen, the results
will match within a couple of numbers time and time again, so repeating
specimens doesn't mean much. A glucose in your range might repeat at 37,
39, 38, 36 and still be statistically correlated, as 1 mg/dl doesn't
mean much clinically.

Take your blood requisition and go to a large hospital that is on your
insurance plan, if you haven't already done so. Make sure to ask your
doc whether you should be fasting or not. A correct fast for glucose
should be eight hours with nothing by mouth except water. No gum, no
coffee, no diet pop, just water. If lipid testing is ordered then your
fast should be 12-14 hours with nothing except water by mouth. They will
transport to the laboratory every half hour or so, and chemistry
specimens like glucoses are loaded onto the analyzers quickly, so there
shouldn't be pre-analytical errors. Docs are notorious in not telling
their patients to fast when they really WANT them to be fasting, so be
sure and check.

Good luck and let us know how things come out.

Thanks for your "hypothetical" promise. We on the group appreciate it.

Judy Dilworth, M.T. (ASCP)
Microbiology

On Sep 25, 4:21 pm, douglas <Protoman2...@gmail.com> wrote:
> On Sep 25, 3:49 pm, Robert <Goldentouch...@yahoo.com> wrote:

One does not check specimen integrity by retesting it. One checks it
by re-submitting another sample.
Robert - 26 Sep 2008 04:13 GMT
On Sep 25, 7:49 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Robert makes an excellent point about glucose testing. If glucose
> specimens are going to be transported and not spun down, a sodium
[quoted text clipped - 92 lines]
> One does not check specimen integrity by retesting it. One checks it
> by re-submitting another sample.

Another case presented to us was a patient on high dose vitamin C that
falsely lowered glucose values by glucose oxidase methods. It was
giving 50 something on such methods and when glucose was given there
was no response. A 250 mg/dl was obtained by a non-glucose oxidase
method. Some methodologies incorporate an ascorbic oxidase additive to
rid the interference but not all. The normal procedure if at all
possible is to perform the questionable assay with an alternative
methodology. This applies to all chemistry testing.

In general terms once one looks into specimen integrity and lab
results are unexpected then drug interference is the first thing one
thinks of.

The repeat sample can also take care of  pre-, analytical, post-
analytical phases errors.
douglas - 26 Sep 2008 04:41 GMT
On Sep 25, 7:49 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Robert makes an excellent point about glucose testing. If glucose
> specimens are going to be transported and not spun down, a sodium
[quoted text clipped - 92 lines]
> One does not check specimen integrity by retesting it. One checks it
> by re-submitting another sample.

Actually, the lab report says that RBCs were present when they
recieved it. , but then it says "verified by repeat analysis". What
does this mean?

The lab was Quest Diagnostics
Robert - 26 Sep 2008 05:06 GMT
> On Sep 25, 7:49 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> wrote:
[quoted text clipped - 106 lines]
>
> - Show quoted text -

RBC's should not be present without an inhibitor especially since
Quest is a reference lab and there were delays in testing. The RBC's
utilize the glucose for energy as they lack mitochondria. If the
results and comment were together then it pertains to the glucose
result as a qualifier pertaining to the integrity of the specimen.
There should be safeguards to ensure the integrity of the specimen as
Judy stated if it can't be done immediately a doctors glucometer
testing in the office might be warranted along with proper collection
and processing of the specimen for glucose testing. The doctor was
probably informed of the problem when he was notified of the result.
There should have been a documentation of such a call as it was a
critical value. It might also explain the doctors response to such a
result.
rickh - 26 Sep 2008 06:58 GMT
informed of the problem when he was notified of the result.
snip
> There should have been a documentation of such a call as it was a
> critical value. It might also explain the doctors response to such a
> result

Absolutley
 Am I missing something ? A 2.1 FBS in an otherwise healthy non
diabetic is a "critical" result and would be repeated and phoned. The
lab can only assure the steps they have control over. There are
several scenarios previously discussed for false low readings, but
presumably the responsible physician interprets the results in light
of the clinical picture.
Robert - 26 Sep 2008 07:12 GMT
>  informed of the problem when he was notified of the result.
> snip
[quoted text clipped - 10 lines]
> presumably the responsible physician interprets the results in light
> of the clinical picture.

Right you are and quite frankly I don't think the doctor believed it
to be that low but was again informed of the condition of the specimen
by the lab as a warning that the results might have been affected by
the condition of the specimen received. In this case they commented
the presence of RBC contact is my interpretation of the comments. A
simple redraw with a preservation of the specimen is the next action
that should be taken and then go from there. Had the circumstances
been different with testing done on a stat basis and quickly then the
results would have been more significant.
It seems the doctor just gave a precautionary warning to eat just in
case there really is hypoglycemia. The degree of hypoglycemia does in
fact have an impact on the differential diagnosis in relation to the
clinical picture as you state.
JEDilworth - 26 Sep 2008 06:15 GMT
Quest is a reference lab - biggest in the country.

http://www.questdiagnostics.com/

The regional lab I used to sell for was eventually absorbed by Quest in
the early 90's. They have hub labs all over the U.S. However, that
doesn't mean that preanalytical errors were not present.

I have never seen the comment "RBC's present" on a glucose report,
although it probably indicates that the serum/plasma was hemolyzed. This
condition, in which the red cells leak their contents into the serum or
plasma, can affect many results - most specifically glucose and
potassium. This could be because they had a hard time drawing blood from
you or the phlebotomist in charge of the draw station let the blood sit
too long before it was spun down. It could have sat in a hot car while
being transported to the lab. There are any number of reasons this could
have happened. Quest techs were obligated to call this result as it is
indeed a critical glucose. However, the technologist helped to explain
the result by putting in the "RBC's present" comment. All reference labs
have to deal with the specimen that they're dealt.

I would definitely opt for a local hospital's lab (if your insurance
will support that choice) over shipping your specimen to one of the big
Quest labs. The courier probably only picks up once a day from their
draw station and there was definitely a delay in testing. Glucose is
always more accurate when it is tested quickly. They can fax the result
over to your doc within hours.

Let us know what happens.

Judy Dilworth, M.T. (ASCP)
Microbiology

Actually, the lab report says that RBCs were present when they
recieved it. , but then it says "verified by repeat analysis". What
does this mean?

The lab was Quest Diagnostics
douglas - 26 Sep 2008 06:21 GMT
On Sep 25, 10:15 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Quest is a reference lab - biggest in the country.
>
[quoted text clipped - 34 lines]
>
> The lab was Quest Diagnostics

I'll inform Dr Phan, then.
Manky Badger - 26 Sep 2008 07:47 GMT
> The lab was Quest Diagnostics

I'll inform Dr Phan, then.

____________________________________

As a matter of courtesy, it's probably best not to broadcast specific
individual's names over the Internet.
douglas - 26 Sep 2008 08:11 GMT
> > The lab was Quest Diagnostics
>
[quoted text clipped - 4 lines]
> As a matter of courtesy, it's probably best not to broadcast specific
> individual's names over the Internet.

There's around several million people w/ the name "Phan".
douglas - 26 Sep 2008 20:02 GMT
> > "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 10 lines]
>
> There's around several million people w/ the name "Phan".

OK, the FBG was redrawn in a tiger-striped-stoppered tube. My PCP
should be calling me this evening to discuss a letter I left in his
office about the investigation and management of my as-of-yet-
idiopathic hypoglycemia.

Btw, I have been mildly euphoric for the past couple of days; is this
related?
Mike Collins - 26 Sep 2008 22:13 GMT
> > > "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 20 lines]
>
> - Show quoted text -

If you have a doctor who takes blood for glucose into any tube not
grey - topped and a lab that measures glucose in a tube without
preservative you need to find a new doctor and a new lab.
douglas - 26 Sep 2008 22:22 GMT
> > > > "douglas" <Protoman2...@gmail.com> wrote in message
>
[quoted text clipped - 26 lines]
>
> - Show quoted text -

I told the MA who did it that. It was a SST tube she used; there was a
grey tube right next to it.
JEDilworth - 27 Sep 2008 00:25 GMT
WHO drew your blood? The doctor's office? Like Mike said - if this was
drawn in any tube besides a gray top (for the glucose - the SST red top
with the stripes can be used for other testing if he ordered it) you
could run into the same problem again unless you went right to a
hospital on-site draw station where they process the blood quickly. SST
tubes are serum separator tubes, have no anti-coagulant and no
preservative. The goo in the tubes separates the cells from the serum
once it is centrifuged. HOWEVER, if it is centrifuged twice (which could
have happened the first time - or the second) for any reason (they
didn't let it clot long enough the first time for some reason, and
thought they could get more serum with a second spin) then the cells
below CAN mess up the serum. Again, this is something that real lab
people wouldn't (shouldn't) do but the bets are off with doc's office
personnel. Gray tubes have sodium fluoride, I believe, as an
anticoagulant AND a preservative for blood glucose and a couple of other
tests that I can't remember off the top of my head (too many years out
of chemistry). It inhibits glycolysis and helps prevent too LOW of a
glucose reading.

http://medical-dictionary.thefreedictionary.com/gray+top+tube

It is best that you do not put your doc's names in these postings. He
would not appreciate it, especially if he has other patients who read
this. It is not difficult to figure people out with the internet
available.

Euphoria implies a state of happiness. Are you sure that's the word you
want to use here?

http://dictionary.reference.com/browse/euphoria - a feeling of
happiness, confidence, or well-being sometimes exaggerated in
pathological states as mania.

Are you manic??? :-|

Judy Dilworth, M.T. (ASCP)
Microbiology

OK, the FBG was redrawn in a tiger-striped-stoppered tube. My PCP
should be calling me this evening to discuss a letter I left in his
office about the investigation and management of my as-of-yet-
idiopathic hypoglycemia.

Btw, I have been mildly euphoric for the past couple of days; is this
related?
douglas - 27 Sep 2008 07:04 GMT
On Sep 26, 4:25 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> WHO drew your blood? The doctor's office? Like Mike said - if this was
> drawn in any tube besides a gray top (for the glucose - the SST red top
[quoted text clipped - 41 lines]
> Btw, I have been mildly euphoric for the past couple of days; is this
> related?

It was a medical assistant...scary, I know.

I meant floaty and in an upbeat mood. I'm not a maniac
Manky Badger - 27 Sep 2008 07:11 GMT
On Sep 26, 4:25 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:

> Are you manic??? :-|
>
[quoted text clipped - 10 lines]
> Btw, I have been mildly euphoric for the past couple of days; is this
> related?

It was a medical assistant...scary, I know.

I meant floaty and in an upbeat mood. I'm not a maniac
_____________________________________________________

Manic, not maniac.
douglas - 27 Sep 2008 08:05 GMT
> On Sep 26, 4:25 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> wrote:
[quoted text clipped - 20 lines]
>
> Manic, not maniac.

Not that either.
JEDilworth - 27 Sep 2008 15:13 GMT
Yes, Douglas, I know that your blood was drawn by an assistant or
phlebotomist. That is almost always the case. What I want to know is....

Did you leave the doc's office and go to a draw site for a big lab (no
need to name names), stay in your doc's office and have one of their
people draw you, or go out to a hospital lab's draw site for the blood
draw? As you MAY recall, we've been discussing at length the transport
time of your specimen to the lab and how it may or may not have affected
your lab results. This seemingly is the critical part of the puzzle and
may help to explain why your glucose level was low the first time.
Please answer the question.

You're probably euphoric because you're getting a LOT of attention here
lately.

FYI, "manic" is an adjective; "maniac" is a noun.

Judy Dilworth, M.T. (ASCP)
Microbiology

It was a medical assistant...scary, I know.

I meant floaty and in an upbeat mood. I'm not a maniac
douglas - 27 Sep 2008 22:23 GMT
On Sep 27, 7:13 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Yes, Douglas, I know that your blood was drawn by an assistant or
> phlebotomist. That is almost always the case. What I want to know is....
[quoted text clipped - 19 lines]
>
> I meant floaty and in an upbeat mood. I'm not a maniac

Stay in the doc's office. I'm going to ask him to send me to the lab,
which is RIGHT next to the office building, next time.

Btw, I was weirdly euphoric BEFORE I posted here.
JEDilworth - 28 Sep 2008 05:31 GMT
If it's low again, then they are probably NOT spinning the blood down in
a timely manner. If they did NOT use a gray top tube that's even worse.
I would demand to get my blood drawn at a draw station at a hospital -
NOT the lab next door. They are going to have the same transit time
issues. Hopefully you don't live way out somewhere far away from a
hospital.

If the insurance company refuses to pay for all of these repeats, I
would challenge it based on the fact that your doc's office probably
doesn't process blood correctly. They may be batching their blood till
the end of the day and taking the specimens over to the lab next door
themselves! I would make sure there are no pre-analytical collection
errors before you go to an endocrinologist. If you feel intimidated by
the doctor, ask your mother to step in.

Judy Dilworth, M.T. (ASCP)
Microbiology

Stay in the doc's office. I'm going to ask him to send me to the lab,
which is RIGHT next to the office building, next time.
douglas - 28 Sep 2008 16:42 GMT
On Sep 27, 9:31 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> If it's low again, then they are probably NOT spinning the blood down in
> a timely manner. If they did NOT use a gray top tube that's even worse.
[quoted text clipped - 16 lines]
> Stay in the doc's office. I'm going to ask him to send me to the lab,
> which is RIGHT next to the office building, next time.

I WILL, next time when I go in for my wart removal!!!!

The lab next door is unaffiliated.
JEDilworth - 28 Sep 2008 18:32 GMT
Make sure you check your insurance provider's list to see which ones
will actually pay for your lab work. In the U.S., at least, this is
important. Again, if "the lab next door" is sitting miles from the
"mother hospital" or the main lab, you have transit issues.

If you were truly hypoglycemic you'd be having a lot of symptoms. My
coworker had lots of problems with hunger that was never satisfied. She
couldn't gain weight. She would get light headed and nearly pass out.
This started in her early 20's.

If you're a teenager, you can't gauge your symptoms on hunger issues, as
most teenage boys are hungry constantly.

Only reason I invoked your mom/dad in the previous post was that they
are the ones that will ultimately have to deal with insurance claims and
issues.

Judy Dilworth, M.T. (ASCP)
Microbiology

I WILL, next time when I go in for my wart removal!!!!

The lab next door is unaffiliated.
douglas - 28 Sep 2008 23:45 GMT
On Sep 28, 10:32 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Make sure you check your insurance provider's list to see which ones
> will actually pay for your lab work. In the U.S., at least, this is
[quoted text clipped - 19 lines]
>
> The lab next door is unaffiliated.

Then again, I haven't been really hungry in the last few days...today
I just drank a Venti Frappachino; could I be in ketosis? Is a low FBG
the cause or sign of ketosis?
JEDilworth - 29 Sep 2008 05:06 GMT
You can buy ketone strips at a drug store and dip your own urine if
you're worried about this. Follow the timing and compare the strip to
the colors on the container. Watch storage conditions and expiration
date. Don't store these in a humid bathroom - they will deteriorate
quickly that way.

What in the h**l is a Venti Frappachino? Are you name dropping? Sounds
expensive with absolutely no nutritive value whatsoever.

Judy Dilworth, M.T. (ASCP)
Microbiology

Then again, I haven't been really hungry in the last few days...today
I just drank a Venti Frappachino; could I be in ketosis? Is a low FBG
the cause or sign of ketosis?
Marsha - 29 Sep 2008 13:03 GMT
Douglas,

Ask the office personnel who their accreditation agency. If they are doing
in house testing then they have to have one. What tests are they doing
"in-house" as opposed to sending to a reference lab. If they are only
drawing/collecting specimens then they may not be accredited. Just ask them.
I would have no way of knowing who their accreditation agency would be.

Marsha Mank, MT(ASCP)
Technical Advisor COLA

> You can buy ketone strips at a drug store and dip your own urine if you're
> worried about this. Follow the timing and compare the strip to the colors
[quoted text clipped - 10 lines]
> I just drank a Venti Frappachino; could I be in ketosis? Is a low FBG
> the cause or sign of ketosis?
JEDilworth - 29 Sep 2008 23:38 GMT
Marsha makes an excellent point. IF they are doing lab work in the
office then they need to be accredited for what they do. They have check
samples they must perform periodically. She knows whereof she speaks, as
COLA is a lab accreditation agency:

http://www.cola.org/

If they are just drawing and sending to a reference lab they are
probably doing it for the drawing fees and/or a discount on account
billing that their lab marketing rep is giving them for non-Medicare
work. You cannot discount Medicare work. Then the doc can do the billing
and pocket the difference. This is still allowed in some states. If you
get a bill directly from the reference lab, then they are doing
"patient" billing and they're only making out on the draw fee. Countries
that have government-run medicine have no idea how complicated billing
is in the US - and how many loopholes there are in it (but that's a
different topic....).

If they are just drawing, they are still responsible for pre-analytical
processing - hence with the potential problem of the serum/plasma
sitting on the cells too long. Non-lab people do not realize the
potential of screwing up lab work by doing this. Many of them spin
specimens in SST tubes twice also, which also can mess up tests like
glucose and potassium.

Go to a lab where transit time from being drawn to getting testing done
is SHORT. Hospital-based lab draw stations are about as fast as you can
get as an outpatient.

Judy Dilworth, M.T. (ASCP)
Microbiology

> Ask the office personnel who their accreditation agency. If they are
> doing in house testing then they have to have one. What tests are they
[quoted text clipped - 5 lines]
> Marsha Mank, MT(ASCP)
> Technical Advisor COLA
douglas - 30 Sep 2008 01:39 GMT
On Sep 29, 3:38 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Marsha makes an excellent point. IF they are doing lab work in the
> office then they need to be accredited for what they do. They have check
[quoted text clipped - 39 lines]
>
> - Show quoted text -

I quote from the phlebotomist "we spin it immediately, then send it to
Quest"; an internist I know says it's okay, but not preferred, to use
an SST IF the serum is immediately seperated from the RBCs.
JEDilworth - 30 Sep 2008 03:55 GMT
Technically that is true. However, they need to let the SST clot before
spinning it. That usually takes about 20 minutes. IF they tried spinning
before clotting was completed, they may not have gotten a good serum
yield. That leads me to my speculation that they they plunked the tube
BACK in the centrifuge and tried spinning a second time, which causes
all sorts of problems with SST tubes. Blood can leak up from below the
gel barrier and mess up the serum. A gray top tube is better but
involves drawing more blood from the patient. However, from a young
person like you that shouldn't be a problem.

BTW, I was thinking more about your sugary coffee drink. When someone
who MAY be hypoglycemic (we don't know in your case) eats (or drinks) a
lot of sugar, their insulin level will go up abnormally, which will then
depress the blood glucose level. In the old days they used to run
glucose tolerance testing and you could see hypoglycemics running into
trouble around the 4th-6th hour of testing. GTT's involve drinking a
test beverage containing 100 gm of glucose. They don't run these too
often any more. Hypoglycemics' glucose levels can plunge below 50 mg/dl
(I think that's the unit) and definitely cause symptoms.

IF you are truly hypoglycemic, you need to stay away from high levels of
glucose and eat more protein. My coworker sticks to protein snacks and
tries to stay away from sugary stuff. This keeps her glucose levels more
stable.

Let us know what your repeat blood sugar is.

Judy Dilworth, M.T. (ASCP)
Microbiology

"douglas" <Protoman2050@gmail.com> wrote in message
news:05232413-2be6-44f7-bd0d->

I quote from the phlebotomist "we spin it immediately, then send it to
Quest"; an internist I know says it's okay, but not preferred, to use
an SST IF the serum is immediately seperated from the RBCs.
rickh - 30 Sep 2008 05:14 GMT
On Sep 29, 10:55 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Technically that is true. However, they need to let the SST clot before
> spinning it. That usually takes about 20 minutes. IF they tried spinning
[quoted text clipped - 5 lines]
> involves drawing more blood from the patient. However, from a young
> person like you that shouldn't be a problem.
snip

 Everyone seems egar to find fault with SST tubes. They are perfectly
fine for measuring most routine analytes, glucose included, when used
appropriately, and when specimen transport and analysis is going to be
delayed, as is the nature of out patient blood work, they are the tube
of choice as they separate the serum/plasma from the red cells and
help maintain specimen integrity
without the need for human handling of open tubes, labelling aliquots
etc, and the errors such handling and transcripion are prone to
produce. We do use gray tops in house for GTT's but I think they only
make a real difference if there's going to be a delay in processing.
 I can understand that such a low glucose in an asymtomatic patient
makes everyome suspect lab error, but I seem to recall acute symptoms
in the OP. It would be interesting to see F.U. blood work and any
input from an endocrinologist if these results are validated

> I quote from the phlebotomist "we spin it immediately, then send it to
> Quest"; an internist I know says it's okay, but not preferred, to use
> an SST IF the serum is immediately seperated from the RBCs.
JEDilworth - 30 Sep 2008 06:06 GMT
I agree, Rick, with your comments about SST's. They are a wonderful
invention that saves LOTS of work. I can remember when I first started
in the lab in late 1971 we used plain red tops with no gel, as SST's had
not been invented yet. We spun, poured off, and respun just the pour-off
serum tubes a second time to get rid of all the red cells (with no caps
on the tubes [shudder]) and poured off AGAIN. All tubes were
hand-labeled with name and room number (no bar code labels in those
days). The morning draw was a pretty labor intensive time.

However, Douglas's low blood sugar was resulted with some caveat that
RBC's were present. Not sure exactly what this means other than that the
specimen might have been hemolyzed or there were red cells floating in
the serum. I think you will agree that a 37 mg/dl fasting is NOT normal.
Before expensive endocrinologists are summoned pre-analytic error MUST
be ruled out and a true low fasting blood sugar must be duplicated.
Otherwise, this could be much ado about nothing.

I am only going from my experience as a marketing rep and the problems I
dealt with in doctor's offices with non-lab personnel dealing with
specimens. Hopefully all specimens were handled appropriately. However,
I still think that, to rule out transport related low glucose levels, a
blood draw should occur close to where the testing will actually be
done. You said yourself that gray tops should be used if there is a
"delay in processing." We don't know how far away this doctor's office
is from the reference laboratory. If he is drawn in the morning and the
blood isn't tested until after 10:30 p.m. (a typical time for reference
labs to START receiving their specimens from afar) that is a good 12-14
hour delay right there! Our local specimens did not reach our "main lab"
until about that time, and our driver left our city at around 5 p.m.
with our daily draw. We spun down the specimens (in SST's AND gray tops)
and kept the specimens in a refrigerator until the driver left, but I
would tend to doubt that ALL doc's offices do that. A hospital lab would
have had the specimens done and reported out by then.

Judy Dilworth, M.T. (ASCP)
Microbiology

"rickh" <harrison6723@rogers.com> wrote in message
news:50236327-12b5-4c00-81cf-

Everyone seems eager to find fault with SST tubes. They are perfectly
fine for measuring most routine analytes, glucose included, when used
appropriately, and when specimen transport and analysis is going to be
delayed, as is the nature of out patient blood work, they are the tube
of choice as they separate the serum/plasma from the red cells and
help maintain specimen integrity
without the need for human handling of open tubes, labelling aliquots
etc, and the errors such handling and transcripion are prone to
produce. We do use gray tops in house for GTT's but I think they only
make a real difference if there's going to be a delay in processing.
 I can understand that such a low glucose in an asymtomatic patient
makes everyome suspect lab error, but I seem to recall acute symptoms
in the OP. It would be interesting to see F.U. blood work and any
input from an endocrinologist if these results are validated
Robert - 30 Sep 2008 06:52 GMT
> On Sep 29, 10:55 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> wrote:> Technically that is true. However, they need to let the SST clot before
[quoted text clipped - 29 lines]
>
> - Show quoted text -

That is correct as they are the tube most widely used for general
chemistry panels with the caveat that they be handled as recommended
by the manufacturers of the SST tubes themselves. It is the
responsibility of the performing laboratory to establish specimen
integrity rejection criteria. From a recent MLO article pertaining to
the performance of testing with unacceptable specimens, hemolysis or
the storage mishandling as denoted by the laboratory with regards to "
presence of blood" denoted in the report can make the laboratory
legally responsible for such actions. There is no discharge of
liability from the laboratory if the doctor, clinician,  insists that
an unacceptable specimen be tested. The laboratory intentionally
performed a test they knew was unacceptable and is an admission of
liability. If one reports out a K of 8 and attaches a comment that the
specimen is hemolyzed this denotes an intentional willful act of
reporting out a value that is inaccurate and incorrect. Any actions
taken as a result of that report with ill consequences to the patient
would expose the laboratory legally.

The bottom line is the laboratory is legally bound by established
policies and procedures on what is an acceptable specimen and must
adhere to it. The only one who is legally mandated through laboratory
legislation, inspections, state and federal and by licensing of
professionals are the laboratory personnel to make those judgement
calls. The reference laboratory that picks up those samples need to be
proactive to ensure that those preanalystical variables affecting
testing are acceptable. If the sample is received by the laboratory
unspun and collected 8 hours previously then no one would know except
for the laboratory who performed it.

With regards to the possibility of hypoglycemia, When one is
specifically looking for glucose then a gray-top tube would be in
order. This wasn't the case with the initial chemistry panel and as
you mentioned glucose tolerance testing routinely uses gray top tubes.
We use gray top tubes with all single glucose testing from remote
units such as clinic testing. It would be an error not to do so in
this case after the possibility of handling errors again mentioned by
the report. There is no safeguards that the same thing won't happen
again. Most doctors offices have glucometers and I would have him come
into the office and have one done along with evaluation of symptoms
and if low less than 50 mg/dl then they would have a lab slip in hand
for an expanded insulin glucose ratio and held for add on testing.
That would have been the quickest and most efficient way of doing it.
Mike Collins - 30 Sep 2008 20:45 GMT
> On Sep 29, 10:55 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> wrote:> Technically that is true. However, they need to let the SST clot before
[quoted text clipped - 29 lines]
>
> - Show quoted text -

I find fault with measuring glucose in SST tubes.
It may be OK for tubes handled correctly but you don't know if they
have been handled correctly. The problem comes mainly with low glucose
results. You don't know whether they have been centrifuged at the
right time. You can't believe the time written on the tubes - or
sometimed even the date. For the trifling extra time and money you can
be sure your results have not been compromised by incorrect handling.
We put about 3.000 tubes per day on our track and each extra glucose
tube ony adds 2 seconds to the processing time over adding glucose to
an SST sample.
Robert - 30 Sep 2008 21:13 GMT
> > On Sep 29, 10:55 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> > wrote:> Technically that is true. However, they need to let the SST clot before
[quoted text clipped - 42 lines]
>
> - Show quoted text -

I have personal experience with my own glucose measurements. When I
did it fresh draw fasting and performed immediately I would
consistently get 102 or about there. When I have it done at a drawing
station for send out testing I consistently get 80's for the glucose
coming back and the drawing station has a centrifuge there and  use
SST's because I also get a lipid panel at the same time. Why that is
or if it's a normal acceptable variant is a good question. Ideally one
would do correlation studies with of having a test performed
immediately versus the standard routine. It might not be clinically
significant. Another option in this case is to perform a
glycohemoglobin in which if hypoglycemia is predominant then a lower
A1C value would be of value. A1C is used for both high or low glucose
conditions.
Mike Collins - 30 Sep 2008 22:09 GMT
> > > On Sep 29, 10:55 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> > > wrote:> Technically that is true. However, they need to let the SST clot before
[quoted text clipped - 58 lines]
>
> - Show quoted text -

In the first hour fluoride blood glucose declines at the same rate or
slightly faster than untreated blood but the level then stabilises in
the fluoride tube but continues to drop in the untreated tube.
See:
http://www.clinchem.org/cgi/reprint/35/2/315

Effectiveness of Sodium Fluoride as a Preservativeof Glucose in Blood
A.Y.W. Chan, A. Swamlnathan,and C. S. Cockram

CLIN. CHEM. 35/2, 315-317(1989)
John Gentile - 30 Sep 2008 23:01 GMT
> Another option in this case is to perform a
> glycohemoglobin in which if hypoglycemia is predominant then a lower
> A1C value would be of value. A1C is used for both high or low glucose
> conditions.

This is an excellent point. Douglas has to realize that the practice of
medicine can't diagnose a serious illness based on a single point lab
test. The doc has to look at a variety of tests that may indicate a
problem, or corroborate a finding. The patient's signs, symptoms and
physical exam also play into it.

Signature

John Gentile MS, M(ASCP)
Laboratory Information Mgr.
VA Medical Center
Providence, RI
yjgent@cox.net

JEDilworth - 01 Oct 2008 04:32 GMT
Thanks, Mike, Robert, and John for all the great information on
chemistry, glucose, etc. It's been awhile since I've thought about all
of this stuff. Nice to know I haven't forgotten it all :-(.

I had never thought about A1C testing for low glucose. Heck, that test
didn't even EXIST when I trained in 1973-74. I also wonder why they
didn't do a fingerstick blood sugar with a glucometer in the doc's
office. That would be quick and easy (making the BIG assumption that
they run QC for this instrument like they should be doing daily).

Douglas, are you having ANY symptoms right now?

Judy Dilworth, M.T. (ASCP)
Microbiology
douglas - 01 Oct 2008 06:54 GMT
On Sep 30, 8:32 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Thanks, Mike, Robert, and John for all the great information on
> chemistry, glucose, etc. It's been awhile since I've thought about all
[quoted text clipped - 10 lines]
> Judy Dilworth, M.T. (ASCP)
> Microbiology

Not that I know of; although when I got my bp tested at school, it
fell 10 mmHg when I stood up vs when I was sitting down.
douglas - 29 Sep 2008 15:41 GMT
On Sep 28, 9:06 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> You can buy ketone strips at a drug store and dip your own urine if
> you're worried about this. Follow the timing and compare the strip to
[quoted text clipped - 11 lines]
> I just drank a Venti Frappachino; could I be in ketosis? Is a low FBG
> the cause or sign of ketosis?

Um, a Starbucks cold coffee milkshake-like drink? I can't believe
you've never heard of it.
Manky Badger - 29 Sep 2008 17:47 GMT
On Sep 28, 9:06 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> You can buy ketone strips at a drug store and dip your own urine if
> you're worried about this. Follow the timing and compare the strip to
[quoted text clipped - 15 lines]
> I just drank a Venti Frappachino; could I be in ketosis? Is a low FBG
> the cause or sign of ketosis?

Um, a Starbucks cold coffee milkshake-like drink? I can't believe
you've never heard of it.
________________________________________________________

I've never heard of it either.
douglas - 29 Sep 2008 20:26 GMT
> On Sep 28, 9:06 pm, "JEDilworth" <bactit...@nospamhortonsbay.com>
> wrote:
[quoted text clipped - 26 lines]
>
> - Show quoted text -

Where do you live?! http://en.wikipedia.org/wiki/Frappuccino
JEDilworth - 29 Sep 2008 23:26 GMT
I don't drink coffee - EVER (especially cold coffee). Ugh. We have a few
in our town but I never go in them. My husband buys their ground coffee.
I am in the upper Midwest (north Central).

Manky is in the UK. I have no idea how far Starbucks has expanded. Some
places don't have them on every corner.

What does this have to do with blood glucose??? How much sugar is in one
of those????

Judy Dilworth, M.T. (ASCP)
Microbiology
Manky Badger - 30 Sep 2008 23:06 GMT
>I don't drink coffee - EVER (especially cold coffee). Ugh. We have a few in
>our town but I never go in them. My husband buys their ground coffee. I am
[quoted text clipped - 5 lines]
> What does this have to do with blood glucose??? How much sugar is in one
> of those????

I've actually had one of those things. It was rather disgusting, and not
that sugary.
Manky Badger - 28 Sep 2008 17:35 GMT
>  If you feel intimidated by the doctor, ask your mother to step in.

That bit made me smile
JEDilworth - 28 Sep 2008 18:34 GMT
Quite possibly his mom may be intimidated by the doctor also. I admit
that's the main reason I got out of marketing - the doc intimidation
factor was something I couldn't overcome. Some of them have two faces:
one for their patients and another for marketing reps. It can get pretty
ugly....

Judy Dilworth, M.T. (ASCP)
Microbiology

That bit made me smile
douglas - 28 Sep 2008 23:41 GMT
On Sep 28, 10:34 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Quite possibly his mom may be intimidated by the doctor also. I admit
> that's the main reason I got out of marketing - the doc intimidation
[quoted text clipped - 6 lines]
>
> That bit made me smile

Actually, my doctor is extremely nice; he's young, too. Probably just
got out of residency. I'll just print out that vacutainer-color-codes-
and-what-they-mean sheet I found on the internet and give to him.

Btw, are chemistries supposed to use an SST, or a green-top tube?
JEDilworth - 29 Sep 2008 05:03 GMT
Depends on what tests are ordered and what lab they go to. There is no
easy answer to this question. Some labs use serum (SST tube), some use
plasma (green top). Also depends on which anticoagulant is present in
the green top (lithium or sodium heparin - latter is not used for
electrolytes due to obvious false elevation of sodium).

Best to check the specimen requirements in the catalog the lab provides.

Judy Dilworth, M.T. (ASCP)
Microbiology

Btw, are chemistries supposed to use an SST, or a green-top tube?
JEDilworth - 04 Oct 2008 18:31 GMT
Douglas,

You created quite a discussion on your low blood sugar. You should have
gotten your repeat results back by now. Please tell us the results. We
are all curious what is going on. Your silence is deafening....

Judy Dilworth, M.T. (ASCP)
Microbiology
douglas - 11 Oct 2008 03:22 GMT
On Oct 4, 10:31 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
wrote:
> Douglas,
>
[quoted text clipped - 4 lines]
> Judy Dilworth, M.T. (ASCP)
> Microbiology

90 mg/dL...NORMAL!
Manky Badger - 26 Sep 2008 21:38 GMT
On Sep 25, 11:47 pm, "Manky Badger" <you.m...@be.joking> wrote:

> As a matter of courtesy, it's probably best not to broadcast specific
> individual's names over the Internet.

There's around several million people w/ the name "Phan".
____________________________________________________

There's no helping you, is there?
douglas - 25 Sep 2008 01:50 GMT
> > On Sep 22, 10:33 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
> > wrote:
[quoted text clipped - 15 lines]
>
> Are you sure it isn't Dr Billass?

Please don't insult my physicians.
Robert - 25 Sep 2008 03:48 GMT
> > > On Sep 22, 10:33 am, "JEDilworth" <bactit...@nospamhortonsbay.com>
> > > wrote:
[quoted text clipped - 19 lines]
>
> - Show quoted text -

I wasn't insulting your physicians as much as questioning your posting
history motives as others here have noted.

I think your doctors are saints in having to deal with difficult
situations, hum patients.
douglas - 22 Sep 2008 16:22 GMT
> If you had a glucose of 37 you'd probably be passed out. Then they would
> take you to the ER and would perform glucose testing. They would
[quoted text clipped - 47 lines]
>
> - Show quoted text -

I will send you my lab results, then. The lab repeated it, twice.
 
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