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Medical Forum / General / Laboratory / April 2007

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Instrument Comparison Procedure--Help!

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JC - 09 Apr 2007 03:14 GMT
I recently took over a very small lab. This is my first lab manager
experience. The week after I started, I found out there was a new hematology
instrument in the storeroom that had a 30 day evaluation period and the
clock was ticking. I could use some advice on how to compare the old and new
methods. We only run about 5 samples a day. I've collected about 30
side-by-side results so far. I think I need to compare the correlation and
slope, but how do I decide what the cutoff is? For example, at the moment,
the correlation coffecient for WBCs is around .95, but the correlation for
plts is around.7. Is that good enough, or should the correlation be closer?
I'm really looking for some methodology that would help me with this
comparison and decision making.

Thanks,

JC
kuhnfucius - 09 Apr 2007 04:48 GMT
Streck produces linearity kit.  I recently did a plt linearity verfication,
FAXed the data and had the results back in two days.  The linearity
confirmed the manufacturer's reportable ranges and gave me my "cutoffs" (as
you say).
5 samples a day sounds like a POC rather than a small lab. (?).  The Streck
kits are expensive and your daily samples probably can't justify the
expense.  Correlation between instruments while necesarry, doesn't give you
your reportable limits on the new instrument (which are probably higher).
Each manufacture usually has an application specialist that will give you
advise.  good luck k
news:6khSh.1881$w41.1508@newssvr19.news.prodigy.net...
>I recently took over a very small lab. This is my first lab manager
>experience. The week after I started, I found out there was a new
[quoted text clipped - 11 lines]
>
> JC
Manky Badger - 09 Apr 2007 18:22 GMT
>I recently took over a very small lab. This is my first lab manager
>experience. The week after I started, I found out there was a new
[quoted text clipped - 7 lines]
>correlation be closer? I'm really looking for some methodology that would
>help me with this comparison and decision making.

Is such a comparison even valid?

Some time ago we went from Bayer/Technicon H1 to Sysmex XE 2100 and because
of the different technologies used the MCVs were very different.
We ran some two hundred samples, and the mean results had differences of
some 6 fl between the two machines.
In the end we just ran them and hoped for the best.

If you've got a new piece of kit, you're probably better off ensuring your
QC is spot on and your precision is up to scratch, and not worrry to much
about comparisons with what went before. If you do find a difference, what
are you going to do? Bias what you're getting towards what you used to have
:o)

Just my 2p worth :o)
JEDilworth - 09 Apr 2007 18:56 GMT
Five per day should be sent out to a reference lab. You are making
absolutely NO money on this procedure. By the time you spend money on
controls and pay for the equipment it will take you a LONG time to cover
your costs, let alone tech time.

How much are you doing of other procedures? Make a deal with a good
reference laboratory. Hopefully you're not attempting
microbiology.....it's frightening what little operations do with micro -
I've seen it.

I used to be a rep for an independent laboratory twenty years ago,
although I have been back in the lab since 1988. It DOES NOT PAY to do
small amounts of work. Your tech will not be proficienct. I used to have
a client who attempted workloads such as yours. I was asked to go in and
check their QC. It was a disaster. It obviously depends on the
certification of your techs, of course, and the management above you,
etc. I used to work in their draw station lab before I became the
marketing rep. Hematology was never my thing. We had absolute STRICT
guidelines on what had to be sent to the main lab and what I was allowed
to sign out. I was probably running abou 10-15 counts a day so I was
doing more than you are now! We did glucoses, protimes, urine pregnancy,
CBC's, mono spots, sodium and potassium. I was bored! Pretty much
everything else was sent to the main laboratory. Our draw station served
a large medical building. Looking back, it was probably a waste of money
to run that lab.

Sorry to be so negative. Reimbursement now are FAR worse than they were
in 1986. Look at your spread sheets!

Judy Dilworth, M.T. (ASCP)
Microbiology

>I recently took over a very small lab. This is my first lab manager
>experience.
 
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