> Question: After blood monitoring from my Neurologist
> who prescribes Tegretol and Depakote (both need blood
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> | http://georgenet.net |
> |======================================|
You don't say whether you are homozygous for the H63D gene.
The following information is taken from an abstract of a published article
(Ruiz-Argüelles GJ, Garcés-Eisele J, Reyes-Núñez V, Sánchez-Anzaldo J,
Ruiz-Delgado GJ, Jiménez-González C, et al
Heterozygosity for the H63D mutation in the hereditary hemochromatosis (HFE)
gene may lead into severe iron overload in b-thalassemia minor: Observations
in a thalassemic kindred
Rev Invest Clin 2001; 53(2): 117-120. )
b-thalassemia (minor) by itself does not lead into iron overload; however,
when it is inherited together with a homozygous state for either the H63D or
the C282Y mutations of the hereditary hemochromatosis gene (HFE gene), iron
overload may ensue and in turn, chronic liver failure with portal
hypertension.
(A Patient) being examined was heterozygote for b-thalassemia and the H63D
mutation of the HFE gene, developed severe iron overload, however, other
family members with the same inheritance, did not.
Assuming you are heterozygous for H63D:
If you are looking at having a family, make sure that you have children with
someone who is not thalassaemic, or a carrier of either common HFE gene
mutation (H63D or C2H2Y) as compound heterozygotes (with both mutations)
still develop iron overload. This will reduce the chances of having an
affected child, to 1 in 4 of passing on thallassaemia minor, 1 in 4 of
passing on hetero HFE and 1 in 16 of passing on both (this is to each
child).
Inheritance pattern for HFE can be looked at here:
http://www.cdnhemochromatosis.ca/disorder/inheritance.php
So, in summary:
marry outside your ethnic group, but never ask for a blood test on a first
date.
Regards
Marco
George Lewycky - 30 Jul 2006 23:49 GMT
Hi Marc
thanks for you reply:
I think I'm Hetero for the H63D gene - ill check it tmrow with my
paperwork.....
I enjoyed your humour on this too
Cheers
George
> > Question: After blood monitoring from my Neurologist
> > who prescribes Tegretol and Depakote (both need blood
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>
> Marco