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Medical Forum / General / Laboratory / February 2005

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Does Soda caffeine, coffee or tea reduce antibiotic effeciency?

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Adam - 13 Feb 2005 21:19 GMT
Hi all ,
I hope this group is an appropriate place to ask his:

If someone is taking some antibiotic, say, a course of penicillin
to treat an infection/inflamation/abscess ...

would you recommend such patients to avoid drinking
"soda" products like Cola (coke), Gingerale ...that contains
carbonic acid ( i think H2CO3 (H2O+CO2)) ?
would it reduce the absorption/efficiency of the antibiotic?

And...
would taking caffeine or the similar stimulating alkaloid, ...etc
like drinking considerable amount of coffee or tea ...
(or maybe ginsing..)
would this boosts up the effeciency of the penicillin or
other antibiotics or would it reduce the effciency of the medication
and obstruct its functionality?
(or would it have just no effect?)

if you don't have an answer, could you please
refer me to web resources/research done in this area that
you would recommend,

thank you very much in advance
Jeff - 14 Feb 2005 01:59 GMT
> Hi all ,
> I hope this group is an appropriate place to ask his:
[quoted text clipped - 6 lines]
> carbonic acid ( i think H2CO3 (H2O+CO2)) ?
> would it reduce the absorption/efficiency of the antibiotic

That would be a good question for  your pharacist or doctor.

I don't think that the carbonic acid would matter, especially because the it
is going into a stomach that is really acidic already.

> And...
> would taking caffeine or the similar stimulating alkaloid, ...etc
[quoted text clipped - 4 lines]
> and obstruct its functionality?
> (or would it have just no effect?)

Probably no effect.

> if you don't have an answer, could you please
> refer me to web resources/research done in this area that
> you would recommend,

scholar.google.com

Jeff
> thank you very much in advance
Robert - 14 Feb 2005 04:47 GMT
There are a variety of issues pertaining to way and antibiotic may work or
not work and absorption is only one them. Differing antibiotics can have
interactions which may inhibit activity or alter other drug interactions.
These are all antibiotic specific and the pharmacist will always have
warnings when other foods can inhibit absorption or drug interactions.
The other issue pertains to whether it is the appropriate antibiotic in the
first place which is dependent on conditions and site of activity. All
antibiotics are given in doses of minimum inhibitory concentrations MIC to
inhibit specific bacteria's. It is not meant to kill the bacteria but to
inhibit the bacteria from growing and then allowing the bodies own defenses
to finish the job.
Certain conditions such as diabetes can alter the host defense to allow
chronic infections to continue. The white cells have altered decreased
phagocytic activity because of the high glucose levels.
Antibiotics may not "cure" the infection in those situations. Wound care
centers have become common place because of these situations.
A soft drink because of the high sugar is not good for diabetics or anyone
else.
As far as tea goes it is well known that some do have positive
immunomodulatory effects.

Biofactors. 2004;21(1-4):119-21. Related Articles, Links

Protective effects of green tea catechins on alveolar macrophages against
bacterial infections.

Yamamoto Y, Matsunaga K, Friedman H.

Department of Basic Laboratory Sciences, Osaka University Graduate School of
Medicine, Suita 565-0871, Japan.

Bacterial pneumonia in immunocompromised patients as well as elderly persons
often becomes a life threatening disease, even when effective antibiotics
are used extensively. In addition, the appearance of antibiotic-resistant
bacteria in medical facilities as well as in patients requires another
approach to treat such patients besides treatment with antibiotics. In this
regard, green tea catechins, such as epigallocatechin gallate (EGCg), may be
one of the potential agents for such purpose due to its possible potential
immunomodulatory as well as antimicrobial activity. The studies by us showed
that EGCg enhanced the in vitro resistance of alveolar macrophages to
Legionella pneumophila infection by selective immunomodulatory effects on
cytokine formation. Furthermore, the tobacco smoking-induced impairment of
alveolar macrophages regarding antibacterial as well as immune activity was
also recovered by EGCg treatment. These results indicate that EGCg may be a
possible potential immunotherapeutic agent against respiratory infections in
immunocompromised patients, such as heavy smokers.

PMID: 15630181 [PubMed - in process]

> Hi all ,
> I hope this group is an appropriate place to ask his:
[quoted text clipped - 21 lines]
>
> thank you very much in advance
Robert - 14 Feb 2005 05:12 GMT
There are a variety of issues pertaining to way and antibiotic may work or
not work and absorption is only one them. Differing antibiotics can have
interactions which may inhibit activity or alter other drug interactions.
These are all antibiotic specific and the pharmacist will always have
warnings when other foods can inhibit absorption or drug interactions.
The other issue pertains to whether it is the appropriate antibiotic in the
first place which is dependent on conditions and site of activity. All
antibiotics are given in doses of minimum inhibitory concentrations MIC to
inhibit specific bacteria's. It is not meant to kill the bacteria but to
inhibit the bacteria from growing and then allowing the bodies own defenses
to finish the job.
Certain conditions such as diabetes can alter the host defense to allow
chronic infections to continue. The white cells have altered decreased
phagocytic activity because of the high glucose levels.
Antibiotics may not "cure" the infection in those situations. Wound care
centers have become common place because of these situations.
A soft drink because of the high sugar is not good for diabetics or anyone
else.
As far as tea goes it is well known that some do have positive
immunomodulatory effects.

Biofactors. 2004;21(1-4):119-21. Related Articles, Links

Protective effects of green tea catechins on alveolar macrophages against
bacterial infections.

Yamamoto Y, Matsunaga K, Friedman H.

Department of Basic Laboratory Sciences, Osaka University Graduate School of
Medicine, Suita 565-0871, Japan.

Bacterial pneumonia in immunocompromised patients as well as elderly persons
often becomes a life threatening disease, even when effective antibiotics
are used extensively. In addition, the appearance of antibiotic-resistant
bacteria in medical facilities as well as in patients requires another
approach to treat such patients besides treatment with antibiotics. In this
regard, green tea catechins, such as epigallocatechin gallate (EGCg), may be
one of the potential agents for such purpose due to its possible potential
immunomodulatory as well as antimicrobial activity. The studies by us showed
that EGCg enhanced the in vitro resistance of alveolar macrophages to
Legionella pneumophila infection by selective immunomodulatory effects on
cytokine formation. Furthermore, the tobacco smoking-induced impairment of
alveolar macrophages regarding antibacterial as well as immune activity was
also recovered by EGCg treatment. These results indicate that EGCg may be a
possible potential immunotherapeutic agent against respiratory infections in
immunocompromised patients, such as heavy smokers.

PMID: 15630181 [PubMed - in process]

> Hi all ,
> I hope this group is an appropriate place to ask his:
[quoted text clipped - 21 lines]
>
> thank you very much in advance
 
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