Home | Contact Us | FAQ | Search & Site Map | Link to Us
Sign In | Join | Other 45 Sites in Network
Home
Discussion Groups
General
GeneralCardiologyVisionDentistryPharmacyLaboratoryNutritionAlternative
Diseases and Disorders
AIDSAlzheimer'sArthritisAsthmaCancerBreast CancerDiabetesEpilepsyGlaucomaHepatitisHerpesLupusProstate BPHProstate CancerProstatitisSinusitisTinnitus

Medical Forum / General / Laboratory / June 2004

Tip: Looking for answers? Try searching our database.

usual suspects

Thread view: 
Enable EMail Alerts  Start New Thread
Thread rating: 
Leo - 28 Jun 2004 13:16 GMT
Amazing - I haven't been following the group for almost a year - and find
the usual knowledgable persons writing, helping each other - nice - and my
G... if it isn't the same old idiot still talking iron...

Well, I am in need of a clever head who perhaps by chance can come up with
an idea.
I am in my mid40'es - had my gall bladder removed a couple of years ago.
Feel quite fit, though a couple of pounds extra cannot be denied.
I contacted my GP after having had my homocysteine measured - just for fun -
a promotional gimmick from a company - it was of course elevated (!).
Well, never have a sample taken if you are not up to taking the
consequenses!
It was discovered that I suffered b12 and folic acid deficiency - and yes, I
was tired and my hair was falling off and was "lifeless" (so much for
feeling fit!) - hey, my father was bald, and my younger brother is , too- I
am now back to normal after having had a series of injections and am now on
oral medication. I am still tired - who isn't? My hair is back to its normal
grey!
Problem was that I now got in the hands of my GP - and he took several
tests - all except the vit Bs and gamma GT were OK. I know that if enough
parameters are analysed you are bound to find something out of range. Only -
my GGT irritates me. And I know that it has not always been too high.
My GP suspected I had a drinking problem because of the elevated GGT -  I do
not drink - and my CDT% is normal. I didn't drink a drop for half a year -
well, then everyone thought I did have a problem and started questioning it
;-)  -anyway,  it was still elevated. So now I drink - I think I may reach
maybe two sixpacks of beer this year - and perhaps a bottle or two of
redwine. Thats it! (Maybe not quite, but that is about the level of it -
there are months I don't drink any alcohol at all - )
I know that some 20 years ago my GGT was normal - when I was educated I had
several runs on my own samples on all kinds of parameters - just for fun, I
mean training.... I have discussed this with my gp, but he is kind of
hesitating to accept that I simply have no reason for this elevation. He
can't come up with any idea, that I can't "reject" - no alcohol, no
medication, nor OTCs. No other enzymes are elevated.And - I do not in any
way feel sick.
So any suggestions are welcome - what can cause my GGT to rise - any ideas??
Robert - 28 Jun 2004 19:36 GMT
> Amazing - I haven't been following the group for almost a year - and find
> the usual knowledgable persons writing, helping each other - nice - and my
[quoted text clipped - 33 lines]
> way feel sick.
> So any suggestions are welcome - what can cause my GGT to rise - any ideas??

Several ideas. From Dr. Wolfs "Clinical Enzymology".
You make no reference as to the degree of the elevation as in "times
normal".
GGT normal values increases with age.
Hypertriglyceridemia and an increased GGT often go together however that is
mainly in women.
Patients with diabetes often have abnormal GGT activities.
Obesity and hyperthyroidism and RA are others.

GGT has been one of the enzymes with known Macroenyzymes.
These are heterophile antibodies causing problems in the assay.
To test for interference
Dilute the specimen and test for linearity
Spike the standard into the specimen and test recovery.
Test the specimen with heterophile blockers and retest.
A lot of people can have non specific low affinity heterophile antibodies of
unknown origin. Potential sources have been proposed such as animal products
in the diet, animal environmental contacts and vaccines.
30-40% of the population has heterophile antibodies but because blocking
agents are incorporated in immunoassays they are usually not a problem. With
enzyme testing you usually see the Macroamylase pattern of high serum and
low urine levels is the model but because of inhibitors present in urine for
GGT it is not accurate to do the urine level.
Electrophoresis can reveal the altered pattern in isoforms.
Leo - 29 Jun 2004 09:21 GMT
> You make no reference as to the degree of the elevation as in "times
normal".

No - I don't remember the exact figures - but it wasn't just out of range -
it is way out of range. But other ezymes as fx alkaline phosphatases are
normal

> GGT normal values increases with age.
> Hypertriglyceridemia and an increased GGT often go together however that is
> mainly in women.
Yes but my lipid profile is very nice - to my doctors surprise as I really
enjoy a good meal.

> Patients with diabetes often have abnormal GGT activities.
Was checked - glucose is normal as is HbA1c.

> Obesity and hyperthyroidism and RA are others.
Obesity is a strong word - I have big bones! ;-)  I have always been to the
upper side of BMI, though I am not fat. I am short but rather broad. But of
course I could loose some pounds without disfiguring myself. TSH is normal.
Arthritis - no, but a bit of arthrosis in my fingers - I had this "new" test
run (is it called ant-CCP?) - nothing.

> GGT has been one of the....snip... pattern in isoforms.
Now that is interesting - i'll see if I can persuade one of the students to
make a report on this and use me as "guinea pig". Otherwise I think they'll
see it as too extensive for this problem.
Thank you for your time and interest!
 
Sign In
Join
My Latest Posts
My Monitored Threads
My Blog
My Photo Gallery
My Profile
My Homepage

Start New Thread
Enable EMail Alerts
Rate this Thread



©2008 Advenet LLC   Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.