Valtrex XR

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Anonymous - 11 Jun 2005 21:23 GMT

Hi all

Does anybody know much/anything about Valtrex XR?

I know that XR means "Extended release", but other than a listing on

http://www.phrma.org/newmedicines/

(Select New Medicines in Development and then Genital Herpes from the
pulldown menu)

I haven't found much

Thanks

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Angela S. - 14 Jun 2005 17:10 GMT

I've never heard of Valtrex XR... only Valtrex, Acyclovir, and Famvir to
treat herpes.

Angela

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> Hi all
>
[quoted text clipped - 10 lines]
>
> Thanks

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Tim Fitzmaurice - 15 Jun 2005 12:09 GMT

> I've never heard of Valtrex XR... only Valtrex, Acyclovir, and Famvir to
> treat herpes.

Its Valtrex eXtended Release form....its in trial at the moment - fairly
early phase (Phase I last time I looked) but should rattle through
quickly. As I understand it its a slow release tab that gives you
valacyclovir..I don't know if its simply a fancy tablet matrix and just
VACV, or if they modify the VACV chemically to give slow release, wild
guess suggests the first is more likely to me.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568

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Angela S. - 15 Jun 2005 17:39 GMT

I learned something new today.

Thanks Tim!

Angela :)

>> I've never heard of Valtrex XR... only Valtrex, Acyclovir, and Famvir to
>> treat herpes.
[quoted text clipped - 10 lines]
> When playing rugby, its not the winning that counts, but the taking apart
> ICQ: 5178568

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Angela S. - 17 Jun 2005 06:33 GMT

Tim,

Got any stuff I can read on the net about Valtrex XR ?

I'm too tired and lazy to search..

I should really be going to bed right about now..

It's 12:33 in the morning..

Thanks,

Angela :)

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Tim Fitzmaurice - 17 Jun 2005 07:57 GMT

> Tim,
>
> Got any stuff I can read on the net about Valtrex XR ?

Erm ,very little Im afraid. I just plugged a google search in for it. It
didnt raise very much. On the gsk site its very heavily buried, the
letters XR are used for extended release on a lot of their drugs so
valtrex and XR togther produce a mass of hits and you cannot force it to
search for Valtrrex XR as a single contiguous string.

www.phrma.org listed it at phase I.

I do wonder how much interest there will be in it....with spruance's work
on single dose interventino for HSV thats a lot of the market that may not
be interested, leaving shingles which is where it will presumably be
extremely useful but its a smaller market - and VACV itself is, when you
get down to it, pretty damn good in the first place....

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568

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Anonymous - 17 Jun 2005 17:22 GMT

>> Tim,
>>
[quoted text clipped - 15 lines]
>
> Tim

On a related note, how much better (bioavailability and blood-plasma
level-wise) is valacyvlocir over acyclovir?

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Angela S. - 19 Jun 2005 20:23 GMT

Not sure what you mean.. ?

Angela :)

---
Herpes Information
www.yoshi2me.com
www.herpes-help.org
www.herpesonline.org

> On a related note, how much better (bioavailability and blood-plasma
> level-wise) is valacyvlocir over acyclovir?

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Tim Fitzmaurice - 20 Jun 2005 16:12 GMT

> On a related note, how much better (bioavailability and blood-plasma
> level-wise) is valacyvlocir over acyclovir?

Erm Ive seen figures of Valacyclovir being 2-5 times more bioavailable
than acyclovir. Depends how they measure it, where they measure it (urine
or plasma) and how they do the dosing comparison and if they use peak
rates or area under the curve to decide.

As I understand it the clinical dosing is designed to use enough
valacyclovir to give the same clinical benefit as the acyclovir dosing so
in effect you are able to reduce the dosing schedule (ACV started at 5
times a day remember) and get the same effect. Thats the clinical change
they were after using the bioavailability.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568

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Angela S. - 19 Jun 2005 20:19 GMT

As a pregnant mom soon to be going back on suppressive therapy towards the
last six weeks of my pregnancy I sure would be interested in what they come
up with regarding a Valtrex XR time release formula.

Thanks for the phrma.org url.. I'll be sure and check it out. I did manage
to ask Terri Warren over on WebMD if she new anything about it and she
didn't seem to at the moment. I would ask Hunter Hansfield over on that
medhelp.org site but you have to pay in order to ask a question. I'm not
about to do THAT.. lol

Should be interesting to follow though..

Thanks Tim,

Angela :)

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>> Tim,
>>
[quoted text clipped - 18 lines]
> When playing rugby, its not the winning that counts, but the taking apart
> ICQ: 5178568

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Tim Fitzmaurice - 20 Jun 2005 16:14 GMT

> As a pregnant mom soon to be going back on suppressive therapy towards the
> last six weeks of my pregnancy I sure would be interested in what they come
> up with regarding a Valtrex XR time release formula.

Not sure how relevant they think it will be given the Spruance work on one
or two days of dosing being as effective as a course. It may be they are
looking at suppression, or it may be a commercial decision to give IP
protection to a new generation of the drug.
I could find very little on the GSK site, but the problem was there are so
many Valtrex references, and XR is a standard addition to their drug
names.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568

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