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Medical Forum / Diseases and Disorders / Herpes / September 2003

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Mr Roper - 29 Aug 2003 23:28 GMT
I read that a pregnant mother can pass along the H antibody to the unborn
baby which helps the baby from getting H itself. Does this mean the baby
will be resistant to getting H as he/she grows up?
arlyn - 29 Aug 2003 23:41 GMT
No.  As with most antibodies passed from the mother to the baby, they fade
soon after birth.

ar

> I read that a pregnant mother can pass along the H antibody to the unborn
> baby which helps the baby from getting H itself. Does this mean the baby
> will be resistant to getting H as he/she grows up?
M.L.S. - 30 Aug 2003 02:34 GMT
>I read that a pregnant mother can pass along the H antibody to the unborn
>baby which helps the baby from getting H itself. Does this mean the baby
>will be resistant to getting H as he/she grows up?

That's a good question, and one I wasn't prepared to answer without
some research, but I believe now I finally understand it, though I'm
always ready to be corrected if need be.

This link gave me most of it:

http://www.bibl.liu.se/liupubl/disp/disp99/Med598s.htm

What it says is that carrying a baby is a huge immunological challenge
to the mother, because the baby is half made up of the father's genes.
If the mother's immune system had full access to the baby, with all
its male bit and blobs, it would think most of it a foreign object and
try to get rid of it.  In fact, some women lose their babies because
of a fault (if working too well is a fault) wherein their own
antibodies actually terminate the pregnancy.

To prevent that happening more often than it does, pregnant women are
equipped with something called a "fetomaternal barrier" which
separates the mother's and child's blood supplies, and other things.
However, certain antibodies, or maybe just the IGG antibodies, are
able to cross the barrier.  It is the IGG antibodies that are the main
virus fighting agents in our blood streams, though antibodies can
wander into or between cells, too (I think).  So that's how fetuses
are given a temporary supply of the mother's HSV IGG antibodies.

However, because of the fetomaternal barrier, and possibly because a
baby's immune system doesn't get going on its own until several months
after birth, what the baby doesn't have in its blood are the coded B
cells that know how to manufacture IGG antibodies.  The baby can't use
the mother's B cells because they would quickly target all the newly
foreign male antigens that the baby is half made up of.  Instead the
baby has to learn to distinguish its own foreign invaders on its own,
and then manufacture its own B cells from scratch, which in turn will
be there when a virus stumbles in years later.

After delivery, the IGG antibodies donated from the mother find they
have nothing to do and so fade from the system.  If HSV is encounted
later in life the body really has no record of having been associated
with it before, and so has to go through the Primary crap.

Hope that helps.  Interesting stuff, at least to me.

Of other interest, I read tonight, and remembered I'd heard it before,
just as the mother's antibodies confer a "passive immunity" on the
unborn or newborn child, it is possible to collect antibodies to some
diseases, say Hepatitus A, and inject them into a person who is
travelling to, say, a Hepatitus ravaged area of the world, and thereby
confer a sort of temporary immunity on the traveller.

That and a little more is here:

http://kidsdirect.net/BD/infants/vaccines/how.htm

Take care,

Mike
Mr Roper - 30 Aug 2003 05:19 GMT
Cool...yea, I thought that question would stir some activity here  ha ha
Angela - 03 Sep 2003 12:57 GMT
Once the baby is delivered ... the antibodies are no longer shared unless
the mother chooses to breastfeed for the next six months. :) By the way you
guys ~ I am 23 weeks pregnant! (For those that didn't know... You can find
more information on herpes and pregnancy on this web site:
http://members.cox.net/yoshi2me/Links/Links.htm .
~Angela

> I read that a pregnant mother can pass along the H antibody to the unborn
> baby which helps the baby from getting H itself. Does this mean the baby
> will be resistant to getting H as he/she grows up?
maree - 04 Sep 2003 08:01 GMT
By the way you guys ~ I am 23 weeks pregnant!

Good for you Angela. You must be due early in the new year. Have you got any
names picked out? I'll knit some cyber booties for you.
Regards, Maree
Angela - 04 Sep 2003 16:53 GMT
Hi Maree~

I have a name that I like but I'm waiting for my husband to come up with a
name that he likes. :)
Will let everybody know what her name will be when we come to some sort of
agreement! lol
I'm due on December 28th. I'm still having a difficult time trying to figure
out why the docs here in the states go with a 40 week pregnancy because the
way I see it ~ this baby is coming in the first two weeks of December! lol

~Angela

> Good for you Angela. You must be due early in the new year. Have you got any
> names picked out? I'll knit some cyber booties for you.
> Regards, Maree
M.L.S. - 04 Sep 2003 13:54 GMT
>Once the baby is delivered ... the antibodies are no longer shared unless
>the mother chooses to breastfeed for the next six months. :) By the way you
>guys ~ I am 23 weeks pregnant!

Congratulations, Angela.  Any word on whether it's a boy or a girl?

Keep up the good work, and remember, you're typing for two, now.

Mike
Angela - 04 Sep 2003 16:53 GMT
Hi Mike~

We found out that we are going to have a little girl three weeks ago.
It was funny because my husband saw the umbilical cord and started to call
the baby a "he".
The ultrasound specialist told him to hold his horses because we didn't get
to that part yet and that he was going to jinx himself. lol I just laughed
and laughed when she told him that part! lol Then we were both shocked and
surprised when she said it was a little girl after finally getting to the
part where she could shoot a picture of the genitals.

You're right Mike ~ I'm definitely typing for two now! lol :)

~Angela

> >Once the baby is delivered ... the antibodies are no longer shared unless
> >the mother chooses to breastfeed for the next six months. :) By the way you
[quoted text clipped - 5 lines]
>
> Mike
 
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