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Medical Forum / Diseases and Disorders / Herpes / August 2004

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Valtrex and Denavir...for HSV-1 or COLDSORES!

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brandon - 14 May 2004 17:11 GMT
I have found that 1000mg of Valtrex at the first sign of an outbreak
and the another 1000mg 12 hours later can dramatically reduce the size
and duration of an outbreak. I also use a creme called Denavir.
Denavir is better than anything sold over the counter because it is an
actual anti-virus. These two drugs are the latest in fighting HSV.

As far as preventitive measures go, I have found that cutting out
nuts, oj, sugars, sunlight, stress, and aggitation of the skin play a
huge roll in not having outbreaks at all. You might want to take in
more of the Amino acid called Lysine. Normally found in Milk, Cheese,
and Yogurt, this amino acid invades normal healthy cells and makes it
harder for the virus to reproduce. Lysine could also be found in
fruits like Apricot and Mangos. Finally... Protect your skin from the
sun! Herpes virus loves sun burnt lips...

Hopefully with the help of your Doctor you can get Valtrex and Denavir
at you local pharmacy to combat outbreaks. With a simple change in
diet you can reduce the number of outbreaks altogether! I went from 6+
major a year to 1-2 minor sometimes unnoticable outbreaks. One year I
actually went outbreak free!
Tim Fitzmaurice - 14 May 2004 19:45 GMT
> I have found that 1000mg of Valtrex at the first sign of an outbreak
> and the another 1000mg 12 hours later can dramatically reduce the size
> and duration of an outbreak. I also use a creme called Denavir.
> Denavir is better than anything sold over the counter because it is an
> actual anti-virus. These two drugs are the latest in fighting HSV.

Denavir is not actually the latest, its been around quite a while, with
something of a hiatus for a while because it was spun out of the Glaxo
and Smithkline merger and in some places is sold as Vectavir - Abreva is
the most recent though its only just crossing territories sort of as we
speak\ and penciclovir [the drug in Denavir] predates both the prodrugs
(Valtrex and Famivir)...also note that in some places acyclovir cream is
also available over the counter...

The company that makes it is trying to get it over the counter to make it
easier to get...and IIRC the penciclovir patent finishes in about 2007
(it got published in 1987 and 20 years fron there) so its not long before
someone can go for generic too....

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568
brandon - 15 May 2004 03:20 GMT
> > I have found that 1000mg of Valtrex at the first sign of an outbreak
> > and the another 1000mg 12 hours later can dramatically reduce the size
[quoted text clipped - 16 lines]
>
> Tim

OK maybe they arent the latest but they are the best. Also, I want to
note that Abreve is NOT a anti-virus and works by effecting the
healthy cells so the virus cant intrude them. I have tried Abeve and
have had little success with it.
Pain Devine - 02 Jun 2004 07:40 GMT
Well, it says "Anti-Viral" right on the friggen tube. So it's either lying
on the label... or your wrong. I wouldn't be surprised if the label was
lying though.

> > > I have found that 1000mg of Valtrex at the first sign of an outbreak
> > > and the another 1000mg 12 hours later can dramatically reduce the size
[quoted text clipped - 21 lines]
> healthy cells so the virus cant intrude them. I have tried Abeve and
> have had little success with it.
Tim Fitzmaurice - 02 Jun 2004 08:27 GMT
> > > someone can go for generic too....
> > >
[quoted text clipped - 3 lines]
> > note that Abreve is NOT a anti-virus and works by effecting the
> > healthy cells so the virus cant intrude them. I have tried Abeve and

Thats heavily on the semantics of what is or isnt an antiviral - there are
those who would say that interferon is not an antiviral compound because
it triggers an immune system cascade that then deals with the virus and
only the nucleoside analogues are true antivirals and its an extention
from microbiology. Most people view in the field is that if it has a
specific or selective action that interferes with the virus lifecycle and
doesnt simply blast everything out of existence its reasonable to describe
it as an antiviral - basically because of the weird biological state of
viruses of being biologically active but not fulfilling the standard
criteria of life.

One paper that indicates this dichotomy is the following

Brown, McCrary and Tyring (2002) Antiviral Agents: Nonantiviral drugs.
Journal of the American Academy of Dermatology Vol 47, p581-599
Where the writer has sat on the fence. Antiviral they are but he steps
away from the phrase 'Antiviral Drug' and uses antiviral agent. Antiviral
is antiviral to my mind and that of most other people. You will alswys see
someone stand up and do this semantic argument whenever something that
doesnt hit the DNA is described as being an antiviral, being antiviral in
action, having antiviral properties or being an antiviral agent. The usual
response is along the lines of 'this semantic argument has been dealt with
many times, the current view is this is a reasonable description'

Abreva selectively interferes with enveloped viruses replication.
One standard paper on the stuff;
KatzDh et al (1991) Antiviral activity of 1-docosanol, an inhibitor of
lipid-enveloped viruses including herpes simplex. PNAS USA Vol 88,
10825-10829

Yes that particular paper is old but the view still holds as the argument
over antiviral/drug/agent/action/etc has raged since interferon was
compared with ACV et al in the 80s and most people in the field do
consider it to be antiviral due to its selective action and specific
interference of a lifecycle pathway (ie cellular entry) - certainly ISAR
accept papers on it for ICAR and their brief is antivirals.

So I'll stand by describing it as an antiviral (and accept it being
marketed as such) while agreeing there is this argument around which some
adhere to based on the semantics of what the word antiviral means in what
precise context...ie yes it is not a classic antiviral that interferes
with the DNA replication step.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568
ColdSoreGone.com - 02 Aug 2004 21:55 GMT
Actually, the latest is "Viroxyn".

It's a tincture of benzalchonium chloride in a vial which works as a
germicidal to kill the active virus in the lesion.

Pain and burning gone in 15 to 20 minutes. And the lesion heals in most
cases in 3.6 days.

See it here:

www.ColdSoreGone.com

Allen

> Well, it says "Anti-Viral" right on the friggen tube. So it's either lying
> on the label... or your wrong. I wouldn't be surprised if the label was
[quoted text clipped - 30 lines]
> > healthy cells so the virus cant intrude them. I have tried Abeve and
> > have had little success with it.
jankin - 03 Aug 2004 20:52 GMT
> Actually, the latest is "Viroxyn".
..

Their own literature says:
"Quadex believes that the technology used in ViroxynÆÊ may someday be
scientifically proven useful in the treatment of other cutaneous
herpes virus infections."

"believes", and "someday" - fair enough, I guess.  And the usual
"testimonials".  Show me the peer-reviewed work, and perhaps I'll
look at it.
ColdSoreGone.com - 12 Aug 2004 19:50 GMT
We've recently updated our website to include clinical studies for you on
the effectiveness of Viroxyn for the treatment of HSV-1, as "cold sores".

Web www.ColdSoreGone.com

Allen

In article <NSxPc.13683$Je5.12663@nwrddc03.gnilink.net>,
info@ColdSoreGone.com says...
> Actually, the latest is "Viroxyn".
..

Their own literature says:
"Quadex believes that the technology used in ViroxynÆÊ may someday be
scientifically proven useful in the treatment of other cutaneous
herpes virus infections."

"believes", and "someday" - fair enough, I guess.  And the usual
"testimonials".  Show me the peer-reviewed work, and perhaps I'll
look at it.
Pain Devine - 14 May 2004 21:42 GMT
There IS an over the counter anti-viral cream sold at any drugstore... I
forget the name but it's around $15 for a tiny little tube. It works great!
M2slo2cht@nospam.invalid - 14 May 2004 22:47 GMT
>There IS an over the counter anti-viral cream sold at any drugstore... I
>forget the name but it's around $15 for a tiny little tube. It works great!

Your description (otc, tiny tube, $15) sounds like the Abreva that Tim
mentioned.

M2
S-Unit - 15 May 2004 23:23 GMT
Hi there :)

I read somewhere that the HSV actually will depreciate in severity
and eventually fade to the point where a person may have no outbreaks
after five years? Is this at all true?

-- S

> I have found that 1000mg of Valtrex at the first sign of an outbreak
> and the another 1000mg 12 hours later can dramatically reduce the size
[quoted text clipped - 16 lines]
> major a year to 1-2 minor sometimes unnoticable outbreaks. One year I
> actually went outbreak free!
Grant - 15 May 2004 23:30 GMT
Yes, it is true.  What generally happens is that as your body becomes more
and more familar with dealing with the herpes virus, it becomes better at
fighting off outbreaks.

ar

> Hi there :)
>
[quoted text clipped - 24 lines]
> > major a year to 1-2 minor sometimes unnoticable outbreaks. One year I
> > actually went outbreak free!
maree - 16 May 2004 12:16 GMT
Herpes is extremely individual. Some people never get outbreaks, some notice
they taper off over a period of time, and some continue to get outbreaks for
20+ years - but fortunately, they are very much in the minority.

It also depends a good deal on your present state of health too, and how
well you look after yourself.

I would go for long intervals without an outbreak, but now that I'm entering
the perimenopausal phase of my life, they are making somewhat of a comeback.
Any situation where the body is stressed, can cause an outbreak, regardless
of the length of time you've had the virus.

Regards, Maree

> Hi there :)
>
[quoted text clipped - 24 lines]
> > major a year to 1-2 minor sometimes unnoticable outbreaks. One year I
> > actually went outbreak free!
brandon - 17 May 2004 17:47 GMT
True... Most people will have less outbreaks with age but since there
is no cure (yet), its a life sentence.
brandon - 17 May 2004 17:52 GMT
True... Most people will have less outbreaks with age but since there
is no cure (yet), its a life sentence.
 
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