No asymptomatic shedding means no OB?

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Perl Molson - 29 Oct 2003 16:12 GMT

It sounds like a beginner question but I can't
recall if I came across this type of question before.

So, presumming that all of the herpes viruses that have been
shedding asymptomatically have died, by various means, whether
taking valtrex or similar pills or through a different treatment
(naturistic),
in this case, how can the viruses situated in the hidden location like
the trigeminal ganglia or sacral ganglia, for type 1 and 2 herpes,
find the way to the OB location.

It was supposed to (the herpes virus) be reativated and cause the OB
in
about the same location; since the trace of the last OB is now gone,
do you see my question?

Secondly, of course, it is practically possible for the body to
get rid of all the shedding viruses? In which context- only under
medication such as valtrex etc?

Looking forward to some of our experts like Tim Fritzmaurice or Mike
to clarify the issue.

As my understanding at the moment goes, the herpes
virus located in the ganglia, when reactivated, they get electrical
charged
from some ions such as K+, Na- Cl+, (you name it) and then follows
some type
of path like an electric current flow.

What was first the egg or the hen?
Greatly appreciated in advance,

Perl Molson

P.S. Folks, did you knew about this forum?

http://www.healthboards.com/cgi/forumdisplay.cgi?action=topics&forum=Herpes&number=63

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Tim Fitzmaurice - 29 Oct 2003 17:44 GMT

> So, presumming that all of the herpes viruses that have been
> shedding asymptomatically have died, by various means, whether

Big presumption on long term shedding. Short term, well shedding looks
episodic so it'll happen on each occasion if thats the case.

> in this case, how can the viruses situated in the hidden location like
> the trigeminal ganglia or sacral ganglia, for type 1 and 2 herpes,
> find the way to the OB location.

Well they are the source of each episode. The ganglion is not a remote
structure....it only contains parts of cells.

A nerve cell has three bits (for our purposes here). The Axon, the dedron
and the cell body. When we are talking the neres going out to the edges of
the body the ganglion is where all the cell bodies are. The axons extend
from here all the way to the skin surface they innervate, while the
dendrons connect up to the spinal cord. Yes that means one single cell
does the entire half metre length from your spine yo your finger tip.
"Nerves' are not a series of cells end to end, but a bunch of cells side
by side.

As such all they have to do is replicate from the reservoir DNA, hop onto
the axon fibres and trot down using the various motor systems. If you want
to see the conxcept of ho such things exist - well our muscles are based
on one - the actin-myosin motor - a quick google search shoul find plenty
on that.

> Secondly, of course, it is practically possible for the body to
> get rid of all the shedding viruses? In which context- only under
> medication such as valtrex etc?

Short term, yes - each episode has virions cleared ultimately by the
immune system, or if a drug interferes with replication by intenral
enzymes breaking down the knackered virus circles.

Long term the problem is the parental DNA doesn't get clobbered. As such
its a permanent source for virus to be replicated from and released. Thats
the sort of target something like antisense molecules could try to hit.

> As my understanding at the moment goes, the herpes
> virus located in the ganglia, when reactivated, they get electrical
> charged

Not really. The herpesvirus particles don;t just sit there. There is a
circle of DNA that will activate and start copying itself, those copies
then migrate into the capsids they themselves make. The Capsids then
migrate picking up an envelope of membrane to form the final virion
particle. Those migrations will more likely be more specific than simply
picking up a charge. Biomotors can be pretty specific, as can various
chaperones. But here we get into unexplained areas.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568

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Perl Molson - 30 Oct 2003 16:18 GMT

> > So, presumming that all of the herpes viruses that have been
> > shedding asymptomatically have died, by various means, whether
[quoted text clipped - 49 lines]
>
> Tim

Thanks.
I recall about a year ago I have addressed the same kind of questions
in this group and the biomotors and actin-myosin motor and all that
kind of got me to a dead end.
I will try to see now how I can currently understand
the issues. Interesting stuff. Kind of busy these days, though.
http://www.cvri.ucsf.edu/CVRIDocuments/Training/Brochure97/Summaries%2097.html
http://www.cwru.edu/dental/web/neuro/af.html
I will get my old related posts to see what's cookin' there.

Perl Molson

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