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Medical Forum / Diseases and Disorders / Herpes / June 2006

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Proposed addition to the Herpes in human coronary arteries

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DrMaynardi - 25 Jun 2006 01:16 GMT
www.healthline.bravehost.com

Proposed addition to the Herpes FAQ.
Evidence of type 2 herpes simplex infection in human coronary arteries
at the time
of coronary artery bypass surgery

www.healthline.bravehost.com
What Is Coronary Artery Disease?

Coronary artery disease (CAD) occurs when the arteries that supply
blood to the heart muscle (the coronary arteries) become hardened and
narrowed. The arteries harden and narrow due to buildup of a material
called plaque (plak) on their inner walls. The buildup of plaque is
known as atherosclerosis (ATH-er-o-skler-O-sis). As the plaque
increases in size, the insides of the coronary arteries get narrower
and less blood can flow through them. Eventually, blood flow to the
heart muscle is reduced, and, because blood carries much-needed oxygen,
the heart muscle is not able to receive the amount of oxygen it needs.
Reduced or cutoff blood flow and oxygen supply to the heart muscle can
result in:

Angina (AN-ji-na or an-JI-na). Angina is chest pain or discomfort that
occurs when the heart does not get enough blood.
Heart attack. A heart attack happens when a blood clot develops at the
site of plaque in a coronary artery and suddenly cuts off most or all
blood supply to that part of the heart muscle. Cells in the heart
muscle begin to die if they do not receive enough oxygen-rich blood.
This can cause permanent damage to the heart muscle.
Over time, CAD can weaken the heart muscle and contribute to:
Heart failure. In heart failure, the heart can't pump blood
effectively to the rest of the body. Heart failure does not mean that
the heart has stopped or is about to stop. Instead, it means that the
heart is failing to pump blood the way that it should.
Arrhythmias (a-RITH-me-as). Arrhythmias are changes in the normal
beating rhythm of the heart. Some can be quite serious.
CAD is the most common type of heart disease. It is the leading cause
of death in the United States in both men and women.
www.healthline.bravehost.com
M2slo2cht@nospam.invalid - 27 Jun 2006 20:34 GMT
I know of no connection between Type 2 Herpes and Coronary Artery
Disease.  And after reading your post I STILL know of no connection.
Neither do I see it on the webpage you listed. Did you inadvertantly
leave something out?
M2

>www.healthline.bravehost.com
>Proposed addition to the Herpes FAQ.
>Evidence of type 2 herpes simplex infection in human coronary arteries
>at the time
>of coronary artery bypass surgery

>www.healthline.bravehost.com
>What Is Coronary Artery Disease?
[quoted text clipped - 27 lines]
>of death in the United States in both men and women.
>www.healthline.bravehost.com
Tim Fitzmaurice - 28 Jun 2006 08:57 GMT
> I know of no connection between Type 2 Herpes and Coronary Artery
> Disease.  And after reading your post I STILL know of no connection.
> Neither do I see it on the webpage you listed. Did you inadvertantly
> leave something out?

Its a recent thing IIRC....some recent papers...

Kotronias D, Kapranos
Herpes simplex virus as a determinant risk factor for coronary artery
atherosclerosis and myocardial infarction.
In Vivo. 2005 Mar-Apr;19(2):351-7

These authors conclude there is a connection....

Schlitt A, Blankenberg S, Weise K, Gartner BC, Mehrer T, Peetz D, Meyer J,
Darius H, Rupprecht HJ.
Herpesvirus DNA (Epstein-Barr virus, herpes simplex virus,
cytomegalovirus) in circulating monocytes of patients with coronary artery
disease.
Acta Cardiol. 2005 Dec;60(6):605-10.

These guys are less inclined to go with the idea but then they are looking
at circulating cells that might be involved.

If you go back further then you find things like this that are the genesis
of the idea..

Raza-Ahmad A, Klassen GA, Murphy DA, Sullivan JA, Kinley CE, Landymore RW,
Wood JR
Evidence of type 2 herpes simplex infection in human coronary arteries at
the time of coronary artery bypass surgery.
Can J Cardiol. 1995 Dec;11(11):1025-9.

also related things like hypertension get a mention....
Sun Y, Pei W, Wu Y, Jing Z, Zhang J, Wang G.
Herpes simplex virus type 2 infection is a risk factor for hypertension.
Hypertens Res. 2004 Aug;27(8):541-4

A quick look does suggest to me that the ideas may still be struggling
with chicken and egg issues a bit, but there would appear to be something
going on...and even if it aint causative if its active in this sort of
area its not something you really want to see.

IIRC Cytomegalovirus has a longer history fo association with this sort of
thing and so they probably started spotting HSV by trying to use it as a
control and realising it was there - as a guess he hastens to add.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568
M2slo2cht@nospam.invalid - 29 Jun 2006 03:30 GMT
>Its a recent thing IIRC....

Thanks Tim.
I couldn't make sense of the original post. There was just enough
there to pique my interest but appeared as if important parts of
sentences and statements were left out (typos maybe?)

>even if it aint causative if its active in this sort of
>area its not something you really want to see.

Considering Coronary Artery Disease is the #1 killer in the US (for
both men and women), with more deaths than the next SIX causes
combined, practically *every*thing must have a hand in it.

It'll be interesting to see if anything ever comes of a possible H
connection though.  Even if only settlement of the chicken/egg issue.

Just what we need. Another can o' worms.

M2
 
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