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Medical Forum / Diseases and Disorders / Herpes / December 2005

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Friggin herpes!

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Al - 17 Dec 2005 03:37 GMT
I guess I spoke too soon about not having painful outbreaks. Now I have a
sore on the genitals and its rather painful and raw feeling. Herpes always
manages to throw me a curved ball. What a nice Christmas present!
Perl Molson - 17 Dec 2005 05:19 GMT
http://www.bactine.com/spray.htm#Ingredients

Dude, buy  this spray. It will do it.

Perl von Molson
Al - 17 Dec 2005 18:05 GMT
I thought that bactine was for cuts and burns. I am not sure I can use it on
the genitals on herpes. This is like a small sore on the side of the shaft.
I'll try it if it works but I don't want to make it worse.

> http://www.bactine.com/spray.htm#Ingredients
>
> Dude, buy  this spray. It will do it.
>
> Perl von Molson
M2slo2cht@nospam.invalid - 17 Dec 2005 19:04 GMT
>I thought that bactine was for cuts and burns.

... and bacteria. Not viruses.
I've heard stranger strategies though. We used to have an advocate
here for frozen peas. Said to just place the bag on the affected area
to make it feel better. And there was the Tea Tree Oil advocates. Same
application directions.
But as long as we're passing out non-FDA approved suggestions, here's
mine:  Buy yourself a tube of Abreva (about $14 American). It's a tiny
tube but the stuff goes a long way. Just dab it on and rub it in a few
times a day.  A couple of people here have raved about it and one or
two had dismal results. Only way to find out if it'll work for you is
to give it a shot.
Naturally, I would normally suggest starting on antivirals but it
sounds like you're a little late for that. You'd need to start pills
immediately for them to do much good. Starting at the first sign of
prodrome is even better.
Anyhow, good luck, and let us know how you're doing.

M2
Grant - 17 Dec 2005 19:46 GMT
And you can always take over-the-counter pain killers for pain and swelling.

ar
Al - 17 Dec 2005 22:26 GMT
Well thanks. I cannot take Ibuprofen because it bothers my stomach and I am
taking Prevacid for that reason. I found Abreva is okay sometimes and
Tylenol also. I take these sometimes when I get more unbearable pain from my
herpes. I also tried nupricainal per my girlfriend to put on the sores.
That's what she uses and her OB-GYN recommended it. I think I tried Tea Tree
Oil and it was too strong. I think I might have tried Abreva also, but not
much good. By the way, Abreva is $18.00 a tube where I live in RI. I cannot
even remember where I put the Abreva now... Plus I think I am getting a
coldsore because my top lip was burning and pinching earlier today, but I
didn't see any sores there.

> And you can always take over-the-counter pain killers for pain and swelling.
>
> ar
Grant - 18 Dec 2005 01:41 GMT
What about buffered aspirin?

ar

>Well thanks. I cannot take Ibuprofen because it bothers my stomach and I am
>taking Prevacid for that reason. I found Abreva is okay sometimes and
[quoted text clipped - 11 lines]
>>
>> ar
Tim Fitzmaurice - 19 Dec 2005 09:35 GMT
> What about buffered aspirin?

If an NSAID like ibuprofen is causing problems then its pretty likely that
the aspirin will IIRC my limited pharmacology.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568
Grant - 19 Dec 2005 11:45 GMT
I don't know.  I know aspirin bothers me and doctors were always trying to get
me to take buffered aspirin.  But then ibuprofin came out and that took care of
that problem for me.

ar

>> What about buffered aspirin?
>
[quoted text clipped - 5 lines]
>When playing rugby, its not the winning that counts, but the taking apart
>ICQ: 5178568
Tim Fitzmaurice - 19 Dec 2005 12:26 GMT
> I don't know.  I know aspirin bothers me and doctors were always trying to get
> me to take buffered aspirin.  But then ibuprofin came out and that took care of
> that problem for me.

Yes thats the other way round though - aspirin is a MUCH messier drug
compared to ibuprofen so you can lose (potentially) a fair number of side
effects by switching to ibuprofen....but going the other way usually means
side effects still happen from my understanding of the drugs in question.

Tim
--
When playing rugby, its not the winning that counts, but the taking apart
ICQ: 5178568
Perl Molson - 18 Dec 2005 02:21 GMT
http://viroxyndirect.com/ExecutiveSummary.pdf
read and compare (where are those old good times when you could just
say RTFM? nevermind, just kidding)

Perl von Molson

P.S. I've posted another answer but I don't see it popping-up here so
I've tried this one now.
Perl Molson - 18 Dec 2005 03:01 GMT
DrugFacts .
Active ingredient Purposes
Benzalkonium Chloride, 0.13%
..............................................................Cold Sore
/ Fever Blister Treatment
Topical Antiseptic

Al, I should rather, say: RTFM, but it's not the case in your
situation.
I know, during an OB even the brain doesn't seem to function as it used
to the mild fever-like symptoms
are pretty draining on our body and mind.

Anyway, back to the topic, I've posted before an article about
Benzalkonium Chloride,
the whole story is in here, a product that contain the same ingredient
in the o.13%
as the product I've mention, that is bactine.
Besides, the other Bactine's component, a derivative of cocaine,
Lidocaine hydrochloride 2.5% w/w (Pain reliever)
it's additionally added for the purpose of relieving the pain.

In fact, Al, Benzalkonium Chloride alone can relieve the pain as seen
here: (you can buy a similar product that have
even only Benzalkonium Chloride in it, but I would say additionaly
Lidocaine may be even better).

·User reports that Viroxyn® (basically Benzalkonium Chloride, Al) is
immediately effective; it can be used at any stage of the infection.
·User reports that when the sore is in full-ruptured weeping stage,
the product stops the cold sore's progress
in a matter of minutes.
·User reports of reduction/elimination of pain caused by the HSV
virus within 10 to 30 minutes.
If you read the article, you will find out that Benzalkonium Chloride
http://viroxyndirect.com/ExecutiveSummary.pdf
History of Clinical Development
Following the development of a product and packaging design that would
be ideally suited to human use,
the Company continued its efforts with a literature search to learn if
work done by others might lend
support to this new approach to treating herpes lesions. It was found
that Benzalkonium chloride, the active
ingredient in ViroxynÒ, has demonstrated in vitro germicidal efficacy
against HSV-1 and HSV-2
(Kawanda, et al., 1997; also Belec, et al., 2000). Additionally,
benzalkonium chloride has been shown to
have germicidal activity within 1 minute against HSV-1 in the presence
of whole human blood (Wood and
Payne, 1998).
In addition to patient case reports from dentists and numerous
testimonials received by the firm from
individuals who desired to use the drug on themselves during the
development process, an open label
human pilot study was conducted under IRB supervision. In this study,
use of Viroxyn was compared to the
average natural history literature value of 10 days to healing
(Essman, 2000). Patient population (n=41)
consisted of a mix of naturally occurring cold sores (44%) and UV
induced cold sores (56%). The clinical
study (QL01-1-01) was conducted at an independent study site by a
Board Certified Dermatologist. Both
study arms had similar demographics. The endpoint for healing was loss
of scab and return to intact skin.
Using this endpoint, the Intent To Treat (ITT) population for both
groups showed a mean time to healing of
5.4 days (median = 4.4 days) versus the literature value of 10 days
(S.D. = 2.6 days). The ITT population
included all patients who developed disease and were issued drug
whether or not they treated their lesions
with study drug or were later withdrawn for protocol violations (eg:
using prohibited medications) or who
were lost to follow-up. (Patients lost to follow-up and patients who
were withdrawn were handled as "last
observation carried forward" to the maximum literature value of 10
days. Patients who developed second
cold sores or who experienced secondary lesions, but who did not treat
with study drug were followed to
complete healing of all lesions and the total time to healing was used
in the ITT analysis.)
A "per protocol" analysis was also done. Patients who were lost to
follow-up, who were withdrawn, or who
experienced second cold sores or secondary events and did not treat
with study drug were excluded from
the this analysis. When the "per protocol" analysis was done the
combined groups showed a mean time to
healing of 3.6 days (median = 3.4 days) versus the literature value of
10 days. (S.D. = 1.1 days)
This is significant to the oral herpes sufferer in that medications
already approved by FDA have only been
shown to improve time to healing by approximately one day when
compared to the placebos in the studies.
The pilot study provided a basis for filing an IND and proceeding with
Phase II human clinical trials. A
Phase II human clinical study was begun in summer of 2002. The
clinical portion of the Phase II trial for
Viroxyn (oral herpes indications) was completed on March 11,2003. The
trial design was for the enrollment
of 180 patients and randomized blinded treatment of 120 patients.
Analysis of the data is not yet complete
and a final report is not yet available.
In preparation for submitting a New Drug Application to FDA, the
company's technical team is working
feverishly on a scientifically sound protocol to test the safety and
efficacy of this new and innovative
technology on cutaneous Herpes Genitalis lesions. Future trials will
also test the drug to obtain FDA
approval for label indications allowing the treatment of genital
herpes that present on the genital mucosa.
These efforts will be followed up with work to test a variant of the
drug on cutaneous lesions caused by
Herpes Zoster (shingles). The Company is also considering the
development of a variant that may be used
to treat Ocular Herpes.
Angela S. - 18 Dec 2005 22:31 GMT
With as much trouble as you have been having lately with  herpes outbreaks
I'm surprised that you would not consider staying on suppressive therapy
with acyclovir. Don't you sometimes feel that this has gone on way too long?

Hang in there,

Angela

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>I guess I spoke too soon about not having painful outbreaks. Now I have a
> sore on the genitals and its rather painful and raw feeling. Herpes always
> manages to throw me a curved ball. What a nice Christmas present!
Al - 19 Dec 2005 03:17 GMT
Thanks for your input everyone.

Ar: I cannot take any aspirin product at all, buffered or not.

Perl: I'll have to think about those options you mentioned, but my sores
don't usually last too long in the pain stage.

Angela: I probably should, but I am on alot of other medicines as it is and
I don't want to overdo it. I figured I can manage it, but sometimes its
worse than others.

I was examining myself and I saw about 4 separate sites of dry scaly skin
that later turned into reddish areas and then clusters of dry looking white
blisters. The funny thing is the blisters this time looked like they were
intact, but already dry, nothing inside that could ooze out...isn't that
weird??!

> With as much trouble as you have been having lately with  herpes outbreaks
> I'm surprised that you would not consider staying on suppressive therapy
[quoted text clipped - 7 lines]
> > sore on the genitals and its rather painful and raw feeling. Herpes always
> > manages to throw me a curved ball. What a nice Christmas present!
William B - 22 Dec 2005 11:39 GMT
At the first sign of an outbreak, take 2 or 3 L-Lysine tablets twice a day.
The symptoms should subside after a couple of days.  

>I guess I spoke too soon about not having painful outbreaks. Now I have a
>sore on the genitals and its rather painful and raw feeling. Herpes always
>manages to throw me a curved ball. What a nice Christmas present!
 
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