why antiHBe before the antiHBs?

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John - 15 Feb 2008 19:38 GMT

Hi,I would like to know something about hepatitis B..here is my
question: why do we find in the blood the anti HBe antibodies before
the anti-Hbs ones??....I just thank you for the next answers

John

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Fee Fi - 21 Feb 2008 04:21 GMT

John pretended :

> Hi,I would like to know something about hepatitis B..here is my
> question: why do we find in the blood the anti HBe antibodies before
> the anti-Hbs ones??....I just thank you for the next answers
>
> John

HBsAg is a marker of HBV replication.
Anti-HBs appears when production of HBsAg decreases.

HBeAg is a marker of high-level HBV replication.
Anti-HBe appears when production of HBeAg decreases.

So, as replication of HBV decreases (due to immune response or
treatment), HBeAg is the first to disappear, and if it (HBV
replication) decreases to low enough levels then HBsAg disappears (and
the antibodies to each become detectable after the antigen is low
enough).

HTH,

Fee Fi

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