 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Hepatitis / July 2009Liver Disease And Iron
This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.mueller@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Spamming Dicksucker On Jul 25, 10:07 am, Ken <flakey...@aol.com> wrote:snip << Atheist .. those losers are you guys .. Don't be cutting this post atheist .. We don't want none of your drinking gay hepatitis ridden blog buddies to miss .. out .. This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.muel...@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >This says fifty percent of those who drink and have hepatitis have 100 >times more chance of dying from iron give or take a couple of losers. No, it doesn't say that, dumbass. >Several molecular mechanisms are discussed that could explain >the synergistic interaction of alcohol and HCV on disease >progression. >They include modulation of the immune response and apoptosis, >increased oxidative stress via induction of CYP2E1 and the >hepatic accumulation of iron. Every time you post you show the world that you really don't have the comprehension skills to be posting at all. "This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. " Not so fast and loose with the facts. It says iron is a resulting effect not the cause of the two disorders. It says iron might be one of 3 factors; not the only one; they are unable to say . Death does not come from iron but the disorders which damage the liver. Bad, bad boy. This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.muel...@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >This says fifty percent of those who drink and have hepatitis have >100 times more chance of dying from iron give or take a couple of >losers. That's NOT what it says you idiot. It says those who have ALD and HCV have a bigger problem. NOT those who drink. You're an illiterate and ignorant a.shole with no reading skills. Now go back to your little life and take a college level reading course to improve your reading comprehension skills. >Alcoholic liver disease and hepatitis C: >A frequently underestimated combination. [quoted text clipped - 53 lines] >DEAD PEOPLE WALKING >http://tinyurl.com/zk9fk >This says fifty percent of those who drink and have hepatitis have >100 times more chance of dying from iron give or take a couple of >losers. That hogwash already was cleared out.  Signature**** WARNING **** The web-hoster Globat.com steals money from your credit card account. If you are a customer of Globat.com, never give them any credit card information. If you can't erase the information, then do delete the old card and get a new one! **** WARNING **** "This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. " Not so fast and loose with the facts. It says iron is a resulting effect not the cause of the two disorders. It says iron might be one of 3 factors; not the only one; they are unable to say . Death does not come from iron but the disorders which damage the liver. Bad, bad boy. >"This says fifty percent of those who drink and have hepatitis have 100 >times more chance of dying from iron give or take a couple of losers. " [quoted text clipped - 5 lines] > >Bad, bad boy. An ignorant fool and liar. >>"This says fifty percent of those who drink and have hepatitis have 100 >>times more chance of dying from iron give or take a couple of losers. " [quoted text clipped - 7 lines] > > An ignorant fool and liar. Mental illness is his biggest fault; he really believes what he posts. Sad that so many people feel compelled to flame, rather than ignore and killfill him, but I guess that's their ignorance. No finger-pointing though, I've been guilty too. Mental illness is his biggest fault; << This group .. hepatitis c is for those with hepatitis and support .. You've been here far longer than you should .. This post has to do with 100X more chance of liver cancer. YOU step on it .. Now .. explain .. yourself .. Or stay off my threads .. Understand you hepatitis ridden .. atheist .. btch .. ? This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.muel...@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Spamming Obsessive Compulsive Suffering Dicksucker > Mental illness is his biggest fault; << > [quoted text clipped - 6 lines] > >Or stay off my threads .. Or what? You're gonna beat him up? Grow the hell up, put him in your filter (if you're not in control enough to ignore him) and move on. >Understand you hepatitis ridden .. atheist .. btch .. ? "atheist"? Where the hell are you going now? Or are you going to tell me only the fairy tale believing conservatives can post here? >This says fifty percent of those who drink and have hepatitis have >100 times more chance of dying from iron give or take a couple of >losers. That's NOT what it says you idiot. It says, and I quote "Alcoholic liver disease (ALD)". It does NOT define what ALD is nor does it anywhere say "fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers." You're a liar. Or your an idiot. I'll let you decide which you are for yourself. >Alcoholic liver disease and hepatitis C: >A frequently underestimated combination. [quoted text clipped - 44 lines] >Who loves ya. >Tom This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.muel...@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk It's been pointed out that you can't read worth a damn...therefore you've defined yourself as an idiot. >This says fifty percent of those who drink and have hepatitis have >100 [quoted text clipped - 57 lines] >DEAD PEOPLE WALKING >http://tinyurl.com/zk9fk On Jul 28, 3:06 pm, h...@yahoo.com wrote: It's been pointed out that you can't read worth a damn << It's been pointed out .. goofs .. don't post here .. Write IT FKG DOWN .. This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.muel...@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >On Jul 28, 3:06 pm, h...@yahoo.com wrote: > It's been pointed out that you can't read worth a damn << > >It's been pointed out .. goofs .. don't post here .. > >Write IT FKG DOWN .. Bad influence... The murderous god, who committed mass murder...? Gott demoliert Jericho und * "Sodann sprach er noch: 'Bauverbot, tötet die Einwohner * sonst schlag ich eure Söhne tot.' (frei nach Josua, Kap. 6) * So zogen sie von Ort zu Ort http://www.reimbibel.de * und übten sich in Massenmord." Signature**** WARNING **** The web-hoster Globat.com steals money from your credit card account. If you are a customer of Globat.com, never give them any credit card information. If you can't erase the information, then do delete the old card and get a new one! **** WARNING **** The murderous god, who committed mass murder...? << Using logic it tells you .. ? If YOUR "murderous god" existed .. you and your ilk would be .. longgggggg .. fkggggggg .. dead .. Wouldn't ya .. atheist .. But .. noooooo .. This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.muel...@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >The murderous god, who committed mass murder...? << > [quoted text clipped - 5 lines] > >But .. noooooo .. Which tells us that the god does not exist BUT those who claim the existence of that god AND THEIR FOLLOWERS, who are THE REAL MURDERERS ***IN THE NAME OF THEIR GOD***. Signature**** WARNING **** The web-hoster Globat.com steals money from your credit card account. If you are a customer of Globat.com, never give them any credit card information. If you can't erase the information, then do delete the old card and get a new one! **** WARNING **** >>On Jul 28, 3:06 pm, h...@yahoo.com wrote: >> It's been pointed out that you can't read worth a damn << [quoted text clipped - 6 lines] > >The murderous god, who committed mass murder...? It figures he'd be stupid enough to believe in a god. On Jul 28, 6:04 pm, h...@yahoo.com wrote: It figures he'd be stupid enough to believe in a god. << He is no less stupid than you .. You both do and say the same stupid sht .. You act like an atheist little btch .. or a lefthandedloon .. Some type of predatory freak .. So does he .. This says fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.muel...@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk On Jul 28, 6:14 pm, ironjustice <ironjust...@rock.com> wrote: fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron << The detractors on this thread / atheists / homosexuals / math whizzes seem to think the reference of "fifty percent of those who drink and have hepatitis have 100 times more chance of dying from iron" .. is "wrong" .. and upon reflection I have to agree. What it actually says is 100% those drunken hepatitis carriers are 100 times more likely to get liver cancer. Liver cancer is a death sentence. I believe that may be more succinct .. You atheists / math whizzes / homosexuals .. let me know if you disagree .. still .. This says 100 percent of those who drink and have hepatitis have 100 times more chance of dying from liver cancer caused by the increased iron .. give or take a couple of losers. Alcoholic liver disease and hepatitis C: A frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71. Mueller S, Millonig G, Seitz HK. Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11-33, 69121 Heidelberg, Germany. sebastian.muel...@urz.uni-heidelberg.de. Alcoholic liver disease (ALD) and hepatitis C virus (HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world. This review discusses the epidemiology and combined impact of ALD and HCV on the progression of liver disease. ALD and HCV affect the progression of liver disease to liver cirrhosis and hepatocellular carcinoma (HCC) in a synergistic manner. Thus, the risk for HCC increases five times with a daily alcohol consumption of 80 g; in the presence of HCV it is increased 20-fold, and a combination of both risk factors leads to a more than 100-fold risk for HCC development. Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication. Several molecular mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression. They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron. Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liver-secreted systemic iron hormone hepcidin. A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future. For now, it can be generally concluded that HCV-infected patients should abstain from alcohol and alcoholics should be encouraged to participate in detoxification programs. PMID: 19630099 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jul 28, 6:04 pm, h...@yahoo.com wrote: > It figures he'd be stupid enough to believe in a god. << [quoted text clipped - 65 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Spamming Retard >> Who loves ya. >> Tom [quoted text clipped - 4 lines] >> >> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Now compare: >On Jul 28, 6:23 pm, Happy Oyster <happy.oys...@ariplex.com> wrote: >The murderous god, who committed mass murder...? << [quoted text clipped - 6 lines] > >But .. noooooo .. Which tells us that the god does not exist BUT those who claim the existence of that god AND THEIR FOLLOWERS, who are THE REAL MURDERERS ***IN THE NAME OF THEIR GOD***. Signature**** WARNING **** The web-hoster Globat.com steals money from your credit card account. If you are a customer of Globat.com, never give them any credit card information. If you can't erase the information, then do delete the old card and get a new one! **** WARNING **** both HCV and alcohol independently cause hepatic iron accumulation << Iron as a co-morbid factor in nonhemochromatotic liver disease Alcohol, Volume 30, Issue 2, June 2003, Pages 137-144 Herbert L. Bonkovsky, Richard W. Lambrecht, Ying Shan Abstract Heavy iron overload, in both primary and secondary hemochromatosis, may cause fibrosis of parenchymal organs, especially the liver. The toxicity of iron is believed to involve increased oxidative stress, with iron-catalyzed production of reactive oxygen species causing oxidative damage to lipids, proteins, and nucleic acids. Lesser degrees of hepatic iron deposition are also associated with, and seem to be risk factors for, certain nonhemochromatotic liver diseases. Porphyria cutanea tarda is associated with hepatic iron overload and responds to iron-reduction therapy. Results of recent studies have demonstrated high prevalences (about 60%–80%) of HFE gene mutations in patients with porphyria cutanea tarda. Chronic hepatitis C is another risk factor for porphyria cutanea tarda. Other recent evidence indicates that the prevalence of HFE gene mutations is increased in chronic viral hepatitis and that patients with chronic hepatitis C harboring especially the C282Y mutation are more likely to suffer from advanced hepatic fibrosis or cirrhosis and to do so at younger ages. A role for modest iron overload in increasing severity of alcohol-induced liver disease has been well established from results of experimental studies. However, it is currently unresolved whether mild-to-moderate hepatic iron deposition or heterozygosity for the C282Y mutation plays a role in human alcoholic liver disease or in nonalcoholic fatty liver disease or nonalcoholic steatohepatitis. There is persuasive evidence that iron reduction decreases insulin resistance, and it likely also decreases oxidative stress, two key pathogenic features of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Iron loading has also been described after portosystemic shunts and in end-stage liver disease. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jul 28, 3:06 pm, h...@yahoo.com wrote: > It's been pointed out that you can't read worth a damn << [quoted text clipped - 61 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk >>>On Jul 28, 3:06 pm, h...@yahoo.com wrote: >>> It's been pointed out that you can't read worth a damn << [quoted text clipped - 8 lines] > >It figures he'd be stupid enough to believe in a god. Exactly. On Tue, 28 Jul 2009 17:52:55 -0700 (PDT), ironjustice <ironjustice@rock.com> wrote: >The murderous god, who committed mass murder...? << > [quoted text clipped - 5 lines] > >But .. noooooo .. Which tells us that the god does not exist BUT those who claim the existence of that god AND THEIR FOLLOWERS, who are THE REAL MURDERERS ***IN THE NAME OF THEIR GOD***. Signature**** WARNING **** The web-hoster Globat.com steals money from your credit card account. If you are a customer of Globat.com, never give them any credit card information. If you can't erase the information, then do delete the old card and get a new one! **** WARNING **** You're useless. Welcome to my filter. >On Jul 28, 3:06 pm, h...@yahoo.com wrote: > It's been pointed out that you can't read worth a damn << [quoted text clipped - 64 lines] >DEAD PEOPLE WALKING >http://tinyurl.com/zk9fk |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2009 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.