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Medical Forum / Diseases and Disorders / Hepatitis / July 2009post treatment questions
I am 75% of the way to my end of treatment and there's a few things I would like clarified. The first is my mind. How long after treatment does it normally take for your mind and body to "normalize"? Post treatment, assuming you have achieved a full SVR, are you now unable to be re-infected with your original genotype or is the virus constantly mutating making immunity impossible? Are you now unable to infect others if your virus has been "cleared". Could you be a blood/organ donor or would the recipient be at severe risk? Would an SVR of 1 or 2 years post TX mean that you can assume that the SVR will hold for say 10 or 20 years or will there always be a risk of relapse? There's been some talk that TX causes the immune system to remain hyperactive for quite some time after TX is finished. Is this true? I know that infection causes the immune system to work over-time in a futile attempt at clearing the virus. I was hoping successful treatment would help with this? >I am 75% of the way to my end of treatment and there's a few things I would >like clarified. The first is my mind. How long after treatment does it [quoted text clipped - 10 lines] >in a futile attempt at clearing the virus. I was hoping successful >treatment would help with this? This site will probably answer quite a few of your questions. http://www.hepatitisdoctor.com/ >I am 75% of the way to my end of treatment and there's a few things I would >like clarified. The first is my mind. How long after treatment does it >normally take for your mind and body to "normalize"? As you might imagine, severity of side effects and recovery from treatment differs from person to person. Some people never experience the "brain fog", some get it in spades. In my case I never really felt out-of-sorts mentally, so recovery in that respect was rapid for me, but some folks posting here have related it took months to shake it off. >Post treatment, assuming you have achieved a full SVR, are you now unable >to be re-infected with your original genotype or is the virus constantly mutating making >immunity impossible? I believe it is prudent to assume you can be re-infected. I don't believe anything about HCV infection, regardless of treatment outcome, protects against re-infection, regardless of genotype. >Are you now unable to infect others if your virus has been "cleared". >Could you be a blood/organ donor or would the recipient be >at severe risk? I'm fairly certain that a person expressing anti-HCV antibodies will not be allowed to donate blood or organs. >Would an SVR of 1 or 2 years post TX mean that you can >assume that the SVR will hold for say 10 or 20 years or will there always be >a risk of relapse? I don't think there is data extending out to that 20 year level, but statistics are clear that SVR is extremely durable. If you get through a year or two the chances of a true relapse (as opposed to re-infection) are extremely small. >There's been some talk that TX causes the immune system >to remain hyperactive for quite some time after TX is finished. Is this >true? Interesting. I hadn't read that, and have no idea if it is true. >I know that infection causes the immune system to work over-time in a >futile attempt at clearing the virus. I was hoping successful treatment >would help with this? Clearly, removing the immune system stimulus (ie: SVR) should result in the immune system returning to a more normal state... Cheers /greyhackles >>I am 75% of the way to my end of treatment and there's a few things I would >>like clarified. The first is my mind. How long after treatment does it [quoted text clipped - 20 lines] >I'm fairly certain that a person expressing anti-HCV antibodies will not be >allowed to donate blood or organs. Some Transplant patients at Emory have been giving the choice of getting a HCV positive organs to allow them to get one sooner. I don't know if they give HCV negative patients HCV positive organs but they do give them to HCV positive patients. >>>I am 75% of the way to my end of treatment and there's a few things I >>>would [quoted text clipped - 30 lines] > Some Transplant patients at Emory have been giving the choice of > getting a HCV positive organs to allow them to get one sooner. WHAT???? Where'd you hear that? I'm glad I gave Emory the boot and went back to Athens. >>>>I am 75% of the way to my end of treatment and there's a few things I >>>>would [quoted text clipped - 34 lines] > >I'm glad I gave Emory the boot and went back to Athens. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VJ0-4H5DR50-21&_user= 10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=946627971& _rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=565 f5ee5b8446cb80d05d9b4b3e8800e I was sitting in the waiting room in the transplant center while a nurse was discussing it with a kidney patient. Emory is a very good hospital IMO. >>>>>I am 75% of the way to my end of treatment and there's a few things I >>>>>would [quoted text clipped - 45 lines] > > Emory is a very good hospital IMO. I take it you never had the pleasure of meeting Dr. Harsh Kapoor then. When I had my last MRI there they used the new contrast, my throat closed, and I could barely breathe. She called a nurse, who never arrived. That was really comforting. I guess my main complaint is that they continually made me feel like I had one foot in the grave. Pre-cancerous, not quite bad enough for a transplant just yet, but hey, don't worry, you'll be there soon. I fled back to Dr.West in Athens (he dx'd me in 2002), whose whole attitude is, "Live your life, you're stable now and if something happens we'll worry about it then." And that's exactly what I'm doing. Interesting to think we might've been in the same waiting room and never knew it though, isn't it? >>>>>>I am 75% of the way to my end of treatment and there's a few things I >>>>>>would [quoted text clipped - 61 lines] >Interesting to think we might've been in the same waiting room and never >knew it though, isn't it? I never heard the name of that doctor before. I guess it is just as well. I have been in and out of Emory since the last part of 2000. I think the chances are pretty good that we have been in the same room. Too bad we never got a chance to meet. (I am not a big talker though) Sounds like you had a tough time with your MRI. It could have happened anywhere though. Glad to hear you are stable. >>>>I am 75% of the way to my end of treatment and there's a few things I >>>>would [quoted text clipped - 34 lines] > >I'm glad I gave Emory the boot and went back to Athens. Well, first, he's correct - there have been instances where an HCV-positive donor liver was used on an HCV-positive recipient - with the full knowledge of the recipient. Sometimes it's the best option available, but it's still an exceedingly rare solution, definitely the exception to the rule, and I didn't think it was worth mentioning in the context of the question... Cheers /greyhackles > On Thu, 02 Jul 2009 10:16:33 -0400, greyhackles > [quoted text clipped - 30 lines] > I don't know if they give HCV negative patients HCV positive organs > but they do give them to HCV positive patients. Do you know if these are from live donors or from cadavers? If you could find out, and they use live donors, I'd be VERY interested... On Jul 2, 1:54 pm, Metspitzer <kilow...@charter.net> wrote: > Some Transplant patients at Emory have been giving the choice of > getting a HCV positive organs to allow them to get one sooner. > > I don't know if they give HCV negative patients HCV positive organs > but they do give them to HCV positive patients. Do you know if these are from live donors or from cadavers? If you could find out, and they use live donors, I'd be VERY interested... Emory doesn't do live donor trransplants. If they did I'd already have one. >On Jul 2, 1:54 pm, Metspitzer <kilow...@charter.net> wrote: >> Some Transplant patients at Emory have been giving the choice of [quoted text clipped - 5 lines] >Do you know if these are from live donors or from cadavers? If you >could find out, and they use live donors, I'd be VERY interested... I would say both, although I base that on nothing. I am sure there are HCV positive organ donors that don't even know they are positive. If the doctors get an HCV positive organ, they could check the recipient's preference and use it if they can. >Emory doesn't do live donor trransplants. If they did I'd already have one. Emory does do live donor transplants. I know of one guy that received one from his sister. I also know of another man that got one from his brother. All 4 were doing fine last time I heard. Being HCV negative and given the choice of an HCV positive organ or maybe nothing would be one hard choice to make. I tried to get you a phone number to Emory but they are closed for July 4. Try this number after the holiday. 404-788-5000 > Emory does do live donor transplants. I know of one guy that received > one from his sister. I also know of another man that got one from his [quoted text clipped - 5 lines] > I tried to get you a phone number to Emory but they are closed for > July 4. Try this number after the holiday. 404-788-5000 Thanks much! As of the last time I was there, they weren't doing live donors and I was told they probably never would because the possibility of affecting 2 lives negatively. I found a hospital in Florida and one in Virginia--too far away, but I've had live donor offers up the wazoo. My brother even offered to pay all living expenses for the donor. I'm due to see Dr. West soon. I'll definitely discuss it with him as well as calling Emory. >> Emory does do live donor transplants. I know of one guy that received >> one from his sister. I also know of another man that got one from his [quoted text clipped - 14 lines] >I'm due to see Dr. West soon. I'll definitely discuss it with him as well >as calling Emory. I heard that you could get a transplant pretty soon in Tennessee. Steve Jobs did. Good luck >>> Emory does do live donor transplants. I know of one guy that received >>> one from his sister. I also know of another man that got one from his [quoted text clipped - 19 lines] > > Good luck I don't have A Name and I'm definitely not rich. :-) Smiling Wickedly, Thip answered: > On Jul 2, 1:54 pm, Metspitzer <kilow...@charter.net> wrote: >> Some Transplant patients at Emory have been giving the choice of [quoted text clipped - 7 lines] > > Emory doesn't do live donor trransplants. If they did I'd already have one. And i can't think of anyone who deserves one more. 8-)  Signature*..· ´¨¨)) ¸.·´ .·´¨¨)) ((¸¸.·´ .·´-:¦:-((¸¸.·´(º·.¸(¨*·.¸ ¸.·*¨)¸.·º) «.·°·. Michael .·°·-:¦:- > Smiling Wickedly, Thip answered: >> On Jul 2, 1:54 pm, Metspitzer <kilow...@charter.net> wrote: [quoted text clipped - 11 lines] >> > And i can't think of anyone who deserves one more. 8-) Thanks, Michael <<<<hugs>>>> > I am 75% of the way to my end of treatment and there's a few things I would > like clarified. The first is my mind. How long after treatment does it > normally take for your mind and body to "normalize"?<< My last injection was on 02-13-09. I am still recovering. If you haven't been on opiates or benzos, however, things will improve dramatically within 2-4 weeks after your last injection. Post treatment, > assuming you have achieved a full SVR, are you now unable to be re-infected > with your original genotype<< No, you can reinfected with ANY genotype. or is the virus constantly mutating making > immunity impossible? Are you now unable to infect others if your virus has > been "cleared".<< Possibly. Could you be a blood/organ donor or would the recipient be > at severe risk? << I found out I had hep c when I tested to see if I could donate a kidney. You MAY be able to donate to someone who has hep c, but almost certainly not to someone who does not. Would an SVR of 1 or 2 years post TX mean that you can > assume that the SVR will hold for say 10 or 20 years<< Yes. or will there always be > a risk of relapse? There's been some talk that TX causes the immune system > to remain hyperactive for quite some time after TX is finished. Is this > true?<< For some people, apparently. > I know that infection causes the immune system to work over-time in a > futile attempt at clearing the virus. I was hoping successful treatment > would help with this?< I certainly hope you recover successfully from both hep c and from treatment. If you've made it this far without horrid sides, you probably will. Would an SVR of 1 or 2 years post TX mean that you can > assume that the SVR will hold for say 10 or 20 years or will there always > be a risk of relapse? Relapse is the wrong term, and perhaps SVR is too. It would be more accurate to say, "we think we've erradicated it, but we're not sure." Hep C, a virus, is either alive and present, or not. It does not "go dormant." The limitation in definition is that minute quantities of the virus cannot be detected (yet), and so would replicate to a detectible level after a period of time, usually within six months. It appears that, after two years, if there is no detectible HCV, it's dead and you're cured. I suspect that, in cases where people "relapse" after this amount of time, that they have been reinfected. Smiling Wickedly, Waterspider answered: > Would an SVR of 1 or 2 years post TX mean that you can >> assume that the SVR will hold for say 10 or 20 years or will there always [quoted text clipped - 9 lines] > suspect that, in cases where people "relapse" after this amount of time, > that they have been reinfected. I haven't been here for a long time, or very much over time since my SVR. I can't believe it's been 6+ years, and the Dragon is still dead dead dead. Happy July 4th everyone.. KILL THE DRAGON.. but keep yourself safe. Live long and prosper.. Signature*..· ´¨¨)) ¸.·´ .·´¨¨)) ((¸¸.·´ .·´-:¦:-((¸¸.·´(º·.¸(¨*·.¸ ¸.·*¨)¸.·º) «.·°·. Michael .·°·-:¦:- > Would an SVR of 1 or 2 years post TX mean that you can > > assume that the SVR will hold for say 10 or 20 years or will there always [quoted text clipped - 3 lines] > to say, "we think we've erradicated it, but we're not sure." > Hep C, a virus, is either alive and present, or not Since it's a virus, it's not alive and present, or not alive and not present:) >> Would an SVR of 1 or 2 years post TX mean that you can >> > assume that the SVR will hold for say 10 or 20 years or will there [quoted text clipped - 8 lines] > Since it's a virus, it's not alive and present, or not alive and not > present:) The virus is either alive and present, or not. If the virus is not alive and not present, and once was, then antibodies for the virus will be present. >>> Would an SVR of 1 or 2 years post TX mean that you can >>> > assume that the SVR will hold for say 10 or 20 years or will there [quoted text clipped - 12 lines] >If the virus is not alive and not present, and once was, then antibodies for >the virus will be present. I think TX is laying a technical tweak on ya, WS ;-) Cheers /greyhackles >>>> Would an SVR of 1 or 2 years post TX mean that you can >>>> > assume that the SVR will hold for say 10 or 20 years or will there [quoted text clipped - 19 lines] > > /greyhackles LOL @ Grey :-) >> Would an SVR of 1 or 2 years post TX mean that you can >> > assume that the SVR will hold for say 10 or 20 years or will there [quoted text clipped - 8 lines] > Since it's a virus, it's not alive and present, or not alive and not > present:) Here's clarification for those of us who don't get the joke. When you go through it though, it merely muddies the water even more. http://serc.carleton.edu/microbelife/yellowstone/viruslive.html >>> Would an SVR of 1 or 2 years post TX mean that you can >>> > assume that the SVR will hold for say 10 or 20 years or will there [quoted text clipped - 12 lines] > When you go through it though, it merely muddies the water even more. > http://serc.carleton.edu/microbelife/yellowstone/viruslive.html Thanks for the link, Chuck, it's excellent. Viroids... who woulda thunk! |
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