Medical Forum / Diseases and Disorders / Hepatitis / June 2009
Liver Disease
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ironjustice - 01 Jun 2009 14:46 GMT Liver disease 'shrunk' by blood-pressure drug June 1st, 2009 A blood-pressure medicine has been shown to reverse the effects of early-stage liver failure in some patients.
Newcastle University researchers analysed a small clinical trial of losartan, a drug normally prescribed for hypertension, on 14 patients in Spain, who had Hepatitis C.
The illness was at an advanced stage causing fibrosis - scarring in the liver - which would usually have progressed to liver failure.
Half of the patients in the trial saw the scars in their liver shrink allowing the organ to repair itself.
Professor Derek Mann from Newcastle University said: "At the moment we have no proven effective way of treating people with chronic liver disease other than transplantation. This early stage trial has shown that we can shrink liver scarring in some patients and shows promise for a treatment that could make a huge difference to the lives of thousands of people."
The team whose work is published today in Gastroenterology, say this early stage trial is promising and they now want to carry out several much larger studies initially involving patients with liver disease caused by obesity and then later alcohol, hereditary and autoimmune diseases.
Mechanism
Liver damage, known as fibrosis, is caused by the unwanted accumulation of excess fibrous connective tissue which is produced and maintained by a specialised cell, the liver myofibroblast.
In chronic liver disease a signalling pathway is created that instructs the liver myofibroblast to stay alive and proliferate. It is this pathway that then causes scar tissue to accumulate, creating the liver damage.
Work carried out in rat and mouse models allowed the researchers to study what was happening inside the liver when losartan, an angiotensin II receptor antagonist drug, was present.
Researchers believe that the drug blocks the signalling pathway so that the liver myofibroblasts die, removing the source of scar tissue. As the scar tissue breaks up, the damaged area of the liver is repaired by the body.
In this research, funded by the Medical Research Council and the British Liver Trust, the Newcastle University researchers discovered a biological marker, NF-kB, was crucial for the activities of scar- forming cells.
Tests on their livers revealed that, before treatment with losartan, half of the patients had a high level of the biomarker NF-kB. After treatment, the level fell indicating that losartan is able to switch off NF-kB with the result that scars are no longer produced or maintained, but instead shrink.
Professor Mann said: "By measuring the amount of active NF-kB in the liver from a biopsy sample, we may be able to tell which patients will benefit from treatment with losartan or similar drugs such as ACE inhibitors. This may prove to be a new treatment for up to half of all liver patients."
More information: Angiotensin II activates IkB kinase phosphorylation of Re1A at Ser536 to promote myofibroblast survival and liver fibrosis, Gastroenterology, June 1, 2009
Source: Newcastle University --------------
"Losartan reduces hematocrit"
More .. pharmacalogical .. bloodletting ..
Coincidence of course .. that it is used for .. diabetes which has been recently found to .. have .. increased red blood cell production ..
Losartan reduces hematocrit in patients with chronic obstructive pulmonary disease and secondary erythrocytosis. Ann Intern Med. 2001 Mar 6;134(5):426-7. Vlahakos DV, Marathias KP, Kosmas EN.
Publication Types: Comment Letter
PMID: 11242510
-----------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/4rq595
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Rusty the Spamming Fuckwadd - 01 Jun 2009 16:16 GMT Spamming Retard
ironjustice - 01 Jun 2009 17:44 GMT On Jun 1, 8:16 am, Rusty the Spamming Fuckwadd <flakey...@earthlink.net> wrote::snip <<
What did I tell you about little atheist .. btches .. ?
No atheist btches on my threads ..
Take your predatorial atheist nature .. elsewhere .. looooon ..
DOOOOO it .. looooon ..
DOOOOO .. it ..
You seem to find .. stay off my threads .. hard to understand .. shteater ..
That would be because you are a .. shteating .. **freak** ..
http://www.traditionalvalues.org/homosexual_movement_and_pedophilia/
http://www.talk2action.org/story/2006/10/3/21245/3789
------------------
Liver disease 'shrunk' by blood-pressure drug June 1st, 2009 A blood-pressure medicine has been shown to reverse the effects of early-stage liver failure in some patients.
Newcastle University researchers analysed a small clinical trial of losartan, a drug normally prescribed for hypertension, on 14 patients in Spain, who had Hepatitis C.
The illness was at an advanced stage causing fibrosis - scarring in the liver - which would usually have progressed to liver failure.
Half of the patients in the trial saw the scars in their liver shrink allowing the organ to repair itself.
Professor Derek Mann from Newcastle University said: "At the moment we have no proven effective way of treating people with chronic liver disease other than transplantation. This early stage trial has shown that we can shrink liver scarring in some patients and shows promise for a treatment that could make a huge difference to the lives of thousands of people."
The team whose work is published today in Gastroenterology, say this early stage trial is promising and they now want to carry out several much larger studies initially involving patients with liver disease caused by obesity and then later alcohol, hereditary and autoimmune diseases.
Mechanism
Liver damage, known as fibrosis, is caused by the unwanted accumulation of excess fibrous connective tissue which is produced and maintained by a specialised cell, the liver myofibroblast.
In chronic liver disease a signalling pathway is created that instructs the liver myofibroblast to stay alive and proliferate. It is this pathway that then causes scar tissue to accumulate, creating the liver damage.
Work carried out in rat and mouse models allowed the researchers to study what was happening inside the liver when losartan, an angiotensin II receptor antagonist drug, was present.
Researchers believe that the drug blocks the signalling pathway so that the liver myofibroblasts die, removing the source of scar tissue. As the scar tissue breaks up, the damaged area of the liver is repaired by the body.
In this research, funded by the Medical Research Council and the British Liver Trust, the Newcastle University researchers discovered a biological marker, NF-kB, was crucial for the activities of scar- forming cells.
Tests on their livers revealed that, before treatment with losartan, half of the patients had a high level of the biomarker NF-kB. After treatment, the level fell indicating that losartan is able to switch off NF-kB with the result that scars are no longer produced or maintained, but instead shrink.
Professor Mann said: "By measuring the amount of active NF-kB in the liver from a biopsy sample, we may be able to tell which patients will benefit from treatment with losartan or similar drugs such as ACE inhibitors. This may prove to be a new treatment for up to half of all liver patients."
More information: Angiotensin II activates IkB kinase phosphorylation of Re1A at Ser536 to promote myofibroblast survival and liver fibrosis, Gastroenterology, June 1, 2009
Source: Newcastle University --------------
"Losartan reduces hematocrit"
More .. pharmacalogical .. bloodletting ..
Coincidence of course .. that it is used for .. diabetes which has been recently found to .. have .. increased red blood cell production ..
Losartan reduces hematocrit in patients with chronic obstructive pulmonary disease and secondary erythrocytosis. Ann Intern Med. 2001 Mar 6;134(5):426-7. Vlahakos DV, Marathias KP, Kosmas EN.
Publication Types: Comment Letter
PMID: 11242510
-----------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/4rq595
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Rusty the Spamming Dickhead - 01 Jun 2009 20:22 GMT Spamming Dickwadd
ironjustice - 02 Jun 2009 03:07 GMT On Jun 1, 12:22 pm, Rusty the Spamming Dickhead <flakey...@earthlink.net> wrote:snip <<
You shteating atheist ..
You homosexual .. atheist .. shteaters .. with .. severe bisexual conflict and confusion .. have been TOLD .. many times .. stay OFF **my** threads ..
What did I tell you about little atheist .. btches .. ?
No atheist btches on my threads ..
Take your predatorial atheist shteating nature .. elsewhere .. looooon ..
DOOOOO it .. looooon ..
DOOOOO .. it ..
You seem to find .. stay off my threads .. hard to understand .. shteater ..
That would be because you are a .. shteating .. **freak** ..
http://www.traditionalvalues.org/homosexual_movement_and_pedophilia/
http://www.talk2action.org/story/2006/10/3/21245/3789
http//tinyurl.com/dxxfr5
Severe bisexual conflict and confusion was discovered to be the cause of schizophrenia over fifty years ago by Dr. Edward J. Kempf and others
-------------------
Liver disease 'shrunk' by blood-pressure drug June 1st, 2009 A blood-pressure medicine has been shown to reverse the effects of early-stage liver failure in some patients.
Newcastle University researchers analysed a small clinical trial of losartan, a drug normally prescribed for hypertension, on 14 patients in Spain, who had Hepatitis C.
The illness was at an advanced stage causing fibrosis - scarring in the liver - which would usually have progressed to liver failure.
Half of the patients in the trial saw the scars in their liver shrink allowing the organ to repair itself.
Professor Derek Mann from Newcastle University said: "At the moment we have no proven effective way of treating people with chronic liver disease other than transplantation. This early stage trial has shown that we can shrink liver scarring in some patients and shows promise for a treatment that could make a huge difference to the lives of thousands of people."
The team whose work is published today in Gastroenterology, say this early stage trial is promising and they now want to carry out several much larger studies initially involving patients with liver disease caused by obesity and then later alcohol, hereditary and autoimmune diseases.
Mechanism
Liver damage, known as fibrosis, is caused by the unwanted accumulation of excess fibrous connective tissue which is produced and maintained by a specialised cell, the liver myofibroblast.
In chronic liver disease a signalling pathway is created that instructs the liver myofibroblast to stay alive and proliferate. It is this pathway that then causes scar tissue to accumulate, creating the liver damage.
Work carried out in rat and mouse models allowed the researchers to study what was happening inside the liver when losartan, an angiotensin II receptor antagonist drug, was present.
Researchers believe that the drug blocks the signalling pathway so that the liver myofibroblasts die, removing the source of scar tissue. As the scar tissue breaks up, the damaged area of the liver is repaired by the body.
In this research, funded by the Medical Research Council and the British Liver Trust, the Newcastle University researchers discovered a biological marker, NF-kB, was crucial for the activities of scar- forming cells.
Tests on their livers revealed that, before treatment with losartan, half of the patients had a high level of the biomarker NF-kB. After treatment, the level fell indicating that losartan is able to switch off NF-kB with the result that scars are no longer produced or maintained, but instead shrink.
Professor Mann said: "By measuring the amount of active NF-kB in the liver from a biopsy sample, we may be able to tell which patients will benefit from treatment with losartan or similar drugs such as ACE inhibitors. This may prove to be a new treatment for up to half of all liver patients."
More information: Angiotensin II activates IkB kinase phosphorylation of Re1A at Ser536 to promote myofibroblast survival and liver fibrosis, Gastroenterology, June 1, 2009
Source: Newcastle University --------------
"Losartan reduces hematocrit"
More .. pharmacalogical .. bloodletting ..
Coincidence of course .. that it is used for .. diabetes which has been recently found to .. have .. increased red blood cell production ..
Losartan reduces hematocrit in patients with chronic obstructive pulmonary disease and secondary erythrocytosis. Ann Intern Med. 2001 Mar 6;134(5):426-7. Vlahakos DV, Marathias KP, Kosmas EN.
Publication Types: Comment Letter
PMID: 11242510
-----------------
Who loves ya. Tom
Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh
Man Is A Herbivore! http://tinyurl.com/4rq595
DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Thip - 02 Jun 2009 23:16 GMT Interesting info. I did a little extra investigating and it might hold some promise for folks like me.
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