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Medical Forum / Diseases and Disorders / Hepatitis / April 2009Iron In Liver In Hepatitis C
Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk FOAD Spammer The problem with most of the abstracts you post like this one is the donkey and cart problem. Because two things, and many others for that matter, occur does not say that either causes the other. It is often the cause of both is the result of some third source. When some disorder causes inflammation stored iron can be released. The inflammation is the cause of the increase in iron blood level or in tissues. The inflammation is a result of the disorder and the disorder is not caused by the released iron. . On Apr 25, 10:43 am, c...@man.com wrote: The inflammation is a result of the disorder and the disorder is not caused by the released iron. << Targeting the iron for removal leads to increased recovery .. The article says there is iron in the heart WHEN there is iron in the liver .. It didn't say how it got there .. You didn't include any articles which showed how it got there .. Really .. I don't care how it got there .. The iron has to be targeted because it causes liver failure and heart failure .. I have cites for ALL of the above .. Iron destroys heart .. iron destroys liver .. WHEN you got your articles together to show iron does NOT cause liver failure and iron does NOT cause heart failure .. get back to this thread .. But your .. opinion .. ? Worthless .. Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "You didn't include any articles which showed how it got there .." That wasn't the point. The point was about your mindless posting of abstracts without explanation, nor usually understanding either. Your "iron" thesis is greatly flawed for it. I use "thesis" to be generous. There are thousands of new abstracts each month. Mindlessly posting some because it contains reference to iron, and even then only those cherry picked that seem to flatter your image of yourself is silly. The problem with most of the abstracts you post like this one is the donkey and cart problem. Because two things, and many others for that matter, occur does not say that either causes the other. It is often the cause of both is the result of some third source. When some disorder causes inflammation stored iron can be released. The inflammation is the cause of the increase in iron blood level or in tissues. The inflammation is a result of the disorder and the disorder is not caused by the released iron. . On Apr 25, 12:25 pm, c...@man.com wrote: The point was about your mindless posting of abstracts without explanation, nor usually understanding either. << Read my lips .. Your opinion to MY .. understanding OF the articles I post .. ? You are a nobody .. I place medical studies; My .. understanding OF those medical studies is of no concern to .. **anyone** but ..**me** .. Whether YOU .. believe .. I understand them or not is of no relevance to me .. WHO exactly are .. YOU .. ? Anybody .. ? Did YOU write the article finding iron in the liver of EVERY untreated hepatitis patient .. ? No .. ? Then what the fk is it to you .. ? They found iron in the liver .. found iron in the heart .. HOW it got there .. ? Who cares .. YOU care .. ? Prove your hypothesis .. Oh yeah .. you don't have an .. hypothesis .. do ya .. Go find one .. This ones' .. mine .. Iron .. increased iron found in liver of EVERY untreated hepatitis C patient. Top it .. or fkff .. Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Especially opinions of two-bit jerkffs .. Your > "iron" thesis is greatly flawed for it. I use "thesis" to be generous. > [quoted text clipped - 11 lines] > tissues. The inflammation is a result of the disorder and the disorder > is not caused by the released iron. . "Read my lips .. Your opinion to MY .. understanding OF the articles I post .. ? You are a nobody .. I place medical studies;" So what, thousands can be posted. "My .. understanding OF those medical studies is of no concern to .. **anyone** but ..**me** .." Ah, so it is a kind of posting masturbation? Why don't you just keep them on your hard drive so the rest of us don't have to be bothered with mindless abstract posting. On Apr 25, 1:54 pm, c...@man.com wrote:Why don't you just keep them on your hard drive so the rest of us don't have to be bothered with mindless abstract posting. << Your questions are stupid .. These are sci med groups .. The hypothesis is .. "Iron accumulates in the body and kills you" .. YOU don't like that I post articles which give evidence to that .. ? Who fkg .. cares .. JUST because YOUR opinion is .. shteaters are NORMAL doesn't mean they are .. IF my hypothesis was homosexuals are .. mutated .. freaks .. then I would post TO .. the sci med groups ABOUT .. how .. homosexuals are .. mutated .. freaks .. and I would use medical studies to prove it .. But .. my hypothesis is iron causes .. **disease** .. In the sci med groups and the disease related groups .. the cause of disease is .. relevant .. The POSTING of articles to BOLSTER that .. hypothesis .. is what the sci med groups .. are all about .. YOU .. **build** .. a hypothesis .. YOU .. POST to bolster .. YOUR .. hypothesis .. or someone elses .. hypothesis .. That's what sci groups are .. YOU cannot find a hypothesis .. ? A banner to foist .. ? THAT is why you post .. nothing .. THAT is why NOBODY posts nothing .. Because .. ? Hypothesis' are few .. and .. far .. between .. You have to come up with the hypothesis and not many people .. doooo .. Don't feel bad though .. You still may be able to come up with one .. Iron .. increased iron found in liver of EVERY untreated hepatitis C patient. Top it .. or fkff .. Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "The hypothesis is .. "Iron accumulates in the body and kills you" .. YOU don't like that I post articles which give evidence to that .. ?" "Like" is irellevant. Irrefutable evidence is relevant which is most lacking in your posts. Which brings me to my original observation. The abstract did not support your "hypothesis". Based on the same reason most you post does not either. Oxygen goes with each and every abstract you post. Is it the cause of being "killed"? There are multiple other elements that could be added to a long list of such things. On Apr 25, 2:46 pm, c...@man.com wrote: snip << Like I said .. pal .. who fkg cares about YOUR .. opinion .. **opinion** .. The .. VERY recent .. article states .. "Iron accumulates in the body and kills you" .. My hypothesis just so happens to BE .. ? "Iron accumulates in the body and kills you" .. Don't like it .. ? WHO FKG CARES .. Top it .. or .. fkff .. Is that hard to understand .. ? Must beee .. Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "The .. VERY recent .. article states .. "Iron accumulates in the body and kills you" .. My hypothesis just so happens to BE .. ? "Iron accumulates in the body and kills you" .." Several substances were shown to go with iron. Which "kills" you? "Accumulation" was not part of their conclusion. You make this basic error in scientific logic again and again and again. As with "accumulate" which was not there, you also see things in abstracts which are not there, wishful thinking. You also miss important items because you ware logical blinders and they can become a problem if you notice hem. On Apr 25, 3:44 pm, c...@man.com wrote: snip << What part of scientific discovery don't you understand .. ? What are you doing in these sci groups since you don't .. ? You are contributing something to these groups are ya .. ? Exactly what are you contributing to these groups .. ? Showing how stupid you are .. ? IRON is .. MENTIONED .. Don't like iron being .. mentioned .. ? WHO .. fkg .. CARES .. Iron IN the heart .. IRON in the liver .. You wish to take it .. farther .. than their findings .. ? Their findings of .. "remove the iron" .. ? Me .. I .. don't .. I .. don't .. need .. to .. The article states .. "increased iron in heart parallels increased iron in liver" .. PERIOD .. Like I said .. post articles which show the iron appeared there .. under inflammation .. say .. WHO .. fkg .. cares .. HOW IT GOT THERE .. Me .. I .. don't .. PROVE it got there through .. inflammation or whatever you believe it appears there .. by .. I DONT CARE .. I'm not about to argue with you HOW it got .. there .. WHY should I .. ? It is there .. JUST .. like I .. said .. THAT is all that matters .. to ME .. other than the .. "must remove the iron" .. part .. It most likely got there through the high iron diet .. though .. JUST .. like has been shown to happen with genetic hemochrotic .. patients .. who .. coincidentally HAVE a VERY high rate of 'catching' .. hep .. IE: that would be **evidence** OF **increased iron** leading TO .. hep .. See how gathering evidence .. works .. ? Do ya .. ? Iron .. increased iron found in liver of EVERY untreated hepatitis C patient JUST like I said .. Top it .. or fkff .. Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > "The .. VERY recent .. article states .. > [quoted text clipped - 13 lines] > important items because you ware logical blinders and they can become a > problem if you notice hem. Let's see if we can show your basic flaw in logic in another way. Find 100 people in perfect health in every way. After testing you find all have iron in all parts of their body. Using your logic because two things are found together, iron must be the cause of the perfect health. Or, perfect health causes iron to be in all parts of the body. Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Reposting an abstract does not make the below disappear. It describes your logical flaws exactly. Let's see if we can show your basic flaw in logic in another way. Find 100 people in perfect health in every way. After testing you find all have iron in all parts of their body. Using your logic because two things are found together, iron must be the cause of the perfect health. Or, perfect health causes iron to be in all parts of the body. Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Reposting an abstract does not make the below disappear. It describes your logical flaws exactly. Let's see if we can show your basic flaw in logic in another way. Find 100 people in perfect health in every way. After testing you find all have iron in all parts of their body. Using your logic because two things are found together, iron must be the cause of the perfect health. Or, perfect health causes iron to be in all parts of the body. Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients Isaias Dichi1, Danielle Venturini2,3, Andrea Colado Simão2, Décio Sabbatini Barbosa2, Edson Lopes Lavado4, Vitor Narciso5 and Jane Bandeira Dichi5 1 Internal Medicine, University of Londrina, Londrina - Paraná, Brazil 2 Department of Pathology, Clinical Analysis and Toxicology 3 Department of Pathology, Clinical Analysis and Toxicology 4 Physiotherapy 5 Internal Medicine, University of Londrina, Londrina, Brazil ABSTRACT The aim of this study was to determine oxidative stress and iron status in untreated patients with chronic hepatitis C (CHC). Two groups (CHC patients and controls) were studied. CHC patients presented significant higher values than the control group in some parameters: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase, iron, ferritin and also in tert-butyl hydroperoxide initiate chemiluminescence, nitric oxide, thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter. TBARS levels showed a significant correlation with serum AST and ALT levels. TBARS levels were also associated with transferrin saturation. In conclusion, lower antioxidant capacity, higher levels of pro- oxidants activity and iron liver storage occurs in untreated CHC patients. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations are needed to define the moment to begin nutritional intervention in CHC patients. Key Terms: Hepatitis C Virus, oxidative stress, antioxidant capacity, iron status. (The FASEB Journal. 2009;23:718.15) © 2009 FASEB Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Unless you can tie this abstract to some larger body of research it is an empty jesture, there are thousands each month that can be posted. Also, don't forget the basic flaw of logic the great bulk of your posts assumes as to cause and effect, remember. Reposting an abstract does not make the below disappear. It describes your logical flaws exactly. Let's see if we can show your basic flaw in logic in another way. Find 100 people in perfect health in every way. After testing you find all have iron in all parts of their body. Using your logic because two things are found together, iron must be the cause of the perfect health. Or, perfect health causes iron to be in all parts of the body. higher levels of pro-oxidants activity and iron liver storage << Elevated hepatic iron: A confounding factor in chronic hepatitis C. Isom HC, McDevitt EI, Moon MS Biochim Biophys Acta 2009 Apr 22. Historically, iron overload in the liver has been associated with the genetic disorders hereditary hemochromatosis and thalassemia and with unusual dietary habits. More recently, elevated hepatic iron levels also have been observed in chronic hepatitis C virus (HCV) infection. Iron overload in the liver causes many changes including induction of oxidative stress, damage to lysosomes and mitochondria, altered oxidant defense systems and stimulation of hepatocyte proliferation. Chronic HCV infection causes numerous pathogenic changes in the liver including induction of endoplasmic reticulum stress, the unfolded protein response, oxidative stress, mitochondrial dysfunction and altered growth control. Understanding the molecular and cellular changes that could occur in a liver which has elevated hepatic iron levels and in which HCV replication and gene expression are ongoing has clinical relevance and represents an area of research in need of further investigation. Biochimica et biophysica acta [Biochim Biophys Acta] Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Decreased Total Antioxidant Capacity and Increased > Oxidative Stress and Serum Ferritin Levels in Untreated [quoted text clipped - 50 lines] > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk |
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