Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels
and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats.
J Hepatol. 2008 Mar;48(3):486-93. Epub 2007 Dec 27.
Tsubota A, Yoshikawa T, Nariai K, Mitsunaga M, Yumoto Y, Fukushima K,
Hoshina S, Fujise K.

Institute of Clinical Medicine and Research (ICMR), Jikei University
School of Medicine, Kashiwa, Chiba, Japan. atsubo@jikei.ac.jp

BACKGROUND/AIMS:
To assess the effect of lactoferrin on oxidative liver damage and its
mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously
develop fulminant-like hepatitis and lethal hepatic failure.
METHODS:
Four-week-old female LEC rats were divided into the untreated and
treated groups. The latter was fed bovine lactoferrin at 2% mixed with
conventional diet.
RESULTS:
The cumulative survival rates were 75.0% vs. 100% at 14 weeks, 37.5%
vs. 91.7% at 15 weeks, and 12.5% vs. 91.7% at 16 weeks, respectively,
for untreated and treated rats (P=0.0008).
The 8-OHdG levels in liver mitochondrial DNA and malondialdehyde in
plasma and liver tissues were significantly lower in treated than
untreated rats (P<0.001, =0.017 and 0.034, respectively).
Mitochondrial DNA mutations were more common in untreated rats. OGG1
mRNA and protein expression levels were significantly lower in
untreated than treated rats (P=0.003 and 0.007, respectively).
Hypermethylation of the second CpG island located upstream of OGG1
gene was observed in untreated rats.
CONCLUSIONS: survival rates were 12.5% vs. 91.7%
Our findings indicated that lactoferrin inhibits oxidative liver
damage in LEC rats. Lactoferrin could be potentially useful for the
treatment of oxidative stress-induced liver diseases.

Publication Types:
Research Support, Non-U.S. Gov't

PMID: 18191270


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Antibiotic Properties and Applications of Lactoferrin.
Curr Pharm Des 2007; 13(8):801-802.
Weinberg ED

Lactoferrin (Lf), a mammalian iron scavenging defense protein,
constitutively is present in exocrine secretions that consistently are
exposed to microbial flora: milk, tears, tubotympanum and nasal
exudate, saliva, bronchial mucus, gastrointestinal fluids,
cervicovaginal mucus, and seminal fluid.
Additionally, Lf is promptly delivered by circulating neutrophils to
sites of microbial invasion.
At these sites, the protein effectively scavenges iron at pH values as
low as 3.5.
Recombinant bovine and human lactoferrin is now available for
development into nutraceutical/preservative/pharmaceutical products.
Among conditions for which the products are being investigated are:
angiogenesis; bone remodeling; food preservation; infection in
animals, humans, plants; neoplasia in animals, humans; inflammation in
intestine, joints; wound healing; as well as enhancement of
antimicrobial and antineoplastic drugs, and prevention of iron induced
oxidation of milk formula.

Curr Pharm Des
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