Medical Forum / Diseases and Disorders / Hepatitis / June 2008
New Technology May Help Treat Hepatitis B and C
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Jamffer - 25 Jun 2008 22:31 GMT Whole story.link... http://www.hepatitis-central.com/mt/archives/2008/06/new_technology.html
"By applying just the right amount of vibration to a virus, scientists believe that it can be rendered harmless."
"As one of the leading causes of liver disease, both the Hepatitis B and C viruses remain difficult to eliminate. Although medical technology has produced some potent medicines to battle these liver-invading viruses, they are ineffective for a significant percentage of those infected. However, scientists from Arizona have stepped into an entirely new field of medicine that proposes a completely different approach to dismantling a virus. By mathematically determining the frequency by which viruses can be shaken to death, physics may trump the biological sciences in the quest to safely eliminate viral pathogens."
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This sounds great. Maybe, in a few years, who knows. This is not a drug so it might get approved on a faster track, if it works. Jamffer
greyhackles - 25 Jun 2008 23:52 GMT >Whole story.link... >http://www.hepatitis-central.com/mt/archives/2008/06/new_technology.html [quoted text clipped - 17 lines] >it might get approved on a faster track, if it works. >Jamffer I read the article. Like all similar schemes, this one left me utterly unimpressed. It describes yet another theoretical method of killing free-floating virions while having no potential to effect the site of replication - not dissimilar to the quackery behind "UVC Light treatment" of HCV.
As has been shown time and time again, simply eliminating free-floating virions from the blood stream - even to a point below the level of detection - will not cure a chronic HCV infection. If it did, the first time a person on therapy received an "undetectable" test result - even using the most sensitive of the current test methods - that person could immediately stop therapy and be "cured".
Of course, it doesn't work that way - the replication machinery isn't in the blood stream - and supposing it takes free-floating virions to maintain those replication sites would be pretty naive thinking, considering the liver - the site of the replication - is the most vascular region of the body.
Simply put, don't hold your breath, because it won't work - even if they could strap a patient down and bombard their entire body with sound waves, light waves, whatever waves, the little bastids will keep reproducing deep within the liver, where none of those externally applied forces can safely reach.
And because of that - and knowing a chronic HCV infection can replicate a TRILLION VIRIONS EVERY DAY - the concept of using this theory to form a periodic therapeutic measure similar to dialysis (the money-making crux behind "UVC Light" wackos) is a non-starter. Within hours if not minutes, virions would be back to pre-treatment levels.
Bottom line: There's hope - and there's false hope. If it isn't a systemically applied compound or combination of compounds, it ain't gonna work. That's the only way to disrupt viral replication in situ...
/greyhackles
Jamffer - 26 Jun 2008 01:14 GMT > >Whole story.link... > >http://www.hepatitis-central.com/mt/archives/2008/06/new_technology.html [quoted text clipped - 52 lines] > > /greyhackles They didn't claim any cure. They are only perusing a new line of research. It's all hypothesis and it may or may not result in an additional line of attack, to add to existing standard treatment. Like with the new therapeutic vaccines in testing, anything to lower the viral numbers can't be bad, especially those who do not respond to standard treatment. I too am skeptical, until real clinical trials have been completed. Until then this is nothing, until proven. I wouldn't call it quackery, to peruse untried avenues of research. At least they are doing it scientifically. So maybe we should cut them some slack, while hoping a shot in the dark might get lucky. Jamffer.
greyhackles - 26 Jun 2008 01:34 GMT >> >Whole story.link... >> >http://www.hepatitis-central.com/mt/archives/2008/06/new_technology.html [quoted text clipped - 83 lines] >might get lucky. >Jamffer. I didn't specifically call this "quackery" yet - though I certainly did associate it with demonstrable quackery ("UVC Light"). Of course, if anyone ever actually proposes an embodiment of this theoretical work as a therapeutic device, then it will indeed have crossed the line from "research" to "quackery". I can wait - though I very much doubt it will ever get that far.
You're entitled to your opinion, and you can cut them all the slack you wish, but this is not a path to cure, nor a path to any viable maintenance strategy. Even as an adjuvant to drug therapy, it makes no sense. And I doubt there will *ever* be any clinical trials, because they won't be able to define any reasonable expectation as an endpoint or goal, thus there won't be any grounds for trials. Which is as it should be...
/greyhackles
Jamffer - 26 Jun 2008 01:59 GMT > >> >Whole story.link... > >> [quoted text clipped - 99 lines] > > /greyhackles Although this innovative technology's potential for fighting Hepatitis B or C is currently in a conceptual stage, the logic behind it is intriguing and hopeful. It's too bad that greyhackles has lost all hope for new research. It's a good thing that the scientists haven't. To think that something as simple as resonate sonic waves on the liver might change treatment outcome is in no way shape or form like UVC light.
greyhackles - 26 Jun 2008 04:01 GMT >> >> On Wed, 25 Jun 2008 17:31:47 -0400, "Jamffer" <jamffer@hotmail.com> >wrote: [quoted text clipped - 92 lines] >simple as resonate sonic waves on the liver might change treatment outcome >is in no way shape or form like UVC light. ahahahahahahaha. Resorting to putting words in my mouth now? Nice try - let's see if you gain any traction with that ;-)
I am a technologist by trade, for nearly four decades now. I have dozens of technology-based patents. I'm a huge fan of basic research, and I am *ever* hopeful for new research in treatments for chronic HCV - research that is intrinsically sound, that is. This isn't even close to intrinsically sound. New drugs are where I put my hope and expectations for the future treatment of chronic HCV.
This "innovative technology" is *exactly* in the same ballpark as "UVC Light" - that you fail to recognize this exposes a critical flaw in your thinking. Both are based on treating peripheral blood with "waves" - UltraViolet-C for the quackery known as "UVC Light" verses sound waves for this "innovative technology". Both seek to break down virions in the blood stream. The former has already been shown to be ineffective, the latter will as well - for the same, intrinsic reason: they do nothing to shut down the viral factories resident in the liver.
You can mischaracterize my verbal thoughts all you want, but it won't change the reality. Misplaced hope is a tragedy in the making. I only hope no significant public funds are wasted in this effort, that could be better spent on research into treatments that have a realistic chance of actually changing the course of chronic HCV.
That's all there is to it...
/greyhackles
Jamffer - 26 Jun 2008 16:36 GMT > ahahahahahahaha. Resorting to putting words in my mouth now? > Nice try - let's see if you gain any traction with that ;-) [quoted text clipped - 24 lines] > > /greyhackles "Technologist by trade", typical boast of a probable GED graduate. And the technology that you are involved with, is in what specialty? I hope it's not drugs because I'm sure you would have called HCV incurable years ago and went on to work on robots, or the like. If someone claimed that a fungus could kill bacteria, you would have laughed at that also, eh? You and I both know that a researcher needs to try a wide comprehensive array of things, no matter how strange, to find the needles in the giant haystack. A one in a million shot could take millions of hours to find but that one or two in a million would seem like a miracle to suffers, who'd rather die of old age, instead of a virus. A few things like milk thistle have been tested in controlled studies and show no remarkable benefit to HCV. Controlled studies are the judge here, not me or you. Cheer up. Jamffer
Sara - 26 Jun 2008 17:58 GMT >> ahahahahahahaha. Resorting to putting words in my mouth now? >> Nice try - let's see if you gain any traction with that ;-) [quoted text clipped - 56 lines] > Controlled studies are the judge here, not me or you. Cheer up. > Jamffer Jamffer, are you on treatment right now, or are you looking for that elusive 'miracle cure' still? Last time you were posting a lot, you were full of it, and seems you still don't know your butt from a hole in the ground.... but of course you'll continue to blather nonsense rather than to listen to anyone who has their sh.t together like Grey has.
It's irritating to read about things that really have no chance of going anywhere -- why don't you try to research some REAL potential breakthroughs in HepC treatment instead of pushing snake oil here on people who deserve better.
Sara
Jamffer - 26 Jun 2008 19:34 GMT > >> ahahahahahahaha. Resorting to putting words in my mouth now? > >> Nice try - let's see if you gain any traction with that ;-) [quoted text clipped - 70 lines] > > Sara Sorry, but I don't rule out anything before it's proven or disproved in the real world. I am the first to be skeptical about any test tube results. The real world of controlled studies, is the judge. I never will advocate anything that has not been proven, and never will. I don't know where you got that impression. I started treatment, but was ordered to stop until (possible ulcer) was cleared up. (Pegasys-Riba), which I think was working, because my lymph nodes became normal, in only day after start of tx. I don't think any (natural) treatment is of much benefit. Cheer up. I promise to keep quiet about very early research, but some need hope for what seems like hopelessness. There are a few phase 3 promising trials in the pipeline, as you all have probably seen. Jamffer
TX-012 - 26 Jun 2008 21:07 GMT even if they could
> strap a patient down and bombard their entire body with sound waves, light > waves, whatever waves, the little bastids will keep reproducing deep within > the liver, where none of those externally applied forces can safely reach. You means I will has to stop curing my hep c by sitting on top of za washing machine?
ohdamn
Jamffer - 26 Jun 2008 21:38 GMT >"TX-012" <withbacon@aol.com> wrote in message news:267402df-360f-42cf-b07e-79ba5b35ca00@j33g2000pri.googlegroups.com... even if they could
>> strap a patient down and bombard their entire body with sound waves, light >> waves, whatever waves, the little bastids will keep reproducing deep within >> the liver, where none of those externally applied forces can safely reach.
>You means I will has to stop curing my hep c by sitting on top of za >washing machine?
>ohdamn Sound waves will penetrate miles of sea water (through liquid). Maybe killing every cell in your body, might be a side effect. This idea will probably be put into the city dump of tried and failed ideas, to combat viruses. I want them to discover that having sex with three cheerleaders at once, will cure HCV. But you need to take them twice a week, for them to work. Jamffer
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