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Medical Forum / Diseases and Disorders / Hepatitis / April 2008

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Anti-cholesterol drug appears to hold promise against hepatitis C

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Frogger - 12 Apr 2008 15:45 GMT
I just found this online and it sounds very encouraging.  Go Sooner
Doc!

cheers,

Frogger

Associated Press - April 11, 2008 10:25 AM ET

OKLAHOMA CITY (AP) - Researchers at the University of Oklahoma Health
Sciences Center say an anti-cholesterol drug is showing promise in
helping treat hepatitis C.

Gastroenterologist Dr. Ted Bader at the Oklahoma City VA Medical
Center used the drug fluvastatin to treat veterans who weren't
responding to standard treatment for hepatitis C.

Bader found the drug reduced the level of the virus six-fold in the
blood of 2 out of every three patients tested. And he says half the
patients showed a reduction of hepatitis C in their blood within a
month.

Bader is now looking for people to take part in phase 2 of the
testing.

His findings appear today in the American Journal of Gastroenterology.
Frogger - 12 Apr 2008 15:52 GMT
Here is a little more information I found online.  It was a very
limited study, but still, I think it is encouraging considering it
involves using a drug that has been approved and in use for so long.

from http://www.physorg.com/news127138395.html

Researchers at the Oklahoma University Health Sciences Center have
found a new use for an old drug. Their findings appear online in the
American Journal of Gastroenterology.

The drug, Fluvastatin, has been approved since 1993 by the U.S. Food
and Drug Administration for the treatment of elevated cholesterol in
adults. Millions of patients have taken Fluvastatin for cholesterol
without difficulty.

In a study of 31 veterans at the Veteran's Administration Medical
Center in Oklahoma City, researchers found that Fluvastatin
significantly lowered the viral load, or levels of hepatitis C virus,
for up to six weeks when used alone.

"This research is the first to demonstrate the antiviral activity of
Fluvastatin in human beings infected with hepatitis C, most of whom
were non-responders to the standard of care treatment," said Ted
Bader, M.D., the principle investigator on the project and director of
liver diseases at the OU Health Sciences Center.

Since Fluvastatin will not completely clear the hepatitis C virus by
itself, researchers have started a phase II randomized, controlled
trial that combines Fluvastatin with the standard treatment of peg-
interferon and ribavirin. They hope to use the combination of
medicines to significantly improve the cure rate for hepatitis C.
After further required testing and approval, the drug could be
available as a new treatment for hepatitis C far sooner than any other
anti-hepatitis C drug currently under research and development.

> I just found this online and it sounds very encouraging.  Go Sooner
> Doc!
[quoted text clipped - 22 lines]
>
> His findings appear today in the American Journal of Gastroenterology.
TX-012 - 14 Apr 2008 21:06 GMT
What was the dose used?
eileen - 17 Apr 2008 00:48 GMT
> I just found this online and it sounds very encouraging.  Go Sooner
> Doc!
[quoted text clipped - 22 lines]
>
> His findings appear today in the American Journal of Gastroenterology.

The study was small indeed and the findings showed the suppressive
effects of HCV are modest, variable, and often short-lived. When I
first read of Statins for the reduction of VL nearly a year ago, my
doctor just laughed.
TX-012 - 17 Apr 2008 02:02 GMT
> > I just found this online and it sounds very encouraging. �Go Sooner
> > Doc!
[quoted text clipped - 29 lines]
>
> - Show quoted text -

Have there been other studies I should check out?
Frogger - 17 Apr 2008 20:57 GMT
> > > I just found this online and it sounds very encouraging. �Go Sooner
> > > Doc!
[quoted text clipped - 31 lines]
>
> Have there been other studies I should check out?

I only post these things I find as a well meaning attempt to share
what information I find online about potential new advancements in the
treatment of the rotten disease.  When I post them I don't know
anything more about them than what they say, other than before I post
something I try and make sure that the news is from a reliable
source.  If you have questions about the studies in the articles, like
any other questions about treatment new or old, it's best to ask your
doctor.

Whenever I have to go in to my gastro doc I bring up some of what I've
heard about recently and he's always familiar with the studies and has
opinions on all of them.  Some good and some bad.  I don't hammer him
with 78 article abstracts or bring up every hit on a Google search for
Hepatitis news, but if there's something interesting or encouraging I
want to know his opinion on it.  Everybody handles having HepC in
their own way, but I am curious about every single study, no matter
how small, and get a little boost whenever I find a new one.  It helps
me, at least on a mental and emotional level, to at least get the
feeling that there are people out there working all the angles trying
to find a way to make Hepatitis C as preventable as polio and as
curable as syphilis.  I've posted a few of them on this list for
anyone who, like me, might find them encouraging or even just
interesting.

cheers,

Frogger
eileen - 18 Apr 2008 03:21 GMT
> > > > I just found this online and it sounds very encouraging. �Go Sooner
> > > > Doc!
[quoted text clipped - 61 lines]
>
> - Show quoted text -

Sorry Frogger, it was insensitive of me to answer your post in that
way.
I was pretty upset over something else and forgot to tell you the
title
we laughed at.  It was something like "New cure using statins on the
way for HCV"
This article was not in AJG either, it was a newspaper article.
Posting Articles to discuss teaches encourages us to discuss them.  I
was rude, and
I admit it and ask you to forgive me.
eileen<~~~~~ a broken cookie
Cactus Jammies - 18 Apr 2008 00:18 GMT
"eileen" <samiamtwoyou@yahoo.com> wrote
.........
The study was small indeed and the findings showed the suppressive
effects of HCV are modest, variable, and often short-lived. When I
first read of Statins for the reduction of VL nearly a year ago, my
doctor just laughed.
......
Eileen, I think what is important in this study is that it shows that FLV
may help reduce the vl in people who need the boost to test test negative
earlier in the routine combo treatment.  this is the essential line:

CONCLUSIONS: FLV used as monotherapy in vivo showed suppressive effects of
HCV clinically that are modest, variable, and often short-lived.

These findings support "proof-of-concept" for pilot trials combining
fluvastatin with standard therapy. Statins and fluvastatin, in particular,
appear to be safe for use in hepatitis C.

(Am J Gastroenterol 2008;103:1-7)

cactus jammies
eileen - 18 Apr 2008 03:23 GMT
On Apr 17, 7:18 pm, "Cactus Jammies"
<cactusjamm...@retinal.circus.orb> wrote:
> "eileen" <samiamtwo...@yahoo.com> wrote
> .........
[quoted text clipped - 17 lines]
>
> cactus jammies

Thank You Jammy Man, I was not intending to hurt, I was rude, and I
asked for Frogger's forgiveness.

Broken cookie, eileen
Frogger - 18 Apr 2008 14:11 GMT
> On Apr 17, 7:18 pm, "Cactus Jammies"
>
[quoted text clipped - 25 lines]
>
> Broken cookie, eileen

It's all cool  I appreciate the apology, I did feel a little zinged by
it. I'm a n00b here, and to HepC, I'm still learning what's what.

BIG HUG!!!!

ribbit,

Frogger
TX-012 - 25 Apr 2008 01:27 GMT
> I just found this online and it sounds very encouraging.  Go Sooner
> Doc!
[quoted text clipped - 22 lines]
>
> His findings appear today in the American Journal of Gastroenterology.

Thanks for posting this, btw. Asked my Dr if we could add this to the
Drug Soup, he agreed, and I took my first 20mg capsule yesterday.

I also puked three times this morning---hopefully the two are in no
way related...
 
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