Medical Forum / Diseases and Disorders / Hepatitis / April 2008
Anti-cholesterol drug appears to hold promise against hepatitis C
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Frogger - 12 Apr 2008 15:45 GMT I just found this online and it sounds very encouraging. Go Sooner Doc!
cheers,
Frogger
Associated Press - April 11, 2008 10:25 AM ET
OKLAHOMA CITY (AP) - Researchers at the University of Oklahoma Health Sciences Center say an anti-cholesterol drug is showing promise in helping treat hepatitis C.
Gastroenterologist Dr. Ted Bader at the Oklahoma City VA Medical Center used the drug fluvastatin to treat veterans who weren't responding to standard treatment for hepatitis C.
Bader found the drug reduced the level of the virus six-fold in the blood of 2 out of every three patients tested. And he says half the patients showed a reduction of hepatitis C in their blood within a month.
Bader is now looking for people to take part in phase 2 of the testing.
His findings appear today in the American Journal of Gastroenterology.
Frogger - 12 Apr 2008 15:52 GMT Here is a little more information I found online. It was a very limited study, but still, I think it is encouraging considering it involves using a drug that has been approved and in use for so long.
from http://www.physorg.com/news127138395.html
Researchers at the Oklahoma University Health Sciences Center have found a new use for an old drug. Their findings appear online in the American Journal of Gastroenterology.
The drug, Fluvastatin, has been approved since 1993 by the U.S. Food and Drug Administration for the treatment of elevated cholesterol in adults. Millions of patients have taken Fluvastatin for cholesterol without difficulty.
In a study of 31 veterans at the Veteran's Administration Medical Center in Oklahoma City, researchers found that Fluvastatin significantly lowered the viral load, or levels of hepatitis C virus, for up to six weeks when used alone.
"This research is the first to demonstrate the antiviral activity of Fluvastatin in human beings infected with hepatitis C, most of whom were non-responders to the standard of care treatment," said Ted Bader, M.D., the principle investigator on the project and director of liver diseases at the OU Health Sciences Center.
Since Fluvastatin will not completely clear the hepatitis C virus by itself, researchers have started a phase II randomized, controlled trial that combines Fluvastatin with the standard treatment of peg- interferon and ribavirin. They hope to use the combination of medicines to significantly improve the cure rate for hepatitis C. After further required testing and approval, the drug could be available as a new treatment for hepatitis C far sooner than any other anti-hepatitis C drug currently under research and development.
> I just found this online and it sounds very encouraging. Go Sooner > Doc! [quoted text clipped - 22 lines] > > His findings appear today in the American Journal of Gastroenterology. TX-012 - 14 Apr 2008 21:06 GMT eileen - 17 Apr 2008 00:48 GMT > I just found this online and it sounds very encouraging. Go Sooner > Doc! [quoted text clipped - 22 lines] > > His findings appear today in the American Journal of Gastroenterology. The study was small indeed and the findings showed the suppressive effects of HCV are modest, variable, and often short-lived. When I first read of Statins for the reduction of VL nearly a year ago, my doctor just laughed.
TX-012 - 17 Apr 2008 02:02 GMT > > I just found this online and it sounds very encouraging. �Go Sooner > > Doc! [quoted text clipped - 29 lines] > > - Show quoted text - Have there been other studies I should check out?
Frogger - 17 Apr 2008 20:57 GMT > > > I just found this online and it sounds very encouraging. �Go Sooner > > > Doc! [quoted text clipped - 31 lines] > > Have there been other studies I should check out? I only post these things I find as a well meaning attempt to share what information I find online about potential new advancements in the treatment of the rotten disease. When I post them I don't know anything more about them than what they say, other than before I post something I try and make sure that the news is from a reliable source. If you have questions about the studies in the articles, like any other questions about treatment new or old, it's best to ask your doctor.
Whenever I have to go in to my gastro doc I bring up some of what I've heard about recently and he's always familiar with the studies and has opinions on all of them. Some good and some bad. I don't hammer him with 78 article abstracts or bring up every hit on a Google search for Hepatitis news, but if there's something interesting or encouraging I want to know his opinion on it. Everybody handles having HepC in their own way, but I am curious about every single study, no matter how small, and get a little boost whenever I find a new one. It helps me, at least on a mental and emotional level, to at least get the feeling that there are people out there working all the angles trying to find a way to make Hepatitis C as preventable as polio and as curable as syphilis. I've posted a few of them on this list for anyone who, like me, might find them encouraging or even just interesting.
cheers,
Frogger
eileen - 18 Apr 2008 03:21 GMT > > > > I just found this online and it sounds very encouraging. �Go Sooner > > > > Doc! [quoted text clipped - 61 lines] > > - Show quoted text - Sorry Frogger, it was insensitive of me to answer your post in that way. I was pretty upset over something else and forgot to tell you the title we laughed at. It was something like "New cure using statins on the way for HCV" This article was not in AJG either, it was a newspaper article. Posting Articles to discuss teaches encourages us to discuss them. I was rude, and I admit it and ask you to forgive me. eileen<~~~~~ a broken cookie
Cactus Jammies - 18 Apr 2008 00:18 GMT "eileen" <samiamtwoyou@yahoo.com> wrote ......... The study was small indeed and the findings showed the suppressive effects of HCV are modest, variable, and often short-lived. When I first read of Statins for the reduction of VL nearly a year ago, my doctor just laughed. ...... Eileen, I think what is important in this study is that it shows that FLV may help reduce the vl in people who need the boost to test test negative earlier in the routine combo treatment. this is the essential line:
CONCLUSIONS: FLV used as monotherapy in vivo showed suppressive effects of HCV clinically that are modest, variable, and often short-lived.
These findings support "proof-of-concept" for pilot trials combining fluvastatin with standard therapy. Statins and fluvastatin, in particular, appear to be safe for use in hepatitis C.
(Am J Gastroenterol 2008;103:1-7)
cactus jammies
eileen - 18 Apr 2008 03:23 GMT On Apr 17, 7:18 pm, "Cactus Jammies" <cactusjamm...@retinal.circus.orb> wrote:
> "eileen" <samiamtwo...@yahoo.com> wrote > ......... [quoted text clipped - 17 lines] > > cactus jammies Thank You Jammy Man, I was not intending to hurt, I was rude, and I asked for Frogger's forgiveness.
Broken cookie, eileen
Frogger - 18 Apr 2008 14:11 GMT > On Apr 17, 7:18 pm, "Cactus Jammies" > [quoted text clipped - 25 lines] > > Broken cookie, eileen It's all cool I appreciate the apology, I did feel a little zinged by it. I'm a n00b here, and to HepC, I'm still learning what's what.
BIG HUG!!!!
ribbit,
Frogger
TX-012 - 25 Apr 2008 01:27 GMT > I just found this online and it sounds very encouraging. Go Sooner > Doc! [quoted text clipped - 22 lines] > > His findings appear today in the American Journal of Gastroenterology. Thanks for posting this, btw. Asked my Dr if we could add this to the Drug Soup, he agreed, and I took my first 20mg capsule yesterday.
I also puked three times this morning---hopefully the two are in no way related...
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