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Medical Forum / Diseases and Disorders / Hepatitis / March 2008Iron Targeting In Nash
Liver Histology Changes in Nonalcoholic Steatohepatitis after One Year of Treatment with Probucol. [JOURNAL ARTICLE] Dig Dis Sci 2007 Nov 30. Merat S, Aduli M, Kazemi R, Sotoudeh M, Sedighi N, Sohrabi M, Malekzadeh R Background Probucol, a lipid-lowering agent with antioxidant effects, is effective in normalizing liver enzymes in patients with nonalcoholic steatohepatitis (NASH). We studied changes in the liver histology of patients with NASH after use of probucol for one year. Methods Ten patients with biopsy-proven NASH were included. Subjects were given 500 mg probucol daily. Liver biopsies were performed before treatment and after one year. Results Eight patients completed treatment. The mean alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels decreased from 94 and 55 to 41 and 26, respectively (P = 0.004 and 0.001 respectively). The scores for hepatic steatosis and necroinflammation decreased from 7.4 to 5.6 (P = 0.03). The fibrosis score changed from 1.1 to 1.3 (P = 0.79). No adverse drug effects were observed. Conclusion Probucol is effective in normalizing aminotransferase levels in patients with NASH. It also significantly reduces the histology grade of steatohepatitis after one year of treatment. Dig Dis Sci ---------------------------------- http://tinyurl.com/ynpdhm "Iron-chelating agents, N-acetyl-L-cysteine (NAC), apocynin,probucol, and edaravone, are useful in preventing cardiovascular injury and diseases." Recent Patents on Anti-Infective Drug Discovery, 2006, 1, 17-31171574-891X/06 $100.00+.00(c) 2006 Bentham Science Publishers Ltd.Recent Progress in Pharmacological Research of Antioxidants inPathological Conditions: Cardiovascular Health Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING On Mar 4, 9:17 pm, ironjustice <teamtan...@hotmail.com> wrote:probucol << I wonder .. is this carvedilol an iron chelator .. too .. ? "Reduced by oral administration of carvedilol or probucol" Wu TC, Chen YH, Leu HB, Chen YL, Lin FY, Lin SJ, Chen JW Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis. [Journal Article] Free Radic Biol Med 2007 Dec 1; 43(11):1508-22. Matrix metalloproteinase (MMP) is critical to the progression of atherosclerosis and neointima hyperplasia after vascular injury. We investigated the effects of carvedilol, a pharmacological antioxidant with alpha- and beta-adrenergic blocking activity, on MMP-2 and MMP-9 expression. Vascular injury was induced with the balloon catheters on abdominal aortas of high-cholesterol-fed rabbits. On Day 21, there was significant aortic neointima formation with increased oxidative DNA damage by immunostaining with 8-hydroxy-2'-deoxyguanosine and enhanced MMP-2 and MMP-9 expressions by Western blotting, which were significantly reduced by oral administration of carvedilol (20 mg/kg/ day) or probucol (100 mg/kg/day). Vascular expression (by Western blot), activity (by gelatin zymography), and mRNA levels of MMP-2 and MMP-9 were also reduced by carvedilol or probucol. Besides, pretreatment with carvedilol or probucol but not propranolol, a beta- blocker, or prazocin, an alpha-blocker, inhibited tumor necrosis factor-alpha-stimulated expressions and activities of MMP-2 and MMP-9 in human aortic smooth muscle cells. On electrophoretic mobility-shift assay, carvedilol inhibited the binding activities of activator protein-1 and specific protein-1, two major transcription factors for MMP promoter regions. Accordingly, carvedilol, a pharmacological antioxidant, inhibited in vivo and in vitro expression of MMP-2 and MMP-9 properly by modulating the redox-related pathways, suggesting its potential clinical implications. Free radical biology & medicine [Free Radic Biol Med] -------------------------------------------------------------------------------- More from this journal Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Liver Histology Changes in Nonalcoholic Steatohepatitis after One Year > of Treatment with Probucol. [JOURNAL ARTICLE] [quoted text clipped - 41 lines] > > DEAD PEOPLE WALKING
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