Medical Forum / Diseases and Disorders / Hepatitis / November 2007
End of Tx
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Sick Boy - 04 Nov 2007 06:03 GMT Man, it seems like it was only recently when some good people convinced me to give Tx a shot--and I'm glad I did. It's too early to celebrate yet, but here's a brief synopsis. I only wish the Dr was more reachable, the bastard--he's a real slacker, forgetting what genotype I was every time he saw me, correcting himself by saying, "Oh, so you have to do only 24 weeks because of your genotype?" I hate that kind of slack attitude, but as long as I'll be find, I don't care anymore. So, here it goes:
Got HepC in 2000 or 2001 Genotype 3a age 30, male, 170 lbs Pre-Tx ALT/AST: around 100/200 Pre-Tx viral load: 2.7 million
Week 1: May 18 (Peg-Intron 120 mcg, Ribavirin 1000 mg) Week 2: ALT/AST back to normal, for the first time in years, staying normal throughout Tx Week 4: VL undetectable (<5 IU/ml) Week 12: VL undetectable Week 24: October 26
I did develop slight anaemia, low RBC, and hemoglobin hovered usually above 11 over the course of Tx. WBC counts were normal throughout. Platelets were good, too.
I saw my Dr the week after my final, 24th shot, and keeping my fingers crossed for the results, although the prognosis is good, according to him.
Looking back at the whole thing, it was nowhere near as bad as some other people report. I guess I was lucky. My hair used to be wavy, now it's straight, of different texture, and not as thick--but I guess it'll pass. Around month 2, anaemia was really annoying--difficult to get up the stairs, etc.--but it passed quickly, too. Um, what else...depression, cognitive problems, etc--I guess that kind of stuff did take place, but not to the point where it significantly affected my functioning. Most of the times, I could not even say I was on some heavy-duty meds if I didn't know already. sh.t, I hope the interferon was properly stored at the warehouse, or something. <g>
Is it normal at all? Don't get me wrong, sometimes I felt like real crap, and depressed like hell, but not all the time--far from it. Just nowhere like I'd expected.
I cannot really think of any horrible experiences. That first shot was very tough, yes, as well as some occasional shots afterwards, but I knew it was going to pass. Sedatives and opiates helped sometimes, as well as occasional small doses of amphetamines. I'm not advocating this--especially amphetamines--but that's how I did it. Vitamins C and E, Omega fish oil--I used them too.
A week before my last shot, I lowered my Ribavirin down from 1000 mg/day to 800 mg, per my Dr's instructions. Then, I took no more of it after the 24th Peg-Intron shot. Is this how it usually happens?
I'm not sure why I'm writing this. I owe a lot to this group, and I thought I'd write an update, I suppose. I'm due to have some root canal procedures done soon, and I'm wondering if NSAIDs like ibuprofen would be best for pain, if there's any, or maybe Tylenol.
Do I truly banish HepC, or is it still lurking in my cells? Can I drink socially now? Not a big deal for me, but I want to know.
I feel strange now, that I don't have to take any more of these meds every day and weekly shots. A bit apprehensive about the final results, but I suppose there's little I can do now about it. Heh.
I'm no longer employed (only partly due to the Tx issues--mostly just lost interested), and thinking of visiting some friends in South Pacific this winter. Well, it's great to see many of you still around here--I sure appreciate your help. If you have any tips for me at this point, I'd be happy to listen, as usual. I think I'll check my eyes, because I used to get a peculiar eye pain in the first couple of days following an interferon injection.
Thanks again, guys and girls...I'll be dropping in, as usual, once in a while. I pray I get SVR--I can only imagine how devastating it is to get the bad news after you think it'll all be great, heh. Thank you all--especially Grey for your wisdom, time, and patience--and I'll be seeing you around. Wishing you all well,
 Signature Sick Boy
Kozure Ookami - 04 Nov 2007 08:56 GMT C Congrats on making it through tx. Don't worry about your meds being bad because it went pretty mild for you. It was pretty mild for me as well most of the time l and I cleared. You don't hear as much from people in support groups who are having an easy time of it. The fact is meds affect people differently.
It's common to be a little apprehensive about whether or not there will be SVR even among 24 weekers. But your chances are excellent of getting an SVR. Does an SVR mean the virus is completely gone. Maybe not. Some studies have suggested the virus persists in some form years beyond SVR but the implications of that are not understood at this time. The question of resuming social drinking is open to debate. My feelings, not backed or refuted by science to my knowledge, is that if liver damage was minimal why not resume drinking if you didn't have a drinking problem. It might be a good idea to wait for the SVR though.
Don
Ghamph - 04 Nov 2007 20:40 GMT > C > Congrats on making it through tx. Don't worry about your meds being [quoted text clipped - 15 lines] > > Don Nice story, Sick Boy.
Don is right, about waiting for SVR.
Even after SVR you shouldn't booze it while doing Tylenol.
Liver damage combo, as it states on the bottle.
Sick Boys' story, gives me slightly less apprehension about starting tx.
Jamffer
Sick Boy - 10 Nov 2007 02:13 GMT >Sick Boys' story, gives me slightly less apprehension about starting tx. > >Jamffer I am glad I could decrease your anxiety about starting Tx. As I've been told here when I began considering it, some people breeze through it, and for others it's a really difficult journey. Under normal circumstances and with good medical care, I think you really have little to worry about. I don't know your details, but best of luck to you...this "monster" became a lot less scary when I actually started Tx, compared to when I would just think about it.
 Signature Sick Boy
Normin - 04 Nov 2007 15:14 GMT hi Sick Boy
your experience sounds a lot like what I went through, only I had to do it for 48 weeks. Mostly I was very very tired and no stamina, but I never felt really 'sick' during tx, and I was able to do many of the things I wanted, only slower (grin) and not as thoroughly!
I never heard of stopping Riba *before* your last week.... I did my last shot, then one more week of Riba. I don't think it's really going to make that big a difference though, you were an early responder and sounds to me like you've beaten the dragon!
as far as drinking goes, I can't really advise you, but I find that in my case, I have no desire to drink. I'd give my liver time to finish healing though if I wanted to drink, then I'd keep it very minimal if I chose to do it.... like I may have a coffee and baileys during the holidays when visiting a particular friend, or a touch of rum in my eggnog, that kind of thing. shrug.
thanks for letting us know how you are doing. We need to read about more experiences like yours! It's good for us all to see that some people can breeze through the treatments without totally falling apart :)
take care, and keep feeling better and better. as a certain Vulcan would say -- "Live Long and Prosper" :))
Sara
> Man, it seems like it was only recently when some good people > convinced me to give Tx a shot--and I'm glad I did. It's too [quoted text clipped - 121 lines] > I'll be > seeing you around. Wishing you all well, greyhackles - 04 Nov 2007 16:35 GMT >Man, it seems like it was only recently when some good people >convinced me to give Tx a shot--and I'm glad I did. It's too early to [quoted text clipped - 78 lines] >all--especially Grey for your wisdom, time, and patience--and I'll be >seeing you around. Wishing you all well, Thanks for posting this, SB. The group loves to hear about success stories, and it may well encourage fence-sitters to get off that fence and take a shot at a cure. The fact that your sides were rather mild helps that much more.
Stopping the Riba with the last shot is no biggie - a bit different than what most folks are advised to do, but for a super-responder g3 it's highly unlikely to have any effect on the outcome.
As Sara said, it's common for folks reaching the end of treatment to experience uncertainty. Don't fret - clearly, the treatment worked for you!
Wrt root canals, discuss the proper OTC meds with your endodontist, who will likely recommend that you avoid drugs that promote bleeding - which is true for ibuprophen and aspirin - both before and after the root canal. Tylenol - taken in a appropriate amounts and NOT WHILE DRINKING ALCOHOL! is usually the way to go. Your endo may prescribe a compound of tylenol and codeine, that ought to do the job just fine.
The hair thing is bizarre, ain't it? My hair went from wicked curly to dead straight end-to-end by the sixth month on therapy. Six months after completing treatment it was back to its old, curly self. I actually enjoyed the straight part, as it was that much easier to deal with when I was being pounded by the drugs. God only knows what actually causes that to happen, but it's pretty typical stuff. Give it time, it'll be back to whatever would be normal for you.
Studies have shown the durability of SVR, with a very small percentage of relapses occurring after the 6 month post-tx test (like in the couple of percentage points). It is only a handful of comparatively tiny studies that appear to have found *something* in a few patients, claiming lingering compartmentalized infections, etc, but again, the vast majority of those that are clear at 6 months will remain clear forever.
I have to say to you: You have been given a precious gift, one that many folks *don't* receive, in spite of their best efforts. Don't f.ck it up by compulsively downing ups, downs, opiates, pain meds, whatever, when you're feeling out of sorts. You're still a young dude, and youth seems to convey a sense of immortality. Trust me - that ain't the way to go - it puts you on that slippery slope that you've heard about.
You only get one ride on the bus of life. Go out and make the most of it.
Cheers - and please, make at least one more post when you pass your 6 month SVR test!
/greyhackles
Sick Boy - 10 Nov 2007 03:08 GMT >>Man, it seems like it was only recently when some good people >>convinced me to give Tx a shot--and I'm glad I did. It's too early to [quoted text clipped - 82 lines] >and it may well encourage fence-sitters to get off that fence and take a shot >at a cure. The fact that your sides were rather mild helps that much more. Thanks, Grey. If my story helps just one person, then it'd be great. And anyway, I was posting here for my own benefit--not to sound cynical, but the support and information I got from this newsgroup is difficult to overestimate. I could always count on you to respond with a useful post whenever I had questions about this.
>Wrt root canals, discuss the proper OTC meds with your endodontist, who will >likely recommend that you avoid drugs that promote bleeding - which is true >for ibuprophen and aspirin - both before and after the root canal. Tylenol - >taken in a appropriate amounts and NOT WHILE DRINKING ALCOHOL! is usually the >way to go. Your endo may prescribe a compound of tylenol and codeine, that >ought to do the job just fine. I don't usually drink--I only brought it up in case there's a social event where drinking a couple of glasses of wine would be the norm. As far as doctors--well, dentists so far, at least--in my opinion, they know f.ck all about the subject. I made the mistake of telling one of them that I was on interferon when I came to have a tooth fixed. Just as it's virutally always been the case when I'd mention my drug history, his attitude immediately changed, followed by a dozen questions that had nothing to do with my dental issue--of course, when I told them I was on interferon for HepC, I was interrogated about the way I had gotten it, and so on. Eventually, that particular dentist gave me an insane price quote on the root canals, and had nothing useful to say wrt interferon, meds for pain, or anything else.
Codeine, and other opiates, is pretty useless for bad tooth pain, unless you take enough to knock yourself out. Tylenol is a difficult choice due to liver concerns. NSAIDs like aspirin or ibuprofen are harsh on the stomach and GI tract, although they are probably the most effective meds for tooth pain--plus, measures can be taken to minimise GI side effects.
I recently saw another dentist who said that I didn't need a root canal--not now, anyway. It seems that it gets done a lot when you don't really need it, because it's an expensive procedure compared to a simple filling (which is what I got). This time, I kept my mouth shut about interferon and HepC. Another lesson learnt. Just like with sharing drug history, especially when it's totally irrelevant, stuff like that only seems to put many doctors in a sadistic or moralistic mood. I guess HepC is still considered to be a disease of junkies and low-lives.
>The hair thing is bizarre, ain't it? My hair went from wicked curly to dead >straight end-to-end by the sixth month on therapy. Same here, LOL! Well, not "wicked curly", but I always had a pretty big head of hair, wavy and full. Now it's slick and straight. I also like it more this way, it's easier to handle--I don't have the patience to tame my wild hair. I wish it stayed the same way (except for getting a bit thinner)...oh well.
>I have to say to you: You have been given a precious gift, one that many folks >*don't* receive, in spite of their best efforts. Don't f.ck it up by [quoted text clipped - 4 lines] > >You only get one ride on the bus of life. Go out and make the most of it. I understand it, mate, I truly do. And I really value your concern for my well-being. I'm way past the "compulsive" phase...only use drugs as tools to cope with depression, anxiety, loneliness, etc. Not the healthiest way to deal, I know--but it's a far cry from doing crazy sh.t just to get high the way I used to. I've cut down my intake to what I deem as a minimum and stick to pharmaceuticals. I'm not some kid who's experimenting, you know? I would not feel a dozen Vicodin, even if I poisoned myself with all the Tylenol in it--so I don't bother. The party days are over for me...now, it's about staying stable and not sinking into depression, which is why I maintain on a couple of things that allow me to have a quality of life that I've tried to achieve in a million other ways. Please don't think I'm in denial about this. I know I have a problem with...um...coping with problems. Too well aware of it, in fact. I also know what alternatives are available to me--so, I try to choose the lesser of two (or more) evils. At the moment, the choice is feeling miserable or taking a prescribed medication. I hope the time comes when I have more choices, I really do. Thank you, again.
>Cheers - and please, make at least one more post when you pass your 6 month >SVR test! Absolutely. The Dr. told me to email him about the end of Tx blood test I had on the week after my last, 24th interferon shot. If that turns out all right, then I'll have to see him 3 months later...and then 6 months. Keeping my fingers crossed... Thank you so much, Grey, and everyone else who supported me in this endeavor--I wouldn't have gone through this without your help, guys. Cheers,
 Signature Sick Boy
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