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Medical Forum / Diseases and Disorders / Hepatitis / September 2007Iron Chelation Treatment of Liver Fibrosis
J Gastroenterol. 2007 Jun;42(6):475-84. Epub 2007 Jun 29. Links The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis. Jin H, Terai S, Sakaida I. Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Japan. BACKGROUND: Hepatic stellate cells (HSCs) play a pivotal role in liver fibrogenesis. Here, we studied whether the iron chelator deferoxamine (DFO) affected cultured HSC activation and apoptosis. METHODS: The effect of DFO on HSCs was investigated using quiescent and activated stellate cells. RESULTS: Treatment with DFO inhibited HSC activation, resulting in the reduced expression of alpha-smooth muscle actin protein and type I procollagen, matrix metalloproteinase-2 and -9, and tissue inhibitors of metalloproteinase-1 and -2 mRNAs. DFO induced apoptosis of activated HSCs, which was associated with decreasing Bcl-2 expression and the release of cytochrome c from the mitochondria to the cytosol with enhanced caspase-3 activity. DFO also induced activated HSCs to express peroxisome proliferator-activated receptor gamma with the reaccumulation of intracellular lipids. CONCLUSIONS: The iron chelation of stellate cells inhibits their activation, causing them to become deactivated as well as to undergo apoptosis. These data suggest a potential role for an iron chelation treatment of liver fibrosis. PMID: 17671763 [PubMed - in process] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Please explain how this relates to the iron causes all disease because people eat meat notion. >> On Sep 18, 11:54 am, ferr...@paris.com wrote: Please explain how this relates to the iron causes all disease because people eat meat notion. << Sure .. buddy .. anything to help you not have to ..cheat .. You seeee .. the iron from the meat you eat builds to higher and higher levels and causes liver fibrosis. When you remove this iron the liver fibrosis stops and gets better .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Please explain how this relates to the iron causes all disease >becausepeople eat meat notion. "Sure .. buddy .. anything to help you not have to ..cheat .. You seeee .. the iron from the meat you eat builds to higher and higher levels and causes liver fibrosis. When you remove this iron the liver fibrosis stops and gets better .." Do all people then who eat meat have this? Because eskimos ate mostly meat did all of them have this? Because they ate mostly meat did they have all diseases constantly throughout their lives? If only a small minority of people have this does it mean the other multiple billions are veggie alone eaters? Because the body controls iron levels how does it "build higher and higher"? >> On Sep 18, 4:17 pm, ferr...@paris.com wrote: Because the body controls iron levels how does it "build higher and higher"? << Actually the Greenland Study shows the higher consumption of meat .. leads TO .. higher iron levels .. and moderate levels of meat intake leads to moderate iron .. stores .. and LOW meat eating leads to .. lower iron .. stores .. Or more succinctly .. the more meat you eat .. the higher the iron stores in the body. You may believe high iron .. stores .. are .. good but .. they are .. bad. They use these higher iron stores as a marker of susceptibility to .. disease. It is a .. marker .. this higher iron store .. Type in this phrase in google .. "meat eating predicts diabetes" .. and the thread will include the study which .. speaks to this known fact .. OF .. different iron .. stores. Print it out .. Make sure you see if you can spot the word .. stores .. This fact is most likely one of the reasons they are now recruiting for a mult-million dollar study in diabetes .. because there IS such a high rate of iron related disease in the Inuit / Eskimo. You did mention the Eskimo / Inuit .. didn't you .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk . > Because the body controls iron levels how does it "build higher and >higher"? "Actually the Greenland Study shows the higher consumption of meat .. leads TO .. higher iron levels .. and moderate levels of meat intake leads to moderate iron .. stores .. and LOW meat eating leads to .. lower iron .. stores .." Happy to see that study. Now getting back to my question. because the body controls iron levels how can it get higher and higher? "Type in this phrase in google .. "meat eating predicts diabetes" .." I did and got an echo of one of your ng postings as the first item, stopped right there. One abstract you posted years ago showed higher risk for diabetes for red meat, not for other meat and no difference for blood doners. The higher sat fat in red meat in other studies is the risk factor. "This fact is most likely one of the reasons they are now recruiting for a mult-million dollar study in diabetes .. because there IS such a high rate of iron related disease in the Inuit / Eskimo. You did mention the Eskimo / Inuit .. didn't you" Yep, you tried to pull this one years ago too. This is for current inuit folk who have adopted a much greater amount of commercial food items, most of it from plant sources such as potatoe chips etc. into their diet. With this change their diabetes also increased. My original question, because they ate mostly meat did they have all human diseases simultaneously all throughout their lives, everyone of them without exception? .. ? > Because the body controls iron levels how does it "build higher and >higher"? [...] fwiw, the human body has no functional mechanism for eliminating iron... Cheers /greyhackles >> Because the body controls iron levels how does it "build higher and >> higher"? [quoted text clipped - 5 lines] > > /greyhackles Paleo man no doubt got regular cuts and scrapes, injuries, etc., which resulted in regular blood loss; a regular way of getting rid of iron and one that evolution adapted for. Modern man doesn't get injured anywhere near as often or regularly so iron stores build up. Go give some blood or take an iron chelator as desired. Pramesh > Because the body controls iron levels how does it "build higher and >higher"? [...] fwiw, the human body has no functional mechanism for eliminating "iron..." Of course, but is that the only way to control levels? Our mr. justice knows the answer, he is trying to pretend it does not exist. To do so means once and for all the death of the quivering corpse of the iron causes all disease because people eat meat notion. One of the legs supporting that stool has been sawed off and he does not want to face it. >> Because the body controls iron levels how does it "build higher and >> higher"? [quoted text clipped - 6 lines] > > /greyhackles Females do for about 50 years of their lives. >>> Because the body controls iron levels how does it "build higher and >>> higher"? [quoted text clipped - 8 lines] > >Females do for about 50 years of their lives. Ah - there's truth to that, of course - although the "50 years" part is fairly optimistic, and even 40 years would be a stretch as a mean, if one considers the entire planet's population of human females. The only point being, while Tom has clearly taken a few factoids and cobbled together a freakin' conspiracy theory, there *are* those bits of underlying truth to consider... Cheers /greyhackles >>>> Because the body controls iron levels how does it "build higher and >>>> higher"? [quoted text clipped - 20 lines] > > /greyhackles I saw a Doctor talking about Hemachromotosis on a TV program the other day and he said one of the reasons that this disorder affects a larger percentage of the male population than female is because of the fact that a male does not sustain a monthly iron loss. "Men usually accumulate over 10 grams of iron in their body before symptoms develop. In women, symptoms often show up after menopause and about five to ten years later than in men. This is because menstruation and pregnancy protect them from building up too much iron. Women who reach menopause before the age of 50 often have more iron in their bodies than those who reach it after age 50." http://aol.mediresource.com/condition_info_details.asp?disease_id=270 And I stand corrected on my time "period". http://www.4women.gov/FAQ/menstru.htm#f >>>>> Because the body controls iron levels how does it "build higher and >>>>> higher"? [quoted text clipped - 37 lines] > >http://www.4women.gov/FAQ/menstru.htm#f No problem - if you had six sisters plus a wife, with the youngest being my wife at 56, you'd have known already ;-) Cheers /greyhackles |
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