Interesting news:
Milk Thistle for Hepatitis C
Many patients use alternative and complementary therapies to manage
hepatitis C and resulting liver fibrosis, but most such agents have not
been studied in Western clinical trials. Again in the May 2007 issue of
Gastroenterology, S.J. Polyak and colleagues reported data from a
laboratory study of the anti-inflammatory and antiviral properties of a
standardized milk thistle (Silybum marianum) silymarin extract known as
MK-001. They found that MK-001 inhibited expression of tumor necrosis
factor-alpha in human peripheral blood mononuclear cells and inhibited
nuclear factor kappa B-dependent transcription in human hepatoma cells.
MK-001 also demonstrated both preventive and therapeutic effects against
HCV infection of cells. When combined with interferon alpha, MK-001
inhibited HCV replication more than interferon alone. The compounds
silybin A, silybin B, isosilybin A, and isosilybin B produced the
strongest anti-HCV activity. These antiviral effects were found to be
independent of MK-001-induced cytotoxicity. The authors concluded that,
The data indicate that silymarin exerts anti-inflammatory and antiviral
effects, and suggest that complementary and alternative medicine-based
approaches may assist in the management of patients with chronic
hepatitis C.
http://www.hcvadvocate.org/news/newsRev/2007/HJR-4.11.html#3
Thomas

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Cody - 16 Jun 2007 00:48 GMT
> Interesting news:
>
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>
> Thomas
What's the recommended daily dosage?
Cody
greyhackles - 16 Jun 2007 01:03 GMT
>> Interesting news:
>>
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>
>Cody
As much as you can afford? ;-)
Note that this was a "laboratory study" - essentially in vitro testing. Seems
pretty weak to me that after all this time of being toited as about the best
thing next to SVR that there haven't been any qualitative studies done with a
living, breathing cohort...
Cheers
/greyhackles
Thomas Wagner - 16 Jun 2007 02:22 GMT
>Note that this was a "laboratory study" - essentially in vitro testing. Seems
>pretty weak to me that after all this time of being toited as about the best
>thing next to SVR that there haven't been any qualitative studies done with a
>living, breathing cohort...
Indeed.... in vitro studies aren't necessarily transferable to human
trials, but maybe this study will trigger some interest and lead to one.
Since this was done using a standardized extract (which I assume is
patentable) it could be financially viable.
Thomas

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john - 20 Jun 2007 19:37 GMT
> > Interesting news:
>
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>
> - Show quoted text -
Hi Cody,
My doctor has me taking 4 capsules a day.I believe they are the
standard 200 or 300m.......john
Cody - 21 Jun 2007 11:46 GMT
>>> Interesting news:
>>> Milk Thistle for Hepatitis C
[quoted text clipped - 28 lines]
> My doctor has me taking 4 capsules a day.I believe they are the
> standard 200 or 300m.......john
Thanks, John.
Cody
Rachel - 22 Jun 2007 04:40 GMT
Here the bottom line
""The data indicate that silymarin exerts anti-inflammatory and antiviral
effects, and ""suggest"" that complementary and alternative medicine-based
approaches ""may assist"" in the management of patients with chronic
hepatitis C."
The words "suggest" and "may assist" say it all. In other words the dragon
will continue to live with or without this treatment.
This Milk Thistle crap was spread all over this newgroup when I was on
treatment nearly three years ago.
Dont waste your time or money on it.
The dragon is dead,
Rachel

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We recovered alcoholics are not so much brothers in virtue as we are
brothers in our defects, and in our common strivings to overcome them.
AS BILL SEES IT, p.167
> Interesting news:
>
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>
> Thomas
bob - 22 Jun 2007 12:58 GMT
> Here the bottom line
> ""The data indicate that silymarin exerts anti-inflammatory and antiviral
[quoted text clipped - 5 lines]
> This Milk Thistle crap was spread all over this newgroup when I was on
> treatment nearly three years ago.
I don't think that anyone claimed that milk thistle cures Hep C. The claim
is that it is beneficial to your liver.
> Dont waste your time or money on it.
> The dragon is dead,
Well for those of us who have been unable to kill it, trying to limit the
damage to the liver is very important.
> Rachel