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Medical Forum / Diseases and Disorders / Hepatitis / April 2007

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surgery during treatment

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DarlinDebo Dreamweaver - 14 Apr 2007 00:38 GMT
I have been reading your posts for several months.  Trying to learn as
much as I possibly can.  My husband has Hepatitis C 1A, & has Cirrhosis.
His viral load is 237,000.  He had bronchitis back in Jan, but never
totally got rid of the cough.  Saw family doc several times...He saw a
specialist today.  He has something on his vocal cords...possibly
pre-cancer, cancer, or maybe nothing serious.  This doc wants to do
surgery right way.  My husband is to be in a trial study by
Schering-Plough that starts this next week.  Have any of you had surgery
during tx?  Is this even possible?  Thank you for your time.  Deb
Terry - 14 Apr 2007 01:01 GMT
>I have been reading your posts for several months.  Trying to learn as
>much as I possibly can.  My husband has Hepatitis C 1A, & has Cirrhosis.
[quoted text clipped - 5 lines]
>Schering-Plough that starts this next week.  Have any of you had surgery
>during tx?  Is this even possible?  Thank you for your time.  Deb

A viral load of 237k is not very high compared to most.

I address this question to the group.

How common is it for someone to have cirrhosis and such a low viral
load?
Thip - 14 Apr 2007 01:16 GMT
> A viral load of 237k is not very high compared to most.
>
> I address this question to the group.
>
> How common is it for someone to have cirrhosis and such a low viral
> load?

Viral load has no bearing on liver damage.

Honestly, I'm thinking the only thing those numbers are good for is as a
baseline when starting tx.  Otherwise, how do you measure the 2-log drop?
Thip - 14 Apr 2007 01:14 GMT
I hate to say this, but the surgery will probably boot him out of the study.
Does the doctor want to do surgery, or a biopsy of whatever is on his vocal
cords?  I don't think tx precludes any type of surgery; emergencies happen
all the time.

>I have been reading your posts for several months.  Trying to learn as
> much as I possibly can.  My husband has Hepatitis C 1A, & has Cirrhosis.
[quoted text clipped - 5 lines]
> Schering-Plough that starts this next week.  Have any of you had surgery
> during tx?  Is this even possible?  Thank you for your time.  Deb
anonymousone - 14 Apr 2007 19:52 GMT
> I hate to say this, but the surgery will probably boot him out of the study.
> Does the doctor want to do surgery, or a biopsy of whatever is on his vocal
[quoted text clipped - 12 lines]
>
> - Show quoted text -

I was on a trial and got booted when they mis-diagnosed me with kidney
cancer. They dont want someone with cancer messing up their studies.
Thip - 14 Apr 2007 22:15 GMT
> I was on a trial and got booted when they mis-diagnosed me with kidney
> cancer. They dont want someone with cancer messing up their studies.

I got booted because my AF-P was too high at 156.
Michael Arends - 15 Apr 2007 00:16 GMT
Smiling Wickedly,  Thip answered:
>> I was on a trial and got booted when they mis-diagnosed me with kidney
>> cancer. They dont want someone with cancer messing up their studies.
>
> I got booted because my AF-P was too high at 156.

Hi Hon.. good to see ya around. i don't get here NEARLY as much as i
want to any more, But is it ever a pleasure to see ya here.
take care, and hope all is well.       ;-)
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                            «.·°·. Michael .·°·-:¦:-

Thip - 15 Apr 2007 12:08 GMT
> Hi Hon.. good to see ya around. i don't get here NEARLY as much as i
> want to any more, But is it ever a pleasure to see ya here.
> take care, and hope all is well.       ;-)

Thanks, Michael [hugs].  Things are still crawling along.  I just got the
results back on my MRI==the nodules haven't changed so no cancer, thank
heavens!  Repeat test in 3 months.  Ugh, that drive to Emory.....
Michael Arends - 15 Apr 2007 20:08 GMT
Smiling Wickedly,  Thip answered:
>> Hi Hon.. good to see ya around. i don't get here NEARLY as much as i
>> want to any more, But is it ever a pleasure to see ya here.
[quoted text clipped - 3 lines]
> results back on my MRI==the nodules haven't changed so no cancer, thank
> heavens!  Repeat test in 3 months.  Ugh, that drive to Emory.....

Good. Glad things are well (as much as they CAN be).

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    ¸.·´ .·´¨¨))
  ((¸¸.·´  .·´-:¦:-((¸¸.·´(º·.¸(¨*·.¸  ¸.·*¨)¸.·º)
                            «.·°·. Michael .·°·-:¦:-

greyhackles - 14 Apr 2007 01:19 GMT
>I have been reading your posts for several months.  Trying to learn as
>much as I possibly can.  My husband has Hepatitis C 1A, & has Cirrhosis.
[quoted text clipped - 5 lines]
>Schering-Plough that starts this next week.  Have any of you had surgery
>during tx?  Is this even possible?  Thank you for your time.  Deb

The potential complications provided by HCV antiviral therapy include lowered
immunity to infection (WBC suppression due to IFN) and impaired clotting
ability (platelet suppression also due to IFN) with anemia thrown in
(hemolytic due to Ribavirin as well as RBC production suppression from the
IFN).

I'd say get the immediate problem resolved before hopping on the therapy
express. Hopefully what hubby's doc is seeing is a benign cyst, but if there's
more to it you don't want the complication of therapy meds in the way.

As your hubby's condition demonstrates, viral loads are pretty much irrelevant
wrt disease progression. On the up side, a low viral load such as your
husband's is a plus when calculating the odds of treatment success...

Cheers - and good luck.

/greyhackles
flifla - 18 Apr 2007 04:47 GMT
On Apr 13, 6:38 pm, DarlinD...@webtv.net (DarlinDebo Dreamweaver)
wrote:
> I have been reading your posts for several months.  Trying to learn as
> much as I possibly can.  My husband has Hepatitis C 1A, & has Cirrhosis.
[quoted text clipped - 5 lines]
> Schering-Plough that starts this next week.  Have any of you had surgery
> during tx?  Is this even possible?  Thank you for your time.  Deb

NO surgery during treatment.

Ask your physician I agree with the responses by readers. By now I am
sure you have come to a conclusion.

Simple dental procedures are discouraged. The lowered WBC (white bllod
cell count) immunity can and do KILL. A hospital environment has what
is called Hospital Acquired Infections. One cannot and should not go
for ANY surgery while on treatment. We are on what is called severe
chemotherapy that must be closely watched. Adding another wrench into
it...well..no respecting Dr would attempt such a thing unless it were
life or death.  We, as one's on treatment, and with a very subdued
immunity due to the Interferon treatment and Ribasphere, are under
strange and mysterious chemical treatments which leave our bodies with
little or no fighting ability toward infection of any kind. Consider
yourselves "Boys in Plastic Bubbles". The very entrance into a
hospital endangers one to dangerous germs that a healthy person needs
their white blood cells to fight, let alone one with little body
defenses. This would be an experiment at least for you doctor and all.
Richard - 20 Apr 2007 16:27 GMT
I had surgery last year, on the treatment, after about 27 weeks.  Different
surgery (hemorrhoids), but I picked up an infection and had to go into the
hospital for about 4 days.  They killed me with antibiotics to get rid of
the infection, but the bottom line was I was off the treatment for about 8
days.  My last qualitative blood test had been 0, at 25 weeks, but when I
had my next test at 31 weeks, the virus had returned.  My doctor insisted
that being off the treatment during my surgery wasn't a factor, but I've
always had my doubts.  Anyway, I had to stop the treatment because the virus
had returned.  My advice to your husband is to try to stay on the treatment
as much as possible during the time of surgery and recovery period.  And
good luck.
>I have been reading your posts for several months.  Trying to learn as
> much as I possibly can.  My husband has Hepatitis C 1A, & has Cirrhosis.
[quoted text clipped - 5 lines]
> Schering-Plough that starts this next week.  Have any of you had surgery
> during tx?  Is this even possible?  Thank you for your time.  Deb
 
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