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Medical Forum / Diseases and Disorders / Hepatitis / March 2007

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I' M in a Combo and have a few questions

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Alphonse - 13 Mar 2007 19:42 GMT
Halo,

January / 30 I started a Combo  2 Peg Interferon 120 microgram, with 5
pill's Rebetol.

The day after the injection I understand that it is not sou good,

Always in the night I get fever ( 37,8-38,2) and all the next day I fell me
really seek.

The doctor said that will be stop after one month, but nothing....

And I find all the treatment hard, I'm often tired and also I can't not good
eating.

If you knows same symptoms?

By my last blood test ( every 14 days) the doctor found a little problem by
my " Leucozite "

and said to take only 4 Rebetol...

Thanks for your answers

Alphonse

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Thomas Wagner - 13 Mar 2007 21:56 GMT
>January / 30 I started a Combo  2 Peg Interferon 120 microgram, with 5
>pill's Rebetol.
[quoted text clipped - 14 lines]
>
>and said to take only 4 Rebetol...

Hi Alphonse,

it looks like you're writing from Luxembourg - welcome!

To your questions... yes, it is very normal during treatment that you
feel tired all the time and have very low appetite. Most of us have gone
through this, for many treatment has been very hard. You'll probably get
a load of tips how to survive treatment in general soon, or look back
through the archived posts (though that can be a daunting task).

One thing you should talk to your doc about, though: Interferon can
cause severe anemia, and that appears to be what's causing your fatigue.
Rather than reducing your dose, try to convince your doctor to give you
Procrit. It helps to produce more leukocytes, and usually also helps
relieve the most severe fatigue. Reducing the ribavirin dose that early
into treatment may endanger your chance for success.

Thomas
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ghibelno - 14 Mar 2007 10:02 GMT
>> January / 30 I started a Combo  2 Peg Interferon 120 microgram, with 5
>> pill's Rebetol.
[quoted text clipped - 8 lines]
>
> Thomas

Hi Alphonse,

    I'm from Europe as well (Italy).
I do agree with everything Thomas said but I'd like to add something.

As far as anemia is concerned, here where I am, doctors are not allowed
to give drugs like the one Thomas suggested (Procrit makes the number of
red blood cells grow up) to people treated for Hepatitis C.

The same goes for white blood cells, which seems to be the problem in
your case (this because you said your doctor was concerned about
leukocytes). In this case, another drug would be used (Neupogen or
whatever - it stimulates the bone marrow to produce much more of them)
but it is not allowed as well in Europe for Hepatitis C treatment side
effects.

These are the reasons why a lot of doctors go for a Ribavirin dosage
reduction to keep anemia at bay.
But a dosage reduction _might_ decrease the effectiveness of treatment,
above all if it occurs before week 12.

Bottom line. I had a similar experience and I strongly suggest:

1. crawl out of this reduction as soon as you can. You're at week 6.
Probably it will do no harm if you start at full regimen after one week.
In order to do this, go in for a lab test, pay on your own (just blood
cells counts is what you need - 5 euros?), show the doctor that cell
counts improved and force him to give you back full dosage;

2. to try and avoid this happen again in the future: look after your
diet. Eat well and ask here or look around to set up a diet that could
help. Drink a lot of water (minimum: 2 liters/day), REST yourself MORE
than you used to do before;

3. if anemia shows up again: look for alternatives before dosage
reduction. In my case doctor prescribed Lederfolin (7,5 mg) later in
treatment and it HELPED _a lot_;

4. learn about treatment: read this NG posts -as they represent the REAL
experience of people like you- and search the Internet for serious
sources of information.

Do your best at it and good luck.

Cheers,
jeeb.
 
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