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Medical Forum / Diseases and Disorders / Hepatitis / March 2007

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Well, what about interferon?

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ironjustice - 05 Mar 2007 18:38 GMT
There is no question that it can control erythrocytosis

http://www.medical-library.org/journals_6a/polycythemia_vera.htm

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
greyhackles - 05 Mar 2007 21:07 GMT
>There is no question that it can control erythrocytosis
>
>http://www.medical-library.org/journals_6a/polycythemia_vera.htm

I have to wonder whether this article carries any real weight in the medical
community. It's written so poorly it's hard to believe it was ever reviewed.
Paragraphs ending in mid-sentence, sentences ending in mid-thought...

As for the conclusion, the author clearly isn't convinced that tx using IFN is
the way to go...

Cheers

/greyhackles
kjoh - 05 Mar 2007 21:56 GMT
That is one funky website.  I wonder if it is a scam...

kj
ironjustice - 06 Mar 2007 01:49 GMT
>>There is no question that it can control erythrocytosis

http://www.medical-library.org/journals_6a/polycythemia_vera.htm

I have to wonder whether this article carries any real weight in the
medical
community. It's written so poorly it's hard to believe it was ever
reviewed.
Paragraphs ending in mid-sentence, sentences ending in mid-thought...

As for the conclusion, the author clearly isn't convinced that tx
using IFN is
the way to go...

Cheers

/greyhackles<<

The link .. full story .. costs ten bucks and a credit card ..

Sooo .. that effectively stops me from accessing .. it ..

But .. it was mainly placed to show .. specifically .. interferon CAN
and does decrease erythrocytosis .. and therefore places
erythrocytosis .. 'possibly' .. involved ..

Soooo .. I placed the article to show it IS used to treat
erythrocytosis .. and since hepatitis is an iron loading disease and
since erythrocytosis is an iron loading disease then the fact it is
USED in hepatitis means .. there may be erythrocytosis ..
lingering ..

Since they purportedly have "no idea" .. why / how it actually is
doing its' .. job / working / mode OF operation.

Sooo .. since iron reduction .. works .. and since interferon also ..
works .. means .. more evidence to .. erythrocytosis BEING ..
involved .. because .. ? both interferon and iron reduction are USED
to treat erythrocytosis.

Sooo .. in conclusion .. increased red blood cell production .. higher
hemoglobin .. 'may' be involved IN the pathogenesis of ANY disease in
which interferon has been shown to have .. efficacy.

IMHO ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
greyhackles - 06 Mar 2007 01:57 GMT
>>>There is no question that it can control erythrocytosis
>
[quoted text clipped - 44 lines]
>Who loves ya.
>Tom

Um....ok, I can see your sense of logic is working hard on this one.

I'm just waiting for someone in authority to ring you up
for ellipses abuse ;-)

Cheers

/greyhackles
Cactus Jammies - 06 Mar 2007 03:11 GMT
Hey grey, look at the spam list you just added iron to.

alt.support.chronic-pain,alt.support.mult-sclerosis,uk.people.support.mult-sclerosis,alt.support.hepatitis-c,sci.med.diseases.hepatitis

cactus jammies

>>>>There is no question that it can control erythrocytosis
>>
[quoted text clipped - 53 lines]
>
> /greyhackles
greyhackles - 06 Mar 2007 03:21 GMT
>Hey grey, look at the spam list you just added iron to.
>
>alt.support.chronic-pain,alt.support.mult-sclerosis,uk.people.support.mult-sclerosis,alt.support.hepatitis-c,sci.med.diseases.hepatitis

Well, no, there was absolutely no iron in my post - no irony either - and the
group list was Tom's doing...

Cheers

/greyhackles
Thip - 06 Mar 2007 02:01 GMT
>>>There is no question that it can control erythrocytosis
>
[quoted text clipped - 28 lines]
> Who loves ya.
> Tom

Ok, Tom, I'm really curious.  What is your story?  I assume you have HCV, is
that correct?  Have you ever tried treatment?  And since iron is such a huge
concern of yours, what do you do for yourself and how has it affected your
HCV and/or liver?

I'm not being sarcastic.  You've popped in and out of here a lot but never
said anything about yourself.
ironjustice - 06 Mar 2007 02:21 GMT
> >>>There is no question that it can control erythrocytosis
>
[quoted text clipped - 38 lines]
>
> - Show quoted text -

>>Ok, Tom, I'm really curious.  What is your story? <<

My 'story' ,, is .. iron reduction is called "an effective alternative
to interferon" ..

THAT is about ALL about my .. story .. which REALLY .. **needs** to
BE .. known ..

AND .. interferon is used to treat erythrocytosis .. and
hyperviscosity has been shown to be caused by .. erythrocytosis .. and
hyperviscosity has been shown to exist in disease .. states ..

THAT .. again .. is about ALL about my .. story .. which REALLY ..
**needs** to BE .. known ..

And .. no .. I am not .. afflicted with every disease I post to ..

I am not a neonatal with erythrocytosis ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Cactus Jammies - 06 Mar 2007 03:16 GMT
tom you are full of your own red sh.t as it turns out, the excess Iron is
just a way for the Great Magnet to deposit you in the coke ovens, you
spamartist!

have a toke, tom.  be a person for a change.  stop inventing things to make
yourself feel important.  And oh by the way Jesus (which one of thousands?)
ate whatever the bugs in the Negyev let the israelites eat in those good old
days.  What about the Galalee fishes?  Oh well, I don't want to debate a
mailing robot.

cactus jammies.
//////////////////////

>> >>>There is no question that it can control erythrocytosis
>>
[quoted text clipped - 73 lines]
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
james thomas - 09 Mar 2007 02:16 GMT
that was and is an idiots response. i thought you were better than
that..
Randy T. - 13 Mar 2007 10:00 GMT
Hey cactus head, you oviously know little about iron overload and the
pancreas,liver, heart, brain,cardiovascular etc. you have shown your
ignorance, now go dry up and blow away....
Cactus Jammies - 13 Mar 2007 15:07 GMT
up your a.s Randy, that's where your head ususally is.  iron justice was my
target.

> Hey cactus head, you oviously know little about iron overload and the
> pancreas,liver, heart, brain,cardiovascular etc. you have shown your
> ignorance, now go dry up and blow away....
Waterspider - 13 Mar 2007 21:14 GMT
> Hey cactus head, you oviously know little about iron overload and the
> pancreas,liver, heart, brain,cardiovascular etc. you have shown your
> ignorance, now go dry up and blow away....

Oh my. So you're too knowledgeable about human physiology to lower yourself
to discussion with CJ...
Well, perhaps you should go dry up and blow away, you're obviously so far
above everyone here that your time is wasted on us ignorant little folks
here.
elmoemerson@webtv.net - 14 Mar 2007 03:52 GMT
Re: Well, what about interferon? To cactus regarding slamming tom  

Group: alt.support.hepatitis-c Date: Tue, Mar 13, 2007, 1:14pm (CDT-2)
From: nospam@all.com (Waterspider)
"Randy T." <RandyThomas777@webtv.net> wrote in message
news:497-45F6682F-703@storefull-3352.bay.webtv.net...
Hey cactus head, you oviously know little about iron overload and the
pancreas,liver, heart, brain,cardiovascular etc. you have shown your
ignorance, now go dry up and blow away....
Oh my. So you're too knowledgeable about human physiology to lower
yourself to discussion with CJ...
Well, perhaps you should go dry up and blow away, you're obviously so
far above everyone here that your time is wasted on us ignorant little
folks here.
////////////
Randy's uncalled for attack on CJ was merely a response to CJ's uncalled
for attack on Tom.  And now you're jumping on the bandwagon too, Spidey.
What a ya say everybody step back from the precipice and start showing a
little respect for one another again?  Isn't anybody doing ribavirin in
this fight.....there's no excuse.  Now let's all light up a cigarette,
smoke a fat one, and get along.  Right, CJ?
elmo
warmin' up the bus

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Waterspider - 14 Mar 2007 04:24 GMT
> Re: Well, what about interferon? To cactus regarding slamming tom
>
[quoted text clipped - 17 lines]
> elmo
> warmin' up the bus

I'm all for that!
<passes joint to CJ>

Thanks for the perspective, Doc.
elmoemerson@webtv.net - 14 Mar 2007 14:09 GMT
Re: Well, what about interferon? To cactus regarding slamming tom  

Group: alt.support.hepatitis-c Date: Tue, Mar 13, 2007, 8:24pm (CDT-2)
From: nospam@all.com (Waterspider)
<elmoemerson@webtv.net> wrote in message
news:12999-45F76357-141@storefull-3251.bay.webtv.net...
Re: Well, what about interferon? To cactus regarding slamming tom
Group: alt.support.hepatitis-c Date: Tue, Mar 13, 2007, 1:14pm (CDT-2)
From: nospam@all.com (Waterspider)
"Randy T." <RandyThomas777@webtv.net> wrote in message
news:497-45F6682F-703@storefull-3352.bay.webtv.net... Hey cactus head,
you oviously know little about iron overload and the pancreas,liver,
heart, brain,cardiovascular etc. you have shown your ignorance, now go
dry up and blow away.... Oh my. So you're too knowledgeable about human
physiology to lower yourself to discussion with CJ...
Well, perhaps you should go dry up and blow away, you're obviously so
far above everyone here that your time is wasted on us ignorant little
folks here.
////////////
Randy's uncalled for attack on CJ was merely a response to CJ's uncalled
for attack on Tom. And now you're jumping on the bandwagon too, Spidey.
What a ya say everybody step back from the precipice and start showing a
little respect for one another again? Isn't anybody doing ribavirin in
this fight.....there's no excuse. Now let's all light up a cigarette,
smoke a fat one, and get along. Right, CJ? elmo
warmin' up the bus
I'm all for that!
<passes joint to CJ>
Thanks for the perspective, Doc.
////////
And NO Bogarting that jay either, CJ!
:-)
elmo
let me wring it out for you, man

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Cactus Jammies - 14 Mar 2007 16:37 GMT
see previous correpsondence this date, other subject header...

cj under attack for being a fucktard and deserving it

ps/  hint to others if you wish to remain not being a fucktard... ask for
translations sometimes. and trim your headers when responding.  and know
when someone replys to a discussion on their own post under a different
name. having said all that, I am sure 'tom' is a great guy.  and know that
its Ok when sometime someone is having a bad day and decides to NOT slam
someone named 'tom'.  I reserve the right to rip into the stinkin Klanners
out there, tho.  arbitrarily.

cactus jammies ===========

> Re: Well, what about interferon? To cactus regarding slamming tom
>
[quoted text clipped - 34 lines]
>
> http://community.webtv.net/elmoemerson/TheFamilyAlbum
dort - 15 Mar 2007 04:59 GMT
> see previous correpsondence this date, other subject header...
>
[quoted text clipped - 9 lines]
>
> cactus jammies ===========

Um...what was a fucktard again? It was discussed a while back but I can't
remember what the final definition was.

dort
tom - 15 Mar 2007 05:07 GMT
> > see previous correpsondence this date, other subject header...
> >
[quoted text clipped - 14 lines]
>
> dort

http://www.urbandictionary.com/define.php?term=fucktard
Waterspider - 15 Mar 2007 06:24 GMT
>> see previous correpsondence this date, other subject header...
>>
[quoted text clipped - 16 lines]
>
> dort

My definition of a fucktard is someone who says that lowering iron levels
will cure hepatitis c.
Dwight - 15 Mar 2007 06:53 GMT
>>>see previous correpsondence this date, other subject header...
>>>
[quoted text clipped - 19 lines]
> My definition of a fucktard is someone who says that lowering iron levels
> will cure hepatitis c.

I'm living proof that it doesn't cure hep-c. I've had lots of
phlebotomies and those damned dragons are still hanging around.

Dwight
elmoemerson@webtv.net - 15 Mar 2007 14:12 GMT
Re: Well, what about interferon? To cactus regarding slamming tom  

Group: alt.support.hepatitis-c Date: Thu, Mar 15, 2007, 5:53am (CDT+5)
From: me@notreal.net (Dwight)
Waterspider wrote:
<dort> wrote in message
news:7K2dnUrv8PRPXmXYnZ2dnUVZ_r6vnZ2d@comcast.com...
"Cactus Jammies" <cactusjammies@imitation.univ.net> wrote in message
news:dFUJh.114855$cE3.113288@edtnps89...
see previous correpsondence this date, other subject header...
cj under attack for being a fucktard and deserving it
ps/ hint to others if you wish to remain not being a fucktard... ask for
translations sometimes. and trim your headers when responding. and know
when someone replys to a discussion on their own post under a different
name. having said all that, I am sure 'tom' is a great guy. and know
that
its Ok when sometime someone is having a bad day and decides to NOT slam
someone named 'tom'. I reserve the right to rip into the stinkin
Klanners
out there, tho. arbitrarily.
cactus jammies ===========
Um...what was a fucktard again? It was discussed a while back but I
can't remember what the final definition was.
dort
My definition of a fucktard is someone who says that lowering iron
levels will cure hepatitis c.
I'm living proof that it doesn't cure hep-c. I've had lots of
phlebotomies and those damned dragons are still hanging around.
Dwight
///////////
Quite true, Dwight.  But wouldn't you agree that the malady (iron
overload) you're getting your blood drawn off for may have been a
contributing factor for you not getting your SVR?  
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Cactus Jammies - 15 Mar 2007 15:08 GMT
ggggeeezzzz   if I knew as much about this virus as I suppose I should know,
then I could just hide in the footnotes from the sucker.  not.   :)

cactus jammies

> I'm living proof that it doesn't cure hep-c. I've had lots of
> phlebotomies and those damned dragons are still hanging around.
[quoted text clipped - 4 lines]
> contributing factor for you not getting your SVR?
> elmo
elmoemerson@webtv.net - 15 Mar 2007 15:32 GMT
You said it! not.  
elmo
/////////////
ggggeeezzzz   if I knew as much about this virus as I suppose I should
know, then I could just hide in the footnotes from the sucker. not.  
:)
cactus jammies
<elmoemerson@webtv.net> wrote
I'm living proof that it doesn't cure hep-c. I've had lots of
phlebotomies and those damned dragons are still hanging around. Dwight
///////////
Quite true, Dwight. But wouldn't you agree that the malady (iron
overload) you're getting your blood drawn off for may have been a
contributing factor for you not getting your SVR? elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Dwight - 15 Mar 2007 18:45 GMT
>  
> Re: Well, what about interferon? To cactus regarding slamming tom  
[quoted text clipped - 35 lines]
>
> http://community.webtv.net/elmoemerson/TheFamilyAlbum

It may have been one of the contributing factors, but I did keep the
iron levels low during tx. Actually, tx kept my iron levels low. I'm not
sure what kept me from clearing the virus, but I haven't given up on
trying to get rid of it.

Dwight
STANLEY STEAMER - 15 Mar 2007 20:38 GMT
very true. excess iron prevents meds from working their best
elmoemerson@webtv.net - 15 Mar 2007 14:06 GMT
Re: Well, what about interferon? To cactus regarding slamming tom  

Group: alt.support.hepatitis-c Date: Wed, Mar 14, 2007, 10:24pm (CDT-2)
From: nospam@all.com (Waterspider)
<dort> wrote in message
news:7K2dnUrv8PRPXmXYnZ2dnUVZ_r6vnZ2d@comcast.com...
"Cactus Jammies" <cactusjammies@imitation.univ.net> wrote in message
news:dFUJh.114855$cE3.113288@edtnps89...
see previous correpsondence this date, other subject header...
cj under attack for being a fucktard and deserving it
ps/ hint to others if you wish to remain not being a fucktard... ask for
translations sometimes. and trim your headers when responding. and know
when someone replys to a discussion on their own post under a different
name. having said all that, I am sure 'tom' is a great guy. and know
that
its Ok when sometime someone is having a bad day and decides to NOT slam
someone named 'tom'. I reserve the right to rip into the stinkin
Klanners
out there, tho. arbitrarily.
cactus jammies ===========
Um...what was a fucktard again? It was discussed a while back but I
can't remember what the final definition was.
dort
////////////
My definition of a fucktard is someone who says that lowering iron
levels will cure hepatitis c.
////////////////
In some instances, NOT lowering iron levels will keep hepc patients from
being cured.  You can't dispute that, Spidey.  It's a well documented
fact.  
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Waterspider - 15 Mar 2007 19:55 GMT
> Re: Well, what about interferon? To cactus regarding slamming tom
>
[quoted text clipped - 25 lines]
> fact.
> elmo

Toms says that lowering iron levels will cure hepatitis c.
That's irresponsible, undocumented and patently wrong.

Spidey

p.s.   But, like Dort, I don't know the definition of "fucktard."
dort - 16 Mar 2007 06:07 GMT
> > Re: Well, what about interferon? To cactus regarding slamming tom
> >
[quoted text clipped - 32 lines]
>
> p.s.   But, like Dort, I don't know the definition of "fucktard."

Psst...Spidey...it's my suspicion that they are on sale at Fredricks of
Hollywood...them there Fucktards I mean...

Sorry...I am being cheeky...

dort
elmoemerson@webtv.net - 16 Mar 2007 14:10 GMT
Re: Well, what about interferon? To cactus regarding slamming tom  

Group: alt.support.hepatitis-c Date: Thu, Mar 15, 2007, 11:55am (CDT-2)
From: nospam@all.com (Waterspider)
<elmoemerson@webtv.net> wrote in message
news:776-45F944BC-196@storefull-3256.bay.webtv.net...
Re: Well, what about interferon? To cactus regarding slamming tom
Group: alt.support.hepatitis-c Date: Wed, Mar 14, 2007, 10:24pm (CDT-2)
From: nospam@all.com (Waterspider)
<dort> wrote in message
news:7K2dnUrv8PRPXmXYnZ2dnUVZ_r6vnZ2d@comcast.com... "Cactus Jammies"
<cactusjammies@imitation.univ.net> wrote in message
news:dFUJh.114855$cE3.113288@edtnps89... see previous correpsondence
this date, other subject header... cj under attack for being a fucktard
and deserving it ps/ hint to others if you wish to remain not being a
fucktard... ask for translations sometimes. and trim your headers when
responding. and know when someone replys to a discussion on their own
post under a different name. having said all that, I am sure 'tom' is a
great guy. and know that
its Ok when sometime someone is having a bad day and decides to NOT slam
someone named 'tom'. I reserve the right to rip into the stinkin
Klanners
out there, tho. arbitrarily.
cactus jammies ===========
Um...what was a fucktard again? It was discussed a while back but I
can't remember what the final definition was. dort
////////////
My definition of a fucktard is someone who says that lowering iron
levels will cure hepatitis c.
////////////////
In some instances, NOT lowering iron levels will keep hepc patients from
being cured. You can't dispute that, Spidey. It's a well documented
fact.
elmo
Toms says that lowering iron levels will cure hepatitis c. That's
irresponsible, undocumented and patently wrong.
Spidey
p.s.   But, like Dort, I don't know the definition of "fucktard."
///////////////////
Welllll, Spidey........... if that's what he said, he is definitely
incorrect.

Hey Tom!  Is that what you said?  You don't really believe that
bullshit, do you?

elmo  

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Cactus Jammies - 16 Mar 2007 16:00 GMT
/////////////////
Toms says that lowering iron levels will cure hepatitis c. That's
irresponsible, undocumented and patently wrong.
Spidey ''''''''''''''''
Hey Tom!  Is that what you said?  You don't really believe that
bullshit, do you?
elmo
=========================

Hey Elmo,
 Do you really expect a straight forward answer?  Maybe I am confused, but
I never found one.  I have looked in other places about metabolism and
minerals and the Hep C patient, and from what I have seen on such places as:
http://www.phac-aspc.gc.ca/hepc/hepatitis_c/pdf/nutritionCareGuidelines/

Iron does not seem to be singled out as a primary issue.  That site btw, has
lots of credentials.

It's really hard to know 'instinctivly' just what opinions are based in fact
and benefit without doubt, and those assertions which are more wishful
thinking than anything else.   It is also confusing now, as some people are
being really coy these days by saying that it is a fact that Hep C is never
cured, but only managed to a point where it doesn't seem to want to damage
our livers.  but anyway...

cactus jammies ==========

<elmoemerson@webtv.net> wrote
//////////// ws said:
My definition of a fucktard is someone who says that lowering iron
levels will cure hepatitis c.
////////////////
In some instances, NOT lowering iron levels will keep hepc patients from
being cured. You can't dispute that, Spidey. It's a well documented
fact.
elmo
/////////////////
Toms says that lowering iron levels will cure hepatitis c. That's
irresponsible, undocumented and patently wrong.
Spidey
p.s. But, like Dort, I don't know the definition of "fucktard."
///////////////////
Welllll, Spidey........... if that's what he said, he is definitely
incorrect.

Hey Tom!  Is that what you said?  You don't really believe that
bullshit, do you?

elmo
elmoemerson@webtv.net - 16 Mar 2007 20:48 GMT
Re: Well, what about interferon? To Spidey and Iron Justice  

Group: alt.support.hepatitis-c Date: Fri, Mar 16, 2007, 3:00pm (CDT+5)
From: cactusjammies@imitation.univ.net (Cactus Jammies)
/////////////////
Toms says that lowering iron levels will cure hepatitis c. That's
irresponsible, undocumented and patently wrong. Spidey ''''''''''''''''
Hey Tom! Is that what you said? You don't really believe that bullshit,
do you?
elmo
=========================
Hey Elmo,
    Do you really expect a straight forward answer? Maybe I am
confused, but I never found one. I have looked in other places about
metabolism and minerals and the Hep C patient, and from what I have seen
on such places as:
http://www.phac-aspc.gc.ca/hepc/hepatitis_c/pdf/nutritionCareGuidelines/
Iron does not seem to be singled out as a primary issue. That site btw,
has lots of credentials.
///////////////////
Evidently, you're looking in all the wrong places, CJ.   Do a google
search of "hepatitis-c and iron overload" and you'll get more
information about it than you can possibly read.  Iron overload isn't so
much of a nutritional topic as much as it is a metabolic issue.  Perhaps
that's why you didn't find much reference to it, credentially speaking.
And no, I rarely expect a straight answer from you. :-)
elmo  

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
ironjustice@aol.com - 17 Mar 2007 11:19 GMT
>>Toms says that lowering iron levels will cure hepatitis c. That's
irresponsible, undocumented and patently wrong. Spidey
''''''''''''''''
Hey Tom! Is that what you said? You don't really believe that
bullshit,
do you?
elmo <<

Let's put it this way .. iron depletion is BETTER than anything ..

If one gets regression of cirrhosis and fibrosis .. BY .. this
'treatment' and this 'treatment' .. just so happens to BE recommended
FOR a disease which is ALSO has fibrosis and cirrhosis AND the target
OF the 'treatment' {hepatitis C];.. then one can simply theorize that
it .. WOULD .. cure it since reversal of fibrosis and cirrhosis in an
organ that regenerates .. means .. ? .. the main problem OF hepatitis
C is the destruction of the liver .. and since THAT is halted and
regressed .. then .. ?

Voila ..

Cure ..

Or as close to it as you are going to come.

Regression of cirrhosis and fibrosis in a disease which iron is
involved .. deposited in the liver .. and when removed .. reversal of
cirrhosis and fibrosis.

Ann Intern Med 2002 May 7;136(9):667-72

Reversibility of cirrhosis in patients cured of thalassemia by bone
marrow
transplantation.

Muretto P, Angelucci E, Lucarelli G
Unita Operativa di Anatomia Patologica, Azienda Ospedaliera San
Salvatore di
Pesaro, 6110 Pesaro, Italy. p.mure...@ospedalesansalvatore.it

BACKGROUND: Cirrhosis is a well-known complication of thalassemia
major. In
this context, it is a consequence of iron overload and hepatitis C
virus
infection and generally seems to be irreversible. OBJECTIVE: To
determine
whether cirrhosis in thalassemia major can be reversible. DESIGN:
Retrospective
study. SETTING: Bone Marrow Transplantation Unit and Pathology
Service, Pesaro
Hospital, Pesaro, Italy. PATIENTS: 6 patients who developed liver
cirrhosis
before or after their thalassemia was cured by bone marrow
transplantation (age
at transplantation, 11 to 25 years). After diagnosis of cirrhosis, the
patients
received iron depletion and antiviral therapies. MEASUREMENTS: Each
liver
biopsy specimen was coded. A liver pathologist and a member of the
transplantation center with expertise in hepatopathology graded the
specimens
by using the Ishak staging and grading systems. Neither knew the
patient's
identity or the sequence of biopsy with regard to the time of
treatment.
RESULTS: After the patients received iron depletion and antiviral
therapies,
liver biopsy specimens showed impressive reduction in liver iron
stores. In 4
patients, iron removal was complete. Serum aminotransferase levels
decreased in
all patients and normalized in 5; histologic inflammatory activity
decreased in
all patients and disappeared in 2. Follow-up biopsies showed
regression of
incomplete or definite cirrhosis in all patients; 3 patients had
presented with
portal fibrosis without bridging, and the others had portal fibrosis
and
portal-to-portal bridging. Several biopsies and the presence of many
portal
spaces confirmed the diagnosis of cirrhosis; follow-up biopsies
confirmed
regression of cirrhosis. CONCLUSION: In some patients in whom bone
marrow
transplantation has cured thalassemia, cirrhosis may be reversible
after iron
removal treatment.

PMID: 11992302, UI: 21987737

--------------------------------------------------------------------------
------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
elmoemerson@webtv.net - 17 Mar 2007 15:23 GMT
Re: Well, what about interferon? To Spidey and Iron Justice  

Group: alt.support.hepatitis-c Date: Sat, Mar 17, 2007, 3:19am (CDT-2)
From: ironjustice@aol.com
Toms says that lowering iron levels will cure hepatitis c. That's
irresponsible, undocumented and patently wrong. Spidey
''''''''''''''''
Hey Tom! Is that what you said? You don't really believe that bullshit,
do you?
elmo <<
Let's put it this way .. iron depletion is BETTER than anything ..
If one gets regression of cirrhosis and fibrosis .. BY .. this
'treatment' and this 'treatment' .. just so happens to BE recommended
FOR a disease which is ALSO has fibrosis and cirrhosis AND the target OF
the 'treatment' {hepatitis C];.. then one can simply theorize that it ..
WOULD .. cure it since reversal of fibrosis and cirrhosis in an organ
that regenerates .. means .. ? .. the main problem OF hepatitis C is the
destruction of the liver .. and since THAT is halted and regressed ..
then .. ?
Voila ..
Cure ..
Or as close to it as you are going to come.
Regression of cirrhosis and fibrosis in a disease which iron is involved
. deposited in the liver .. and when removed .. reversal of cirrhosis
and fibrosis.
Ann Intern Med 2002 May 7;136(9):667-72
Reversibility of cirrhosis in patients cured of thalassemia by bone
marrow
transplantation.
Muretto P, Angelucci E, Lucarelli G
Unita Operativa di Anatomia Patologica, Azienda Ospedaliera San
Salvatore di
Pesaro, 6110 Pesaro, Italy. p.mure...@ospedalesansalvatore.it
BACKGROUND: Cirrhosis is a well-known complication of thalassemia
major. In
this context, it is a consequence of iron overload and hepatitis C virus
infection and generally seems to be irreversible. OBJECTIVE: To
determine
whether cirrhosis in thalassemia major can be reversible. DESIGN:
Retrospective
study. SETTING: Bone Marrow Transplantation Unit and Pathology Service,
Pesaro
Hospital, Pesaro, Italy. PATIENTS: 6 patients who developed liver
cirrhosis
before or after their thalassemia was cured by bone marrow
transplantation (age
at transplantation, 11 to 25 years). After diagnosis of cirrhosis, the
patients
received iron depletion and antiviral therapies. MEASUREMENTS: Each
liver
biopsy specimen was coded. A liver pathologist and a member of the
transplantation center with expertise in hepatopathology graded the
specimens
by using the Ishak staging and grading systems. Neither knew the
patient's
identity or the sequence of biopsy with regard to the time of treatment.
RESULTS: After the patients received iron depletion and antiviral
therapies,
liver biopsy specimens showed impressive reduction in liver iron stores.
In 4
patients, iron removal was complete. Serum aminotransferase levels
decreased in
all patients and normalized in 5; histologic inflammatory activity
decreased in
all patients and disappeared in 2. Follow-up biopsies showed regression
of
incomplete or definite cirrhosis in all patients; 3 patients had
presented with
portal fibrosis without bridging, and the others had portal fibrosis and
portal-to-portal bridging. Several biopsies and the presence of many
portal
spaces confirmed the diagnosis of cirrhosis; follow-up biopsies
confirmed
regression of cirrhosis. CONCLUSION: In some patients in whom bone
marrow
transplantation has cured thalassemia, cirrhosis may be reversible after
iron
removal treatment.
PMID: 11992302, UI: 21987737
----------------------------------------------
------
Who loves ya.
Tom
///////////
I didn't see any mention of the word 'hcv cure' during this discussion.
And in the context of this NG, 'cure' means the total eradication of the
hepc virus.  The article also mentioned the use of antiviral therapy in
combination with iron depletion to get a reduction in fibrosis and
cirrhosis. elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
ironjustice@aol.com - 17 Mar 2007 17:09 GMT
>> I didn't see any mention of the word 'hcv cure' during this discussion.
And in the context of this NG, 'cure' means the total eradication of
the
hepc virus.  The article also mentioned the use of antiviral therapy
in
combination with iron depletion to get a reduction in fibrosis and
cirrhosis. elmo<<

Well the .. article .. supplied didn't speak to .. hep .. at .. all ..

I've supplied the study by Herbert in which iron reduction therapy is
called "an effective alternative to interferon and ribavarin " ..
soooo .. the fact fibrosis and cirrhosis is .. **reversed** BY iron
reduction .. means .. extrapolate THAT to .. hepatitis .. C ..

If it is as effective as anti-virals .. then .. anti-virals are not
needed .. and if iron reduction is effective in regression of fibrosis
and cirrhosis .. and if fibrosis and cirrhosis ARE .. a 'problem' ..
IN .. hepatitis C .. then ..

That would mean .. no anti-virals needed and reversal of fibrosis and
cirrhosis ..

And if you cannot .. SEE .. that it CAN be .. extrapolated .. then ..
buddy .. you are wasting your time questioning ANYONE in regards to ..
medical .. studies.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
elmoemerson@webtv.net - 17 Mar 2007 17:23 GMT
Re: Well, what about interferon? To Spidey and Iron Justice  

Group: alt.support.hepatitis-c Date: Sat, Mar 17, 2007, 9:09am (CDT-2)
From: ironjustice@aol.com
I didn't see any mention of the word 'hcv cure' during this discussion.
  And in the context of this NG, 'cure' means the total eradication
of the
  hepc virus. The article also mentioned the use of antiviral
therapy in
  combination with iron depletion to get a reduction in fibrosis and
cirrhosis. elmo<<
Well the .. article .. supplied didn't speak to .. hep .. at .. all ..
I've supplied the study by Herbert in which iron reduction therapy is
called "an effective alternative to interferon and ribavarin " .. soooo
. the fact fibrosis and cirrhosis is .. **reversed** BY iron reduction
. means .. extrapolate THAT to .. hepatitis .. C ..
If it is as effective as anti-virals .. then .. anti-virals are not
needed .. and if iron reduction is effective in regression of fibrosis
and cirrhosis .. and if fibrosis and cirrhosis ARE .. a 'problem' .. IN
. hepatitis C .. then ..
That would mean .. no anti-virals needed and reversal of fibrosis and
cirrhosis ..
And if you cannot .. SEE .. that it CAN be .. extrapolated .. then ..
buddy .. you are wasting your time questioning ANYONE in regards to ..
medical .. studies.
Who loves ya.
Tom
/////////////
Tom, I appreciate that you're posting info about iron overload and iron
reduction, but your logic in interpreting these articles is flawed, to
say the least.  If phlebotomy was as effective in controlling or
eradicating hcv as you say, why wouldn't health professionals be using
that regimen in place of standard therapy?  After all, it's much less
expensive than combo drugs.  And don't try to tell me that it's because
the drug companies have some sort of conspiracy to get all your money.
elmo  

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
ironjustice@aol.com - 17 Mar 2007 17:50 GMT
>>Tom, I appreciate that you're posting info about iron overload and iron
reduction, but your logic in interpreting these articles is flawed,
to
say the least.  If phlebotomy was as effective in controlling or
eradicating hcv as you say, why wouldn't health professionals be
using
that regimen in place of standard therapy?  After all, it's much less
expensive than combo drugs.<<

According to Herbert .. it is .. effective ..

WHY 'they' do not use it is a matter of .. question ..

Most likely has to do with the fact they have to approach .. YOU /
hepatitis C carrier .. WITH a .. needle ..

And their abilities to actually .. handle a needle .. IE: needle
sticks .. would give them that added .. incentive to .. continue
using .. drugs.

>>  And don't try to tell me that it's because
the drug companies have some sort of conspiracy to get all your
money.
elmo   <<

No .. I believe it has to do with the fact they have to ..
physically .. get 'involved' WITH .. the hepatitis .. patient .. and
UNLESS the one is proven to be MORE effective .. then they are going
to CONTINUE to use the drugs ..

And as to your 'conspiracy' theory .. that is PRECISELY why the
studies of epoeitin were conducted ..

The doctors were suspected of going off label .. using EXTREME AMOUNTS
of epoeitin .. because .. ? .. they were / are getting more
**MONEY** .. because..? .. they get PAID to use the drug and the more
OF the drug they use the more money .. they .. get ..

Sooo .. you can say .. "money doesn't come into it" .. when in fact
money DOES come into the prescription of drugs .. and it has been
ESTABLISHED the use of interferon and ribavirin DOES cost .. a ..
**lot** ..

Sooo .. whether the doctors get any commission as they did / do with
epoeitin .. is a matter of .. research ..

Research that I have not done ..

I didn't know the doctors got paid by .. QUANTITIY of drug .. used ..
either .. IE:epoeitin ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
ironjustice - 17 Mar 2007 18:47 GMT
I didn't know the doctors got paid by .. QUANTITIY of drug .. used ..
either .. IE:epoeitin .. <<

Now that they are talking about "second courses" of interferon and
ribavirin DUE TO .. "failure to respond" .. it would be interesting to
see IF they DO get paid BY .. quantity ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
ironjustice - 17 Mar 2007 19:38 GMT
One could "forward look" and forsee the use of .. infected .. nurses /
doctors TO implement / prove the theory .. and at the very same
time .. **put to good use** .. medical professionals who have been ..
ostracized / forced to resign due TO .. their infection ..?

Sooo .. one could find medical professionals who would be
**receptive** to this theory .. because / and .. they themselves would
be getting back .. into .. the profession they most likely chose ..
because .. of you and your ilk / disease stricken people.

Sooo .. they are .. back in the game .. so to speak ..

I think a prison population would be the way to go .. captive audience
and **food intake** is **controlled** ..

The food intake .. iron intake / absorption / 8mcg / day .. is what
**has** to be .. proven ..

If it comes to the fact the prison system **has** to begin to pay for
the transplants which will happen in 70% .. ? .. of the infected
prisoners .. ? .. then the dollar savings will be astronomical due to
the fact NONE of the patients advanced to carcinoma WHEN iron was ..
**restricted** ..

And the .. implications .. are ..

The government .. us .. is advocating an addition of a substance to
our food which .. disallows .. YOU .. from getting food which ALLOWS
for this .. reduction .. because .. ? .. they have / are adding at
such a high rate to ALL our foods that it is virtually impossible
to .. adhere TO the 8mcg / day .. diet.

For sure impossible by inclusion of the highly absorbable form of
iron .. heme iron / blood ...

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
ironjustice - 17 Mar 2007 20:05 GMT
Just a .. reminder ..
------------------------------

Dr. Amy Elizabeth Wallace decided to test thiamine for HBV after a
"very
bright
and aware patient" observed that his aminotransferase levels rose and
fell
depending on whether he was taking the vitamin. High levels of
aminotransferase
enzymes indicate more active infection of the liver. In reviewing his
chart,
Wallace found a relationship--the patient's aminotransferase levels
fell
when
he took thiamine.

Wallace and her colleague, Dr. William Brinson Weeks, conducted a
trial in
this
patient and two others with HBV infection to investigate the
relationship.
All
had either failed treatment with interferon or could not tolerate the
drug.

"While patients were on thiamine treatment, their aminotransferase
levels
fell
from abnormally high to normal levels; these levels increased when
thiamine
was
subsequently withdrawn," Wallace and Weeks write in the March issue of
The
American Journal of Gastroenterology. And in subsequent liver biopsies
after
thiamine treatment, HBV DNA was undetectable.

This is the first study to investigate thiamine for treating hepatitis
B
infection. There are several potential ways that the vitamin might
fight the
infection, according to Wallace, an assistant professor of psychiatry
at
Dartmouth Medical School in Hanover, New Hampshire.

For example, thiamine binds to iron and thus reduces the iron load in
the
liver. Past studies have linked high iron levels in the liver to more
severe
HBV infection, as well as a worse response to interferon.

"Thiamine is so cheap, way cheaper than any of the treatments that are
on
the
market," Wallace said. And, she noted, the vitamin has no side
effects.

However, more research is clearly needed to determine if thiamine
does
indeed
help patients with HBV, Dr. Raymond S. Koff, a professor in the
division of
digestive diseases and nutrition at the University of Massachusetts
Medical
School in Worcester, told Reuters Health.

"The very small number of patients studied is a major limitation of
this
[study]," he said. "There is no information about thiamine levels
before,
during or after treatment. A prospective, randomized controlled trial
in
previously interferon-untreated patients or in nonresponders to
interferon
therapy will be needed to determine the utility of thiamine in the
treatment
of
chronic hepatitis B."

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Cactus Jammies - 17 Mar 2007 20:49 GMT
You will know them by their aluminium foil hats...

> One could "forward look" and forsee the use of .. infected .. nurses /
> doctors TO implement / prove the theory .. and at the very same
> time .. **put to good use** .. medical professionals who have been ..
> ostracized / forced to resign due TO .. their infection ..?

> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
Dwight - 17 Mar 2007 23:19 GMT
>  
> Re: Well, what about interferon? To Spidey and Iron Justice  
[quoted text clipped - 37 lines]
>
> http://community.webtv.net/elmoemerson/TheFamilyAlbum

I wish it were true, I'd do a Keith Richards and change out all of the
old blood and replace it with fresh. Isn't that how you beat heroin
addiction as well? :)

Dwight
Randy T. - 20 Mar 2007 20:14 GMT
Elmo, just to clarify an important fact. one can have hcv with no damage
from inflammation from hcv. given this individual also has iron
overload/hemachromatosis. And this patient has had iron loading in
excess for years, resulting in mild to moderate fibrosis and
inflammation directly caused by too much iron storage in the liver.(not
mentioning other over stored sites/organs) This happens and sometimes a
sharp doc catches it. Sometimes, a dumbass with a wall full of plaques
overlooks the latter scenario. The key to this happening is either a
most recent hcv infection of about 10 yrs. This was the case.....  Randy
Thomas Wagner - 17 Mar 2007 15:33 GMT
>Let's put it this way .. iron depletion is BETTER than anything ..
>
[quoted text clipped - 10 lines]
>
>Cure ..

Well, Elmo, there you have it, in his own words. Still wonder why Tom is
regarded by many as a nutcase?

Thomas
Signature

To reach me, complete my last name in the address.

elmoemerson@webtv.net - 17 Mar 2007 16:01 GMT
Re: Well, what about interferon? To Spidey and Iron Justice  

Group: alt.support.hepatitis-c Date: Sat, Mar 17, 2007, 10:33am (CDT+1)
From: tomw@capecod.com (Thomas Wagner)
On 17 Mar 2007 03:19:08 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:
Let's put it this way .. iron depletion is BETTER than anything ..
If one gets regression of cirrhosis and fibrosis .. BY .. this
'treatment' and this 'treatment' .. just so happens to BE recommended
FOR a disease which is ALSO has fibrosis and cirrhosis AND the target OF
the 'treatment' {hepatitis C];.. then one can simply theorize that it ..
WOULD .. cure it since reversal of fibrosis and cirrhosis in an organ
that regenerates .. means .. ? .. the main problem OF hepatitis C is the
destruction of the liver .. and since THAT is halted and regressed ..
then .. ?
Voila ..
Cure ..
Well, Elmo, there you have it, in his own words. Still wonder why Tom is
regarded by many as a nutcase?
Thomas
-----------
I'm beginning to see the light.  :-)  
elmo


http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
greyhackles - 17 Mar 2007 17:24 GMT
>Re: Well, what about interferon? To Spidey and Iron Justice  
>
[quoted text clipped - 19 lines]
>I'm beginning to see the light.  :-)  
>elmo

That's ok - some folks are a bit slower than others ;-)

Really, I don't know wtf his agenda actually is, but he consistently plays
fast and loose with his associations between various diseases, their
manifestations, and resolutions, such that his conclusions end up generally
unsupported...

Cheers

/greyhackles
elmoemerson@webtv.net - 17 Mar 2007 18:12 GMT
Re: Well, what about interferon? To Spidey and Iron Justice  

Group: alt.support.hepatitis-c Date: Sat, Mar 17, 2007, 12:22pm From:
greyhackles@NOSPAMyahoo.com (greyhackles)
Re: Well, what about interferon? To Spidey and Iron Justice
Group: alt.support.hepatitis-c Date: Sat, Mar 17, 2007, 10:33am (CDT+1)
From: tomw@capecod.com (Thomas Wagner)
On 17 Mar 2007 03:19:08 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:
Let's put it this way .. iron depletion is BETTER than anything .. If
one gets regression of cirrhosis and fibrosis .. BY .. this 'treatment'
and this 'treatment' .. just so happens to BE recommended FOR a disease
which is ALSO has fibrosis and cirrhosis AND the target OF the
'treatment' {hepatitis C];.. then one can simply theorize that it ..
WOULD .. cure it since reversal of fibrosis and cirrhosis in an organ
that regenerates .. means .. ? .. the main problem OF hepatitis C is the
destruction of the liver .. and since THAT is halted and regressed ..
then .. ?
Voila ..
Cure ..
Well, Elmo, there you have it, in his own words. Still wonder why Tom is
regarded by many as a nutcase?
Thomas
-----------
I'm beginning to see the light. :-)
elmo
That's ok - some folks are a bit slower than others ;-)
Really, I don't know wtf his agenda actually is, but he consistently
plays fast and loose with his associations between various diseases,
their manifestations, and resolutions, such that his conclusions end up
generally unsupported...
Cheers
/greyhackles  
//////////
Yeah, duhhhhhhhh! :-) They say 'you can't argue with a sick mind'.  So
I'm not going to.  I guess he's fair game for pot shots, no pun
intended.  Tom, good buddy, you're on your own from here.  Best of luck!
ahahahahahahahahaha!!!!!
elmo
farting on the Blarney Stone

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Waterspider - 17 Mar 2007 19:13 GMT
Re: Well, what about interferon? To Spidey and Iron Justice

Group: alt.support.hepatitis-c Date: Sat, Mar 17, 2007, 12:22pm From:
greyhackles@NOSPAMyahoo.com (greyhackles)
Re: Well, what about interferon? To Spidey and Iron Justice
Group: alt.support.hepatitis-c Date: Sat, Mar 17, 2007, 10:33am (CDT+1)
From: tomw@capecod.com (Thomas Wagner)
On 17 Mar 2007 03:19:08 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:
Let's put it this way .. iron depletion is BETTER than anything .. If
one gets regression of cirrhosis and fibrosis .. BY .. this 'treatment'
and this 'treatment' .. just so happens to BE recommended FOR a disease
which is ALSO has fibrosis and cirrhosis AND the target OF the
'treatment' {hepatitis C];.. then one can simply theorize that it ..
WOULD .. cure it since reversal of fibrosis and cirrhosis in an organ
that regenerates .. means .. ? .. the main problem OF hepatitis C is the
destruction of the liver .. and since THAT is halted and regressed ..
then .. ?
Voila ..
Cure ..
Well, Elmo, there you have it, in his own words. Still wonder why Tom is
regarded by many as a nutcase?
Thomas
-----------
I'm beginning to see the light. :-)
elmo
That's ok - some folks are a bit slower than others ;-)
Really, I don't know wtf his agenda actually is, but he consistently
plays fast and loose with his associations between various diseases,
their manifestations, and resolutions, such that his conclusions end up
generally unsupported...
Cheers
/greyhackles
//////////
Yeah, duhhhhhhhh! :-) They say 'you can't argue with a sick mind'.  So
I'm not going to.  I guess he's fair game for pot shots, no pun
intended.  Tom, good buddy, you're on your own from here.  Best of luck!
ahahahahahahahahaha!!!!!
elmo
farting on the Blarney Stone

<sigh>
Well, I guess he is a fucktard after all.
Psst, Dort! Now we know what it means!
;-)
ironjustice@aol.com - 17 Mar 2007 17:21 GMT
>> Well, Elmo, there you have it, in his own words. Still wonder why Tom is
regarded by many as a nutcase?
<<

Sooo .. the fact iron reverses fibrosis reverses cirrhosis prevents
progression and DISALLOWS .. hepatocellular carcinoma .. in ALL
subjects tested .. means .. it IS .. an **effective** treatment .. as
effective as .. **anything**.

<<snip>>
None of these patients developed hepatocellular carcinoma (HCC).
<<snip>>

http://cancerres.aacrjournals.org/cgi/content/abstract/61/24/8697

Clinical Investigations

Normalization of Elevated Hepatic 8-Hydroxy-2'-Deoxyguanosine Levels
in

Chronic Hepatitis C Patients by Phlebotomy and Low Iron Diet1
Junji Kato, Masayoshi Kobune, Tokiko Nakamura, Ganji Kuroiwa, Kohichi
Takada, Rishu Takimoto, Yasuhiro Sato, Koshi Fujikawa, Minoru
Takahashi, Tetsuji Takayama, Tatsuru Ikeda and Yoshiro Niitsu2
Fourth Department of Internal Medicine [J. K., T. N., G. K., K. T.,
R.
T., Y. S., K. F., M. T., T. T., Y. N.] and Department of Molecular
Medicine [M. K.], Sapporo Medical University School of Medicine, and
Department of Clinical Pathology, Sapporo Medical University Hospital
[T. I.], Sapporo 060-8543, Japan

Accumulation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in DNA, which
may
result from the continuous reactive oxygen species (ROS) generation
associated with chronic inflammation, has been reported in various
human preneoplastic lesions and in cancerous tissues. However, no
direct causative relationship between the 8-OHdG formation and
carcinogenesis has been thus far demonstrated in humans. Directly
proving the causality requires showing that depletion of 8-OHdG
levels
in tissue by interfering with ROS generation results in a reduction
in
cancer. Chronic hepatitis C virus (HCV) infection is associated with
a
high risk of hepatocellular carcinoma (HCC). Several studies on
patients with chronic HCV have shown that hepatic iron overload is
attributable to liver injury and that iron depletion improved serum
aminotransferase levels. Excess iron is known to generate ROS within
cells, which causes mutagenic lesions, such as 8-OHdG. In this study,
therefore, we have evaluated whether therapeutic iron reduction
(phlebotomy and low iron diet) with a long-term follow-up (6 years)
would decrease the hepatic 8-OHdG levels and the risk of HCC
development in patients with chronic HCV. Patients (34) enrolled were
those who had undergone standard IFN therapy but had no sustained
response. Quantitative immunohistochemistry using the KS-400 image
analyzing system and electrochemical detection was used for 8-OHdG
detection. With this treatment, elevated hepatic 8-OHdG levels in
patients with chronic hepatitis C (8.3 ± 4.6/105 dG) significantly
decreased to almost normal levels (2.2 ± 0.9/105 dG; P < 0.001) with
concomitant improvement of hepatitis severity, including fibrosis,
whereas HCV titers were unaffected. None of these patients developed
HCC. Thus, long-term iron reduction therapy in patients with chronic
hepatitis C may potentially lower the risk of progression to HCC.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
STANLEY STEAMER - 15 Mar 2007 20:36 GMT
fact true fact thats the main point sir!
dort - 16 Mar 2007 06:13 GMT
> fact true fact thats the main point sir

You sed..."fucktard" ...heh...heh....

dort
Cactus Jammies - 16 Mar 2007 15:43 GMT
lol

next in the line of lingerie and lingering thongs for this season...
(hint... women will not wear red underwear in public)...  especially iron
oxide.  (words of experience from frillies maker and tie dyer who does not
use any scarlet red, but pink is ok, and dusty rose is still hot in some
parts of town)

cactus jammies   tie dye to dialate for...!
============================

>> fact true fact thats the main point sir
>
> You sed..."fucktard" ...heh...heh....
>
> dort
Cactus Jammies - 15 Mar 2007 15:05 GMT
>> Um...what was a fucktard again? It was discussed a while back but I can't
>> remember what the final definition was.
[quoted text clipped - 3 lines]
> My definition of a fucktard is someone who says that lowering iron levels
> will cure hepatitis c.

/////////////

LOL  what have I done!!!???
elmoemerson@webtv.net - 15 Mar 2007 15:26 GMT
Re: Well, what about interferon? To cactus regarding slamming tom  

Group: alt.support.hepatitis-c Date: Thu, Mar 15, 2007, 2:05pm (CDT+5)
From: cactusjammies@imitation.univ.net (Cactus Jammies)
"Waterspider" <nospam@all.com> wrote
Um...what was a fucktard again? It was discussed a while back but I
can't remember what the final definition was.
dort
My definition of a fucktard is someone who says that lowering iron
levels will cure hepatitis c.
/////////////
LOL what have I done!!!???
///////////
You don't really want me to answer that one, do you?
ahahahahahahaha!!!!!
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Sylv - 07 Mar 2007 01:11 GMT
> > Ok, Tom, I'm really curious.  What is your story?  I assume you have HCV, is
> > that correct?  Have you ever tried treatment?  And since iron is such a huge
[quoted text clipped - 11 lines]
> BE .. known ..
> And .. no .. I am not .. afflicted with every disease I post to ..

Ah, ha!

The first real truth anyone anywhere has gotten out of Tommy!

He has none of the diseases he's perpetually posting about!

The only part of his story which needs to be known: he is an Internet
nutcase with a "thing" about iron.

Sylvia
james thomas - 09 Mar 2007 02:19 GMT
do your homework on iron excess and hcv while doing hcv meds. they work
terribly. Are you a dumbass also...?
james thomas - 09 Mar 2007 02:20 GMT
eve yor bleeding a.s can be overloaded with iron. ignorant bitch
Waterspider - 09 Mar 2007 05:06 GMT
Oh cool. Another troll. Oh well, it's been a while...
james thomas - 10 Mar 2007 22:23 GMT
Hey girl, i'm not a troll. ive been around along time. thank goodness.
sad to say with a liver full of dragons........ now you should know
trolls dont have dragons....... now be a good little recluse and get in
your corner.....
Waterspider - 11 Mar 2007 01:53 GMT
> Hey girl, i'm not a troll. ive been around along time. thank goodness.
> sad to say with a liver full of dragons........ now you should know
> trolls dont have dragons....... now be a good little recluse and get in
> your corner.....

Ya have to admit that your "iron overload...bleeding a.s... ignorant
bitch...dumbass" rant sounded a bit trollish. That aside, sorry to hear
about your resident dragons. Take care.

Waterspider
<reclusing back to her corner>
Ku Klux Klan - 14 Mar 2007 01:55 GMT
my brother died of HH-ironoverload, spIderfreak DO YOU KNOW NOT YOUR a.s
FROM A HOLE IN THE GROUND? AND I DEFINITELY AM NO TROLL.......
Waterspider - 14 Mar 2007 02:27 GMT
> my brother died of HH-ironoverload, spIderfreak DO YOU KNOW NOT YOUR a.s
> FROM A HOLE IN THE GROUND? AND I DEFINITELY AM NO TROLL.......

And I'm sorry to hear about your brother.
But, you still sound like a troll.
bitchslapper - 14 Mar 2007 02:27 GMT
>my brother died of HH-ironoverload, spIderfreak DO YOU KNOW NOT YOUR a.s
>FROM A HOLE IN THE GROUND? AND I DEFINITELY AM NO TROLL.......

<sniff> <sniff>  eeeewwwwwwwwwwwwwwwwwwwwwwwwwwwwwww!

You sure smell like a particularly odious, nasty troll from here, fuckwit.
And your sheet is showing. Ku Klux Klansman indeed.

<SLAP!> <SLAP!> <SLAP!>

Be gone, bitch!
And never soil this place with your foul presence again, tardboy.
elmoemerson@webtv.net - 14 Mar 2007 15:28 GMT
Re: Well, what about interferon?  

Group: alt.support.hepatitis-c Date: Tue, Mar 6, 2007, 5:11pm (CDT-3)
From: Sylv772003@yahoo.com (Sylv)
ironjustice wrote:
Ok, Tom, I'm really curious. What is your story? I assume you have HCV,
is that correct? Have you ever tried treatment? And since iron is such a
huge concern of yours, what do you do for yourself and how has it
affected your HCV and/or liver?
I'm not being sarcastic. You've popped in and out of here a lot but
never said anything about yourself.-
Ok, Tom, I'm really curious. What is your story? <<
My 'story' ,, is .. iron reduction is called "an effective alternative
to interferon" ..
THAT is about ALL about my .. story .. which REALLY .. **needs** to
BE .. known ..
And .. no .. I am not .. afflicted with every disease I post to ..
Ah, ha!
//////////////
The first real truth anyone anywhere has gotten out of Tommy!
He has none of the diseases he's perpetually posting about!
The only part of his story which needs to be known: he is an Internet
nutcase with a "thing" about iron.
Sylvia
////////////
And who the hell are you, Sylvia?
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
*GED* - 18 Mar 2007 20:28 GMT
> > > Ok, Tom, I'm really curious.  What is your story?  I assume you have HCV, is
> > > that correct?  Have you ever tried treatment?  And since iron is such a huge
[quoted text clipped - 22 lines]
>
> Sylvia

What would make somebody who hasn't got this dreadful shitty disease
want to post things on a Web group like this ?.Unfortunately for me I
am Hep C positive otherwise I wouldn't be reading these texts,and
another thing  even though
I for some obscure reason I had a hard on for Iron,[we all get our
jollies one way or another] wouldn't be writing in all the time
singing it's not very useful praises.I can assure any one in my
increasing desperate need for something to give my
very badly scarred Liver a helping hand I have tried just about any
thing I could get my hands on,the only thing which for
me showed any sign of an improvement was Milk Thistle and this was
only for short bursts I,E, about six months at a
time.Taking this for much longer forced me to endure some very bad
reactions,with things like a near death 24 hour flu
type reaction.The specialist I see said that it's the manufacturing
process which is to blame,the quality control are no where near as
good as it is for real pharmacuticals and the amounts in each capsule/
tablet vary greatly.Like I say to all
who I know are taking this preperation watch what you are doing,and
the first signs of lethargy/sickness/sweats/shivers
stop taking it,I hope non of you get this type of reaction all I am
saying is be careful.The flu like symptons are awful and it very
nearly turns into some thing far worse like Pneumonia,be lucky.Also I
have never taken or ever been told to take the "MIGHTY IRON" I
seriously doubt I would do it anyway.*GED*
james thomas - 09 Mar 2007 02:11 GMT
Having HH and HCV is a double dose of a big chance for developing liver
cancer(HCC) plus more! Tom has pushed thru with info which is very
important to hemachromatosis patients with HCV. Toms posts are
informative to people who do not have HH or HCV. Why? Because too much
iron is dangerous. Period. This Snake in the grass is over-looked by the
general population. Bacteria,cancers etc thrive on iron. One bowl of
Kelloggs corn flakes has 45% daily allow. of iron. That does not include
snacks, lunch, supper and more snacks. Hamburgers, t-bones booze
(compounds iron uptake) breads etc. We are fed too much iron.  Free
Radical scavengers I.E iron ions smash into cells bursting them.
Sometimes just damaging them. These damaged cells can cause various
problems. Not to mention the permanent damage to DNA which after damaged
can be passed on to future generations as Damaged DNA. So he cruises in
and out of this NG! Everyone else does at various intervals. Whats your
point? Excess Iron causes everything from diebetes type 2, depression,
and alot more. Now, I say that is important to anyone with HCV. And
information that needs passing on to everyone.
dort - 06 Mar 2007 05:00 GMT
> >>>There is no question that it can control erythrocytosis
> >
[quoted text clipped - 36 lines]
> I'm not being sarcastic.  You've popped in and out of here a lot but never
> said anything about yourself.

I've actually met this man. He lived near where I once worked. Small
work..'eh?

dort
ironjustice - 06 Mar 2007 03:14 GMT
This article shows .. at the very least .. overdosing causing
erythrocytosis leads to increased ALT ..

<<snip>>
side-effects we found were elevated liver enzyme and haemoglobin
levels.
<<snip>>

Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):222-4.  Links
Accidental ten times overdose administration of recombinant human
erythropoietin (rh-EPO) up to 318,000 units a day in acute myocardial
infarction: report of two cases.Shin DH, Kwon YI, Choi SI, Park US,
Lee J, Shin JH, Lee JU, Kim SG, Kim JH, Lim HK, Lee BH, Kim KS.
Cardiology Division, Hanyang University College of Medicine, Seoul,
Korea.

The cytokine erythropoietin protects the heart from ischaemic injury,
in part by preventing apoptosis. But appropriate dose of
erythropoietin for the protection of injured heart has not been
studied. While we were researching the cardiac protective effects of
erythropoietin in acute myocardial infarction, we experienced two
cases of accidental nearly ten times overdose administration of
erythropoietin up to 318,000 units instead of 33,000 units on the
second day of three scheduled days of treatment. So a total of 384,000
units of erythropoietin were administered during three days. In case
1, the ALT level soared up to 386 U/l on the second day of
administration and decreased slowly. It was back to normal state 3
months later. The AST level increased slowly up to 391 U/l and
normalized 3 months later. Haemoglobin level was elevated up to 15.7 g/
dl (14.7 g/dl at admission) and, 3 months later, normalized to 14.8 g/
dl. In case 2, the ALT level was elevated up to 98 U/l on the second
day of administration and decreased slowly. Three months later, the
ALT level was normalized. The AST level also increased slowly up to 71
U/l and normalized 3 months later. Haemoglobin level was elevated up
to 15.6 g/dl (13.8 g/dl at admission) and, 3 months later, normalized
to 13.6 g/dl. In these two cases reported, these patients, even after
massive overdose, tolerated it relatively well and the only side-
effects we found were elevated liver enzyme and haemoglobin levels.

PMID: 16445599 [PubMed - indexed for MEDLINE]

Who loves ya.
Tom

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