Re: Side Effects  

Group: alt.support.hepatitis-c Date: Wed, Feb 14, 2007, 9:24am (CST+1)
From: greyhackles@NOSPAMyahoo.com (greyhackles)
Here's what you can expect, Guy.
In the fourth week, all your hair is gonna drop out. The fifth week your
teeth turn green. Then you get uncontrollable vomiting and diarrhea.
Migraines start about the eighth week. The whole time your abdomen is
turning black from all the tissue necrosis at the shot sites. About the
10th week, you'll crash your car into the back of a schoolbus because
you're so spaced out. The 11th week gives you some relief because of the
pain killers they are giving you in the hospital for the broken pelvis
you suffered in the accident. But now you have dragon breath and noone
will come visit you in the hospital. More relief the next two weeks.
Still in the hospital because of the staph infection you got from the
compound fracture in the accident. The bill already came for the first
month of television while in the hospital. Work calls today and says
that you were fired. Finally out of the hospital in the 23rd week. Your
muscles have atrophy to the point you can barely lift your head anymore.
Back pains and hallucinations begin about the 28th week. Your family has
told you not to come over anymore til you feel better. Mom didn't
appreciate being hit in the face with the creme pie. In the 30th week,
palpatations and twitches and belching fart gas drive you to the doctor.
He just says they are not due to the hep, sorry. Long, gray hair begins
to grow from your forehead but the rest of your hair is long gone by
now. In the 40th week you spend the night in jail for assaulting the
produce clerk at the local grocery store, That makes 4 lawsuits pending
against you now. One for the auto accident (DUI), one suit by the
township for knocking down the traffic light post, and a fourth suit by
the produce clerk. In your 44th week you get more relief. It suddenly
occurs to you that you don't remember ANYTHING anymore. You can't go
anywhere without being led by the hand. You will overhear a guy at a
restaurant who has serious Alzheimer Disease say, "Man, that guy is one
f.cked up dude." On the way out of the restaurant you will stumble in
the parking lot and split the back of your pants out. By the 47th week,
they are giving you your shots in your scalp, you need skin grafts on
your abdomen when you finally come off treatment. Just when you think
you have come to the end of the road and it's your last shot, you get an
allergic reaction to the meds and spend the next 7 weeks in the
hospital. It will take a long time for your trachea to heal completely
from being ripped open when they insert the endotracheal tube during
surgery. You will celebrate the end of your ordeal with a new bag of IV
fluids. Then your kidneys will shut down, your thyroid will say 'adios
amigo', you will get serious lifelong tremors and the uncontrollable
urge to fart in public. The hairs growing from your nose will need
trimming every day, they will grow over an inch each night while you
sleep.
You will look back after they give you the good news you're still
undetectable six months post treatment and recall that the treatment
wasn't all that bad. You didn't lose too much of your savings from the
law suit settlements nor do you need anymore surgeries (5 was enough!).
Thank God for amnesia and bankruptcy laws. It will have been a long,
strange trip.
Good luck, Elmo
<SPLORK!> (coffee shoots out nose all over screen and keyboard)
Yup. That's how we roll.
And thank The Big Hairy Thunderer In The Sky for the amnesia - I can't
remember *any* of that ;-)
/greyhackles  
////////////
I wrote that account of tx several years ago while I was on the tx
drugs.  I think it was in response to someone else's inquiry as to what
they could expect.  ahhahahahahaha!!

I used to write alot of stories and post em way back when.  I'll see if
I can dig another one out and post it.  How 'bout my 'trip to the
doctor' story....I'll see if I can find it.  
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

Re: Side Effects  

Group: alt.support.hepatitis-c Date: Wed, Feb 14, 2007, 3:46pm (CST+7)
From: ghibelno@_NOSPAMME_yahoo.it (ghibelno)
elmoemerson@webtv.net wrote:
Here's what you can expect, Guy.
[...]
Elmo, I'll tell you once again: you're great, man. You made me laugh
like an idiot in from of my collegues' inquiring faces :) Thank you.
cheers,
jeeb.  
//////////
ahahahahahahaha

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

Re: Side Effects  

Group: alt.support.hepatitis-c Date: Wed, Feb 14, 2007, 8:02am (CST-2)
From: phxazhepc@cox.net (Guy)
On Feb 14, 7:06 am, elmoemer...@webtv.net wrote:
Here's what you can expect, Guy.
In the fourth week, all your hair is gonna drop out. The fifth week your
teeth turn green. Then you get uncontrollable vomiting and diarrhea.
Migraines start about the eighth week. The whole time your abdomen is
turning black from all the tissue necrosis at the shot sites. About the
10th week, you'll crash your car into the back of a schoolbus because
you're so spaced out. The 11th week gives you some relief because of the
pain killers they are giving you in the hospital for the broken pelvis
you suffered in the accident. But now you have dragon breath and noone
will come visit you in the hospital. More relief the next two weeks.
Still in the hospital because of the staph infection you got from the
compound fracture in the accident. The bill already came for the first
month of television while in the hospital. Work calls today and says
that you were fired. Finally out of the hospital in the 23rd week. Your
muscles have atrophy to the point you can barely lift your head anymore.
Back pains and hallucinations begin about the 28th week. Your family has
told you not to come over anymore til you feel better. Mom didn't
appreciate being hit in the face with the creme pie. In the 30th week,
palpatations and twitches and belching fart gas drive you to the doctor.
He just says they are not due to the hep, sorry. Long, gray hair begins
to grow from your forehead but the rest of your hair is long gone by
now. In the 40th week you spend the night in jail for assaulting the
produce clerk at the local grocery store, That makes 4 lawsuits pending
against you now. One for the auto accident (DUI), one suit by the
township for knocking down the traffic light post, and a fourth suit by
the produce clerk. In your 44th week you get more relief. It suddenly
occurs to you that you don't remember ANYTHING anymore. You can't go
anywhere without being led by the hand. You will overhear a guy at a
restaurant who has serious Alzheimer Disease say, "Man, that guy is one
f.cked up dude." On the way out of the restaurant you will stumble in
the parking lot and split the back of your pants out. By the 47th week,
they are giving you your shots in your scalp, you need skin grafts on
your abdomen when you finally come off treatment. Just when you think
you have come to the end of the road and it's your last shot, you get an
allergic reaction to the meds and spend the next 7 weeks in the
hospital. It will take a long time for your trachea to heal completely
from being ripped open when they insert the endotracheal tube during
surgery. You will celebrate the end of your ordeal with a new bag of IV
fluids. Then your kidneys will shut down, your thyroid will say 'adios
amigo', you will get serious lifelong tremors and the uncontrollable
urge to fart in public. The hairs growing from your nose will need
trimming every day, they will grow over an inch each night while you
sleep.
You will look back after they give you the good news you're still
undetectable six months post treatment and recall that the treatment
wasn't all that bad. You didn't lose too much of your savings from the
law suit settlements nor do you need anymore surgeries (5 was enough!).
Thank God for amnesia and bankruptcy laws. It will have been a long,
strange trip.
Good luck, Elmo
http://community.webtv.net/elmoemerson/DocElmosHepFile
http://community.webtv.net/elmoemerson/TheFamilyAlbum
Thanks Elmo, I knew I could count on you :-)
////////////
Wellllll, Guy.  The truth is often spoken in jest.  :-)
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

Re: Side Effects  

Group: alt.support.hepatitis-c Date: Wed, Feb 14, 2007, 11:28am (CST-2)
From: phxazhepc@cox.net (Guy)
On Feb 14, 7:06 am, elmoemer...@webtv.net wrote:
Here's what you can expect, Guy.
In the fourth week, all your hair is gonna drop out. The fifth week your
teeth turn green. Then you get uncontrollable vomiting and diarrhea.
Migraines start about the eighth week. The whole time your abdomen is
turning black from all the tissue necrosis at the shot sites. About the
10th week, you'll crash your car into the back of a schoolbus because
you're so spaced out. The 11th week gives you some relief because of the
pain killers they are giving you in the hospital for the broken pelvis
you suffered in the accident. But now you have dragon breath and noone
will come visit you in the hospital. More relief the next two weeks.
Still in the hospital because of the staph infection you got from the
compound fracture in the accident. The bill already came for the first
month of television while in the hospital. Work calls today and says
that you were fired. Finally out of the hospital in the 23rd week. Your
muscles have atrophy to the point you can barely lift your head anymore.
Back pains and hallucinations begin about the 28th week. Your family has
told you not to come over anymore til you feel better. Mom didn't
appreciate being hit in the face with the creme pie. In the 30th week,
palpatations and twitches and belching fart gas drive you to the doctor.
He just says they are not due to the hep, sorry. Long, gray hair begins
to grow from your forehead but the rest of your hair is long gone by
now. In the 40th week you spend the night in jail for assaulting the
produce clerk at the local grocery store, That makes 4 lawsuits pending
against you now. One for the auto accident (DUI), one suit by the
township for knocking down the traffic light post, and a fourth suit by
the produce clerk. In your 44th week you get more relief. It suddenly
occurs to you that you don't remember ANYTHING anymore. You can't go
anywhere without being led by the hand. You will overhear a guy at a
restaurant who has serious Alzheimer Disease say, "Man, that guy is one
f.cked up dude." On the way out of the restaurant you will stumble in
the parking lot and split the back of your pants out. By the 47th week,
they are giving you your shots in your scalp, you need skin grafts on
your abdomen when you finally come off treatment. Just when you think
you have come to the end of the road and it's your last shot, you get an
allergic reaction to the meds and spend the next 7 weeks in the
hospital. It will take a long time for your trachea to heal completely
from being ripped open when they insert the endotracheal tube during
surgery. You will celebrate the end of your ordeal with a new bag of IV
fluids. Then your kidneys will shut down, your thyroid will say 'adios
amigo', you will get serious lifelong tremors and the uncontrollable
urge to fart in public. The hairs growing from your nose will need
trimming every day, they will grow over an inch each night while you
sleep.
You will look back after they give you the good news you're still
undetectable six months post treatment and recall that the treatment
wasn't all that bad. You didn't lose too much of your savings from the
law suit settlements nor do you need anymore surgeries (5 was enough!).
Thank God for amnesia and bankruptcy laws. It will have been a long,
strange trip.
Good luck, Elmo
http://community.webtv.net/elmoemerson/DocElmosHepFile
http://community.webtv.net/elmoemerson/TheFamilyAlbum
So basically, you can't slow down,
you can't let go and you can't hold on,
you can't go back and you can't stand still, if the thunder don't get ya
then the lightning will ?
It not matter :-) matter is energy.
Life is just a game, fly a paper plane there is no end there is no end.
Elmo for Dick Tater in 2008
///////////
Don't think...don't think...
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

Central nervous system involvement in patients with HCV-related

cryoglobulinemia: review and a case report

D. Filippini, F. Colombo, S. Jann1 , R. Corneo2, B. Canesi

Divisione di Reumatologia, 1Divisione di Neurologia, 2Servizio
Immuno-Trasfusionale

Ospedale Niguarda Cà Granda, Milano

SUMMARY

Introduction: Few well-documented cases of central nervous system
involvement in patients with mixed cryoglobulinemia

and/or HCV infection have been reported. We can distinguish between acute or
subacute diffuse and focal lesions (transient

ischemic attack-like syndromes and cerebrovascular accidents).

Methods: A search of two electronic databases (Medline and EMBASE) was
conducted from the year of their inception

(1966 for Medline and 1988 for EMBASE) to September 2000. The search
strategy employed entailed combining

these terms: Cryoglobulinemia, Central Nervous System, Hepatitis C, chronic
hepatitis. Cryoglobulinemia and Central

Nervous System were also used as free test words. We analysed articles with
case reports and the most frequent

articles on the references list.

Pathogenesis: The main pathophysiologic mechanism of cerebral involvement is
ischemia (or rarely hemorrhage) due

to diffuse or segmental vasculitis of the small cerebral vessels. In these
cases a brain MRI usually shows single or multiple

increased T2 signals. Furthermore an occasional occlusive vasculopathy
without vasculitis was documented histologically.

In these patients ischemia could be started or enhanced by the engorgement
of the microvasculature by

clumps of red cells and by aggregates of cryoglobulins. In the same patients
vasculitis and hemoreological abnormalities

can affect the clinical picture of the cerebral involvement in mixed
cryoglobulinemia. Finally, the detection

of HCV in the lesions induces a hypothesis that, in some cases, CNS
involvement could be directly related to chronic

HCV infection, even in the absence of cryoglobulin production.

Case report: We describe a 63 year-old woman with acute severe
encephalopathy. Laboratory evaluation revealed a

high positive test result for rheumatoid factor (3390 U/ml) and
hypocomplementemia (C4 less than 1.67 mg/dl). Protein

immunofixation electrophoresis demonstrated 5% monoclonal proteins (IgM/k
and IgG/k), 3% cryoglobulins were

present, HCV antibody and HCV-RNA (type 2a-2c) were positive. Cryoglobulins
were never typed, because they disappeared

after plasma exchanges. Liver enzymes, renal function and findings on
cerebrospinal fluid were normal. Cerebral

CT and MRI were also normal. Antinuclear antibodies, anti nDNA antibodies,
antiphospholipid antibodies, lupus

anticoagulant, ANCA, Lyme disease serology, complete tests for thrombophilia
were negative. Bone aspiration

was normal. The patient, in coma, was treated with two plasma exchanges.
During the first treatment she recovered

consciousness. Prednisone (1 mg/Kg/day) and cyclophosphamide (400 mg iv for
three days) were added. After a week

two plasma exchanges were performed again. Liver enzymes and rheumatoid
factor were analyzed monthly for six

months and than every two months for another six month period up to the
present. Liver enzymes were always normal,

rheumatoid factor was always at a lower level than the first evaluation (now
it's 311 U/ml). At present she is taking

Prednisone 5 mg once a day, neurologic syntoms are absent and neurologic
examination is normal.

Discussion: We can conclude that: central neurologic involvement may be the
clinical presentation of HCV infection

and mixed cryoglobulinemia. HCV serologic tests and cryoglobulins should be
considered in patient with encephalopathy

of non-obvious cause; plasma exchange is the treatment of choice in acute
severe forms; in some patients

HCV could involve directly CNS, even in the absence of cryoglobulin
production.