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Medical Forum / Diseases and Disorders / Hepatitis / January 2007

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ALT results

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Terry - 06 Jan 2007 15:24 GMT
When I get my lab results, the results have the normal range listed in
the border.  My lab says the range should be 10-40 U/L

I have a friend that gets his labs done at a different lab.  His wife
is trying to make sense of his labs.  I told her to find this place and
ask her questions here.

She says his labs came back with a note that the ALT was abnormal.
Someone want to enlighten us more on why the doc is so concerned with
the ALT number and what the range should be?

This is kind of a head start message for her.  Some of you guys explain
this stuff so much better than I ever could.

I guess is she chimes in we will know is she has found us.  I hope she
can get as much info and support from this group as I have.
Di Di - 06 Jan 2007 16:51 GMT
> When I get my lab results, the results have the normal range listed in
> the border.  My lab says the range should be 10-40 U/L
[quoted text clipped - 12 lines]
> I guess is she chimes in we will know is she has found us.  I hope she
> can get as much info and support from this group as I have.

Terry - My ALT has never gone down to normal (for my lab normal is
0-31). Right now it's at 40 and I have one week left of treatment. My
doctor is not too concerned about it though. He said there can be other
reasons to have a higher ALT and the fact that it used to be 155 and
has gone down over 100 U/L is significant.

Di
greyhackles - 06 Jan 2007 17:29 GMT
>When I get my lab results, the results have the normal range listed in
>the border.  My lab says the range should be 10-40 U/L
[quoted text clipped - 12 lines]
>I guess is she chimes in we will know is she has found us.  I hope she
>can get as much info and support from this group as I have.

ALT measured in the blood is significant because it is a substance released
due to tissue injury. The causes range from muscle injury through heart damage
to liver damage, so an elevated ALT is something that really must be
investigated to come up with a root-cause.

Each lab lists their "normal" ranges as a way to help correlate any variations
between their procedures/specific brand tests and their patient population
against other labs (eg: there are many commercially available liver enzyme
test kits that each lab could be using) and other populations. That said, ALT
tests aren't going to vary much from lab to lab, so you/she could use the same
"normal" range with her actual test results.

A few weeks ago a lass posted her blood work here as she was concerned that
she might be infected with Hepatitis C. Her labs showed only a moderately
elevated ALT, but there really wasn't anything else much out of sorts. I think
the consensus was she likely didn't have HCV, and indeed the HCV-specific
tests later showed she wasn't infected.

Now I'm wondering if that could be her?

Cheers

/greyhackles
Di Di - 06 Jan 2007 17:35 GMT
So Grey - Are you saying you think I should try to figure out why my
ALT is still slightly elevated after treatment or do you mean in
general? I was thinking I didn't have to worry about it since the
elevation is minimal. What do you think?

Di

> >When I get my lab results, the results have the normal range listed in
> >the border.  My lab says the range should be 10-40 U/L
[quoted text clipped - 36 lines]
>
> /greyhackles
elmoemerson@webtv.net - 06 Jan 2007 18:09 GMT
Hope you don't mind me butting in here with my two cents, but I would
think you should finish your tx and get all the drugs out of your system
before getting concerned about your ALT.  There's a good chance that's
what's causing your slightly higher numbers.  Alot of people experience
a spike in their LFT's while on the tx drugs, not to mention all the
other drugs prescribed to combat side-effects.
Most of all, relax....
elmo
///////////////
So Grey - Are you saying you think I should try to figure out why my ALT
is still slightly elevated after treatment or do you mean in general? I
was thinking I didn't have to worry about it since the elevation is
minimal. What do you think?
Di
greyhackles wrote:
When I get my lab results, the results have the normal range listed in
the border. My lab says the range should be 10-40 U/L
I have a friend that gets his labs done at a different lab. His wife is
trying to make sense of his labs. I told her to find this place and ask
her questions here.
She says his labs came back with a note that the ALT was abnormal.
Someone want to enlighten us more on why the doc is so concerned with
the ALT number and what the range should be?
This is kind of a head start message for her. Some of you guys explain
this stuff so much better than I ever could.
I guess is she chimes in we will know is she has found us. I hope she
can get as much info and support from this group as I have.
ALT measured in the blood is significant because it is a substance
released due to tissue injury. The causes range from muscle injury
through heart damage to liver damage, so an elevated ALT is something
that really must be investigated to come up with a root-cause.
Each lab lists their "normal" ranges as a way to help correlate any
variations between their procedures/specific brand tests and their
patient population against other labs (eg: there are many commercially
available liver enzyme test kits that each lab could be using) and other
populations. That said, ALT tests aren't going to vary much from lab to
lab, so you/she could use the same "normal" range with her actual test
results.
A few weeks ago a lass posted her blood work here as she was concerned
that she might be infected with Hepatitis C. Her labs showed only a
moderately elevated ALT, but there really wasn't anything else much out
of sorts. I think the consensus was she likely didn't have HCV, and
indeed the HCV-specific tests later showed she wasn't infected.
Now I'm wondering if that could be her?
Cheers
/greyhackles

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Di Di - 06 Jan 2007 18:39 GMT
Elmo - No problem "butting in" as you say - that's what this forum is
for, right? I am not going to worry about the slight elevation of my
ALT. I've been through so much this year that seems really minimal and
not worthy of alot of attention. I'll just keep an eye on things with
my post-treatment labs. As long as I'm SVR, that's all I really care
about!
D

> Hope you don't mind me butting in here with my two cents, but I would
> think you should finish your tx and get all the drugs out of your system
[quoted text clipped - 46 lines]
>
> http://community.webtv.net/elmoemerson/TheFamilyAlbum
elmoemerson@webtv.net - 07 Jan 2007 15:16 GMT
Wellllll...... you were asking Grey for his opinion, not mine.  I was
more concerned about stepping on HIS toes.  Last time I said something
that irritated Grey, he wouldn't speak to me for a year.  LOL.
elmo
//////////////
Elmo - No problem "butting in" as you say - that's what this forum is
for, right? I am not going to worry about the slight elevation of my
ALT. I've been through so much this year that seems really minimal and
not worthy of alot of attention. I'll just keep an eye on things with my
post-treatment labs. As long as I'm SVR, that's all I really care about!
D
elmoemerson@webtv.net wrote:
Hope you don't mind me butting in here with my two cents, but I would
think you should finish your tx and get all the drugs out of your system
before getting concerned about your ALT. There's a good chance that's
what's causing your slightly higher numbers. Alot of people experience a
spike in their LFT's while on the tx drugs, not to mention all the other
drugs prescribed to combat side-effects. Most of all, relax....
elmo
    ///////////////
So Grey - Are you saying you think I should try to figure out why my ALT
is still slightly elevated after treatment or do you mean in general? I
was thinking I didn't have to worry about it since the elevation is
minimal. What do you think?
Di
greyhackles wrote:
On 6 Jan 2007 07:24:06 -0800, "Terry" <kilowatt@charter.net> wrote: When
I get my lab results, the results have the normal range listed in the
border. My lab says the range should be 10-40 U/L I have a friend that
gets his labs done at a different lab. His wife is trying to make sense
of his labs. I told her to find this place and ask her questions here.
She says his labs came back with a note that the ALT was abnormal.
Someone want to enlighten us more on why the doc is so concerned with
the ALT number and what the range should be? This is kind of a head
start message for her. Some of you guys explain this stuff so much
better than I ever could. I guess is she chimes in we will know is she
has found us. I hope she can get as much info and support from this
group as I have. ALT measured in the blood is significant because it is
a substance released due to tissue injury. The causes range from muscle
injury through heart damage to liver damage, so an elevated ALT is
something that really must be investigated to come up with a root-cause.
Each lab lists their "normal" ranges as a way to help correlate any
variations between their procedures/specific brand tests and their
patient population against other labs (eg: there are many commercially
available liver enzyme test kits that each lab could be using) and other
populations. That said, ALT tests aren't going to vary much from lab to
lab, so you/she could use the same "normal" range with her actual test
results.
A few weeks ago a lass posted her blood work here as she was concerned
that she might be infected with Hepatitis C. Her labs showed only a
moderately elevated ALT, but there really wasn't anything else much out
of sorts. I think the consensus was she likely didn't have HCV, and
indeed the HCV-specific tests later showed she wasn't infected. Now I'm
wondering if that could be her?
Cheers
/greyhackles
http://community.webtv.net/elmoemerson/DocElmosHepFile
http://community.webtv.net/elmoemerson/TheFamilyAlbum

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
greyhackles - 08 Jan 2007 03:14 GMT
Was it really that long?  ahahahahahahaha! ;-)

Step away, but it seems we were in agreement anyway :-)

Cheers

/greyhackles

>Wellllll...... you were asking Grey for his opinion, not mine.  I was
>more concerned about stepping on HIS toes.  Last time I said something
[quoted text clipped - 58 lines]
>
>http://community.webtv.net/elmoemerson/TheFamilyAlbum
elmoemerson@webtv.net - 08 Jan 2007 12:46 GMT
I wasn't counting the days, or anything, but it sure felt like a year.
:-)
elmo
/////////
Was it really that long? ahahahahahahaha! ;-)
Step away, but it seems we were in agreement anyway :-)
Cheers
/greyhackles
Wellllll...... you were asking Grey for his opinion, not mine. I was
more concerned about stepping on HIS toes. Last time I said something
that irritated Grey, he wouldn't speak to me for a year. LOL. elmo
//////////////
Elmo - No problem "butting in" as you say - that's what this forum is
for, right? I am not going to worry about the slight elevation of my
ALT. I've been through so much this year that seems really minimal and
not worthy of alot of attention. I'll just keep an eye on things with my
post-treatment labs. As long as I'm SVR, that's all I really care about!
D
elmoemerson@webtv.net wrote:
Hope you don't mind me butting in here with my two cents, but I would
think you should finish your tx and get all the drugs out of your system
before getting concerned about your ALT. There's a good chance that's
what's causing your slightly higher numbers. Alot of people experience a
spike in their LFT's while on the tx drugs, not to mention all the other
drugs prescribed to combat side-effects. Most of all, relax.... elmo
    ///////////////
So Grey - Are you saying you think I should try to figure out why my ALT
is still slightly elevated after treatment or do you mean in general? I
was thinking I didn't have to worry about it since the elevation is
minimal. What do you think?
Di
greyhackles wrote:
On 6 Jan 2007 07:24:06 -0800, "Terry" <kilowatt@charter.net> wrote: When
I get my lab results, the results have the normal range listed in the
border. My lab says the range should be 10-40 U/L I have a friend that
gets his labs done at a different lab. His wife is trying to make sense
of his labs. I told her to find this place and ask her questions here.
She says his labs came back with a note that the ALT was abnormal.
Someone want to enlighten us more on why the doc is so concerned with
the ALT number and what the range should be? This is kind of a head
start message for her. Some of you guys explain this stuff so much
better than I ever could. I guess is she chimes in we will know is she
has found us. I hope she can get as much info and support from this
group as I have. ALT measured in the blood is significant because it is
a substance released due to tissue injury. The causes range from muscle
injury through heart damage to liver damage, so an elevated ALT is
something that really must be investigated to come up with a root-cause.
Each lab lists their "normal" ranges as a way to help correlate any
variations between their procedures/specific brand tests and their
patient population against other labs (eg: there are many commercially
available liver enzyme test kits that each lab could be using) and other
populations. That said, ALT tests aren't going to vary much from lab to
lab, so you/she could use the same "normal" range with her actual test
results.
A few weeks ago a lass posted her blood work here as she was concerned
that she might be infected with Hepatitis C. Her labs showed only a
moderately elevated ALT, but there really wasn't anything else much out
of sorts. I think the consensus was she likely didn't have HCV, and
indeed the HCV-specific tests later showed she wasn't infected. Now I'm
wondering if that could be her?
Cheers
/greyhackles
http://community.webtv.net/elmoemerson/DocElmosHepFile
http://community.webtv.net/elmoemerson/TheFamilyAlbum
http://community.webtv.net/elmoemerson/DocElmosHepFile
http://community.webtv.net/elmoemerson/TheFamilyAlbum

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
greyhackles - 06 Jan 2007 18:24 GMT
>> >When I get my lab results, the results have the normal range listed in
>> >the border.  My lab says the range should be 10-40 U/L
[quoted text clipped - 43 lines]
>
>Di

As the OP never actually said anything about HCV with respect to his friend's
current status in this thread, I hope it's clear the context of my comments
were for an undiagnosed condition.

In contrast, you were diagnosed as HCV+.

As is well known, there is a wide variation of ALT expression with respect to
HCV infection. Some people get truly hammered during the acute phase pushing
ALT well into triple digits (raises hand) and then show moderately elevated
levels through the chronic phase, while others never have a clue during their
acute phase and then go through decades without their ALT getting much if at
all out of the normal range.

We also have seen a wide variation of on-therapy ALT expression related here.
Some folks have their ALT plummet early in therapy, others drift down, some
had their ALT actually jump up (!) before falling, and finally at least one
person here *ended* tx with an SVR - and an end-of-therapy ALT reading almost
four times the upper end of normal before it started falling (man, I'd be a
nervous wreck about that ;-)

Given that, I would expect there to be significant variation of post-therapy
ALT expression, leaving some folks at the upper side of the normal range,
others at the lower end. And I'm not sure there's any easily correlated reason
- I don't think it's existing liver damage that drives it - I was F2-F3
pre-tx, my ALT dropped from 166 to 26 in the first four weeks of tx, and is
now below 10 g/dl, 15 months post-treatment.

So...with all that to consider, and you being near the end of therapy,  I
certainly wouldn't worry about your modestly elevated ALT for the time being.
When you have your 6 month post-therapy blood tests, make sure they include
your LFTs. I bet if you get your SVR you'll totally forget about your ALT :-)

Cheers - and good luck!

/greyhackles
elmoemerson@webtv.net - 06 Jan 2007 18:14 GMT
Re: ALT results  

Group: alt.support.hepatitis-c Date: Sat, Jan 6, 2007, 12:29pm (CST+1)
From: greyhackles@NOSPAMyahoo.com (greyhackles)
When I get my lab results, the results have the normal range listed in
the border. My lab says the range should be 10-40 U/L
I have a friend that gets his labs done at a different lab. His wife is
trying to make sense of his labs. I told her to find this place and ask
her questions here.
She says his labs came back with a note that the ALT was abnormal.
Someone want to enlighten us more on why the doc is so concerned with
the ALT number and what the range should be?
This is kind of a head start message for her. Some of you guys explain
this stuff so much better than I ever could.
I guess is she chimes in we will know is she has found us. I hope she
can get as much info and support from this group as I have.
ALT measured in the blood is significant because it is a substance
released due to tissue injury. The causes range from muscle injury
through heart damage to liver damage, so an elevated ALT is something
that really must be investigated to come up with a root-cause.
Each lab lists their "normal" ranges as a way to help correlate any
variations between their procedures/specific brand tests and their
patient population against other labs (eg: there are many commercially
available liver enzyme test kits that each lab could be using) and other
populations. That said, ALT tests aren't going to vary much from lab to
lab, so you/she could use the same "normal" range with her actual test
results.
A few weeks ago a lass posted her blood work here as she was concerned
that she might be infected with Hepatitis C. Her labs showed only a
moderately elevated ALT, but there really wasn't anything else much out
of sorts. I think the consensus was she likely didn't have HCV, and
indeed the HCV-specific tests later showed she wasn't infected.
Now I'm wondering if that could be her?
Cheers
/greyhackles  
//////////
She was suffering from a number of other afflictions that had her labs
turned inside-out.  But not hepc.  
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
 
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