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Medical Forum / Diseases and Disorders / Hepatitis / December 2006

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sulphasalazine

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Boogie On - 01 Dec 2006 12:33 GMT
i hear salazopyrin (sulphasalazine) "melts away" scare tissue in the
liver......  thus reversing liver damage...... does anyone have any info
on this drug? Randy
greyhackles - 01 Dec 2006 14:50 GMT
>i hear salazopyrin (sulphasalazine) "melts away" scare tissue in the
>liver......  thus reversing liver damage...... does anyone have any info
>on this drug? Randy

And you heard this...where?

The only info I can find regarding salazopyrin and liver health is the
contraindications and side effects: don't take it if you have liver disease,
and if you are taking it, it can drive up LFTs. Which is interesting as it is
primarily used as an anti-inflammatory for various forms of arthritis and
bowel disease. But it appears to be liver-hostile...

Cheers

/greyhackles
Burke Gilman - 01 Dec 2006 19:45 GMT
http://news.bbc.co.uk/2/hi/health/5382172.stm
greyhackles - 01 Dec 2006 21:22 GMT
>http://news.bbc.co.uk/2/hi/health/5382172.stm

Ah, ok. It will be interesting to see if the animal testing translates into
being useful in humans with HCV...

Cheers

/greyhackles
Cactus Jammies - 04 Dec 2006 12:27 GMT
Grey,
 I was away when you made your very subjective pronouncements on what might
be a promising aid to reducing scar tissue in the live.  Even though it may
result in some temporary liver inflammation, which is not new to the vast
majority of the readers of this group.  How did you get so narrow minded,
guy?

cactus jammies

>>http://news.bbc.co.uk/2/hi/health/5382172.stm
>
[quoted text clipped - 5 lines]
>
> /greyhackles
Boogie On - 04 Dec 2006 14:44 GMT
he fell in a narrow hole? lol ( humor only, here)
greyhackles - 04 Dec 2006 16:04 GMT
>>>http://news.bbc.co.uk/2/hi/health/5382172.stm
>>
[quoted text clipped - 13 lines]
>
>cactus jammies

So, someone raises a drug question here, and if I do some research on the
particular drug, reflect on what is currently known about its activity in the
human body wrt elevating LFTs, cite the manufacturer's precautionary
statements wrt use by someone with liver disease, and observe the current
state of clinical research on this drug - this is "narrow minded" to you?

Interesting construct...

/greyhackles
ghibelno - 04 Dec 2006 16:15 GMT
> [snip]
>> cactus jammies
[quoted text clipped - 8 lines]
>
> /greyhackles

Hey Grey,
    don't mind. Have you already read the other posts from CJ, today?

Cheers,
jeeb.
Cactus Jammies - 04 Dec 2006 16:30 GMT
Grey,
so this is a balance in the discussion, then?  I've done that research too.
A lot of it.  and a lot of other unconventional methods for needing to live
with the virus.  In the end, will this cheap stuff prove to aid in
rejuvinating liver function in those for which tx is not an option?  that
was all at the start of the thread.  so, there are precautions yes, well
heeded, certainly.  there is no acceptable final word either way, but for
those of us that took the tx badly or did not respond or relapsed, or cannot
take it for any other reasons, we need the hope that there may be promise of
keeping the creeping threat of cirrohsis at bay temporarily while Pharma
does it's magic and finds some things we can use to smite the beast once and
for all,  that we can tolerate.
well some of us need that hope.  and this is hep-c support afterall.  :)

maybe I used harsh reactionary language.  i will correct that practice.

zero minus one no limit

thanks.

cactus jammies ========

> On Mon, 04 Dec 2006 12:27:52 GMT, "Cactus Jammies"
> <cactusjammies@phish.net>
[quoted text clipped - 30 lines]
>
> /greyhackles
Randy Thomas - 02 Dec 2006 04:48 GMT
note "has the potential to reverse"...... thats sounding much better...
Thomas Wagner - 02 Dec 2006 14:28 GMT
>i hear salazopyrin (sulphasalazine) "melts away" scare tissue in the
>liver......  thus reversing liver damage...... does anyone have any info
>on this drug? Randy

We discussed this just a few weeks ago (thread "Research reversing
fibrosis in the liver" 11/11/06). As Greyhackles noted, this was tested
in animals only, and in humans, side effects may include higher LFTs. So
beware. Animal models do NOT always smoothly translate to humans.

Thomas
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Boogie On - 04 Dec 2006 14:43 GMT
ahhh but sometimes they do..... kinda like some are negative and some
are positive. in a gun battle i prefere my comrades to be 101% positive
about anything to do with survival. LFT's can go up and then they can
come down.... Against all odds. Randy
 
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