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Medical Forum / Diseases and Disorders / Hepatitis / November 2006

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FYI two new milk thistle studies.

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kjoh - 18 Nov 2006 18:51 GMT
Hi group.
I don't know if anyone has posted this yet.  I find it noteworthy: two new
government  clinical trials on safety and drug interactions of milk
thistle.  NCCAM is the National Center for Complementary and Alternative
Medicine, a subset of  U.S. National Institutes of Health

On bioavailability and drug interactions (recruiting)
http://www.clinicaltrials.gov/ct/show/NCT00200798

On safety and tolerability in HCV and NASH patients (not yet recruiting)
http://www.clinicaltrials.gov/ct/show/NCT00389376?order=1

tally ho
kj
Thomas Wagner - 19 Nov 2006 00:58 GMT
>I don't know if anyone has posted this yet.  I find it noteworthy: two new
> government  clinical trials on safety and drug interactions of milk
[quoted text clipped - 6 lines]
>On safety and tolerability in HCV and NASH patients (not yet recruiting)
>http://www.clinicaltrials.gov/ct/show/NCT00389376?order=1

Cool. Maybe we'll finally get a definitive answer to the question of
milk thistle during treatment.

Thomas
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Cactus Jammies - 19 Nov 2006 17:41 GMT
> Cool. Maybe we'll finally get a definitive answer to the question of
> milk thistle during treatment.
>
> Thomas
///////////////////////////////////////

Hi Thomas,
 Its particularly nice to see that there may be some value taking MT while
either waiting for treatment for one reason or another, or having failed
treatment.

I see no reference to MT and IFN Rba, except that prospective participants
(url 2) will not have been on clinical treatment for HCV for at least six
months.

So that means this study would probably be of most value to those that have
relapsed, are waiting to be treated for various reasons, or otherwise want
to maintain as healthy a liver as they can despite the infection.

 The Steatosis (Fatty Liver) connection, bile production factors and
fibrosis reversal or reduction seem to me to be a critical factor for those
of us in that category.   I personally, and perhaps hastily or mistakenly
have come to believe that there is a possibility of managing the effects of
the virii on the liver, and that the recent Sulphasalzine discoveries seem
to fit into this somehow.

There is now the chance that these compounds can reverse fibrosis in a
alcohol-induced  cirrhotic livers.  Apparently coincidentally, it is used in
managing the effects of Rheumatoid Arthritis, which has been a sub topic in
this group lately.  Merely coincidences, I suppose.

Did you ever try to visualize the body trying to deal with the virus, in a
physical sense?

I think we've all done that to a certain extent.   But to carry that further
(and across the lines of the Scientific Method and quantitative indexes) it
'seems' to me that it is entirely possible that the virii can migrate when
under effective assault, to the farthest and densest parts of the body,
namely extremities and big boned joints or tendons.  Or perhaps that is
where the bastions of infection really are.  So it is worth my while in
fact, that theraputic use these two seemingly unrelated compounds and their
complementary functions might increase my chances of Crossing the Bar from
something else besides the effects of the HCV virus.

Yes, I used a little Voodoo to come up with that idea.  However, I certainly
am not expecting Kahoutek to beam me up and away.  I have paid lots of
attention to the effectiveness of current treatment methods plus all the
criteria for why I would likely not succeed at this point, again, or want to
take the chance.  I should add I have personal reasons to believe, without
ancedotes, that measuring the amount of bile in the stool might be of use in
determining the ability of MT to enhance processing and elimination,
streamlining the passageways of our guts to allow the body to most
effectively deal with the carci of the virii and the scar tissue and the
excess fat in the liver, which slows the liver down to a trickle.  So there.
Call me a kite mind.  :-)

regards,

cactus jammies -------------------------------------

"Thomas Wagner" <tomw@capecod.com> wrote
about MT trials:
http://www.clinicaltrials.gov/ct/show/NCT00200798

and tolerability in HCV and NASH patients (not yet recruiting)

http://www.clinicaltrials.gov/ct/show/NCT00389376?order=1

> Cool. Maybe we'll finally get a definitive answer to the question of
> milk thistle during treatment.
>
> Thomas
kjoh - 19 Nov 2006 22:15 GMT
Hi again people.  I have been cruising the milk thistle reasearch.   Here
are three excerpts from recent articles that I scrounged from the
pubmed.gov database (Silymarin is the Latin name of the plant).  The first
excerpt is from a review of 148 scientific papers.  They concluded liver
enzyme reductions were "likely" following milk thistle use in heppers.  
The second is from a clinical study involving 24 heppers who took
600-1200mg milk thistle daily for 12 weeks.  Liver enzyme levels were not
reduced.  The third excerpt is from 4 month study using milk thistle to
treat type II diabetes.  It is relevant because they found that milk
thistle reduced liver enzymes among other things (SGOT = AST and
SGPT=ALT).  The dose was 600 mg daily.  

So the question for me is, should I consider milk thistle if my ALT and
AST are normal?  I am still tryng to figure out what it actually does,
other than change lab test numbers. It does not appear to be antifibrotic
(?) fyi I am NOT on tx.  

Back to the books.  I hope you all are having a good weekend.
Kj

Silymarin treatment of viral hepatitis: a systematic review.  

"...Silymarin from the milk thistle herb (Silybum marianum) is used by
many patients with chronic viral hepatitis, but its efficacy remains
unknown.....In conclusion, silymarin compounds likely decrease serum
transaminases in patients with chronic viral hepatitis, but do not appear
to affect viral load or liver histology. Nevertheless it may be worthwhile
to determine its effects in conjunction with standard antiviral
treatment."

Effects of Silybum marianum on serum hepatitis C virus RNA, alanine
aminotransferase levels and well-being in patients with chronic hepatitis
C.  

"...BACKGROUND/AIMS: Silybum marianum is a herbal preparation commonly
used by subjects with chronic hepatitis C (CHC). The aims of this pilot
study were to assess the efficacy and safety of S. marianum on serum
hepatitis C virus (HCV) RNA, alanine aminotransferase levels and
well-being in patients with CHC... CONCLUSIONS: S. marianum is well
tolerated in subjects with CHC, but does significantly affect serum HCV
RNA, alanine aminotransferase levels, quality of life or psychological
well-being in subjects with this condition."

The efficacy of Silybum  in the treatment of type II diabetes: a
randomized, double-blind, placebo-controlled, clinical trial.  

"...The present study was designed to investigate the effects of the
herbal medicine, Silybum marianum seed extract (silymarin), which is known
to have antioxidant properties on the glycemic profile in diabetic
patients......The results showed a significant decrease in HbA(1)c, FBS,
total cholesterol, LDL, triglyceride SGOT and SGPT levels in silymarin
treated patients compared with placebo as well as with values at the
beginning of the study in each group. In conclusion, silymarin treatment
in type II diabetic patients for 4 months has a beneficial effect on
improving the glycemic profile."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=R
etrieve&dopt=abstractplus&list_uids=16460486


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=16255756&query_hl=3&itool=pubmed_docsum


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstra
ctPlus&list_uids=17072885&query_hl=13&itool=pubmed_docsum

Waterspider - 26 Nov 2006 06:40 GMT
> Hi again people.  I have been cruising the milk thistle reasearch.   Here
> are three excerpts from recent articles that I scrounged from the
> pubmed.gov database (Silymarin is the Latin name of the plant).   <snip>

Silybum marianum is the Latin name of milkthistle. Silymarin (or silymarnie)
and silybine are flavonoids obtained from the plant.

Kojoh, did I ever mention that I was so terrified of / opposed to tx that I
obsessively and manically researched every possible alternative to what I
soon learned was the only thing that would Kill the f.cking Dragon? <g>
 
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