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Medical Forum / Diseases and Disorders / Hepatitis / November 2006

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Michael J Fox campaign for Stem Cell Research

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Cactus Jammies - 01 Nov 2006 01:10 GMT
just in the nick of time, this report comes forward from Britain.

http://news.bbc.co.uk/2/hi/health/6101420.stm

cactus jammies -----------

Michael J Fox is a Quesnel lad, I believe, or somewhere in the BC Cariboo.
He became an American citizen after he moved south with his acting jobs.
He suffers from Parkinson's Disease.

=========  www.bbc.co.uk ========

     Liver cells grown from cord blood

           The Newcastle team is hoping to use their work in drug testing
     Scientists in the UK say they have grown tiny sections of human liver.
     The sections of liver were created using stem cells from umbilical
cords by a team at Newcastle University.

     It is hoped the "mini-livers" will be used to test drugs, avoiding
incidents like the Northwick Park trial in which six patients became
seriously ill.

     But other experts warned, because the work was unpublished, it was not
possible to assess its worth and that cells made in this way were
unreliable.

     Researchers Dr Nico Forraz and Professor Colin McGuckin have started a
company called ConoStem in an effort to market their stem cell work.

     They believe it will be decades before a grown liver can be used in a
human transplant operation.

     But they say the use of small sections of liver, which are less than
the size of a penny, could be used to treat patients within 10-15 years.

           We're a long way from producing a whole liver - the liver has
its own blood supply, its own fibrous skeleton

           Professor Ian Gilmore
           Liver specialist

     A more realistic short-term use would be to replace some of the
testing on humans and animals of pharmaceuticals.

     The extent of the team's work emerged after publicity following a
local business award.

     The tissue is grown using a microgravity bioreactor, a piece of
equipment derived from Nasa technology, which aids the creation of cells by
mimicking weightlessness.

     Professor McGuckin said if human testing could be reduced by using
organ cells grown from stem cells an incident like that at Northwick Park
Hospital could be avoided.

     Animal campaigners

     "We take the stem cells from the umbilical cord blood and make small
mini-livers," he said.

     "We then give them to pharmaceutical companies and they can use them
to test new drugs on.

     "It could prevent the situation that happened earlier this year when
those six patients had a massive reaction to the drugs they were testing."

           It is impossible to know whether this work is meaningful or not

           Dr Stephen Minger
           Stem cell biologist

     The news was welcomed by the British Union for the Abolition of
Vivisection which said the government should pump money into the creation of
"ethically-sourced human tissue".

     But Professor Malcolm Alison, from the Centre for Diabetes and
Metabolic Medicine at Queen Mary's School of Medicine and Dentistry, said
the use of the term "mini-liver" constituted a bold claim.

     "Many groups, including the Newcastle one, have been able to turn stem
cells from the blood into cells that look like liver cells [hepatocytes],
but these have been difficult to expand in culture into a mass of cells that
was therapeutically useful."

     And Dr Stephen Minger, director of the Stem Cell Biology Laboratory,
Kings College London, said: "This research hasn't been through the proper
scientific channels yet - it hasn't been peer reviewed. It is impossible to
know whether this work is meaningful or not."

     Dr Mike Nicholds, acting chief executive of ConoStem, said
peer-reviewed papers would be in the pipeline, and that it was hoped the
first liver cells would be used in a drugs test within 12 months.

     Ethical leap

     Professor Ian Gilmore, a liver specialist at the Royal Liverpool
Hospital, told BBC News the team's work was significant.

     "Firstly that they are able to do it from umbilical cord blood and not
requiring embryos. That's quite a big ethical leap forward.

     "And they are producing such a significant amount of tissue."

     But he said: "We're a long way from producing a whole liver. The liver
has its own blood supply, its own fibrous skeleton, they are just producing
the individual liver cells.

     "But nonetheless it is exciting because there is a real dearth of
treatments available for people with liver disease."

     It is estimated that up to 10% of the UK population have problems with
their liver - most are linked to lifestyle factors, such as heavy drinking
and obesity.
Waterspider - 01 Nov 2006 08:20 GMT
> just in the nick of time, this report comes forward from Britain.
>
[quoted text clipped - 111 lines]
> with their liver - most are linked to lifestyle factors, such as heavy
> drinking and obesity.

Michael J. Fox is a Canadian idol-- we're all backing hm... except Barclay
Mayo and a few other Christians :-(
 
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