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Medical Forum / Diseases and Disorders / Hepatitis / October 20063,074,450 => 237,645
34 year old handsome white male, shoe size 10, 6 feet tall, LOL, Hep C Genotype 1 THE GOOD: after 4 weeks of treatment my viral load dropped from 3,074,450 to 237,645 Hold the medals, I'm not trying to sprain my elbow patting myself on the back, just providing some feedback to those newbies like me wondering if this treatment of Ribavirin 600 mg twice a day and a healthy shot of Pegasys works - at least I hope this means it's working THE BAD: side effects, fatigue and dry cough, (I swear I will have a six pack from all the coughing I'm doing, my abdomen muscles are getting a workout) or one day I'll cough up a lung AND THE UGLY: after 5 weeks my white cell count dropped significantly, so they gave me NEUPOGEN again a lovely shot - I do this once a week also, in between the Pegasys as they supposedly counter act with all the needles I feel like a Rock Star If your whites weren't already in the toilet, I'd suggest you toss a couple of weeks of daily Infergen into the mix, along with the Pegasys, to realize a truly dramatic drop in your viral load. Going 'undetectable' as early as possible in tx is the major determinant in whether you're going to get a SVR. Are you having another pcr done at 8 wks? At the rate you're going, I'd expect a 2-log drop from baseline by that point. Keep after it!! elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum thanks elmo, however no habla tx too well, so could you please spell out for me PCR and even SVR and this whole 2-log drop, and you won't believe this but I did take calculus once, I guess another side effect for me could be dumming me up, LOL > If your whites weren't already in the toilet, I'd suggest you toss a > couple of weeks of daily Infergen into the mix, along with the Pegasys, [quoted text clipped - 8 lines] > > http://community.webtv.net/elmoemerson/TheFamilyAlbum > thanks elmo, however no habla tx too well, so could you please spell > out for me PCR and even SVR and this whole 2-log drop, and you won't [quoted text clipped - 13 lines] > > > > http://community.webtv.net/elmoemerson/TheFamilyAlbum MZ, Some brief definitions: PCR = Polymerase Chain Reaction. It is the methodology used to detect/measure DNA of organisms (like Hep C virus); can be a quantitative or qualitative assay. SVR = Sustained Viral Response. Lack of detectable virus in the blood after tx is complete. Usually defined as no detectable virus six months post tx. 2 log decrease = A reduction in viral load by a factor of 100 (10 x 10 = 2 log). For example, viral load goes from 600,000 to 6,000. This is the minimal target goal for monitoring the effectiveness of tx at the 12 week point. The greater the log decrease, the less detectable virus in the blood. Here's a link to a good site with easy-to-understand info to which my lab has made some small contributions: www.labtestsonline.org Thom Your baseline was 3,074,450 which is about 6.5 log. (10 to the power of 6.5) Just use your PC calculator to work it out. Calculus not needed. After 4 weeks you have 237,645 which is about 5.3 log. The difference is 1.2 log, so you've had a 1.2 log drop by week four. A 2 log drop by week 12 is required if you're to have a chance of getting an SVR (sustained viral response - ie. no virus 6 months after end of tx). Elmo thinks you'll get the famous 2 log drop by about week 8 at this rate. cheers Jack > thanks elmo, however no habla tx too well, so could you please spell > out for me PCR and even SVR and this whole 2-log drop, and you won't [quoted text clipped - 13 lines] >> >> http://community.webtv.net/elmoemerson/TheFamilyAlbum Yep, what Thom and Jack said. elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum |
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