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Medical Forum / Diseases and Disorders / Hepatitis / October 2006

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Liver staging defined?

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Lonesomedave - 24 Oct 2006 21:51 GMT
I was reading "The Russians" post regarding his last liver biopsy came
back at stage 3.
My first & only liver biopsy came back betyween a 2 and a 3.
Since I've just been recently diagnosed with Hep C and waiting to begin
tx, can anybody take a sec to explain the different degrees of staging.
I understand it relates to scarring of the tissue, but like:
What stage is cirrhosis  ?
What stage do you get on a liver transplant list?
How fast can someone not drinking advance to the next stage?

I was told anyone above stage 2 should consider the treatment...which
is why I am going for it...

I think I may have had it since 1989, after being flagged and not
allowed to give blood in a job related blood drive.

All thoughts & info greatly appreciated.
Lonesomedave-
greyhackles - 24 Oct 2006 23:37 GMT
>I was reading "The Russians" post regarding his last liver biopsy came
>back at stage 3.
>My first & only liver biopsy came back betyween a 2 and a 3.
>Since I've just been recently diagnosed with Hep C and waiting to begin
>tx, can anybody take a sec to explain the different degrees of staging.
>I understand it relates to scarring of the tissue, but like:

"Metavir" fibrosis staging is expressed from 0 through 4.

0 = no scarring
1 = minimal scarring
2 = scarring is present and extends beyond the areas of the liver that contain
blood vessels
3 = bridging fibrosis
4 = cirrhosis

fwiw, I was between stage 2 and 3 just prior to starting therapy, but
essentially asymptomatic. That's one of the important aspects about chronic
HCV - most people don't experience symptoms until the liver is nearly shot.

>What stage is cirrhosis  ?

Stage 4.

>What stage do you get on a liver transplant list?

I'd be surprised if someone below Stage 4 could actually get on the list.

>How fast can someone not drinking advance to the next stage?

This is something that cannot be determined, as it clearly would vary from
patient to patient. Bottom line: don't drink if you are HCV positive.

>I was told anyone above stage 2 should consider the treatment...which
>is why I am going for it...

Interesting advice, but I disagree with it. Anyone chronically infected with
HCV should consider treatment, with the level of urgency increasing with
Fibrosis staging.

>I think I may have had it since 1989, after being flagged and not
>allowed to give blood in a job related blood drive.
>
>All thoughts & info greatly appreciated.
>Lonesomedave-

In a post made just yesterday here (by Bob "Cactus Jammies", iirc) there was a
particular paragraph that caught my eye, describing some favorable statistics
in reversal of cirrhotic levels of fibrosis following a successful HCV
treatment. That should give hope to a lot of folks - but I would advise
against relying on such an outcome to delay treatment...

Cheers

/greyhackles
shawn2 - 25 Oct 2006 02:20 GMT
Dear lonesomedave a liver transplant is not a bed of roses. Talk to your
doc and find others that have had one. I have. I wouldn't do it, if I knew
then what I know now. That's just me though. Everyone has a different
outlook. Are you a foghat fan? If not get to put on the "foghat" it's
coming!! hahahah! Keep your sense of humor! I'ts one thing that will keep
you sane through all this!!
Terry - 27 Oct 2006 00:52 GMT
On Oct 24, 9:20 pm, "shawn2" <shawn.oxf...@nospam.sbcglobal.net>
wrote:
> Dear lonesomedave a liver transplant is not a bed of roses. Talk to your
> doc and find others that have had one. I have. I wouldn't do it, if I knew
> then what I know now. That's just me though. Everyone has a different
> outlook. Are you a foghat fan? If not get to put on the "foghat" it's
> coming!! hahahah! Keep your sense of humor! I'ts one thing that will keep
> you sane through all this!!

A transplant is not a bed of roses, but it beats the alternative.  I
think you had more than your share of problems.  The meds were your
problem, not the transplant.  Right?

They made a huge mistake in your case.  I know you will never get
anyone, that counts, to agree with you, but you should have had a much
better outcome.

They made a whopper mistake.  The cure almost killed you.
george - 30 Oct 2006 09:33 GMT
Hi all - a newbie speaking, so apologies if I am off topic etc.

I have grade 2, stage 2, Geno 3 hep c and my doctor suggests a 6 month
treatment. Age 44, infection bewteen 5 and 25 years ago

I know there will never be a good time for treatment, but I was just
about to try to move jobs and if I did so, a new employer would not
appreciate 6 months of under, or non-perfromance.

Do you think I can reliably stall treatment for a year or two?
Is the risk to my health too high?
Are there any sources of statistics on progression rates appropriate to
my situation?
Is there a more appropriate forum, or source of another medical opinion
on the net?

Thanks.

George

> I was reading "The Russians" post regarding his last liver biopsy came
> back at stage 3.
[quoted text clipped - 14 lines]
> All thoughts & info greatly appreciated.
> Lonesomedave-
Cactus Jammies - 30 Oct 2006 10:19 GMT
Hey George,
 I don't know if you can still get it on your news server but on on Oct 23,
I posted the
"HCV treatment options from clinicaloptions.com (Very Long)" article which
should help you find what you're looking for.

-cactus jammies =============

> Hi all - a newbie speaking, so apologies if I am off topic etc.
>
[quoted text clipped - 34 lines]
>> All thoughts & info greatly appreciated.
>> Lonesomedave-
 
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