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Medical Forum / Diseases and Disorders / Hepatitis / September 2006ping Anje, re: liver test in France?
Hi, I see that you have the archive in google groups set to one week for your postings. I was looking for the one you made concerning the test you are going to have in France, that costs ?70. If you read this, could you explain a bit about what information the results of this test is supposed to provide. And the name. I lost track of what you called the procedure. Thanks in advance Cactus Jammies ================= >Hi, > I see that you have the archive in google groups set to one week for your [quoted text clipped - 7 lines] >Cactus Jammies >================= Probably FibroSpec or FibroSure. Google them and you'll get hits on the manufacturer, labs that utilize the test(s), and results of analysis of predictive value for each test. These "tests" are actually algorithms that utilize a number of discrete test values to combine to a net result. From what I read last year the tests are good at determining the ends of the liver fibrosis spectrum, not so good for differentiating the middle range. In other words, they'll likely provide close matches to biopsy results for those with little damage or a lot of damage, but may be off by a stage for those in the middle... Cheers /greyhackles Thanks Grey. cj ---------- >>Hi, >> I see that you have the archive in google groups set to one week for [quoted text clipped - 29 lines] > > /greyhackles FYI clinicalcareoptions.com has an article: "Debate: Are Noninvasive Tests Ready to Replace Liver Biopsy?" kj More. (I stole this from the Clinical Care Options webswite). kj "Fibrotest Several biochemical and imaging tests have been developed to evaluate liver histology and identify patients with cirrhosis. Many of these tests have been developed for use in patients with chronic HCV,[97] and their utility in other chronic liver disorders currently remains speculative. Although all of these tests appear to easily differentiate patients with absent or mild fibrosis from patients with advanced fibrosis or cirrhosis, none currently appears to accurately match liver biopsy for the ability to determine the stage-for-stage status of a patient. Serum Inflammation Markers: FibroTest FibroTest was developed retrospectively by correlating liver fibrosis scores in patients with chronic HCV to a vast array of serum biochemical and hematologic markers. Five serum markers were chosen, which together had strong correlation with the fibrosis score by multivariate analysis. These 5 factors are alpha-2 macroglobulin, haptoglobin, gamma-glutamyl transpeptidase, total bilirubin, and apolipoprotein A1.[91] It is interesting to note that none of these 5 markers is a precursor to or a breakdown product of collagen or a matrix protein of fibrosis. Rather, most are markers of the inflammation associated with chronic HCV infection.[58] ActiTest, another noninvasive measure of hepatic inflammation, utilizes the same 5 factors plus serum alanine transaminase, suggesting that FibroTest is more appropriate for measuring liver inflammation than fibrosis. For patients with chronic HCV, FibroTest appears to provide good separation between patients above and below METAVIR stage II fibrosis (Figure 4).[58,30] By contrast, there is significant overlap in FibroTest values between absent and METAVIR stage I fibrosis, as well as between stage II fibrosis, stage III fibrosis, and cirrhosis. As a result, FibroTest is not a precise enough measure of liver histology for patients with greater than stage II fibrosis; more than 60% of patients with chronic HCV fall into this group. FibroTest has been evaluated exclusively in patients with HCV, and its utility in accurately assessing liver histology in patients with other liver diseases remains to be determined." www.clinicalcareoptions.com greyhackles <greyhackles@NOSPAMyahoo.com> <ojlih2tvuqcepl9td8n4tfbc8fbj6fc955@4ax.com> : >>Hi, >> I see that you have the archive in google groups set to one week for your [quoted text clipped - 18 lines] >matches to biopsy results for those with little damage or a lot of damage, but >may be off by a stage for those in the middle... my doctor said that if the results were in the middle, i'd still had to have a biopsy. but i had score 0.07 which matches fibro=0, so i was a happy camper and didn't mind paying the 70 euro for it. >Cheers > >/greyhackles -- mhm 35x6 smeeter 37(?) wsd40 we are all in the gutter but some of us are looking at the stars wilde "Cactus Jammies" <CactusJammies@tetrahedron.net> <nTbSg.37464$E67.6159@clgrps13> : >Hi, > I see that you have the archive in google groups set to one week for your [quoted text clipped - 7 lines] >Cactus Jammies >================= hey cactus jammies it is called a fibro test. my blood was sent to a lab in france by my hepatologist. here is some information about how it's done: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1572-0241.2005.00284.x (english) http://www.labcorp.com/datasets/labcorp/html/chapter/mono/nf10003100.htm (english) http://www.paris-nord-sftg.com/patients.vhc.0307.php3 (french) and here is the machine that does it http://www.referanslab.com/yazilar.asp?dosya=tr-yazi-fat&brosur=var (i have no clue what language it is, that page, but pictures are nice and clear) hope you can get one too, better a pinch in the arm than a punch up the liver, i say! <smeps> anja -- mhm 35x6 smeeter 37(?) wsd40 we are all in the gutter but some of us are looking at the stars wilde Thanks for all this, Anje, and Kjoh and Grey cactus jammies ============= > "Cactus Jammies" <CactusJammies@tetrahedron.net> > <nTbSg.37464$E67.6159@clgrps13> : [quoted text clipped - 41 lines] > we are all in the gutter but some of us are looking at the stars > wilde |
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