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Medical Forum / Diseases and Disorders / Hepatitis / July 2006

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alpha-fetoprotein

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expat - 16 Jul 2006 05:20 GMT
Hi Folks,

I've got a bit of a communication problem with my doctor - I live in Asia -
and I'm hoping with your experience you can fill in some blank spots for me a
bit on the AFP test.

I've had hepatitis C for 35 years, and B for 15.  I've had a CT and
ultrasound scans which show nothing other than enlarged lymph nodes, but have
(thus far) no specific symptoms of lymph node disease. I have had significant
weight loss (from 75 to 65 KG) but have gained a bit back. I'm waiting to see
if insurance will pay for a PET/CT scan which has been recommended.

My AFP test is 86, and SGOT and SGPT are about 8 times normal. The last two
have always been 5-10 X normal. My question is about the AFP test. I was told
normal is <10. I found one post in the archives here  from someone who had a
level of 150 but was not seriously ill, and another saying liver cancer would
produce a level of somewhere around 500. I'll like to hear any comments on
that and particularly would like to know if cronic hepatitis could in and of
itself produce the high AFP.

Thanks,

Peter
Burke Gilman - 16 Jul 2006 07:09 GMT
> Hi Folks,
>
[quoted text clipped - 23 lines]
> Message posted via MedKB.com
> http://www.medkb.com/Uwe/Forums.aspx/hepatitis-forum/200607/1

A Google search for AFP (serum alpha-fetoprotein) produces the
following information, much of it directly quoted:

A level of  500 (ng/mL) positively confirms presence of GI carcinoma in
adults, but low levels of
AFP do not rule out cancer. Some sources state a level of 200 is
diagnostic of hepatocellular carcinoma (HCC). AFP is the most widely
used biochemical test for liver cancer. AFP is not normally used for
screening or primary diagonosis of hepatitis. Normal levels of AFP are
below 10 ng/mL. Occasionally AFP level can be elevated in hepatitis,
but the value will drop on repeat testing. Says one source: A rising
AFP level is almost always associated with live cancer. Says another
source: AFP is, however, not specific for HCC. Titers also rise with
flares of active hepatitis, and may be persistently elevated in
patients with cirrhosis. Also stated: There are no guidelines as to
when a rise in AFP level in the presence of a normal ultrasound should
tirgger further investigations to exclude HCC.

http://www.medicinenet.com/alpha-fetoprotein_blood_test/article.htm
http://hepatitis-central.com/hcv/labs/afp2.html
http://liver.stanford.edu/Edu/Edu_blood.php
http://www.hepnet.com/update17.html

Best wishes there Peter,

-BG
 
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