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Medical Forum / Diseases and Disorders / Hepatitis / July 2006

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Considering giving up on Tx.

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ChefX - 08 Jul 2006 22:43 GMT
I've been doing pretty wee so far on tx, I just took my 13th shot and am
awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
VL945,000).
I had been feeling damn good about things until all at once everything
changed. I won full custody of my kids (daughter 6, son 4) I had to drive
800miles each way in two days to retrieve them, that ordeal took more out of
me than I was expecting. and last week my Dr. increases my riba dose to
1600mg/day. All these responsabilities and I'm really feeling the sides now.
I just don't know if this is the right time for me to be on tx.
I couldn't keep up w/ the kids before tx, how am I supposed to do it now???

ChefX
Puckertoe - 09 Jul 2006 00:37 GMT
That's going to be really tough ChefX.

You'd be surprised at what you can do even under your conditions. I suspect
that once your paternal instincts kick in that the tx won't be that bad.

I think you can stick it out. It won't be easy. I'd hate to see you regret
it later.

> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 11 lines]
>
> ChefX
anonymousone - 09 Jul 2006 00:40 GMT
> That's going to be really tough ChefX.
>
[quoted text clipped - 12 lines]
> > of
> > me than I was expecting. and

last week my Dr. increases my riba dose to
> > 1600mg/day. All these responsabilities and I'm really feeling the sides
> > now.
[quoted text clipped - 3 lines]
> >
> > ChefX

Hows your Liver?
ChefX - 09 Jul 2006 00:57 GMT
> > That's going to be really tough ChefX.
> >
[quoted text clipped - 23 lines]
>
> Hows your Liver?

AST 79
ALT 85

NTB???
anonymousone - 10 Jul 2006 04:48 GMT
> > > That's going to be really tough ChefX.
> > >
[quoted text clipped - 35 lines]
>
> NTB???

In my opinion, you need a liver biopsy. You cant make an informed
decision without knowin the condition of your liver. VX-950 is coming
on strong. I would have waited if I could have, but stage 3 liver
disease did not allow for it.
ChefX - 10 Jul 2006 13:24 GMT
I did have a biopsy, Stage 2, grade 2
But at the time(before tx)  my enzymes were off the chart...
AST 179
ALT 300
BTW... I will NEVER have another biopsy..... I'm a recovering drug addict,
and in my moment of holier than tho'ism. I refused any narcotics or
sedatives. Basically, I got stabbed in the liver twice as clear headed as
could be.
NOT something I recommend by the way. My advice (dare I dispense any) TAKE
THE DAMN DRUGS!

> > > > That's going to be really tough ChefX.
> > > >
[quoted text clipped - 40 lines]
> on strong. I would have waited if I could have, but stage 3 liver
> disease did not allow for it.
anonymousone - 10 Jul 2006 14:31 GMT
> I did have a biopsy, Stage 2, grade 2
> But at the time(before tx)  my enzymes were off the chart...
[quoted text clipped - 58 lines]
> > on strong. I would have waited if I could have, but stage 3 liver
> > disease did not allow for it.

In that case, I would opt for continuing treatment. You'll work out the
details somehow.
Your children need somebody alive not dead.
Paul - 10 Jul 2006 14:38 GMT
On Mon, 10 Jul 2006 08:24:07 -0400, "ChefX"
<ChefTomAnson@insightbb.com>, in message ID
<1NednUNep5IW2i_ZnZ2dnUVZ_u-dnZ2d@insightbb.com>, in the newsgroup
alt.support.hepatitis-c wrote:

>I did have a biopsy, Stage 2, grade 2
>But at the time(before tx)  my enzymes were off the chart...
[quoted text clipped - 6 lines]
>NOT something I recommend by the way. My advice (dare I dispense any) TAKE
>THE DAMN DRUGS!

Oh dear.  I'm in the same position as you.  Didn't anyone mention that
a local anasthetic needn't get you stoned?  I had a local and it
numbed the area beautifully.  Didn't feel the tiniest bit mood altered
(stress excepted).  I've had teeth pulled as well after my years of
self neglect were over.  Never got stoned once - damned dentist :-)
Waterspider - 11 Jul 2006 08:23 GMT
> On Mon, 10 Jul 2006 08:24:07 -0400, "ChefX"
> <ChefTomAnson@insightbb.com>, in message ID
[quoted text clipped - 14 lines]
>
> Oh dear.  I'm in the same position as you.

No, no and no.
Burke Gilman - 10 Jul 2006 18:48 GMT
> I did have a biopsy, Stage 2, grade 2
> But at the time(before tx)  my enzymes were off the chart...
[quoted text clipped - 58 lines]
> > on strong. I would have waited if I could have, but stage 3 liver
> > disease did not allow for it.

Those improved AST and ALT levels indicate inflammation is down, but
where does it say that we can reasonably draw correlations to SVR based
on those liver enzyme levels? Seems to me that what matters as far as
forecasting goes is the very early virological response that you have!

In my opinion, to keep pointing at the improved liver enzyme levels is
to keep reaching for denial. You might as well be saying the moon is in
the seventh house. Such musings may entertain, depending upon your
personal disposition, but they are  no rationale to stop treatment.

You know the fight is not over because the battle plans are already
drawn and you know those plans are based on solid intelligence gained
by the fate of those who have gone before you. From this you know the
rule: Those who strike upon the dragon a deadly blow are those who go
the distance.

To be sure, one day you can look yourself in the mirror and know you
did all you can.

One day at a time.

- BG
Richard Klein - 10 Jul 2006 19:19 GMT
I'm a recovering drug addict too.   I woke up from my biopsy with no recall
of the feelings associated with the sedative.  I don't think there is any
risk of relapse related to the sedative they use during surgery.  At least
there wasn't any with me.

>I did have a biopsy, Stage 2, grade 2
> But at the time(before tx)  my enzymes were off the chart...
[quoted text clipped - 58 lines]
>> on strong. I would have waited if I could have, but stage 3 liver
>> disease did not allow for it.
anonymousone - 10 Jul 2006 14:33 GMT
> > > > That's going to be really tough ChefX.
> > > >
[quoted text clipped - 40 lines]
> on strong. I would have waited if I could have, but stage 3 liver
> disease did not allow for it.

Stupid Doctors btw. Why the would allow someone to undergo a biopsy
wthout a local is beyond me.
Burke Gilman - 10 Jul 2006 19:41 GMT
> > > > > That's going to be really tough ChefX.
> > > > >
[quoted text clipped - 43 lines]
> Stupid Doctors btw. Why the would allow someone to undergo a biopsy
> wthout a local is beyond me.

Anonymouse,

Please note the biopsy procedure as it was done was performed with
success and safety, and that it would have been battery to administer
that local without consent.

-BG
Abby - 10 Jul 2006 16:42 GMT
> > > That's going to be really tough ChefX.
> > >
[quoted text clipped - 35 lines]
>
> NTB???

My AST = 99
    ALT = 72
Burke Gilman - 09 Jul 2006 01:43 GMT
> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 8 lines]
>
> ChefX

Now that, I dare say, is a true problem -- how to continue to cope with
Tx sides while at once adapting your household and behavior to
accomodate a young daughter and son.

I hope you don't have to give up Tx, but imagine the idea must present
quite a dilemna for you, given the choice of giving up Tx to take care
of your kids or not giving up Tx -- to take care of your kids.

My son is now 19, and I got custody when he was 6, as things turned out
back then. Now I'm on Tx, and gotta say I'm glad that I did not go
through Tx when my son was 6. At the same time, I recall that young
children can be incredibily understanding of caregiving adults who are
sick.

Can you find and/or afford a regular nanny or household assistant to
help keep your responsibilities to a tolerable level while you continue
with Tx?

- BG
ChefX - 09 Jul 2006 13:13 GMT
Hell no I can't afford a nanny(Oh to dream the impossible dream...) I'm only
35yo I have been a chef all of my adult life, (hell I've been cooking longer
than I've been f***ing).
If it wasn't for the minimal assistance I get from my family and state
resources, I'd be in a shelter.
What I need is an independently wealthy, attractive young single mother
who's lookin' for a babies daddy...Any Takers????? I do cook...

Feeling a bit better today, maybe I have simply been knocked out of my
comfortable equilibrium....

Thanx for the support, ChefX

> > I've been doing pretty wee so far on tx, I just took my 13th shot and am
> > awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 28 lines]
>
> - BG
Paul - 09 Jul 2006 12:18 GMT
On Sat, 8 Jul 2006 17:43:28 -0400, "ChefX"
<ChefTomAnson@insightbb.com>, in message ID
<39WdndHzFK3Rui3ZnZ2dnUVZ_qadnZ2d@insightbb.com>, in the newsgroup
alt.support.hepatitis-c wrote:

>I've been doing pretty wee so far on tx, I just took my 13th shot and am
>awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 8 lines]
>
>ChefX

Yeah I believe ya.  I remember doing a 150 mile drive while on tx and
that wiped me out.  Also, it sounds like you may need help with those
kids - at least until tx has been over for a few weeks.
I don't understand where your doc is coming from - though obviously he
knows more about you than I do.  The tx sounds like it's working
really well and he/she has upped the riba dose.  I thought the usual
maximum was 1200mg a day (6 pills).  I see your virus is undetectable
in under 4 weeks.  Some places try for a shorter tx when this happens.
Is the doc hoping to do a shorter tx with you than the standard 48
weeks?  That's the only possible reason I can think of for upping the
riba and, even then, it may not be of benefit.
ChefX - 09 Jul 2006 13:25 GMT
Well, I asked about shortening the tx to 24 wks, he and his "boss" who
happens to be the dir. of liver disease research here at the university
hospital I goto decided it wasn't worth the risk. Again, I am eagerly
awaiting the results of my 12 wk labs. If I'm still Undetectable, we may
revisit the concept of shortening tx.
As for the high dose riba, I'm a big guy, 6'7" 258lbs.(117kgs for you euro
types) and I'm not very obese.I'm down about 32lbs since I began tx. My Dr.
told me that the max dose of riba (and most meds.) is weight-based. So my
max dose is about 1578mg/day. He also told me that the riba is what keeps
the virus from returning (replicating). I'ts been 10 days at this new dose
and if the sides don't balance back out soon I'm going back to 1400mg.

ChefX

> On Sat, 8 Jul 2006 17:43:28 -0400, "ChefX"
> <ChefTomAnson@insightbb.com>, in message ID
[quoted text clipped - 25 lines]
> weeks?  That's the only possible reason I can think of for upping the
> riba and, even then, it may not be of benefit.
Paul - 09 Jul 2006 13:58 GMT
On Sun, 9 Jul 2006 08:25:57 -0400, "ChefX"
<ChefTomAnson@insightbb.com>, in message ID
<NJCdnROIOLymay3ZnZ2dnUVZ_vudnZ2d@insightbb.com>, in the newsgroup
alt.support.hepatitis-c wrote:

>Well, I asked about shortening the tx to 24 wks, he and his "boss" who
>happens to be the dir. of liver disease research here at the university
[quoted text clipped - 9 lines]
>
>ChefX

I'm inclined to agree that shortening the tx to 24 weeks is too risky.
I feel that tx should only be shortened if it's medically or
psychiatrically impossible to continue.  Your bodyweight may well be
the reason for upping the dose - though I had always believed the
absolute maximum to be 1200mg a day regardless of weight.  Anyway, as
you say,if it gets too much you can always drop down a pill or two.  
elmoemerson@webtv.net - 09 Jul 2006 13:29 GMT
Whatever you do, ChefX, DON'T stop tx!!  You've got the dragon on the
run....it'd be crazy to stop now.  Get help with the children from
wherever you can get it.  It's not going to be easy raising kids while
on tx, but you CAN do it.  You'll find the inner strength you need.
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Paul - 09 Jul 2006 13:59 GMT
On Sun, 9 Jul 2006 07:29:56 -0500, elmoemerson@webtv.net, in message
ID <19261-44B0F6C4-377@storefull-3254.bay.webtv.net>, in the newsgroup
alt.support.hepatitis-c wrote:

>Whatever you do, ChefX, DON'T stop tx!!  You've got the dragon on the
>run....it'd be crazy to stop now.  Get help with the children from
>wherever you can get it.  It's not going to be easy raising kids while
>on tx, but you CAN do it.  You'll find the inner strength you need.
>elmo

Yeah.  What he said.
ChefX - 09 Jul 2006 16:04 GMT
Thanks Elmo...

> Whatever you do, ChefX, DON'T stop tx!!  You've got the dragon on the
> run....it'd be crazy to stop now.  Get help with the children from
[quoted text clipped - 5 lines]
>
> http://community.webtv.net/elmoemerson/TheFamilyAlbum
john - 10 Jul 2006 01:27 GMT
Hi Chefx,
I must be one of the lucky ones.2nd tx and i commute 120 miles a day
5days a week.
You must be a real big guy too get 1600m of rib.i am only doing
1200m.Slay the dragon and do the best you can.youll get thru it.best
wishes. john...........................

> On Sat, 8 Jul 2006 17:43:28 -0400, "ChefX"
> <ChefTomAnson@insightbb.com>, in message ID
[quoted text clipped - 25 lines]
> weeks?  That's the only possible reason I can think of for upping the
> riba and, even then, it may not be of benefit.
pajaritaflora - 09 Jul 2006 15:07 GMT
> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 8 lines]
>
> ChefX

imho I don't think you should give up either. Kids will be difficult
I'm sure, but there is also some inate ability that they have to be
cool when it is absolutely most needed.....maybe not always when you
"want " them to. I'm sure that ride to get them sucked, but that part
is over and you made it through....on to the next challenge.:).....Do
they know how to make sandwiches yet? That will be helpful.

Mary Ann
Richard Klein - 09 Jul 2006 16:44 GMT
You owe it to yourself and your kids to continue with the TX.  If you don't
see it through to the end you risk ending up with a virus in your body that
has built up a bit of tolerance to the TX and would be harder to eliminate
if you decide to try again.

> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 11 lines]
>
> ChefX
brian - 09 Jul 2006 16:52 GMT
> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 11 lines]
>
> ChefX

If there is anything that I can do to help you let me know.I don't have kids
but many of my single friends do.So I kind of understand the ordeal of
raising them alone.I can't imagine doing it on tx.You know what's best for
you,but try not to make any decision without a clear head.What is your
BCLD's opinion?
I didn't make it to last weeks meeting.I had a 3:40 doc appt.Hopefully I'll
be there next month.

Peace,
BrianD
Waterspider - 09 Jul 2006 20:59 GMT
> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 9 lines]
> I couldn't keep up w/ the kids before tx, how am I supposed to do it
> now???

DO NOT GIVE UP!

We're talking about the rest of *your life* here, Cheffie, not just the few
mere months of remaining treatment, and if you were undetectable at four
weeks you're in damn fine shape! You'll find a way to do it, maybe with the
help of a friend or neighbour, maybe with the help of social services or
maybe with some strenght inside you that you'll never know exists until you
call on it. Finishing tx is not only the smartest thing you can do right now
but, in the long term, the absolute best thing you can do for your kidlets.

Try it this way: come shot day, decide if you can do just one more, or not.
If not, do it anyway cuz you can always pack it in the next week. Yeah, it's
a silly head game, but it got me through treatment (which worked) and my
life has never been finer.

One day at a time.

Waterspider
Richard Klein - 10 Jul 2006 02:12 GMT
You owe it to yourself and your kids to continue with the TX.  If you don't
see it through to the end you risk ending up with a virus in your body that
has built up a bit of tolerance to the TX and would be harder to eliminate
if you decide to try again.

> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 11 lines]
>
> ChefX
Sourdo - 10 Jul 2006 07:48 GMT
take a deep breath, saddle up, cowboy up, pull up your boots, grip a little
harder, and keep going man. One day at a time man. Talk to your kids, let
them know your having a tough time, they are smarter then you think.

Best of luck to you, I know how it is.

Signature

Russ

http://www.tannersacre.com
sourdo55 at yahoo.com

> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 8 lines]
>
> ChefX
Sourdo - 10 Jul 2006 07:48 GMT
take a deep breath, saddle up, cowboy up, pull up your boots, grip a little
harder, and keep going man. One day at a time man. Talk to your kids, let
them know your having a tough time, they are smarter then you think.

Best of luck to you, I know how it is.

Signature

Russ

http://www.tannersacre.com
sourdo55 at yahoo.com

> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 8 lines]
>
> ChefX
ChefX - 10 Jul 2006 13:28 GMT
Thanx everyone, I really needed to hear that stuff. I'm feeling much more
positive today. As WS said, just like everything else in my life, gotta take
it one day at a time.( I have a nagging tendency to forget that
sometimes.;-)

Damn the Dragon!
Save the Empire!!!

> take a deep breath, saddle up, cowboy up, pull up your boots, grip a little
> harder, and keep going man. One day at a time man. Talk to your kids, let
[quoted text clipped - 22 lines]
> >
> > ChefX
Stretch - 11 Jul 2006 19:43 GMT
> I've been doing pretty wee so far on tx, I just took my 13th shot and am
> awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 8 lines]
>
> ChefX

er, why did your doc up your does to 1600? what changed?
ChefX - 11 Jul 2006 20:39 GMT
> > I've been doing pretty wee so far on tx, I just took my 13th shot and am
> > awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 10 lines]
> >
> er, why did your doc up your does to 1600? what changed?

I had hardly any sides, I'm big and was undetectable @4wks.
greyhackles - 11 Jul 2006 21:20 GMT
>> > I've been doing pretty wee so far on tx, I just took my 13th shot and am
>> > awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 13 lines]
>
>I had hardly any sides, I'm big and was undetectable @4wks.

With all due respect to the treating physician, that makes no sense at all.

It's as if he's measuring effectivity by the degree of side effects, instead
of recognizing that you *already* did the heavy lifting, as measured by viral
load, and now you should be cruising at whatever levels you were at for the
first 12 weeks, for the rest of your journey...

Cheers

/greyhackles
Stretch - 12 Jul 2006 01:03 GMT
>>>>I've been doing pretty wee so far on tx, I just took my 13th shot and am
>>>>awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
[quoted text clipped - 24 lines]
>
> /greyhackles
Agreed. Never heard of this method. Your doctor is a hack.
Cactus Jammies - 12 Jul 2006 02:01 GMT
It seems to me from what I've read that the standard weight based dosage
that Phizer et al set out on the market underappreciated the fact that many
of us do not fit in the constraints of the weight catagories.  Many of us
are not spot on their BMI numbers.  Like me.  Many, and I know two, are
under and it damn near rubs them out.  It was my concern when the treatment
was laid out for me, and I was told not to worry about it, but I was on the
Orange dosage, which at the time was six caps a day.  I thought then that
because of my outside the boundaries physical size that I would not be
successful.  And I was right although perhaps not for that reason. Now that
the numbers are rolling back to the physicians, vis a vis the success rate
at the rx dosage, they are venturing to add more riba and maybe even space
out the IFN through the week, too.  It will come to that I believe,
subjective dosing, not off the shelf crap.  hasta vx 950 or statins or
whathaveyou.  combo tx can and is a torture to many of us.  I would not
willingly go into a longer treatment cycle with that stuff.  (pardon if I
misquote the originals)  His doctor is not a hack.  he is trying to help
ChefX succeed.  Stretch, do you read any of the current Hepatology journals
on line?  It might be time for you to do that, imho.

cactus jammies ------------------------
"Stretch" <lonepawn@mail.com> wrote in message
Greyhackles asked:
>>>>er, why did your doc up your does to 1600? what changed?

>>> ChefX replied....
>>>I had hardly any sides, I'm big and was undetectable @4wks.
[quoted text clipped - 14 lines]
>> /greyhackles
> Agreed. Never heard of this method. Your doctor is a hack.
greyhackles - 12 Jul 2006 02:59 GMT
>"Stretch" <lonepawn@mail.com> wrote in message
>Greyhackles asked:
[quoted text clipped - 37 lines]
>ChefX succeed.  Stretch, do you read any of the current Hepatology journals
>on line?  It might be time for you to do that, imho.

This is not the old fixed dosage vs weight based dosage argument revisited. I
think that's been fairly well resolved in favor of WBD.

Some of us are well aware of recent studies showing elevated Ribavirin dosages
beyond the standard weight-based dosage regimens provides incremental
increases in SVR rates. I've made that point - when appropriate - quite often,
as you are likely aware.

If you actually read such studies, what you usually see are patients that
failed conventional therapy and/or slow responders to conventional therapy,
going through for another try, not patients that are "super responders" on
their first go-around using fairly standard weight-based dosage as is our
ChefX.

The point remains: he was undetectable at week 4, and he's still undetectable
at week 12. It makes no sense - nada, zilch, gesphincto - to be boosting his
Ribavirin dosage *now*. At best, it's gilting the lily.

The good news is his blood work to this point is freakin' miraculous! It's
like he isn't on treatment at all! So another 200 mg is unlikely to put him in
the dumpster. But it's also not likely to help him at all...

Cheers

/greyhackles
Stretch - 12 Jul 2006 04:25 GMT
> It seems to me from what I've read that the standard weight based dosage
> that Phizer et al set out on the market underappreciated the fact that many
[quoted text clipped - 40 lines]
>>
>>Agreed. Never heard of this method. Your doctor is a hack.

No, he's a hack. He's experimenting where he should not be. If I hear
that he's one of the top hep-c docs in the field and he increased the
dosage based upon careful consideration then I might change my opinion.
Until then, he's a hack.
ChefX - 12 Jul 2006 05:01 GMT
> > It seems to me from what I've read that the standard weight based dosage
> > that Phizer et al set out on the market underappreciated the fact that many
[quoted text clipped - 45 lines]
> dosage based upon careful consideration then I might change my opinion.
> Until then, he's a hack.

I'm certainly not going to defend the credentials, or judgment of my
physician. As far as I'm concerned, the results speak for themselves. The
way I understand the pharmicodynamics of the meds. Interferon mobilizes the
immune system to destroy the virus cells. Ribavirin, inhibits the process by
which the virus replicates. The logic works for me....Better too much than
not enough.(my life's credo).

I'm fortunate enough to have a Dr. who respects me and my opinions/concerns
enough to allow my course of treatment to be a collaborative effort.

If it ain't broke don't fix it.... ChefX
Cactus Jammies - 12 Jul 2006 16:37 GMT
Hey stretch try this:
http://clinicaloptions.cn/Hepatitis/Conference%20Coverage/Shanghai%202006.aspx

or if your Chinese isn't very good, then try this:

http://clinicaloptions.com/Hepatitis/Conference%20Coverage/Vienna%202006.aspx

clinical care options  CCO    the .cn stands for China.  There is more out
there.  The lid appears to be off the standardized combo tx approach.
Perhaps I was a little pointed in my remark about reading more up to date
info.  Did you ever think that using the IFN - Riba 48 week tx was written
in stone for ever?  I don't think it is.  No slagging from this computer.

cheers

cactus jammies ==================

>> It seems to me from what I've read that the standard weight based dosage
>> that Phizer et al set out on the market underappreciated the fact that
[quoted text clipped - 46 lines]
> based upon careful consideration then I might change my opinion. Until
> then, he's a hack.
Paul - 13 Jul 2006 08:40 GMT
>>>Agreed. Never heard of this method. Your doctor is a hack.
>>
>No, he's a hack. He's experimenting where he should not be. If I hear
>that he's one of the top hep-c docs in the field and he increased the
>dosage based upon careful consideration then I might change my opinion.
>Until then, he's a hack.

The way I read Chefx's original post indicates that he *is* having a
bit of trouble with some side effects - to the point where he was
thinking of quitting tx.  It's not clear if this has only happened
since the riba dose increased.  I understand where his doc is coming
from (I think) but it does look like he is trying to fix something
that isn't broken.  I wouldn't call him a hack but it does look like
he may be causing a bit of extra pain for what is almost certainly no
extra gain.  I could understand it better if he upped the dose for a
patient who was clearing the virus more slowly.
Stretch - 12 Jul 2006 04:28 GMT
> It seems to me from what I've read that the standard weight based dosage
> that Phizer et al set out on the market underappreciated the fact that many
[quoted text clipped - 40 lines]
>>
>>Agreed. Never heard of this method. Your doctor is a hack.

"Stretch, do you read any of the current Hepatology journals
on line?  It might be time for you to do that, imho."

Oh, and BTW, go f.ck yourself.
elmoemerson@webtv.net - 12 Jul 2006 13:37 GMT

Re: Considering giving up on Tx.  

Group: alt.support.hepatitis-c Date: Tue, Jul 11, 2006, 8:03pm (CDT+1)
From: lonepawn@mail.com (Stretch)
greyhackles wrote:
On Tue, 11 Jul 2006 15:39:43 -0400, "ChefX" <ChefTomAnson@insightbb.com>
wrote:
"Stretch" <lonepawn@mail.com> wrote in message
news:12b7sbbegikk5ff@corp.supernews.com...
ChefX wrote:
I've been doing pretty wee so far on tx, I just took my 13th shot and am
awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
VL945,000).
I had been feeling damn good about things until all at once everything
changed. I won full custody of my kids (daughter 6, son 4) I had to
drive 800miles each way in two days to retrieve them, that ordeal took
more out of me than I was expecting. and last week my Dr. increases my
riba dose to 1600mg/day. All these responsabilities and I'm really
feeling the sides now.
I just don't know if this is the right time for me to be on tx. I
couldn't keep up w/ the kids before tx, how am I supposed to do it
now???
ChefX
er, why did your doc up your does to 1600? what changed?
I had hardly any sides, I'm big and was undetectable @4wks.
With all due respect to the treating physician, that makes no sense at
all.
It's as if he's measuring effectivity by the degree of side effects,
instead of recognizing that you *already* did the heavy lifting, as
measured by viral load, and now you should be cruising at whatever
levels you were at for the first 12 weeks, for the rest of your
journey...
Cheers
/greyhackles
Agreed. Never heard of this method. Your doctor is a hack.  
<Stretch>
/////////////
I don't think so.  
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
elmoemerson@webtv.net - 12 Jul 2006 13:35 GMT

Re: Considering giving up on Tx.  

Group: alt.support.hepatitis-c Date: Tue, Jul 11, 2006, 4:20pm (CDT+1)
From: greyhackles@NOSPAMyahoo.com (greyhackles)
On Tue, 11 Jul 2006 15:39:43 -0400, "ChefX" <ChefTomAnson@insightbb.com>
wrote:
"Stretch" <lonepawn@mail.com> wrote in message
news:12b7sbbegikk5ff@corp.supernews.com...
ChefX wrote:
I've been doing pretty wee so far on tx, I just took my 13th shot and am
awaiting my 12 week lab results, I was undetectable at 4 weeks, (Gn 1a,
VL945,000).
I had been feeling damn good about things until all at once everything
changed. I won full custody of my kids (daughter 6, son 4) I had to
drive 800miles each way in two days to retrieve them, that ordeal took
more out of me than I was expecting. and last week my Dr. increases my
riba dose to 1600mg/day. All these responsabilities and I'm really
feeling the sides now.
I just don't know if this is the right time for me to be on tx. I
couldn't keep up w/ the kids before tx, how am I supposed to do it
now???
ChefX
er, why did your doc up your does to 1600? what changed?
I had hardly any sides, I'm big and was undetectable @4wks.
With all due respect to the treating physician, that makes no sense at
all.
It's as if he's measuring effectivity by the degree of side effects,
instead of recognizing that you *already* did the heavy lifting, as
measured by viral load, and now you should be cruising at whatever
levels you were at for the first 12 weeks, for the rest of your
journey...
Cheers
/greyhackles  
/////////
Chef's doc just wants to see him suffer, like everyone else.  Or maybe
his doctor realizes that Chef tolerates the medicine so well, that he
can handle the higher dose.  He probably knows that more is better when
it comes to percentages and genotype 1 cases.  Statistical advantage and
all that rot.
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
 
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