 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Hepatitis / July 2006ALT and AST during tx
I've just had my labs back after 9 weeks of tx. Everything was looking pretty good. I had a 3 log drop in VL at week 4 and ALT and AST have been down in the normal range. Neutrophils have been taking it a bit hard requiring interferon dose reductions on a couple of occasions. My latest results show neutrophils are back up to 1.4 g/l (which is good) but ALT and AST have pretty well doubled, taking them out of the normal range Alt is 64 (normal 5-50) and Ast is 53 (normal 10-45). The first time I did tx I recall that Alt and Ast were quickly normalised and remained that way the whole time. That was non-peg interferon. Does anyone know if it is normal (ie not a bad sign for eventual SVR) for Alt and Ast to be highish during tx? My doctor has mentioned the possibility of Neupogen for low neutrophils rather than an interferon dose reduction. Anyone know at what point is Neupogen usually recommended rather than simple dose reduction? Jack >I've just had my labs back after 9 weeks of tx. Everything was looking >pretty good. I had a 3 log drop in VL at week 4 and ALT and AST have been [quoted text clipped - 14 lines] > >Jack Experiences vary, but elevated ALT/AST isn't "abnormal" under TX. While my levels rapidly normalized in the first few weeks of therapy, others here cleared the virus and ended therapy with ALT 3x times the normal high limit, but eventually normalized. And they obtained SVR. So I suspect enzyme levels are all over the map and cannot be counted upon to hint of the success of treatment. As for the Neupogen to battle crashed neuts: I don't know what the recommended level is to trigger intervention, but if offered, you should surely take it, as opposed to tx-meds dosage reduction... Cheers /greyhackles > I've just had my labs back after 9 weeks of tx. Everything was looking > pretty good. I had a 3 log drop in VL at week 4 and ALT and AST have been [quoted text clipped - 14 lines] > > Jack My neuts (abs) have dipped very low (.73 most recently) but my doc has not been too worried about them. Said that he'd never had a problem with an otherwise-normal hep-c (now that sounds odd) patient. Wasn't interested in prescribing growth-factor for the WBC's (but had no problem prescribing Procrit for the RBC's). I'd fight very hard before I'd let my doc reduce my dosage. I've heard that AST/ALT are just markers and that you can't really use them for much else. Thanks for your comments. Good advice as usual. Basically I shouldn't worry too much about ALT and AST and I should do what I can to keep up the full dose of interferon. Just thought there may have been a rule (like if neutrophils fall below 750 for 2 weeks in a row then start using Neupogen). But I guess it's up to each doctor. cheers Jack > I've just had my labs back after 9 weeks of tx. Everything was looking > pretty good. I had a 3 log drop in VL at week 4 and ALT and AST have been [quoted text clipped - 14 lines] > > Jack |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2009 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.