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Medical Forum / Diseases and Disorders / Hepatitis / July 2006Ribavirin
What exactly does it do? I've had a look around and everywhere is tons of info on the side effects and how it is used, all thisngs I am personally familiar with already but I was curious about what exactly it does. After scoping thru many articles the only thing I came up with is that it assists the Interferon with suppressing viral replication. Is that it? If that is all it does then why is it a weight based dosage? Anyway, just curious. If I'm going to be sucking these down for another 11 months, I'd just kinda like to know what I am taking them for, you know, so I can deal with the emotional side of it all with logic if you know what I mean. Thanks, Ally > What exactly does it do? I've had a look around and everywhere is tons > of info on the side effects and how it is used, all thisngs I am [quoted text clipped - 10 lines] > > Thanks, Ally Riba kills the virus by suppressing replication. Interferon twiddles your immune system to facilitate the magic. Think of it like this, Ally. The hcv virii are these big, mean guys dressed in black, type 1 meanies being the worst. Interferon and riba are specially trained midgets wearing white and red leotards, respectively. It takes a whole bunch of both types of midgets to beat up one of bad guys. elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum Here's an even more accurate description...think of it this way: The hcv virii are like especially horny little midgets, all they ever do is lay around and screw. And because of that, they multiply like crazy. Along comes the dynamic duo of 'Interferon' and 'Ribavirin' to keep them from multiplying any way they can. Intereron works on the female midget's menstrual cycle turning them into bleeding, nasty little bitches while Ribavirin concentrates on the male midgets, kicking them in the balls each time they mount the females. Doc Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum > Here's an even more accurate description...think of it this way: > [quoted text clipped - 7 lines] > > Doc Elmo OMG! Whew! Finally! An explanation that makes sense! Thanks, I've been edified. Doug Re: Ribavirin Group: alt.support.hepatitis-c Date: Tue, Jul 4, 2006, 12:46pm (CDT+1) From: dt12@adelphia.net (dt12) <elmoemerson@webtv.net> wrote in message news:28636-44AA96BA-94@storefull-3257.bay.webtv.net... Here's an even more accurate description...think of it this way: The hcv virii are like especially horny little midgets, all they ever do is lay around and screw. And because of that, they multiply like crazy. Along comes the dynamic duo of 'Interferon' and 'Ribavirin' to keep them from multiplying any way they can. Intereron works on the female midget's menstrual cycle turning them into bleeding, nasty little bitches while Ribavirin concentrates on the male midgets, kicking them in the balls each time they mount the females. Doc Elmo OMG! Whew! Finally! An explanation that makes sense! Thanks, I've been edified. Doug ////////// You're welcome , Doogie. Just remember to keep it simple. elmo simple is better http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum On Tue, 4 Jul 2006 11:26:34 -0500, elmoemerson@webtv.net, in message ID <28636-44AA96BA-94@storefull-3257.bay.webtv.net>, in the newsgroup alt.support.hepatitis-c wrote: >Here's an even more accurate description...think of it this way: > [quoted text clipped - 7 lines] > >Doc Elmo LOL. You been smoking again? :-) Re: Ribavirin Group: alt.support.hepatitis-c Date: Wed, Jul 5, 2006, 12:07am (CDT+6) From: dontspamme@westgreen.freeserve.co.uk (Paul) On Tue, 4 Jul 2006 11:26:34 -0500, elmoemerson@webtv.net, in message ID <28636-44AA96BA-94@storefull-3257.bay.webtv.net>, in the newsgroup alt.support.hepatitis-c wrote: Here's an even more accurate description...think of it this way: The hcv virii are like especially horny little midgets, all they ever do is lay around and screw. And because of that, they multiply like crazy. Along comes the dynamic duo of 'Interferon' and 'Ribavirin' to keep them from multiplying any way they can. Intereron works on the female midget's menstrual cycle turning them into bleeding, nasty little bitches while Ribavirin concentrates on the male midgets, kicking them in the balls each time they mount the females. Doc Elmo ///////// LOL. You been smoking again? :-) ///////// How did you know? elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum >What exactly does it do? I've had a look around and everywhere is tons >of info on the side effects and how it is used, all thisngs I am [quoted text clipped - 10 lines] > >Thanks, Ally Well, you've read some of the theories ;-) but the one that makes the most sense is that Ribavirin inhibits viral replication, while Interferon jolts the immune system to kill any virions it encounters. Between stopping production of new virions (Ribavirin) and killing existing virions (Interferon) eventually there aren't any virions left to infect virgin cells. Hence "the cure"... Cheers /greyhackles Wow, well, I've been both informed and entertained. I couldn't have asked for anything better as I sit here impatiently waiting for my 12 week results. My Dr went on vacation so won't be getting them till (hopefully) next week (week 14 for me). Another thing I read was how to take it. Apparently many articles say you take more at night then in the morning whereas I take 3 in the morning and 2 at night. Wonder if that is why I am so blasted tired all day and wide awake at night. Ally >Wow, well, I've been both informed and entertained. I couldn't have >asked for anything better as I sit here impatiently waiting for my 12 [quoted text clipped - 5 lines] > >Ally I don't think it makes any difference how you split your five Riba pills between AM and PM, other than to minimize digestive system disorders by not taking them all at once. I took 4 in the AM and 3 in the PM, fwiw. What really does make a difference is taking your Ribavirin with some kind of fatty meal, as it increases uptake by around 60%. And maximizing effectivity is a good thing... Cheers /greyhackles > What really does make a difference is taking your Ribavirin with some kind of > fatty meal, as it increases uptake by around 60%. [quoted text clipped - 4 lines] > > /greyhackles OMG, really???? Oh dear... I swallow mine down with a shot of espresso then head to the gym then have a dry bagel afterward. Why don't they tell you these things, grrrrrrr. Ally >> What really does make a difference is taking your Ribavirin with some kind of >> fatty meal, as it increases uptake by around 60%. [quoted text clipped - 10 lines] > >Ally Good question, to which I have no good answer. I have a lot of *bad* answers, though, which indict the medical community's lack of knowledge in such matters... You should have received a Product Information sheet with the Riba and/or the Peg. You'll find the above noted therein. Cheers /greyhackles Ally, I know it sounds odd, but try a jigger of extra virgin olive oil mixed with a bit of balsamic vinegar. It gives you a jolt and it maximizes the riba. i kid you not. Alternately, I used that or Silk chocolate drink if there was any around. that stuff is toooooo good tasting though. cactus jammies > OMG, really???? Oh dear... I swallow mine down with a shot of espresso > then head to the gym then have a dry bagel afterward. Why don't they > tell you these things, grrrrrrr. > > Ally >> What really does make a difference is taking your Ribavirin with some >> kind of [quoted text clipped - 11 lines] > > Ally Don't worry, Ally, I did my entire tx thinking that any fat was evil for liver disease and so I virtually eliminated it from my diet. Oh yeah, the tx worked anyway :-) Waterspider >>> What really does make a difference is taking your Ribavirin with some >>> kind of [quoted text clipped - 16 lines] >Oh yeah, the tx worked anyway :-) >Waterspider Um....well, ok, but I don't think it's prudent to suggest folks follow the same course. The Product Information sheets are pretty clear on the heightened effects of taking Ribavirin with a high fat content meal. And you were a G3, right? G1s should avail themselves of every opportunity to slam the bastid virus, and that ought to mean doing whatever it takes to increase the effectivity of the current drug regimen... Cheers /greyhackles > Um....well, ok, but I don't think it's prudent to suggest folks follow the > same course. The Product Information sheets are pretty clear on the heightened [quoted text clipped - 7 lines] > > /greyhackles Yep I'm G1 so did make the dietary change. I will do anything to help make this a success. Apparently I didn't get any sheets on the Ribavirin only on the Interferon, don't know why but that's the VA for you. I'm just grateful they are allowing me to do this tx as apparently they give a lot ppl a hard time. Ally >> Um....well, ok, but I don't think it's prudent to suggest folks follow the >> same course. The Product Information sheets are pretty clear on the heightened [quoted text clipped - 15 lines] > >Ally You can grab your very own copy of the Rebetol (Schering-Plough's brand of Ribavirin) Product Information sheet here: http://www.spfiles.com/pirebetol.pdf First page, bottom-left corner, notes a 70% increase in absolute bioavailability when taken with high fat content food. That said, they also note that insufficient study data exists to analyze exactly what that means. *That* said, recent studies have shown higher levels of Ribavirin results in higher rates of SVR. Logically, then, it follows that higher bioavailability is a good thing - particularly when considering the still-rather-dreadful SVR rates for G1s... Cheers /greyhackles Has anyone tried snorting their Ribavirin? What a rush!!!!!!!!! >>> Um....well, ok, but I don't think it's prudent to suggest folks follow >>> the [quoted text clipped - 40 lines] > > /greyhackles > Has anyone tried snorting their Ribavirin? What a rush!!!!!!!!! Way better than snorting the 'feron... that just gives you the sniffles ;-) > > Um....well, ok, but I don't think it's prudent to suggest folks follow the > > same course. The Product Information sheets are pretty clear on the heightened [quoted text clipped - 15 lines] > > Ally Geno-3 and still taking the riba with oil. After all. -- BG > On Thu, 6 Jul 2006 14:52:57 -0700, "Waterspider" > <waterspider@moonlight.net> [quoted text clipped - 30 lines] > slam the bastid virus, and that ought to mean doing whatever it takes to > increase the effectivity of the current drug regimen... Of course you're right, Grey, and it never occurred to me that someone might think I was suggesting that someone be as stupid as I was with my diet (although, when I did tx, that information wasn't readily available). I was attempting to reassure Ally that, if she didn't always consume fat with riba, there was still hope for the SVR. Thanks for clarifying it, though. Re-reading my post, I think it's possible that someone could misunderstand. Spidey Re: Ribavirin Group: alt.support.hepatitis-c Date: Tue, Jul 4, 2006, 7:35pm (CDT-2) From: 4thMoon@gmail.com (Ally) Wow, well, I've been both informed and entertained. I couldn't have asked for anything better as I sit here impatiently waiting for my 12 week results. My Dr went on vacation so won't be getting them till (hopefully) next week (week 14 for me). Another thing I read was how to take it. Apparently many articles say you take more at night then in the morning whereas I take 3 in the morning and 2 at night. Wonder if that is why I am so blasted tired all day and wide awake at night. Ally ////////// I'm not sure what articles you read, but you're supposed to take the larger dose of riba in the morning rather than in the evening. The reason for that is that the riba causes insomnia. Also, if you ARE taking the lower dose in the evening and still having trouble with insomnia, take the riba with food no later than 6pm. That might help. If insomnia continues to be a problem, you might want your doc to give you sleep meds. Getting enough sleep is important, you need more during tx, it affects your immune system. elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum |
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