 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Hepatitis / June 2006What percentage of responders get SVR?
Any studies on what perscentage of responders achieve SVR? Any studies where they break it down by genotype? You know, stuff like that. > Any studies on what perscentage of responders achieve SVR? > Any studies where they break it down by genotype? > You know, stuff like that. Forgive my ignorance but what does SVR stand for? Ally Ally ha scritto: >> Any studies on what perscentage of responders achieve SVR? >> Any studies where they break it down by genotype? [quoted text clipped - 3 lines] > > Ally Sustained Viral Response. It is what you, and all people undergoing Hepatitis C treatment, are looking for. It is defined as no detectable (<50 IU/ml or <10 IU/ml, depends from the essay used for the lab test) viral load in the blood stream 24 weeks (6 months) after completing treatment. Cheers, jeeb. Say Ally, do you need any internet resourses from web pages for Hep C and treatment? There is more out there than you can shake a syringe at or for me to capsule ate at once. There are frequent postings on this list about something new coming up or resources on the web all the time. SVR that's on the way to killing or at least stunning the ash sea dragon a good one for quite a while. You're looking for an SVR six months afer your treatment is over. cactus jammies >> Any studies on what perscentage of responders achieve SVR? >> Any studies where they break it down by genotype? [quoted text clipped - 3 lines] > > Ally > Say Ally, do you need any internet resourses from web pages for Hep C and > treatment? There is more out there than you can shake a syringe at or for [quoted text clipped - 6 lines] > > cactus jammies 6 months after treatment, okay, I'd better get it for all this crap I am going thru. Oops, did that sound irritable? Can't be from watching my hair going down the drain this morning. Ho hum, the joys of tx. Yes, I know there is so much info out there but it is overwhelming so I don't know who to read and who to trust. Is there maybe a couple of good trustworthy websites you could recommend? I might as well get some reading done while I'm zonked out at home. Thanks, Ally It depends on how many bananas you've consumed during your course of tx. elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum mango says hi, buddy meow meow cj guardian and feeder of The Mangulator ................................................................. > It depends on how many bananas you've consumed during your course of tx. > elmo Buddy-Mango woof woofs elmo buddy toots ////////////// mango says hi, buddy meow meow cj guardian and feeder of The Mangulator ............................................. <elmoemerson@webtv.net> wrote in message news:19138-449448B9-461@storefull-3252.bay.webtv.net... It depends on how many bananas you've consumed during your course of tx. elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum Viral Response (VR) exists when Viral Load (VL) has been reduced to a level so low that it cannot be detected by laboratory assay. A Sustained Viral Response (SVR) exists when VR continues after six months past discontinuance of antiviral chemotherapy. Once SVR is attained, as a matter of statistical probability, the virus is gone for good, unless the subject is reinfected. -BG > > Any studies on what perscentage of responders achieve SVR? > > Any studies where they break it down by genotype? [quoted text clipped - 3 lines] > > Ally Anonymouseone, Right with showing me my lab results that confirmed I was infected with HCV geno-3, my PA explained my chances of attaining SVR with first round of standard of care Tx. I'd already learned that HCV geno-1 has about 40% chance of attaining SVR with first round of standard 48-week treatment with pegylated interferon and ribabirin. And that chances for attaining SVR are better for geno-3 and geno-2 patients at around 80 and 85% respectively after the first round of Tx. Since I started Tx, I've learned about other factors that corrrespond to various chances of SVR, such as the attainment of Early Viral Response (EVR -- in my case defined as an undectable VL at 4 weeks; I think for geno-1, an EVR is defined as an undectable VL at 12 weeks, so if you have VR already at 12 weeks, then your expected outcome now is that associated with patient who as attained EVR.) Also, the topography of sides and symptoms related to treatment - as it effects compliance - is an important factor that can effect chances of SVR. And then there are various outcomes associated with various second treatment strategies, and all the while new strategies are introduced. Some URLs: http://clinicaloptions.com/Hepatitis.aspx (great source for findng latest Hep studies) http://www.hivandhepatitis.com/hep_c/hepc_news_svr.html http://www.hepatitisdoctor.com/ -BG > Any studies on what perscentage of responders achieve SVR? > > Any studies where they break it down by genotype? > > You know, stuff like that. > I'd already learned that HCV geno-1 has about 40% chance of attaining > SVR with first round of standard 48-week treatment with pegylated > interferon and ribabirin. CORRECTION: I'd learned that chances for SVR with genotype-1 is 40% to 60% at start of first round of Tx. - BG >> I'd already learned that HCV geno-1 has about 40% chance of attaining >> SVR with first round of standard 48-week treatment with pegylated [quoted text clipped - 4 lines] > >- BG I think your first answer is closer to the "correct" one. From all of the studies I've read over the last two years that used PegIFN and Riba, I believe the net SVR rate for g1s using *Intention To Treat* metrics is roughly 35%. Using different metrics, the SVR percentage will always report higher because the cohort reductions are usually focused on patients that would not have obtained SVR - for whatever reason. Imho the only metric prospective patients can (and should) relate to is ITT based... Cheers /greyhackles > > I'd already learned that HCV geno-1 has about 40% chance of attaining > > SVR with first round of standard 48-week treatment with pegylated [quoted text clipped - 4 lines] > > - BG I dont think you are understanding the question. I have been told that genotype 1 is 40%-50% SVR, but I believe that number includes non-responders also. My question is that for those who di respond to treatment , what is the percentage of SVR? >> > I'd already learned that HCV geno-1 has about 40% chance of attaining >> > SVR with first round of standard 48-week treatment with pegylated [quoted text clipped - 9 lines] >non-responders also. My question is that for those who di respond to >treatment , what is the percentage of SVR? So, basically, you want to know the relapse rate for g1s? My bcld said in the PegIFN/Riba era is has been around 20%. But I suspect this is declining as test sensitivity increases, identifying patients that never actually cleared the virus before the end-of-therapy. Cheers /greyhackles > >> > I'd already learned that HCV geno-1 has about 40% chance of attaining > >> > SVR with first round of standard 48-week treatment with pegylated [quoted text clipped - 19 lines] > > /greyhackles Yes, maybe I didnt explain myself very well, but thats what I wanted to know. I wonder if their have been studies where they f break it down further by race.? Yeah, I didn't clearly understand what you were asking about chances of responders getting SVR versus chances of all persons who receive Tx. I'm much too messed up to be thinking about it much -- Shot #12 has been beating me up like despised step-child, and I should have known better than speak out on any complicated stuff over the past couple days. Anyway, fwiw, I did see a study that found ER is not much of a predictor for SVR among African Americans with geno-1. Over and totally frigging out, dump me in a 1970s boxing ring and say I went 15 rounds with Ali. BG > > >> > I'd already learned that HCV geno-1 has about 40% chance of attaining > > >> > SVR with first round of standard 48-week treatment with pegylated [quoted text clipped - 25 lines] > I wonder if their have been studies where they f break it down further > by race.? Thanks BG for those links. I've been reading up and there's a lot of info on them. Ally Re: What percentage of responders get SVR? Group: alt.support.hepatitis-c Date: Sun, Jun 18, 2006, 9:38am (CDT-2) From: 4thMoon@gmail.com (Ally) Thanks BG for those links. I've been reading up and there's a lot of info on them. Ally //////////////////// I like 'Doctor's Guide'. You have to subscribe and tell them you're a health professional when you sign up, LOL, their information is top notch and reputable. If you ask them too, they'll even email you with updates on the latest info on treating liver disease. I think you can easily find them by googling 'doctor's guide homepage'. elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum Ally, I was (am) Genotype 1A. My liver was shot and I had a liver transplant 6/8/2000. I knew after the transplant that should it return, I would have to go through treatment. About 3 years post transplant, my viral load had climbed to a level that made my gastro doc start treatment. I knew all the risks and data associated with it. After 48 weeks of the Pegasys/Copegus treatment, I was undetectable. At 1 year post treatment, I was still undetectable. At my last clinic visit, June 6, 2006, they did one last test to check. I am still undetectable. That is more than 2 years post treatment and with no immune system! They also informed me that they use a new test to measure viral loads. It is extremely sensitive and can detect levels in the hundreds, not less than 50,000 as the previous test. I may be some sort of exception to the general rule, but do not give up hope. This was my first and only treatment for HCV. My doctors tell me that there are a couple of new drugs out there that show great promise as well. Eric Liver TX 6/8/2000 |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2010 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.