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Medical Forum / Diseases and Disorders / Hepatitis / May 2006Hyperuricemia / erythrocytosis / smoking
I wonder what the full text .. says .. The American Journal of Gastroenterology Volume 97, Issue 5 , May 2002, Pages 1264-1265 doi:10.1016/S0002-9270(02)04074-1 Copyright © 2002 Am. Coll. of Gastroenterology. Published by Elsevier Science Inc. Letter to the editor Heavy cigarette smoking induces hypoxic polycythemia (erythrocytosis) and hyperuricemia in chronic hepatitis C patients with reversal of clinical symptoms and laboratory parameters with therapeutic phlebotomy Abdel-Rahman El-Zayadi M.D.a, , Osaima Selim M.D.b, Hassan Hamdy M.D.a, Ahmed El-Tawil M.D.c and Hanaa Moustafa M.D.d a Department of Tropical Medicine, Ain Shams University, Cairo, Egypt b Department of Clinical Pathology, Ain Shams University, Cairo, Egypt c Department of Pathology, Ain Shams University, Cairo, Egypt d Department of Tropical Medicine, National Liver Institute, Menoufeya, Egypt Received 21 November 2001; accepted 3 December 2001. Available online 1 May 2002. Reprint requests and correspondence: Abdel-Rahman El-Zayadi, M.D., Cairo Liver Center, 5, El Gergawy Street, Dokki-Giza, Cairo, Egypt The American Journal of Gastroenterology Volume 97, Issue 5 , May 2002, Pages 1264-1265 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >I wonder what the full text .. says .. Well, until you drop a dime on that article (the bastards!) we'll have to think a bit for ourownselves. Considering the meaning of erythrocytosis, the effects of phlebotomy on that condition ought to be self-evident. Ie: You have a condition that is expressed as an abnormal proliferation of blood cells, which in turn presents a set of clinically evident symptoms, all of which can apparently be reversed by drawing off blood at some rate which presumably exceeds the rate of erythrocyte production. Duh. What isn't obvious is how any of that is specifically related to chronic HCV, but if I had to hazard a guess, bone marrow is affected by the chronically over-active immune system, and adding heavy smoking to that (heavy meaning the patient's O2SAT is seriously affected - like down in the low 90's% range or worse) must drive the marrow into major overdrive to try to compensate for the hypoxic state. Now, what REALLY isn't clear is how one might try to draw a positive view on the use of phlebotomy in *treating HCV* from the above. I mean, that's *really* stretching it ;-) Cheers /greyhackles >>Now, what REALLY isn't clear is how one might try to draw a positive view on the use of phlebotomy in *treating HCV* from the above. I mean, that's *really* stretching it ;-) << Not .. that .. hard .. Erythrocytosis / increased red blood cells .. is 'diagnosed' .. through a LARGE .. window .. The analogy I will use is marbles for red blood cells. Normally they would like us to have around 11 red blood cells / marbles . They .. graciously .. allow us .. up to men / 18 red blood cells .. women / 16 red blood cells / marbles. So WHEN you are .. diagnosed WITH .. erythrocytosis .. we might think 'they' .. have .. graciously allowed us the .. 18 red blood cells / marbles .. when in fact .. 13.5 red blood cells have been shown to have increased .. death .. rate .. kidney disease. So .. the fact you smoke .. isn't the death knell .. it is the FACT .. they .. graciously allow us to HAVE red blood cells / marbles .. that have been shown to kill us .. With .. friends .. like .. 'them' .. Sooooo .. since bloodletting has been shown to be .. "an effective alternative to interferon / ribavarin .. " .. then one might consider the FACT .. the bloodletting in hep C .. reversal of clinical symptoms and laboratory parameters with therapeutic phlebotomy .. CLOSELY .. mimics the outcome of SMOKERS with hep C .. reversal of clinical symptoms and laboratory parameters with therapeutic phlebotomy .. Geez .. even the same wording .. ;-) So if one looks closer .. hep C is most likely found with .. erythrocytosis .. 'across the board' .. what 'they' .. consider / diagnose .. to BE .. minor .. therefore .. cost effectively .. not 'treatable' .. AT THIS TIME. Maybe later when you .. are .. fkg .. near .. dead .. and your organs .. are beyond .. redemption .. But .. hey .. I'm a cynical .. guy .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Bloodletting is what got me in this mess in the first place! ChefX > >>Now, what REALLY isn't clear is how one might try to draw a positive view on > the use of phlebotomy in *treating HCV* from the above. I mean, that's [quoted text clipped - 56 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk >>Now, what REALLY isn't clear is how one might try to draw a positive view on >>the use of phlebotomy in *treating HCV* from the above. I mean, that's [quoted text clipped - 23 lines] >Sooooo .. since bloodletting has been shown to be .. "an effective >alternative to interferon / ribavarin .. " Stop right there. Please provide citations that back that statement up. Otherwise there's no point in continuing as your entire posit is based on that one statement... Cheers /greyhackles >>Stop right there. Please provide citations that back that statement up.<< <<snip>> They suggest that chronic iron reduction is a good alternative to interferon in treatment of CHC. <<snip>> http://tinyurl.com/d2mtz Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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