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Medical Forum / Diseases and Disorders / Hepatitis / April 2006

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NEWS: Spontaneous HCV Clearance More Common Than Previously Thought

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Thomas Wagner - 20 Apr 2006 23:37 GMT
Spontaneous HCV Clearance More Common Than Previously Thought

NEW YORK (Reuters Health) Apr 19 - Spontaneous clearance of hepatitis C
virus (HCV) after chronic infection is thought to be a rare event, but
new research suggests that clearance rates as high as 8% may occur.

Roughly 15% to 30% of people who become infected with HCV will clear the
virus during the acute phase. Until recently, it was believed that the
remaining patients with chronic infection seldom, if ever, clear the
virus.

In a Japanese study reported in 2003, an HCV clearance rate of 3.7% was
described in patients with chronic infection. The present findings,
which appear in Clinical Infectious Diseases for April 1, suggest that
the rate may be higher still.

The study involved 139 Alaskan natives who had tested positive for HCV
RNA on three separate occasions and were followed on a regular basis for
a mean period of 7 years.

Eleven of the patients (8%) had at least one test with undetectable HCV
RNA during follow-up. Seven of these patients were considered to have
probable or possible HCV clearance, yielding an annual clearance rate of
0.74% per person year.

Follow-up testing of nine of the seronegative patients identified five
that still appeared to be virus-free, the report indicates. A low HCV
RNA titer predicted spontaneous nondetectability of HCV RNA.

In a related editorial, Dr. Georg M. Lauer and Dr. Arthur Y. Kim, from
Harvard Medical School in Boston, point out that "more studies are
needed before we can feel confident about the incidence of spontaneous
viral clearance in chronic HCV infection or before we start
investigating the genetic disposition of Alaska Natives and its
relevance to viral control."

"Meanwhile, clinicians should stay alert to this rare outcome of HCV
infection, and further investigations of this phenomenon should be
strongly encouraged," the editorialists add.

Clin Infect Dis 2006;42:945-954.

http://www.medscape.com/viewarticle/530299

Thomas
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elmoemerson@webtv.net - 21 Apr 2006 00:30 GMT

NEWS: Spontaneous HCV Clearance More Common Than Previously Thought  

Group: alt.support.hepatitis-c Date: Thu, Apr 20, 2006, 6:37pm (CDT+1)
From: tomw@capecod.com (Thomas Wagner)
Spontaneous HCV Clearance More Common Than Previously Thought
NEW YORK (Reuters Health) Apr 19 - Spontaneous clearance of hepatitis C
virus (HCV) after chronic infection is thought to be a rare event, but
new research suggests that clearance rates as high as 8% may occur.
Roughly 15% to 30% of people who become infected with HCV will clear the
virus during the acute phase. Until recently, it was believed that the
remaining patients with chronic infection seldom, if ever, clear the
virus.
In a Japanese study reported in 2003, an HCV clearance rate of 3.7% was
described in patients with chronic infection. The present findings,
which appear in Clinical Infectious Diseases for April 1, suggest that
the rate may be higher still.
The study involved 139 Alaskan natives who had tested positive for HCV
RNA on three separate occasions and were followed on a regular basis for
a mean period of 7 years.
Eleven of the patients (8%) had at least one test with undetectable HCV
RNA during follow-up. Seven of these patients were considered to have
probable or possible HCV clearance, yielding an annual clearance rate of
0.74% per person year.
Follow-up testing of nine of the seronegative patients identified five
that still appeared to be virus-free, the report indicates. A low HCV
RNA titer predicted spontaneous nondetectability of HCV RNA.
In a related editorial, Dr. Georg M. Lauer and Dr. Arthur Y. Kim, from
Harvard Medical School in Boston, point out that "more studies are
needed before we can feel confident about the incidence of spontaneous
viral clearance in chronic HCV infection or before we start
investigating the genetic disposition of Alaska Natives and its
relevance to viral control."
"Meanwhile, clinicians should stay alert to this rare outcome of HCV
infection, and further investigations of this phenomenon should be
strongly encouraged," the editorialists add.
Clin Infect Dis 2006;42:945-954.
http://www.medscape.com/viewarticle/530299
Thomas
Signature

It's probably due to the whale blubber the Eskimos are so fond of
eating.  :-)
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

kjoh - 21 Apr 2006 03:02 GMT
It is.  Eat oolichan oil and pickled herring.  Seriously. :-)  (Good find,
Thomas!)

kj

"It's probably due to the whale blubber the Eskimos are so fond of
eating."  :-)
elmo
Russ - 22 Apr 2006 14:26 GMT
f.cker, you took the words out of my mouth!!!!!  ;)

I'll bet it's the stinky fish heads they eat... you know, bury a bunch of
fish heads till they are nice and "soft", yum, yum..... Call me around
dinner time I'll tell ya some more tasty recipes..... LOL.....

Signature

Russ

Visit Alaska @ http://www.tannersacre.com

NEWS: Spontaneous HCV Clearance More Common Than Previously Thought

Group: alt.support.hepatitis-c Date: Thu, Apr 20, 2006, 6:37pm (CDT+1)
From: tomw@capecod.com (Thomas Wagner)
Spontaneous HCV Clearance More Common Than Previously Thought
NEW YORK (Reuters Health) Apr 19 - Spontaneous clearance of hepatitis C
virus (HCV) after chronic infection is thought to be a rare event, but
new research suggests that clearance rates as high as 8% may occur.
Roughly 15% to 30% of people who become infected with HCV will clear the
virus during the acute phase. Until recently, it was believed that the
remaining patients with chronic infection seldom, if ever, clear the
virus.
In a Japanese study reported in 2003, an HCV clearance rate of 3.7% was
described in patients with chronic infection. The present findings,
which appear in Clinical Infectious Diseases for April 1, suggest that
the rate may be higher still.
The study involved 139 Alaskan natives who had tested positive for HCV
RNA on three separate occasions and were followed on a regular basis for
a mean period of 7 years.
Eleven of the patients (8%) had at least one test with undetectable HCV
RNA during follow-up. Seven of these patients were considered to have
probable or possible HCV clearance, yielding an annual clearance rate of
0.74% per person year.
Follow-up testing of nine of the seronegative patients identified five
that still appeared to be virus-free, the report indicates. A low HCV
RNA titer predicted spontaneous nondetectability of HCV RNA.
In a related editorial, Dr. Georg M. Lauer and Dr. Arthur Y. Kim, from
Harvard Medical School in Boston, point out that "more studies are
needed before we can feel confident about the incidence of spontaneous
viral clearance in chronic HCV infection or before we start
investigating the genetic disposition of Alaska Natives and its
relevance to viral control."
"Meanwhile, clinicians should stay alert to this rare outcome of HCV
infection, and further investigations of this phenomenon should be
strongly encouraged," the editorialists add.
Clin Infect Dis 2006;42:945-954.
http://www.medscape.com/viewarticle/530299
Thomas
Signature

It's probably due to the whale blubber the Eskimos are so fond of
eating.  :-)
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

elmoemerson@webtv.net - 24 Apr 2006 04:49 GMT
Nothing like greasy farts just before dinner unless it's greasy farts
after dinner. (sounds really romantic, don't it
Dort.......aahahahhahahahaha)  sh.t, Russ!!  You're going to have to get
down here for some real Ozarks hospitality......fantastic bbq and
jammin' blues music.  I got me a real smokin' machine and there's plenty
of good music. Don't forget to bring 'Suzie Q', I aint seen her since I
sent her to you UPS.  :-)
A friend of mine is 'procuring' me a gallon of the real McCoy Arkansas
moonshine next week.  With a little luck, I'll go blind from it.  :-0
elmo
/////////////  
f.cker, you took the words out of my mouth!!!!! ;)
I'll bet it's the stinky fish heads they eat... you know, bury a bunch
of fish heads till they are nice and "soft", yum, yum..... Call me
around dinner time I'll tell ya some more tasty recipes..... LOL.....
Signature

Russ
Visit Alaska @ http://www.tannersacre.com 
<elmoemerson@webtv.net> wrote in message
news:20809-44481990-358@storefull-3251.bay.webtv.net...
NEWS: Spontaneous HCV Clearance More Common Than Previously Thought
Group: alt.support.hepatitis-c Date: Thu, Apr 20, 2006, 6:37pm (CDT+1)
From: tomw@capecod.com (Thomas Wagner)
Spontaneous HCV Clearance More Common Than Previously Thought NEW YORK
(Reuters Health) Apr 19 - Spontaneous clearance of hepatitis C virus
(HCV) after chronic infection is thought to be a rare event, but new
research suggests that clearance rates as high as 8% may occur. Roughly
15% to 30% of people who become infected with HCV will clear the virus
during the acute phase. Until recently, it was believed that the
remaining patients with chronic infection seldom, if ever, clear the
virus.
In a Japanese study reported in 2003, an HCV clearance rate of 3.7% was
described in patients with chronic infection. The present findings,
which appear in Clinical Infectious Diseases for April 1, suggest that
the rate may be higher still.
The study involved 139 Alaskan natives who had tested positive for HCV
RNA on three separate occasions and were followed on a regular basis for
a mean period of 7 years.
Eleven of the patients (8%) had at least one test with undetectable HCV
RNA during follow-up. Seven of these patients were considered to have
probable or possible HCV clearance, yielding an annual clearance rate of
0.74% per person year.
Follow-up testing of nine of the seronegative patients identified five
that still appeared to be virus-free, the report indicates. A low HCV
RNA titer predicted spontaneous nondetectability of HCV RNA. In a
related editorial, Dr. Georg M. Lauer and Dr. Arthur Y. Kim, from
Harvard Medical School in Boston, point out that "more studies are
needed before we can feel confident about the incidence of spontaneous
viral clearance in chronic HCV infection or before we start
investigating the genetic disposition of Alaska Natives and its
relevance to viral control."
"Meanwhile, clinicians should stay alert to this rare outcome of HCV
infection, and further investigations of this phenomenon should be
strongly encouraged," the editorialists add. Clin Infect Dis
2006;42:945-954.
http://www.medscape.com/viewarticle/530299 Thomas
--
It's probably due to the whale blubber the Eskimos are so fond of
eating. :-)
elmo
http://community.webtv.net/elmoemerson/DocElmosHepFile
http://community.webtv.net/elmoemerson/TheFamilyAlbum

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

Russ Tanner - 25 Apr 2006 04:33 GMT
ah the les paul,,, I don't play it much.. I'm way into the banjo, hot licks
man!!! Fingers smoking! I love it.....

Yea love those BBQ,s. Your high on my visit list buddy.. Cya next winter!

Signature

Russ

http://www.tannersacre.com

> Nothing like greasy farts just before dinner unless it's greasy farts
> after dinner. (sounds really romantic, don't it
[quoted text clipped - 11 lines]
> of fish heads till they are nice and "soft", yum, yum..... Call me
> around dinner time I'll tell ya some more tasty recipes..... LOL.....
elmoemerson@webtv.net - 25 Apr 2006 13:20 GMT
I'll keep the smoker warmed up for ya, Russ!
elmo
////////////
ah the les paul,,, I don't play it much.. I'm way into the banjo, hot
licks man!!! Fingers smoking! I love it.....
Yea love those BBQ,s. Your high on my visit list buddy.. Cya next
winter!
Signature

Russ
http://www.tannersacre.com
<elmoemerson@webtv.net> wrote in message
news:6366-444C4AE5-849@storefull-3252.bay.webtv.net...
Nothing like greasy farts just before dinner unless it's greasy farts
after dinner. (sounds really romantic, don't it
Dort.......aahahahhahahahaha) sh.t, Russ!! You're going to have to get
down here for some real Ozarks hospitality......fantastic bbq and
jammin' blues music. I got me a real smokin' machine and there's plenty
of good music. Don't forget to bring 'Suzie Q', I aint seen her since I
sent her to you UPS. :-)
A friend of mine is 'procuring' me a gallon of the real McCoy Arkansas
moonshine next week. With a little luck, I'll go blind from it. :-0 elmo
/////////////
f.cker, you took the words out of my mouth!!!!! ;) I'll bet it's the
stinky fish heads they eat... you know, bury a bunch of fish heads till
they are nice and "soft", yum, yum..... Call me around dinner time I'll
tell ya some more tasty recipes..... LOL.....
--
Russ
Visit Alaska @ http://www.tannersacre.com <elmoemerson@webtv.net> wrote
in message news:20809-44481990-358@storefull-3251.bay.webtv.net... NEWS:
Spontaneous HCV Clearance More Common Than Previously Thought Group:
alt.support.hepatitis-c Date: Thu, Apr 20, 2006, 6:37pm (CDT+1) From:
tomw@capecod.com (Thomas Wagner) Spontaneous HCV Clearance More Common
Than Previously Thought NEW YORK (Reuters Health) Apr 19 - Spontaneous
clearance of hepatitis C virus (HCV) after chronic infection is thought
to be a rare event, but new research suggests that clearance rates as
high as 8% may occur. Roughly 15% to 30% of people who become infected
with HCV will clear the virus during the acute phase. Until recently, it
was believed that the remaining patients with chronic infection seldom,
if ever, clear the virus.
In a Japanese study reported in 2003, an HCV clearance rate of 3.7% was
described in patients with chronic infection. The present findings,
which appear in Clinical Infectious Diseases for April 1, suggest that
the rate may be higher still.
The study involved 139 Alaskan natives who had tested positive for HCV
RNA on three separate occasions and were followed on a regular basis for
a mean period of 7 years.
Eleven of the patients (8%) had at least one test with undetectable HCV
RNA during follow-up. Seven of these patients were considered to have
probable or possible HCV clearance, yielding an annual clearance rate of
0.74% per person year.
Follow-up testing of nine of the seronegative patients identified five
that still appeared to be virus-free, the report indicates. A low HCV
RNA titer predicted spontaneous nondetectability of HCV RNA. In a
related editorial, Dr. Georg M. Lauer and Dr. Arthur Y. Kim, from
Harvard Medical School in Boston, point out that "more studies are
needed before we can feel confident about the incidence of spontaneous
viral clearance in chronic HCV infection or before we start
investigating the genetic disposition of Alaska Natives and its
relevance to viral control."
"Meanwhile, clinicians should stay alert to this rare outcome of HCV
infection, and further investigations of this phenomenon should be
strongly encouraged," the editorialists add. Clin Infect Dis
2006;42:945-954.
http://www.medscape.com/viewarticle/530299 Thomas
--
It's probably due to the whale blubber the Eskimos are so fond of
eating. :-)
elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

 
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