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Medical Forum / Diseases and Disorders / Hepatitis / March 2006valopicitabine trial lowering dosage due to side effects
http://www.businessweek.com/ap/financialnews/D8GHI5VG7.htm?campaign_id=apn_home_ down&chan=db I believe Valopicitabine to be the furhest advanced among the various drugs having clinical trials.However, due to the side effects and lower dosages it appears it will only be a modest improvement over existing treatment. It may be the first to hit the market but VX-950, the Schering-Plough PROTEASE INHIBITOR, or AVI-4065 (just entering phase I trials) are probably the future of Hep C treatment. They called me yesterday and lowered me from 800 to 400 mg. According to the info I got, short term effects were better at 800 mg but post 8 - 12 weeks 200 mg achieved similar results to 800 mg. The major side at 800 mg was the nausea which is what they are hoping to improve with the lower dose. I have never taken Ribavirin but from what I have read, the sides are much worse. Don't think valopicitabine has caused the anemia related problems that are associated with Ribavirin. If they can get the dose correct and it still be effective, I think it will be another good tool in the arsenal to slay the dragon. They dropped anyone with a viral load above 600, which was about 20 people. I was just under the wire with a viral load of 451. I am glad to still be in the trial, and I am glad they are lowering the dosage. Here is a link to a 1 hour conference call web cast addressing the details if you are interested. http://ir.idenix.com/phoenix.zhtml?c=131556&p=irol-news >http://www.businessweek.com/ap/financialnews/D8GHI5VG7.htm?campaign_id=apn_home_ down&chan=db > [quoted text clipped - 4 lines] >Schering-Plough PROTEASE INHIBITOR, or AVI-4065 (just entering phase I >trials) are probably the future of Hep C treatment. They dropped 20 out of how many? elmo //////// They called me yesterday and lowered me from 800 to 400 mg. According to the info I got, short term effects were better at 800 mg but post 8 - 12 weeks 200 mg achieved similar results to 800 mg. The major side at 800 mg was the nausea which is what they are hoping to improve with the lower dose. I have never taken Ribavirin but from what I have read, the sides are much worse. Don't think valopicitabine has caused the anemia related problems that are associated with Ribavirin. If they can get the dose correct and it still be effective, I think it will be another good tool in the arsenal to slay the dragon. They dropped anyone with a viral load above 600, which was about 20 people. I was just under the wire with a viral load of 451. I am glad to still be in the trial, and I am glad they are lowering the dosage. Here is a link to a 1 hour conference call web cast addressing the details if you are interested. http://ir.idenix.com/phoenix.zhtml?c=131556&p=irol-news On 24 Mar 2006 21:10:42 -0800, "anonymousone" <tedw2@earthlink.net> wrote: http://www.businessweek.com/ap/financialnews/D8GHI5VG7.htm?campaign_id=apn_home_ down&chan=db I believe c to be the furhest advanced among the various drugs having clinical trials.However, due to the side effects and lower dosages it appears it will only be a modest improvement over existing treatment. It may be the first to hit the market but VX-950, the Schering-Plough PROTEASE INHIBITOR, or AVI-4065 (just entering phase I trials) are probably the future of Hep C treatment. http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum 20 out of about 175 Mark >They dropped 20 out of how many? >elmo [quoted text clipped - 28 lines] > >http://community.webtv.net/elmoemerson/TheFamilyAlbum That's not shabby, Mark! Hope the results are just as good down the road. Where can I buy stock? hehe elmo /////// 20 out of about 175 Mark They dropped 20 out of how many? elmo //////// They called me yesterday and lowered me from 800 to 400 mg. According to the info I got, short term effects were better at 800 mg but post 8 - 12 weeks 200 mg achieved similar results to 800 mg. The major side at 800 mg was the nausea which is what they are hoping to improve with the lower dose. I have never taken Ribavirin but from what I have read, the sides are much worse. Don't think valopicitabine has caused the anemia related problems that are associated with Ribavirin. If they can get the dose correct and it still be effective, I think it will be another good tool in the arsenal to slay the dragon. They dropped anyone with a viral load above 600, which was about 20 people. I was just under the wire with a viral load of 451. I am glad to still be in the trial, and I am glad they are lowering the dosage. Here is a link to a 1 hour conference call web cast addressing the details if you are interested. http://ir.idenix.com/phoenix.zhtml?c=131556&p=irol-news On 24 Mar 2006 21:10:42 -0800, "anonymousone" <tedw2@earthlink.net> wrote: http://www.businessweek.com/ap/financialnews/D8GHI5VG7.htm?campaign_id=apn_home_ down&chan=db I believe c to be the furhest advanced among the various drugs having clinical trials.However, due to the side effects and lower dosages it appears it will only be a modest improvement over existing treatment. It may be the first to hit the market but VX-950, the Schering-Plough PROTEASE INHIBITOR, or AVI-4065 (just entering phase I trials) are probably the future of Hep C treatment. http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum > They called me yesterday and lowered me from 800 to 400 mg. According > to the info I got, short term effects were better at 800 mg but post 8 [quoted text clipped - 23 lines] > >Schering-Plough PROTEASE INHIBITOR, or AVI-4065 (just entering phase I > >trials) are probably the future of Hep C treatment. Thanks. No, Im sure valopicitabine does not have the anemia problems of Ribavirin. Thats why I tried to get in on the trial. I was told the nausea had previously been affecting only smaller people. I wonder why they kicked people off the study who had viral loads above 600. The difference between say 700 or 600 is so insignificant it doesnt seem right. The people barely above the cut off must have been terribly disappointed. It looks like their stock may have overcorrected based on what your saying. > They called me yesterday and lowered me from 800 to 400 mg. According > to the info I got, short term effects were better at 800 mg but post 8 [quoted text clipped - 23 lines] > >Schering-Plough PROTEASE INHIBITOR, or AVI-4065 (just entering phase I > >trials) are probably the future of Hep C treatment. Thanks. No, Im sure valopicitabine does not have the anemia problems of Ribavirin. Thats why I tried to get in on the trial. I was told the nausea had previously been affecting only smaller people. I wonder why they kicked people off the study who had viral loads above 600. The difference between say 700 or 600 is so insignificant it doesnt seem right. The people barely above the cut off must have been terribly disappointed. It looks like their stock may have overcorrected based on what your saying. Just think if you hadnt been on the 800 mg dose to begin with you probably wouldnt have made the cut. Re: valopicitabine trial lowering dosage It looks like their stock may have overcorrected based on what your saying. ////////////////// You might want to consider selling now. Deal? Or no deal? elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum |
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