This is interesting.   kj

NIH Clinical Research Studies
http://clinicalstudies.info.nih.gov/cgi/detail.cgi?A_05-DK-0207.html
Keywords: Itching Fatigue Liver Disease [...]
Last update: 02/24/2006

Summary: This study will examine the effect of S-adenosyl methionine
(SAMe) on itching and fatigue in patients with primary biliary cirrhosis,
a disease of the small bile ducts in the liver. Ursodiol, the only
currently available treatment for biliary cirrhosis, does not cure the
disease, and many people continue to have symptoms or liver test
abnormalities despite treatment. SAMe is a naturally occurring substance
found in most cells of the body. The highest levels of the substance are
produced by the liver, where it helps to rid the body of toxins and
breakdown products of metabolism. Studies in Europe suggest that SAMe may
help to: 1) decrease the fatigue and itching that are common in persons
with liver problems, and 2) decrease levels of liver enzymes in the blood,
suggesting that it may decrease the amount of liver injury [...] more