Re: Alinia

Group: alt.support.hepatitis-c Date: Sat, Jan 14, 2006, 12:07am (CST+1)
From: coinsinwell1111@webtv.net (Whatsup Doc)
hcv hits rich people also, Cody.
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That's sooo profound of you, Randy.  To what do you attribute your
knowledge and intelligence?

Aw, take it easy on the kid... he is only 12.
Isn't he?

Beaver peeps?  Sorta like the pussy's version of Tom Thumb, eh?
elmo
"Hello in there!  Anybody home?" <echo echo>
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(sorry; top-post)
Thanks, Kojoh and Koko.
Hey, Elmo, d'yah see where the stuff was tested on peeps with Beaver
Fever? Ahahahahahaha!
"kjoh" <kjohyayhoo@nospamyahoo.com> wrote in message
news:4fe10341f903b33c4ad02baec0173488@localhost.talkaboutsupport.com...
Hi Folks, the info below is from the 2005 Physician's Desk Reference
(CD):
ALINIA (nitazoxanide) www.romark.com 
Metabolism:   Following oral administration in humans, nitazoxanide is
rapidly hydrolyzed to an active metabolite, tizoxanide
(desacetyl-nitazoxanide). Tizoxanide then undergoes conjugation,
primarily by glucuronidation. In vitro metabolism studies have
demonstrated that tizoxanide has no significant inhibitory effect on
cytochrome P450 enzymes.
Elimination:   Tizoxanide is excreted in the urine, bile and feces,
and
tizoxanide glucuronide is excreted in urine and bile. Approximately
two-thirds of the oral dose of nitazoxanide is excreted in the feces and
one-third in the urine.
Special Populations
Patients with Impaired Hepatic and/or Renal Function: The
pharmacokinetics of nitazoxanide in patients with impaired hepatic
and/or renal function has
not been studied.
Geriatric Patients:   The pharmacokinetics of nitazoxanide in
geriatric patients has not been studied.
MICROBIOLOGY
Mechanism of action
The antiprotozoal activity of nitazoxanide is believed to be due to
interference with the pyruvate:ferredoxin oxido-reductase (PFOR)
enzyme-dependent electron transfer reaction which is essential to
anaerobic energy metabolism. Studies have shown that the PFOR enzyme
from Giardia lamblia directly reduces nitazoxanide by transfer of
electrons in the absence of ferredoxin. The DNA-derived PFOR protein
sequence of Cryptosporidium parvum appears to be similar to that of
Giardia lamblia . Interference with the PFOR enzyme-dependent electron
transfer reaction may not be the only pathway by which nitazoxanide
exhibits antiprotozoal activity.
PRECAUTIONS
General:   The pharmacokinetics of nitazoxanide in patients with
compromised renal or hepatic function have not been studied. Therefore,
nitazoxanide must be administered with caution to patients with hepatic
and biliary disease, to patients with renal disease and to patients with
combined renal and hepatic disease.
ADVERSE REACTIONS
Alinia Tablets:   In controlled and uncontrolled clinical studies of
1,628 HIV-uninfected patients age 12 years and older who received
various dosage regimens of Alinia Tablets, the most common adverse
events reported regardless of causality assessment were: abdominal pain
(6.7%), diarrhea (4.3%), headache (3.1%) and nausea (3.1%). In
placebo-controlled clinical trials using the recommended dose, the rates
of occurrence of these events did not differ significantly from those of
the placebo. In placebo-controlled trials of HIV-uninfected patients age
12 years and older who received Alinia Tablets for the treatment of
diarrhea caused by Giardia lamblia , approximately 1% of patients
discontinued therapy because of an adverse event.
Adverse events occurring in less than 1% of the patients age 12 years
and older participating in clinical trials of Alinia Tablets are listed
below:
Body as a Whole:   asthenia, fever, pain, allergic reaction, pelvic
pain, chills, chills and fever, flu syndrome.
Nervous System:   dizziness, somnolence, insomnia, tremor,
hypesthesia.
Digestive System:   vomiting, dyspepsia, anorexia, flatulence,
constipation, dry mouth, thirst.
Urogenital System:   discolored urine, dysuria, amenorrhea,
metrorrhagia, kidney pain, edema labia.
Metabolic & Nutrition:   increased SGPT.
Hemic & Lymphatic Systems:   anemia, leukocytosis.
Skin:   rash, pruritus.
Special Senses: eye discoloration, ear ache.
Respiratory System:   epistaxis, lung disease, pharyngitis.
Cardiovascular System:   tachycardia, syncope, hypertension.
Muscular System:   myalgia, leg cramps, spontaneous bone fracture.

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum

Gordo, my insurance covers transplants (I checked) and I should be hearing
from the transplant coordinator in a few days (or so they tell me).  I'd
happily pay for those pills myself if it meant I could avoid it.