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Medical Forum / Diseases and Disorders / Hepatitis / October 2005The First Shot
Hello all. Let me first say you are a great support group here. You guys really stick together. Well, I just took my first shot about an hour ago. Less painful than intramuscular injections so all in all it wasn't that bad. I used to give my mom insulin injections so I had a little experience. So we'll see what happens as far as tolerating this stuff. Right now I feel a little constipated but that's probably from nerves as I was shaking like a leaf. ;} So wish me luck. I'll be back and good luck to you all still going through it and congrats to those who beat it's a.s. >Hello all. Let me first say you are a great support group here. You guys >really stick together. [quoted text clipped - 7 lines] >So wish me luck. I'll be back and good luck to you all still going through it >and congrats to those who beat it's a.s. Hello, Frank, and welcome to the group. If you've been lurking for more than few weeks, you know there's a whole bunch of folks recently gone on to therapy, so you should have plenty of company on your trek. Cheers - and good luck to you. /greyhackles >>Hello all. Let me first say you are a great support group here. You guys >>really stick together. [quoted text clipped - 16 lines] > >/greyhackles Thanks GH. I do have a question that you or others might be able to answer. Does the Interferon injection remain sub-cutaneously throughout the week until its ultimately absorbed or is it all absorbed and has a blood stream time-release aspect to it? Hi Frank, Welcome to C-club. Don't forget to drink your gallon of water a day. Sleep near the bathroom:-) Sue In article <cb1dda6be0f1ee01d5a80011ee19cbd1@localhost.talkaboutsupport.com>, burningdaylight@nospam.com says... >Hi Frank, >Welcome to C-club. >Don't forget to drink your gallon of water a day. >Sleep near the bathroom:-) >Sue Thanks Sue, but I'm afraid my kids might walk over me in the middle of the night. >Don't forget to drink your gallon of water a day. >Sleep near the bathroom:-) Does this mean you are up at odd times from the water intake? Graham >>Don't forget to drink your gallon of water a day. >>Sleep near the bathroom:-) > >Does this mean you are up at odd times from the water intake? > >Graham HECK YEAH that's what it means! >>>Don't forget to drink your gallon of water a day. >>>Sleep near the bathroom:-) [quoted text clipped - 4 lines] > > HECK YEAH that's what it means! LOL! Or keep a bottle in the bedroom ... not to drink, of course ;-) Cody >>>>Don't forget to drink your gallon of water a day. >>>>Sleep near the bathroom:-) [quoted text clipped - 8 lines] > >Cody The therapy version of Russian Roulette? ;-) /greyhackles >>>>Don't forget to drink your gallon of water a day. >>>>Sleep near the bathroom:-) [quoted text clipped - 8 lines] > > Cody Just do both, drink and then refill. Hopefully the riba won't confuse you on which order. Dwight > >>Don't forget to drink your gallon of water a day. > >>Sleep near the bathroom:-) [quoted text clipped - 4 lines] > > HECK YEAH that's what it means! I learned to always keep a clear path to the bathroom and I got a little nightlight so I wouldn't have to remember where the lightswitch was. If I was running for the potty it wasn't to pee!!!!!!!!!!!!!!  SignatureRuss Visit Alaska @ http://www.tannersacre.com > > >>Don't forget to drink your gallon of water a day. > > >>Sleep near the bathroom:-) [quoted text clipped - 7 lines] > I learned to always keep a clear path to the bathroom and I got a little > nightlight so I wouldn't have to remember where the lightswitch was. >>>Hello all. Let me first say you are a great support group here. You guys >>>really stick together. [quoted text clipped - 23 lines] >until its ultimately absorbed or is it all absorbed and has a blood stream >time-release aspect to it? Both. Injecting the IFN into the fat layer slows absorption, while the Pegylated form slows clearance. This flattens the peak and delays the trough, keeping the level of IFN in the body longer, so you don't hit the trough until 6 or even 7 days after a properly administered injection. Most of that is in the Product Information sheet that should accompany your meds. It's worth reading - if you can focus on the damned tiny type ;-) Cheers /greyhackles Ho Frank, Welcome. Good question. First glance at a CDC website glossary implies that it is time- released in the bloodstream rather than from a subcutaneous blob: "Pegylated interferon: ... pegylated interferon remains active in the bloodstream longer and at a more constant level than standard interferon and can be given less often than standard interferon..." Not really a definite answer though. I'll look again. Kathy Week 34/48 Sittin here in Limbo... Waitin for the tide to roll... Here are a couple more random factoids that seems to say pegylation causes the big molecule to persist in the bloodstream, rather than at the injection site. kj The process of PEGylation is used to increase drug circulation time in the bloodstream, to improve drug solubility and stability, and to reduce immunogenicity. The greater polymer size of pegylated IFN alfa-2a acts to reduce glomerular filtration, markedly prolonging its serum half-life (72-96 hours) compared with standard IFN alfa-2a (6-9 hours). Pegylation refers to the attachment of a molecule of polyethylene glycol (PEG) to a large protein such as IFN. The PEG molecule shields IFN from enzymatic degradation and lowers clearance from the body. This enhances the duration that IFN resides in the systemic circulation and may improve its distribution as well as help target IFN to its site of action in the liver. In article <b4bd1fc4dbd714c1cc5db9d11b67718e@localhost.talkaboutsupport.com>, kjohyayhoo@nospamyahoo.com says... >Here are a couple more random factoids that seems to say pegylation causes >the big molecule to persist in the bloodstream, rather than at the [quoted text clipped - 14 lines] >its distribution as well as help target IFN to its site of action in the >liver. Kath. I read your first response and thanks. This one explains it much better. I have a BS in Bio-Med which will make Hell a little more tolerable and more importantly, understandable. Hey that's great Frank, we could use a BS in Biomed here. My PhD in forestry isn't entirely useful to me at this point in time... :) kj Welcome to the group! Don't worry about your constipation too much, it'll turn to diarrhea soon enough. LOL. elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum amen....... SignatureRuss Visit Alaska @ http://www.tannersacre.com > Welcome to the group! Don't worry about your constipation too much, > it'll turn to diarrhea soon enough. LOL. [quoted text clipped - 3 lines] > > http://community.webtv.net/elmoemerson/TheFamilyAlbum I wish you all the luck in the world Frank. We seem to have quite a few newbies starting up and lots of experienced shooters in here. Mags week 3 - 45 to go > Hello all. Let me first say you are a great support group here. You guys > really stick together. [quoted text clipped - 11 lines] > through it > and congrats to those who beat it's a.s. I tried this Torecan injection and my doctor told me that thi medication is injected into a muscle (intramuscular) as prescribed. D not use this more often or increase your dose without consulting you doctor. Your condition will not improve any faster but the risk of sid effects will be increased -- rand |
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