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Medical Forum / Diseases and Disorders / Hepatitis / September 2005Sucess rate by Genotype
My Doctor told me that, at best, the cure rate was 40% for hepatitis. However,based on what I am reading that may be misleading. Does anybody know what the success rate of SVR is by Genotype? I know for genotype 1a/1b the rate is < 50%, for the other geno's the rate is much better >I know for genotype 1a/1b the rate is < 50%, for the other geno's the > rate is much better Genotype 1 and 4 have a success rate well over 60%. Genos 2 & 3 are over 80%. Waterspider > My Doctor told me that, at best, the cure rate was 40% for hepatitis. Your doctor is misinformed; at best he's quoting stats from outdated treatments. Waterspider http://www.hivandhepatitis.com/hep_c/hepc_bas.html#man2 According to my source up to 50% SVR for Genotype 1 and up to 80% for Genotype 2 or 3 > My Doctor told me that, at best, the cure rate was 40% for hepatitis. > However,based on what I am reading that may be misleading. > > Does anybody know what the success rate of SVR is by Genotype? > My Doctor told me that, at best, the cure rate was 40% for hepatitis. > However,based on what I am reading that may be misleading. > > Does anybody know what the success rate of SVR is by Genotype? Hi "anonymousone", I used Schering-Plough PegIntron and Rebetol. I found a detailed PegIntron information paper on the Internet that carries the success rates by groups of genotypes. You can reach it at: http://www.spfiles.com/pipeg-intron.pdf Roche Pegasys probably has something similar that can be accessed through their web site. Probably that information does not reflect the reality as it is released by the company that owns the drugs, but it isn't so far from it. Anyway I found useful reading the documents of the Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). You can find a lot of links through Google, but here's the one I used last year: http://www.hcvadvocate.org/news/reports/AASLD_2004/Posters_AASLD_2004.htm Now, given all the above it's _just_ _my_ _understanding_ that SVR rates by genotype could be: genotype 1: ~50-60%; genotype 4: ~55-65%; genotype 2 or 3: ~75-85%; Hope this helps. Cheers, jeeb. These numbers are general. In truth it depends on a host of factors. If you are Geno 1, have had the virus for 20-30 years, you have a very high viral load, you are male and you are over 50 the chances of clearence are very low. Drug companys always stack the numbers in the favor. Ron > These numbers are general. [...] True, your comment is correct and I did mean to say that the above numbers are general. Cheers, jeeb. >These numbers are general. In truth it depends on a host of factors. >If you are Geno 1, have had the virus for 20-30 years, you have a very >high viral load, you are male and you are over 50 the chances of >clearence are very low. Drug companys always stack the numbers in the >favor. Quantify "very low"? I had geno 1, had the virus for 30 years, and was 49 at treatment, but still cleared in less than 48 weeks. You're generalizing as well. Thomas  SignatureTo reach me, complete my last name in the address. good for you Mr. Wagner. Some clear hcv some dont. step right up folks. take a chance. (perhaps the chance of a lifetime?) Randy > good for you Mr. Wagner. Some clear hcv some dont. step right up folks. > take a chance. (perhaps the chance of a lifetime?) Randy Yes, it is the chance of a lifetime. Some get run over by busses, and some die a horrible death of liver failure. Step right up, folks, the choice (and the chance) is all yours. Waterspider > These numbers are general. In truth it depends on a host of factors. > If you are Geno 1, have had the virus for 20-30 years, you have a very [quoted text clipped - 3 lines] > > Ron Lets say you are over 50, Geno 1, and had the virus 30+ years, then how low are your chances of clearance? All I can do is share my experiences,Genotype 1, viral load of 700,000, 54 years old, and have been infected for about 32 years.After 12 weeks of TX, the virus was undetectable. At the end of TX it was still undetectable. I am truly hoping that it stays that way six months after treatment. I finished at the end of this last June, so there may be a present for me under the tree this Xmas. My SVR. That's all I want for Christmas. John > These numbers are general. In truth it depends on a host of factors. > If you are Geno 1, have had the virus for 20-30 years, you have a very [quoted text clipped - 3 lines] > > Ron >My Doctor told me that, at best, the cure rate was 40% for hepatitis. >However,based on what I am reading that may be misleading. Well... I'm not sure what your doc really meant by "at best", but 40% would be baloney for an "at best" number. "At best" for geno 1 is 60%+, general is around 50%. If your doc didn't really mean general numbers but numbers specific to your situation, he may be right depending on your age and status. But if he meant it in general, then it may be time to look for a better educated doc, as this one wouldn't be up to date and might not give you the best available treatment. Thomas SignatureTo reach me, complete my last name in the address. I would bet your viral load was under 10 million. You know as well as I do that the higher the viral load the less likely of clearing. How can you group everyone in to your 50% group when in reality some people have less than a 20% chance. This isn't rocket sicence just common since. Ron >I would bet your viral load was under 10 million. You know as well as I >do that the higher the viral load the less likely of clearing. How can >you group everyone in to your 50% group when in reality some people >have less than a 20% chance. Hmmm? When one asks "what are the odds", that's generally expected to cover *everyone* that initiates treatment, regardless of VL going in. Otherwise, whatever number was given in response wouldn't be "the odds" at all, eh? >This isn't rocket sicence just common since. Indeed. Cheers /greyhackles Re: Sucess rate by Genotype Group: alt.support.hepatitis-c Date: Tue, Sep 27, 2005, 12:06pm (CDT-2) From: smith21347@hotmail.com (smith21347@msn.com) I would bet your viral load was under 10 million. You know as well as I do that the higher the viral load the less likely of clearing. How can you group everyone in to your 50% group when in reality some people have less than a 20% chance. This isn't rocket sicence just common since. Ron ///////////// High viral load isn't so much of a factor if you've got a doctor that knows they've got to get it as low as possible very early on in tx. Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum Thomas, I believe you when you say 60% plus for genotype 1 but in my 5 years fighting hep C I have never ever read that. Could you share your source? I would like to know what the parameters of the study were. Age, drugs used, duration ect. Thanks buster >>My Doctor told me that, at best, the cure rate was 40% for hepatitis. >>However,based on what I am reading that may be misleading. [quoted text clipped - 8 lines] > > Thomas Thomas excuse me, Duh, I have Riba brain ouster! Your saying "Best" I was thinking "Mean" or average. buster > Thomas, I believe you when you say 60% plus for genotype 1 but in my 5 > years fighting hep C I have never ever read that. Could you share your [quoted text clipped - 13 lines] >> >> Thomas This is good stuff. A great exchange. I get so tired of all the BS posted by some members. Ron Re: Sucess rate by Genotype Group: alt.support.hepatitis-c Date: Tue, Sep 27, 2005, 6:24pm (CDT-2) From: smith21347@hotmail.com (smith21347@msn.com) This is good stuff. A great exchange. I get so tired of all the BS posted by some members. Ron ////////// You don't have to read all the BS posted by other members, Ron. Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum > Thomas, I believe you when you say 60% plus for genotype 1 but in my 5 > years fighting hep C I have never ever read that. Could you share your > source? I would like to know what the parameters of the study were. Age, > drugs used, duration ect. Thanks buster The stats are general; in clinical trials there was no consideration for factors other than genotype and the fact that the subjects had not tried previous treatments (thus, some subjects with all the lucky breaks would likely have a higher svr rate and the unlucky ones would have lower). These figures are not hidden, they are well publicized. Do some research. Waterspider I have done my research volumes of it and 104 weeks of treatment with 22 more weeks ahead, I still have not read what your stating but sure would like too. I referenced my source I was just hoping someone would show me their source. I do understand if you take a room full of stage 1 folks with less than 5 years expose to the virus you would end of with good SVR percentages. (But in general well over 60 %????????????) Show me I'm from Missouri. I just don't take everything someone says as gospel such as, "What are you smoking? Interferon does NOT cure diabetes". buster >> Thomas, I believe you when you say 60% plus for genotype 1 but in my 5 >> years fighting hep C I have never ever read that. Could you share your [quoted text clipped - 8 lines] > > Waterspider >I have done my research volumes of it and 104 weeks of treatment with 22 >more weeks ahead, I still have not read what your stating but sure would [quoted text clipped - 3 lines] >percentages. (But in general well over 60 %????????????) Show me I'm from >Missouri. Can you Google in Missouri? > I just don't take everything someone says as gospel such as, "What are you > smoking? Interferon does NOT cure diabetes". buster Good boy. Now your next step is to look at everything that's posted in the thread, i.e. the one where I was corrected and acknowledged that I was wrong. On the other hand, you could read the entire thread to realize that the topic was not diabetes but hep c-induced diabetes. Research. Waterspider Your quote, "Genotype 1 and 4 have a success rate well over 60%. Genos 2 & 3 are over 80%. Waterspider I just ask you for your source and twice you tell me to go look it up. I have tried to look it up and since you wont reveal your source, I assume your packing my a.s full of sand. buster >>I have done my research volumes of it and 104 weeks of treatment with 22 >>more weeks ahead, I still have not read what your stating but sure would [quoted text clipped - 17 lines] > > Waterspider > Your quote, "Genotype 1 and 4 have a success rate well over 60%. Genos 2 & > 3 are over [quoted text clipped - 3 lines] > have tried to look it up and since you wont reveal your source, I assume > your packing my a.s full of sand. buster I sure wish you'd assume less and do more of your own research, but in the meantime... Note that these study results were for the use of Pegasys and Copegus (peg-interferon and ribavirin) to compare Pegasys and Pegetron (Schering's vs Roche's brand of combo) ... Sustained virological response = (SVR) rates: . Overall SVR was 63%, which is the highest response rate ever reported in a hepatitis C treatment clinical trial. . Genotype 1 = 52% SVR. . Genotype 1, high viral load = 47% SVR. . Genotype 1, low viral load = 65% SVR. . Genotypes 2 and 3 = 84% SVR. . Genotypes 2 and 3, high viral load = 82% SVR. . Genotypes 2 and 3, low viral load = 88% SVR. This is from the Janis & Friends hep c website but you can (yes, you *really* can, but it will take you a little bit of time Googling) find it on other sites of more acceptible medical repute. >>>I have done my research volumes of it and 104 weeks of treatment with 22 >>>more weeks ahead, I still have not read what your stating but sure would [quoted text clipped - 17 lines] >> >> Waterspider Hey waterspider, Tks very much for the info, and your no sand packer! If you could see my red face! I do want you to know I'm sorry and again thanks for sharing. I know we will never meet but if we would you can whip the tar out of me and I would deserve it all. buster >> Your quote, "Genotype 1 and 4 have a success rate well over 60%. Genos 2 >> & 3 are over [quoted text clipped - 46 lines] >>> >>> Waterspider > Hey waterspider, Tks very much for the info, and your no sand packer! If > you could see my red face! I do want you to know I'm sorry and again > thanks for sharing. I know we will never meet but if we would you can whip > the tar out of me and I would deserve it all. buster LOL! Thanks, Buster, no harm done. I guess one should be prepared to dig out the info if they're going to post it here, so I accept half the blame too. All the best to you, Waterspider Re: Sucess rate by Genotype Group: alt.support.hepatitis-c Date: Wed, Sep 28, 2005, 5:55pm (CDT+5) From: waterspider@moonshine.net (Waterspider) "buster" <askme@cox.net> wrote in message news:Fvn_e.7377$P34.3151@okepread07... I have done my research volumes of it and 104 weeks of treatment with 22 more weeks ahead, I still have not read what your stating but sure would like too. I referenced my source I was just hoping someone would show me their source. I do understand if you take a room full of stage 1 folks with less than 5 years expose to the virus you would end of with good SVR percentages. (But in general well over 60 %????????????) Show me I'm from Missouri. Can you Google in Missouri? I just don't take everything someone says as gospel such as, "What are you smoking? Interferon does NOT cure diabetes". buster Good boy. Now your next step is to look at everything that's posted in the thread, i.e. the one where I was corrected and acknowledged that I was wrong. On the other hand, you could read the entire thread to realize that the topic was not diabetes but hep c-induced diabetes. Research. Waterspider //////////// C'mon, Spidey. Give Buster a break. He's from Missouri. We can't google here. ahahahahaha Where in Missouri are you at, Buster? Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum Wow, spidey put me in my place and taught me a good lesson, keep my mouth shut! She came thru and so far she has not rubbed my nose in it and I know I deserve it. Actually Im in Wichita about 4 hours from table rock, springfield, branson ect. been working here for Cessna for the last 31 years! Going to retire at 55 in about 2 1/2 years and smell the roses. Your from SW Missouri? Branson would be a great place for a Hep feast. buster Re: Sucess rate by Genotype Group: alt.support.hepatitis-c Date: Wed, Sep 28, 2005, 5:55pm (CDT+5) From: waterspider@moonshine.net (Waterspider) I have done my research volumes of it and 104 weeks of treatment with 22 more weeks ahead, I still have not read what your stating but sure would like too. I referenced my source I was just hoping someone would show me their source. I do understand if you take a room full of stage 1 folks with less than 5 years expose to the virus you would end of with good SVR percentages. (But in general well over 60 %????????????) Show me I'm from Missouri. Can you Google in Missouri? I just don't take everything someone says as gospel such as, "What are you smoking? Interferon does NOT cure diabetes". buster Good boy. Now your next step is to look at everything that's posted in the thread, i.e. the one where I was corrected and acknowledged that I was wrong. On the other hand, you could read the entire thread to realize that the topic was not diabetes but hep c-induced diabetes. Research. Waterspider //////////// C'mon, Spidey. Give Buster a break. He's from Missouri. We can't google here. ahahahahaha Where in Missouri are you at, Buster? Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum Yep, I'm in SW Missouri. Actually, Branson sucks. ahahahahahah It's a senior citizen hangout. Seriously, you can't go to a show in Branson without a dozen buses loaded with seniors parked out front. A hepfeast is definitely in order, tho. Elmo //////// Wow, spidey put me in my place and taught me a good lesson, keep my mouth shut! She came thru and so far she has not rubbed my nose in it and I know I deserve it. Actually Im in Wichita about 4 hours from table rock, springfield, branson ect. been working here for Cessna for the last 31 years! Going to retire at 55 in about 2 1/2 years and smell the roses. Your from SW Missouri? Branson would be a great place for a Hep feast. buster <elmoemerson@webtv.net> wrote in message news:5229-433BE0A1-223@storefull-3257.bay.webtv.net... Re: Sucess rate by Genotype Group: alt.support.hepatitis-c Date: Wed, Sep 28, 2005, 5:55pm (CDT+5) From: waterspider@moonshine.net (Waterspider) "buster" <askme@cox.net> wrote in message news:Fvn_e.7377$P34.3151@okepread07... I have done my research volumes of it and 104 weeks of treatment with 22 more weeks ahead, I still have not read what your stating but sure would like too. I referenced my source I was just hoping someone would show me their source. I do understand if you take a room full of stage 1 folks with less than 5 years expose to the virus you would end of with good SVR percentages. (But in general well over 60 %????????????) Show me I'm from Missouri. Can you Google in Missouri? I just don't take everything someone says as gospel such as, "What are you smoking? Interferon does NOT cure diabetes". buster Good boy. Now your next step is to look at everything that's posted in the thread, i.e. the one where I was corrected and acknowledged that I was wrong. On the other hand, you could read the entire thread to realize that the topic was not diabetes but hep c-induced diabetes. Research. Waterspider //////////// C'mon, Spidey. Give Buster a break. He's from Missouri. We can't google here. ahahahahaha Where in Missouri are you at, Buster? Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum |
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