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Medical Forum / Diseases and Disorders / Hepatitis / September 2005

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Has anyone heard of this before?

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hepmeplz - 21 Sep 2005 05:21 GMT
Hi All, I just went to my Dr. today to get my results from the battery
of blood tests they did- genotype, VL, etc..- and my G.I. told me that
I did have  hep c antibodies and was exposed to the virus, however my
immune system somehow fought it off and there were no detectable virus
in my blood. Is that possible? Would I be stupid to believe that and
not have my blood tested again by another Dr.? It really made my head
spin and it's hard for me to believe. I mean its definitely good news,
but I just want to be absolutely sure it's true. Have a beautiful day
all.
twice_redeemed@yahoo.com - 21 Sep 2005 05:51 GMT
Yes, it can happen. You probably just have an awesome immune system. My
nextdoor neighbor has the same story. She tested positive, but has
cleared herself of all virus
hepmeplz - 21 Sep 2005 06:21 GMT
It still makes me suspicious. Thank you for replying to my post. I read
some of your other posts previously and want to let you know that the
one you posted on the hard drugs group was great. I grew up in San
Diego (P.B.) and started my drug career there, I am coming up on three
years clean thanks to the fellowship of N.A. in Santa Barbara. I just
wanted to give you some positive feedback not only on your post, but
for taking interest in my situation. So thank you, I hope that my Dr.
is correct. Take good care, Dale.
captain - 21 Sep 2005 11:06 GMT
Hi Dale,
It happens and you are one of the few happy cured.
Important is how is your lever now. If the lft's are
OK, than you can celebrate even with alcohol (if lowed for
you after the drugs cleaning).
Wish you success and good health!
Captain Backo
> It still makes me suspicious. Thank you for replying to my post. I read
> some of your other posts previously and want to let you know that the
[quoted text clipped - 4 lines]
> for taking interest in my situation. So thank you, I hope that my Dr.
> is correct. Take good care, Dale.
twice_redeemed@yahoo.com - 21 Sep 2005 20:23 GMT
Thanks. I was in San Diego in the navy, and got off drugs in '78 at
Navy Drug Rehab at Miramar NAS. Went to PB many times, especially to
the mexican restaurant on Garnet. Great town.
Paul - 21 Sep 2005 09:56 GMT
On 20 Sep 2005 21:21:50 -0700, "hepmeplz" <pbv1488@hotmail.com>, in
message ID <1127276510.755069.129280@z14g2000cwz.googlegroups.com>, in
the newsgroup alt.support.hepatitis-c wrote:

>Hi All, I just went to my Dr. today to get my results from the battery
>of blood tests they did- genotype, VL, etc..- and my G.I. told me that
[quoted text clipped - 5 lines]
>but I just want to be absolutely sure it's true. Have a beautiful day
>all.

Apparently, it happens like this about 20% of the time so it's not
exactly a rare event.  Just be grateful I suppose.  Maybe get it
checked again sometime if you feel nervous about it.  I personally
know a few people who have never been on interferon yet they have
antibodies but no detectable virus.
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Paul

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Gordo Mondragon - 21 Sep 2005 11:42 GMT
> Hi All, I just went to my Dr. today to get my results from the battery
> of blood tests they did- genotype, VL, etc..- and my G.I. told me that
> I did have  hep c antibodies and was exposed to the virus, however my
> immune system somehow fought it off and there were no detectable virus
> in my blood. Is that possible?

It's very possible.

The number 20% is sometimes used but there could be even more, people
who don't show symptoms and then clear on their own.

It also seems to make a difference it got into you, and how strong an
initial reaction you have.

> Would I be stupid to believe that and
> not have my blood tested again by another Dr.? It really made my head
> spin and it's hard for me to believe. I mean its definitely good news,
> but I just want to be absolutely sure it's true. Have a beautiful day
> all.

I'd have the test redone by another lab just to be sure.

G
greyhackles - 21 Sep 2005 14:55 GMT
>Hi All, I just went to my Dr. today to get my results from the battery
>of blood tests they did- genotype, VL, etc..- and my G.I. told me that
[quoted text clipped - 5 lines]
>but I just want to be absolutely sure it's true. Have a beautiful day
>all.

Spontaneous clearance is the outcome for roughly 20% of all HCV acute-stage
infections, so sure, it's possible you're showing antibodies but no active
virus.

Chalk it up to genetic luck - both the genetics of the virus strain you were
exposed to, and the genetics of your immune system that refused to allow the
virus to thrive....

Cheers

/greyhackles
ps: This would be a fine day to buy a handful of Lottery tickets :-)
Russ - 21 Sep 2005 17:07 GMT
In fact, Kiaks brother did the same thing, has the antibodies and no VL, I
forgot about that.

Signature

Russ

Visit Alaska @ http://www.tannersacre.com

> Hi All, I just went to my Dr. today to get my results from the battery
> of blood tests they did- genotype, VL, etc..- and my G.I. told me that
[quoted text clipped - 5 lines]
> but I just want to be absolutely sure it's true. Have a beautiful day
> all.
JV - 21 Sep 2005 17:34 GMT
Your a lucky guy. I know 3, anibodies and NO VL. Some just shuck it off
like you :›)
in 6 months get retested just to be on the safe side and  one more test
now to be sure your clear.            Juanita
Russ - 22 Sep 2005 23:56 GMT
Juanita, I did not clear the virus, my 6 month post tx PCR was 4
million...... About 3 1/2 months after finishing treatment, and I felt great
then, I started to feel "flu" like and not well. It was like having an acute
response to "getting it all over again". For about 2 months I felt crappy,
but I haven't had any of those symptoms for quite a while now. Just had a
PCR done last week and see what that says like it really matters. If you got
it, you got it.......

I'll wait a while and redo the treatment, but not for a year or two. Right
now I feel pretty good and energy is fine. Working my butt off and keeping
up with the kids on the crew half my age.

Yesterday, one of the laborers had to go home because he was "sick" and
didn't feel well with 3 hours left on the shift. I thought, "what a pussy,
he don't know what sick is!!" I wouldn't leave a job unless I was hurling
all over the place, and sometimes I would go anyway... I think he was hung
over.

Signature

Russ

Visit Alaska @ http://www.tannersacre.com

Your a lucky guy. I know 3, anibodies and NO VL. Some just shuck it off
like you :>)
in 6 months get retested just to be on the safe side and  one more test
now to be sure your clear.            Juanita
JV - 23 Sep 2005 01:39 GMT
Hi Russ
I know your a relapser. I got antibodies and labs today. I have very low
abs. all under range, but I do have them. I'm having fun adjusting to
steroids for my adrenal insuffiency. Its been a hell of a week but on my
second week now. I think I am better. I have been refereed to a Endo to
figure out my chemical imbalances. In the last week my free t4 took a 20
point drop now it is 10 points above cut off and I do feel kinda hypo.
My FreeT3 is holding, but looks like I am going to be changing to
synthroid or at least adding it to the mix. Since armour isn't doing a
whole lot and i am already taking 1gram seems like Armour for most
raises T3 but leaves T4 behind.  Glad you feeling better.
Juanita.
Russ - 24 Sep 2005 00:20 GMT
My brother is taking about 25mg of synthroid and armour, he says he is doing
pretty good.

Signature

Russ

Visit Alaska @ http://www.tannersacre.com

> Hi Russ
> I know your a relapser. I got antibodies and labs today. I have very low
[quoted text clipped - 8 lines]
> raises T3 but leaves T4 behind.  Glad you feeling better.
> Juanita.
Russ - 21 Sep 2005 17:07 GMT
I know a guy, him and his brother both have the antibodies and no viral
load, but his 3rd brother has the virus. I have read anywhere from 15-20% of
people infected with HCV have killed it on their own.

Signature

Russ

Visit Alaska @ http://www.tannersacre.com

> Hi All, I just went to my Dr. today to get my results from the battery
> of blood tests they did- genotype, VL, etc..- and my G.I. told me that
[quoted text clipped - 5 lines]
> but I just want to be absolutely sure it's true. Have a beautiful day
> all.
Waterspider - 23 Sep 2005 20:18 GMT
> Hi All, I just went to my Dr. today to get my results from the battery
> of blood tests they did- genotype, VL, etc..- and my G.I. told me that
[quoted text clipped - 5 lines]
> but I just want to be absolutely sure it's true. Have a beautiful day
> all.

Of those exposed to HCV, the immune system of 15% will destroy the virus
within six months. Antibodies remain for life.

Waterspider
hepmeplz - 24 Sep 2005 02:06 GMT
It seems to me that if 15% of the population who are infected do clear
the virus, isn't it a possibility that of those 15% there could be a
cure, or a vaccine hiding in the genes? I would gladly volunteer my
time ( what little I do have) & blood to science in an effort to help
find such a breakthrough. I know it's not that easy, but there has to
be an answer.
Shawn - 24 Sep 2005 03:09 GMT
There's no money in curing anyone. But, there's riches beyond the wildest
dreams of avarice to "manage" a disease!

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Shawn
(use the "reply feature on your browser to send a private reply via E-Mail.)

> It seems to me that if 15% of the population who are infected do clear
> the virus, isn't it a possibility that of those 15% there could be a
> cure, or a vaccine hiding in the genes? I would gladly volunteer my
> time ( what little I do have) & blood to science in an effort to help
> find such a breakthrough. I know it's not that easy, but there has to
> be an answer.
hepmeplz - 24 Sep 2005 06:36 GMT
Thomas Wagner - 24 Sep 2005 17:53 GMT
>There's no money in curing anyone. But, there's riches beyond the wildest
>dreams of avarice to "manage" a disease!

What nonsense. Lots of companies are trying to achieve just that, a
cure, and the first one through the gates is going to cash in
handsomely. Not everything you read on conspiracy websites is true...

For what's in the pipeline:
http://www.hcvadvocate.org/hepatitis/hepC/HCVDrugs.html

Thomas
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Shawn - 26 Sep 2005 08:10 GMT
Thomas, I didn't mention anything about conspiracies or websites.
Signature

Shawn
(use the "reply feature on your browser to send a private reply via E-Mail.)

>>There's no money in curing anyone. But, there's riches beyond the wildest
>>dreams of avarice to "manage" a disease!
[quoted text clipped - 7 lines]
>
> Thomas
Thomas Wagner - 26 Sep 2005 18:07 GMT
>Thomas, I didn't mention anything about conspiracies or websites.

Sorry, should have put a smiley at the end - that was a tongue-in-cheek
remark. It's just that so much crap is written and said (including the
mass media) about the big bad drug companies and how everybody in
"traditional" medicine is just in it for the money (yeah right, with
80-hour work-weeks) that I sometimes react badly to yet another
stereotype. With over 20 companies doing research for a HCV cure, it's a
bit absurd to claim that there's no money in a cure. Those companies
wouldn't be doing the research if there wasn't a lot of money in it.

Thomas
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ghibelno - 27 Sep 2005 13:50 GMT
<quote>

Hi All, I just went to my Dr. today to get my results [...]

</quote>

Hi hepmeplz,

 I was diagnosed with HepC in 1997 and I probably was in the acute
phase, then, as I think I know how I got it and I am quite sure about
the  circumstances.
Anyway, I had anti-HCV antibodies and slightly elevated LFTs at the
time.
Doctors decided to wait for just few weeks or months, I don't remember
well, and then try and look for viral load.
Results were negative, meaning that it seemed that I was exposed to the
virus but I had no detectable HCV-RNA in my bloodstream.
I had LFTs and PCR determinations redone several times, even after the
acute phase period (6 months) expired, and they always came back
undetectable.
Just _once_ labs showed elevated LFTs again, but the PCR still remained
undetectable.
That fact made the doctors think that I probably had the virus cleared
by myself and that I didn't need any treatment.
Years went by, and I kept checking LFTs every one year or so, always
good.
I even had the joy to have a son in 2003.
Then, in 2004 I checked for LFTs as usual, they were elevated again
(100), asked for a PCR and quantitative determination and it came back
detectable, with a low viral count.
It's important to say that in that period, between 1997 and 2004, I
hadn't any previously intended (drug related) hazardous behavior,
always had safe sexual intercourses and no surgery (but few dental
ones) or transfusions.
I had to do treatment and I finished it one week ago.

I minded to post this, I didn't want you to be worried by my reply.
Probably PCR determination had an higher cut-off by that time and,
probably, I had a small, hidden amount of virus that kept on
replicating and showed up later.
But, in your case, I would suggest another accurate (I have heard about
10 or 5 viral units/ml sensibility kits) PCR determination, in another
lab.
Just to be on the safe side.

"My two cents", hope this helps,
jeeb.
Gordo Mondragon - 27 Sep 2005 22:00 GMT
[...]

> Just to be on the safe side.

I showed symptoms during the acute phase and my doctor said that the
tradeoff was >90% chance of clearing it with 6 months of treatment vs
<50% chance with a year of treatment if I waited to see if I was going
to become chronic or not.

There have been more recent studies that show a high rate of clearance
just using interferon for something like two months if you're in the
initial six-month acute infection period.  Maybe something to consider.

Gordo
hepmeplz - 28 Sep 2005 03:10 GMT
Thanx guys, I know I was infected sometime between 1986 and 2003( when
I finally got clean from heroin). I haven't done anything since that
would facilitate infection with the virus. I have had the same
girlfriend, who is negative, and other than dental work and blood tests
no needles have been in my body. I do plan on testing at another lab
soon and would like to know more about sensitivity as far as tests are
concerned. What should I be telling another DR. other than the truth
about my concerns when I do go for more tests? -if anything. Thank you
all for your input and interest-Dale
greyhackles - 28 Sep 2005 03:19 GMT
>Thanx guys, I know I was infected sometime between 1986 and 2003( when
>I finally got clean from heroin). I haven't done anything since that
[quoted text clipped - 5 lines]
>about my concerns when I do go for more tests? -if anything. Thank you
>all for your input and interest-Dale

Current tests are around 3 to 4 orders of magnitude more sensitive than what
was available 5 years ago.

"Heptimax" low cutoff is 5 IU/ml, and has a narrow dynamic range.
Good for "The Last Word", not so good for Viral Load determination.

"Quantasure" low cutoff is 10 IU/ml, with a far superior dynamic range. Best
for VL, but pretty darned good at HCV yes/no, too.

As for the hows and whys, do you know if you're currently showing the same
genotype & subtype now as before?

Cheers

/greyhackles
hepmeplz - 28 Sep 2005 04:09 GMT
I just got my labs back  and they show no level of the virus, only
antibodies. Dr. said I cured myself, this was the first round of tests
ever done.
hepmeplz - 28 Sep 2005 04:09 GMT
I just got my labs back  and they show no level of the virus, only
antibodies. Dr. said I cured myself, this was the first round of tests
ever done.
greyhackles - 28 Sep 2005 04:15 GMT
>I just got my labs back  and they show no level of the virus, only
>antibodies. Dr. said I cured myself, this was the first round of tests
>ever done.

Well *that* certainly doesn't suck :-)
hepmeplz - 28 Sep 2005 04:20 GMT
Yeah, tell me about it!! It took a couple days to really sink in, I
mean I really didn't believe it at first. I just got used to the idea
of going on treatment for a year and preparing myself for it and this
happened. It really made my head spin. I rarely have anything good
happen for me it sometimes seems, but this, this is too incredible!! I
still want to get tested again and talk to another Dr. just to be sure.
It's hard to wrap my head around with all the insane stuff I've done to
myself in the past!
Gordo Mondragon - 28 Sep 2005 10:26 GMT
> I just got my labs back  and they show no level of the virus, only
> antibodies. Dr. said I cured myself, this was the first round of tests
> ever done.

So the latest you were exposed was in 2003, I'd think if another lab
confirms the results you should consider yourself very lucky.

Gordo
hepmeplz - 29 Sep 2005 01:26 GMT
Yeah, I'll say! Actually that's probably an understatement considering
drug abuse history.
 
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