Medical Forum / Diseases and Disorders / Hepatitis / September 2005
Has anyone heard of this before?
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hepmeplz - 21 Sep 2005 05:21 GMT Hi All, I just went to my Dr. today to get my results from the battery of blood tests they did- genotype, VL, etc..- and my G.I. told me that I did have hep c antibodies and was exposed to the virus, however my immune system somehow fought it off and there were no detectable virus in my blood. Is that possible? Would I be stupid to believe that and not have my blood tested again by another Dr.? It really made my head spin and it's hard for me to believe. I mean its definitely good news, but I just want to be absolutely sure it's true. Have a beautiful day all.
twice_redeemed@yahoo.com - 21 Sep 2005 05:51 GMT Yes, it can happen. You probably just have an awesome immune system. My nextdoor neighbor has the same story. She tested positive, but has cleared herself of all virus
hepmeplz - 21 Sep 2005 06:21 GMT It still makes me suspicious. Thank you for replying to my post. I read some of your other posts previously and want to let you know that the one you posted on the hard drugs group was great. I grew up in San Diego (P.B.) and started my drug career there, I am coming up on three years clean thanks to the fellowship of N.A. in Santa Barbara. I just wanted to give you some positive feedback not only on your post, but for taking interest in my situation. So thank you, I hope that my Dr. is correct. Take good care, Dale.
captain - 21 Sep 2005 11:06 GMT Hi Dale, It happens and you are one of the few happy cured. Important is how is your lever now. If the lft's are OK, than you can celebrate even with alcohol (if lowed for you after the drugs cleaning). Wish you success and good health! Captain Backo
> It still makes me suspicious. Thank you for replying to my post. I read > some of your other posts previously and want to let you know that the [quoted text clipped - 4 lines] > for taking interest in my situation. So thank you, I hope that my Dr. > is correct. Take good care, Dale. twice_redeemed@yahoo.com - 21 Sep 2005 20:23 GMT Thanks. I was in San Diego in the navy, and got off drugs in '78 at Navy Drug Rehab at Miramar NAS. Went to PB many times, especially to the mexican restaurant on Garnet. Great town.
Paul - 21 Sep 2005 09:56 GMT On 20 Sep 2005 21:21:50 -0700, "hepmeplz" <pbv1488@hotmail.com>, in message ID <1127276510.755069.129280@z14g2000cwz.googlegroups.com>, in the newsgroup alt.support.hepatitis-c wrote:
>Hi All, I just went to my Dr. today to get my results from the battery >of blood tests they did- genotype, VL, etc..- and my G.I. told me that [quoted text clipped - 5 lines] >but I just want to be absolutely sure it's true. Have a beautiful day >all. Apparently, it happens like this about 20% of the time so it's not exactly a rare event. Just be grateful I suppose. Maybe get it checked again sometime if you feel nervous about it. I personally know a few people who have never been on interferon yet they have antibodies but no detectable virus.
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Gordo Mondragon - 21 Sep 2005 11:42 GMT > Hi All, I just went to my Dr. today to get my results from the battery > of blood tests they did- genotype, VL, etc..- and my G.I. told me that > I did have hep c antibodies and was exposed to the virus, however my > immune system somehow fought it off and there were no detectable virus > in my blood. Is that possible? It's very possible.
The number 20% is sometimes used but there could be even more, people who don't show symptoms and then clear on their own.
It also seems to make a difference it got into you, and how strong an initial reaction you have.
> Would I be stupid to believe that and > not have my blood tested again by another Dr.? It really made my head > spin and it's hard for me to believe. I mean its definitely good news, > but I just want to be absolutely sure it's true. Have a beautiful day > all. I'd have the test redone by another lab just to be sure.
G
greyhackles - 21 Sep 2005 14:55 GMT >Hi All, I just went to my Dr. today to get my results from the battery >of blood tests they did- genotype, VL, etc..- and my G.I. told me that [quoted text clipped - 5 lines] >but I just want to be absolutely sure it's true. Have a beautiful day >all. Spontaneous clearance is the outcome for roughly 20% of all HCV acute-stage infections, so sure, it's possible you're showing antibodies but no active virus.
Chalk it up to genetic luck - both the genetics of the virus strain you were exposed to, and the genetics of your immune system that refused to allow the virus to thrive....
Cheers
/greyhackles ps: This would be a fine day to buy a handful of Lottery tickets :-)
Russ - 21 Sep 2005 17:07 GMT In fact, Kiaks brother did the same thing, has the antibodies and no VL, I forgot about that.
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> Hi All, I just went to my Dr. today to get my results from the battery > of blood tests they did- genotype, VL, etc..- and my G.I. told me that [quoted text clipped - 5 lines] > but I just want to be absolutely sure it's true. Have a beautiful day > all. JV - 21 Sep 2005 17:34 GMT Your a lucky guy. I know 3, anibodies and NO VL. Some just shuck it off like you :) in 6 months get retested just to be on the safe side and one more test now to be sure your clear. Juanita
Russ - 22 Sep 2005 23:56 GMT Juanita, I did not clear the virus, my 6 month post tx PCR was 4 million...... About 3 1/2 months after finishing treatment, and I felt great then, I started to feel "flu" like and not well. It was like having an acute response to "getting it all over again". For about 2 months I felt crappy, but I haven't had any of those symptoms for quite a while now. Just had a PCR done last week and see what that says like it really matters. If you got it, you got it.......
I'll wait a while and redo the treatment, but not for a year or two. Right now I feel pretty good and energy is fine. Working my butt off and keeping up with the kids on the crew half my age.
Yesterday, one of the laborers had to go home because he was "sick" and didn't feel well with 3 hours left on the shift. I thought, "what a pussy, he don't know what sick is!!" I wouldn't leave a job unless I was hurling all over the place, and sometimes I would go anyway... I think he was hung over.
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Your a lucky guy. I know 3, anibodies and NO VL. Some just shuck it off like you :>) in 6 months get retested just to be on the safe side and one more test now to be sure your clear. Juanita
JV - 23 Sep 2005 01:39 GMT Hi Russ I know your a relapser. I got antibodies and labs today. I have very low abs. all under range, but I do have them. I'm having fun adjusting to steroids for my adrenal insuffiency. Its been a hell of a week but on my second week now. I think I am better. I have been refereed to a Endo to figure out my chemical imbalances. In the last week my free t4 took a 20 point drop now it is 10 points above cut off and I do feel kinda hypo. My FreeT3 is holding, but looks like I am going to be changing to synthroid or at least adding it to the mix. Since armour isn't doing a whole lot and i am already taking 1gram seems like Armour for most raises T3 but leaves T4 behind. Glad you feeling better. Juanita.
Russ - 24 Sep 2005 00:20 GMT My brother is taking about 25mg of synthroid and armour, he says he is doing pretty good.
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> Hi Russ > I know your a relapser. I got antibodies and labs today. I have very low [quoted text clipped - 8 lines] > raises T3 but leaves T4 behind. Glad you feeling better. > Juanita. Russ - 21 Sep 2005 17:07 GMT I know a guy, him and his brother both have the antibodies and no viral load, but his 3rd brother has the virus. I have read anywhere from 15-20% of people infected with HCV have killed it on their own.
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> Hi All, I just went to my Dr. today to get my results from the battery > of blood tests they did- genotype, VL, etc..- and my G.I. told me that [quoted text clipped - 5 lines] > but I just want to be absolutely sure it's true. Have a beautiful day > all. Waterspider - 23 Sep 2005 20:18 GMT > Hi All, I just went to my Dr. today to get my results from the battery > of blood tests they did- genotype, VL, etc..- and my G.I. told me that [quoted text clipped - 5 lines] > but I just want to be absolutely sure it's true. Have a beautiful day > all. Of those exposed to HCV, the immune system of 15% will destroy the virus within six months. Antibodies remain for life.
Waterspider
hepmeplz - 24 Sep 2005 02:06 GMT It seems to me that if 15% of the population who are infected do clear the virus, isn't it a possibility that of those 15% there could be a cure, or a vaccine hiding in the genes? I would gladly volunteer my time ( what little I do have) & blood to science in an effort to help find such a breakthrough. I know it's not that easy, but there has to be an answer.
Shawn - 24 Sep 2005 03:09 GMT There's no money in curing anyone. But, there's riches beyond the wildest dreams of avarice to "manage" a disease!
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> It seems to me that if 15% of the population who are infected do clear > the virus, isn't it a possibility that of those 15% there could be a > cure, or a vaccine hiding in the genes? I would gladly volunteer my > time ( what little I do have) & blood to science in an effort to help > find such a breakthrough. I know it's not that easy, but there has to > be an answer. hepmeplz - 24 Sep 2005 06:36 GMT Thomas Wagner - 24 Sep 2005 17:53 GMT >There's no money in curing anyone. But, there's riches beyond the wildest >dreams of avarice to "manage" a disease! What nonsense. Lots of companies are trying to achieve just that, a cure, and the first one through the gates is going to cash in handsomely. Not everything you read on conspiracy websites is true...
For what's in the pipeline: http://www.hcvadvocate.org/hepatitis/hepC/HCVDrugs.html
Thomas
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Shawn - 26 Sep 2005 08:10 GMT Thomas, I didn't mention anything about conspiracies or websites.
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>>There's no money in curing anyone. But, there's riches beyond the wildest >>dreams of avarice to "manage" a disease! [quoted text clipped - 7 lines] > > Thomas Thomas Wagner - 26 Sep 2005 18:07 GMT >Thomas, I didn't mention anything about conspiracies or websites. Sorry, should have put a smiley at the end - that was a tongue-in-cheek remark. It's just that so much crap is written and said (including the mass media) about the big bad drug companies and how everybody in "traditional" medicine is just in it for the money (yeah right, with 80-hour work-weeks) that I sometimes react badly to yet another stereotype. With over 20 companies doing research for a HCV cure, it's a bit absurd to claim that there's no money in a cure. Those companies wouldn't be doing the research if there wasn't a lot of money in it.
Thomas
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ghibelno - 27 Sep 2005 13:50 GMT <quote>
Hi All, I just went to my Dr. today to get my results [...]
</quote>
Hi hepmeplz,
I was diagnosed with HepC in 1997 and I probably was in the acute phase, then, as I think I know how I got it and I am quite sure about the circumstances. Anyway, I had anti-HCV antibodies and slightly elevated LFTs at the time. Doctors decided to wait for just few weeks or months, I don't remember well, and then try and look for viral load. Results were negative, meaning that it seemed that I was exposed to the virus but I had no detectable HCV-RNA in my bloodstream. I had LFTs and PCR determinations redone several times, even after the acute phase period (6 months) expired, and they always came back undetectable. Just _once_ labs showed elevated LFTs again, but the PCR still remained undetectable. That fact made the doctors think that I probably had the virus cleared by myself and that I didn't need any treatment. Years went by, and I kept checking LFTs every one year or so, always good. I even had the joy to have a son in 2003. Then, in 2004 I checked for LFTs as usual, they were elevated again (100), asked for a PCR and quantitative determination and it came back detectable, with a low viral count. It's important to say that in that period, between 1997 and 2004, I hadn't any previously intended (drug related) hazardous behavior, always had safe sexual intercourses and no surgery (but few dental ones) or transfusions. I had to do treatment and I finished it one week ago.
I minded to post this, I didn't want you to be worried by my reply. Probably PCR determination had an higher cut-off by that time and, probably, I had a small, hidden amount of virus that kept on replicating and showed up later. But, in your case, I would suggest another accurate (I have heard about 10 or 5 viral units/ml sensibility kits) PCR determination, in another lab. Just to be on the safe side.
"My two cents", hope this helps, jeeb.
Gordo Mondragon - 27 Sep 2005 22:00 GMT [...]
> Just to be on the safe side. I showed symptoms during the acute phase and my doctor said that the tradeoff was >90% chance of clearing it with 6 months of treatment vs <50% chance with a year of treatment if I waited to see if I was going to become chronic or not.
There have been more recent studies that show a high rate of clearance just using interferon for something like two months if you're in the initial six-month acute infection period. Maybe something to consider.
Gordo
hepmeplz - 28 Sep 2005 03:10 GMT Thanx guys, I know I was infected sometime between 1986 and 2003( when I finally got clean from heroin). I haven't done anything since that would facilitate infection with the virus. I have had the same girlfriend, who is negative, and other than dental work and blood tests no needles have been in my body. I do plan on testing at another lab soon and would like to know more about sensitivity as far as tests are concerned. What should I be telling another DR. other than the truth about my concerns when I do go for more tests? -if anything. Thank you all for your input and interest-Dale
greyhackles - 28 Sep 2005 03:19 GMT >Thanx guys, I know I was infected sometime between 1986 and 2003( when >I finally got clean from heroin). I haven't done anything since that [quoted text clipped - 5 lines] >about my concerns when I do go for more tests? -if anything. Thank you >all for your input and interest-Dale Current tests are around 3 to 4 orders of magnitude more sensitive than what was available 5 years ago.
"Heptimax" low cutoff is 5 IU/ml, and has a narrow dynamic range. Good for "The Last Word", not so good for Viral Load determination.
"Quantasure" low cutoff is 10 IU/ml, with a far superior dynamic range. Best for VL, but pretty darned good at HCV yes/no, too.
As for the hows and whys, do you know if you're currently showing the same genotype & subtype now as before?
Cheers
/greyhackles
hepmeplz - 28 Sep 2005 04:09 GMT I just got my labs back and they show no level of the virus, only antibodies. Dr. said I cured myself, this was the first round of tests ever done.
hepmeplz - 28 Sep 2005 04:09 GMT I just got my labs back and they show no level of the virus, only antibodies. Dr. said I cured myself, this was the first round of tests ever done.
greyhackles - 28 Sep 2005 04:15 GMT >I just got my labs back and they show no level of the virus, only >antibodies. Dr. said I cured myself, this was the first round of tests >ever done. Well *that* certainly doesn't suck :-)
hepmeplz - 28 Sep 2005 04:20 GMT Yeah, tell me about it!! It took a couple days to really sink in, I mean I really didn't believe it at first. I just got used to the idea of going on treatment for a year and preparing myself for it and this happened. It really made my head spin. I rarely have anything good happen for me it sometimes seems, but this, this is too incredible!! I still want to get tested again and talk to another Dr. just to be sure. It's hard to wrap my head around with all the insane stuff I've done to myself in the past!
Gordo Mondragon - 28 Sep 2005 10:26 GMT > I just got my labs back and they show no level of the virus, only > antibodies. Dr. said I cured myself, this was the first round of tests > ever done. So the latest you were exposed was in 2003, I'd think if another lab confirms the results you should consider yourself very lucky.
Gordo
hepmeplz - 29 Sep 2005 01:26 GMT Yeah, I'll say! Actually that's probably an understatement considering drug abuse history.
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