 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Hepatitis / May 2005Dietary intake of iron / hepatitis C
<<snip>> decreased dietary intake of iron may constitute an important adjuvant therapy in patients with CH-C. <<snip>> Poster 341: EFFICACY OF LONG-TERM DIETARY IRON RESTRICTION IN PATIENTS WITH CHRONIC HEPATITIS C Kazuko Iwata, Mie University Hospital, Tsu City, Mie, Japan; Motoh Iwasa, Masahiko Kaito, Masaki Takeo, Jiro Ikoma, Yukihiko Adachi, Mie University School of Medicine, Tsu City, Mie, Japan. Objectives It is important to maintain reduced serum alanine aminotransferase (ALT) levels in cases with chronic hepatitis C (CH-C) that do not respond to interferon (IFN) and in those with no indication of IFN therapy. We reported previously that dietary restriction of iron intake reduces serum ALT levels in such patients. We evaluated CH-C patients treated with iron-restricted diet for two or more consecutive years, mainly focusing on the balance of energy intake, physical examination, and changes in hematological indices of nutrition. Methods Twenty-two patients with CH-C (males, 18; females, 4; mean age, 56 year-old) that consulted our outpatient department were enrolled in this study. The inclusion criteria were as follows: 1) elevation of ALT levels above the upper normal limit for 3 months or more; 2) positive tests for HCV-antibody and HCV-RNA; 3) absence of other causes of CH (alcoholic liver disease, drug-induced liver injury, hemochromatosis) and negativity for hepatitis B surface antigen and for serum anti-nuclear and anti-mitochondrial autoantibodies. Twenty cases had received IFN therapy for more than 12 months before the beginning of the study; none of them responded to IFN therapy. Dietary prescriptions included iron intake 7 mg/day or less, energy intake 30 kcal/kg/day, protein intake 1.1-1.2 g/kg/day, and a fat energy fraction of 20%. Nutritional balance was evaluated based on meal records, and instructions was given when necessary. Results The average energy intake before dietary prescription was 2184 kcal (36.7 kcal/kg)/day, and it was significantly reduced to 1655 kcal (28.5 kcal/kg)/day (p < 0.01), and then maintained stable at 30 kcal/kg/day. The average protein intake before dietary prescription was 85.7 g (1.45 g/kg)/day and it was reduced to 1.1-1.2 g/kg/day after the prescription. The average fat intake of 66.5 g (1.1 g/kg)/day and the average fat energy fraction of 27% before the dietary prescription were significantly decreased to 30.8 g (0.52 g/kg)/day; p < 0.01 and 16% (p < 0.001), respectively, after dietary instructions. The fat energy fraction was maintained at a level of 20% or less. Carbohydrate intake did not change remarkably during the observation period, although the carbohydrate energy fraction significantly (p < 0.001) increased. The average iron intake decreased significantly (p < 0.001) from 9.6 (before) to 6.1, 5.2, 5.1, 5.2, and 5.1 mg/day 6, 12, 18, and 24 months after dietary prescription, respectively. Body mass index (BMI) before diet prescription was 23.9 on average; BMI had no significant change throughout the course. The body fat percentage was 24.6% on average before the diet instructions, and it significantly decreased after the diet. The average values of aspartate aminotransferase and ALT before diet prescription were 65 IU/l and 66 IU/l, respectively, and they were significantly reduced to 48 IU/l and 49 IU/l, respectively, after 24 months (p < 0.01). Serum iron levels significantly decreased after 18 (p < 0.01) and 24 (p < 0.05) months, while unsaturated iron binding capacity tended to increase. The average serum ferritin levels were 376, 210, 189, 189, 141 ng/ml before and 6, 12, 18, and 24 months after diet, respectively; there was a significant reduction (p < 0.01) in the values measured before and after the diet instructions. The average levels of hemoglobin, albumin and cholinesterase did not change significantly during the follow-up period. Conclusions Restriction of iron intake is safe and well tolerated for a long period. The results of our present study suggest that decreased dietary intake of iron may constitute an important adjuvant therapy in patients with CH-C. Who loves ya. Tom Interesting. I understand the connection between iron and HC. What are the best foods to avoid that are high in iron? ><<snip>> >decreased dietary intake of iron may constitute an important adjuvant [quoted text clipped - 73 lines] >Who loves ya. >Tom I'm not sure .. WHAT .. the study diet .. was .. I have no access to full text articles .. The diet used in the study most likely would give one an idea .. I know .. meat .. is .. ALL meat .. is .. Who loves ya. Tom >I'm not sure .. WHAT .. the study diet .. was .. > [quoted text clipped - 6 lines] >Who loves ya. >Tom When was that study actually published? 2001? :: On 8 May 2005 17:42:38 -0700, "ironjustice@aol.com" :: <ironjustice@aol.com> wrote: ::: I know .. meat .. is .. ALL meat .. is .. :: When was that study actually published? 2001? Year 2004. Organ meats are highest in iron. Also red meat. Link to the abstract: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15043853  SignatureJuhana > Interesting. I understand the connection between iron and HC. What are the > best foods to avoid that are high in iron? I don't really think you do otherwise you wouldn't be asking that question. HC is a genetic disease and there is a screen for the gene available right now. If a family member has been diagnosed with HC then you should get the test done. There are tests out there that can pick up HC. You want to avoid foods high in iron without any evidence you have HC then you don't understand what you have read. People with HC need therapeutic interventions and not simply rely on diet. Other disorders associated with iron overload need to get the condition under control and therapeutic interventions done. Iron deficiency anemia is very common out there. It is common in children, in women and in bleeding disorders. > ><<snip>> > >decreased dietary intake of iron may constitute an important adjuvant [quoted text clipped - 74 lines] > >Who loves ya. > >Tom DC that not familiar with your abbreviations. > > Interesting. I understand the connection between iron and HC. What are > the [quoted text clipped - 30 lines] > > >respond to interferon (IFN) and in those with no indication of IFN > > >therapy. We reported previously that dietary restriction of iron intake > > >reduces serum ALT levels in such patients. We evaluated CH-C patients > > >treated with iron-restricted diet for two or more consecutive years, [quoted text clipped - 56 lines] > > >Who loves ya. > > >Tom > > Interesting. I understand the connection between iron and HC. What are > the [quoted text clipped - 11 lines] > Iron deficiency anemia is very common out there. It is common in children, > in women and in bleeding disorders. When did Hep C become a genetic disease? Zee > > ><<snip>> > > >decreased dietary intake of iron may constitute an important adjuvant [quoted text clipped - 74 lines] > > >Who loves ya. > > >Tom > > > Interesting. I understand the connection between iron and HC. What > are [quoted text clipped - 21 lines] > > When did Hep C become a genetic disease? Your abbreviations are not normal abbreviations used in medicine. HCV hepatitis C Virus. Confusion, yes. > > > > Interesting. I understand the connection between iron and HC. What > > are [quoted text clipped - 24 lines] > hepatitis C Virus. > Confusion, yes. Are you referring to the virus known as Hepatitis C when you say "HC is a genetic disease"? If you are referring to Hepatitis C (Hep C or HCV) when you use the term HC I repeat my question: when did Hepatitis C become genetic? IronJustice made the initial post. His reference was to Hepatitis C Virus, variously known as HCV, or Hep C. Whatever we call it, it is not called genetic. Please clarify. Zee Re: Dietary intake of iron / hepatitis C Group: alt.support.hepatitis-c Date: Tue, May 10, 2005, 1:33pm (CDT-2) From: outrider@despammed.com (outrider) Robert wrote: "outrider" <outrider@despammed.com> wrote in message news:1115682000.871443.35490@o13g2000cwo.googlegroups.com... Robert wrote: "Mondino" <mondino@verizon.com> wrote in message news:g5qdnYcmMKtMMOPfRVn-uw@comcast.com... Interesting. I understand the connection between iron and HC. What are the best foods to avoid that are high in iron? I don't really think you do otherwise you wouldn't be asking that question. HC is a genetic disease and there is a screen for the gene available right now. If a family member has been diagnosed with HC then you should get the test done. There are tests out there that can pick up HC. You want to avoid foods high in iron without any evidence you have HC then you don't understand what you have read. People with HC need therapeutic interventions and not simply rely on diet. Other disorders associated with iron overload need to get the condition under control and therapeutic interventions done. Iron deficiency anemia is very common out there. It is common in children, in women and in bleeding disorders. When did Hep C become a genetic disease? Your abbreviations are not normal abbreviations used in medicine. HCV hepatitis C Virus. Confusion, yes. Are you referring to the virus known as Hepatitis C when you say "HC is a genetic disease"? If you are referring to Hepatitis C (Hep C or HCV) when you use the term HC I repeat my question: when did Hepatitis C become genetic? IronJustice made the initial post. His reference was to Hepatitis C Virus, variously known as HCV, or Hep C. Whatever we call it, it is not called genetic. Please clarify. Zee /////////// Noone is or was saying hepatitis-c is a gentetic disease. They were referring to hemochromotosis as a genetic disease. Can it get any clearer than that? Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum Clandestine code? Fun, one thing, Malfesance, another. > Clandestine code? > > Fun, one thing, > Malfesance, another. The yellow pumpkin disease YPD is another Huh ~ ? Sobriety on the job, essential. Distorted judgement? Unacceptable. Simple enough issue. > > > > > Interesting. I understand the connection between iron and HC. > What [quoted text clipped - 44 lines] > > Zee You can call it what ever you want and cause confusion if you like. The original article mentioned CHC. I was referring to HHC or HC as some call it. I hope that clarifies it. HHC - hereditary hemochromatosis HC - hemochromatosis .. sometimes rererred AS .. 'genetic' .. hemochromatosis .. BUT .. normally .. HHC .. refers to the genetic .. and HC .. simply .. iron overload / secondary / acquired iron overload with NO genetic factors .. Who loves ya. Tom Hep-C is not a genetic disease, it's an infectious disease. The acronym 'HC' refers to the condition called 'hemochromotosis', which is inherited. It probably shouldn't be used in this forum because it's easily confused with HCV. In addition to meat, dark green veges are high in iron. Almost all foods contain some iron, it's a matter of choosing foods that have less iron (for those with 'HC') Hey....I'm lazy too. Elmo //////// Re: Dietary intake of iron / hepatitis C Group: alt.support.hepatitis-c Date: Mon, May 9, 2005, 4:40pm (CDT-2) From: outrider@despammed.com (outrider) Robert wrote: "Mondino" <mondino@verizon.com> wrote in message news:g5qdnYcmMKtMMOPfRVn-uw@comcast.com... Interesting. I understand the connection between iron and HC. What are the best foods to avoid that are high in iron? I don't really think you do otherwise you wouldn't be asking that question. HC is a genetic disease and there is a screen for the gene available right now. If a family member has been diagnosed with HC then you should get the test done. There are tests out there that can pick up HC. You want to avoid foods high in iron without any evidence you have HC then you don't understand what you have read. People with HC need therapeutic interventions and not simply rely on diet. Other disorders associated with iron overload need to get the condition under control and therapeutic interventions done. Iron deficiency anemia is very common out there. It is common in children, in women and in bleeding disorders. When did Hep C become a genetic disease? Zee In article <1115584024.866020.225110@o13g2000cwo.googlegroups.com>, ironjustice@aol.com says... <<snip>> decreased dietary intake of iron may constitute an important adjuvant therapy in patients with CH-C. <<snip>> Poster 341: EFFICACY OF LONG-TERM DIETARY IRON RESTRICTION IN PATIENTS WITH CHRONIC HEPATITIS C Kazuko Iwata, Mie University Hospital, Tsu City, Mie, Japan; Motoh Iwasa, Masahiko Kaito, Masaki Takeo, Jiro Ikoma, Yukihiko Adachi, Mie University School of Medicine, Tsu City, Mie, Japan. Objectives It is important to maintain reduced serum alanine aminotransferase (ALT) levels in cases with chronic hepatitis C (CH-C) that do not respond to interferon (IFN) and in those with no indication of IFN therapy. We reported previously that dietary restriction of iron intake reduces serum ALT levels in such patients. We evaluated CH-C patients treated with iron-restricted diet for two or more consecutive years, mainly focusing on the balance of energy intake, physical examination, and changes in hematological indices of nutrition. Methods Twenty-two patients with CH-C (males, 18; females, 4; mean age, 56 year-old) that consulted our outpatient department were enrolled in this study. The inclusion criteria were as follows: 1) elevation of ALT levels above the upper normal limit for 3 months or more; 2) positive tests for HCV-antibody and HCV-RNA; 3) absence of other causes of CH (alcoholic liver disease, drug-induced liver injury, hemochromatosis) and negativity for hepatitis B surface antigen and for serum anti-nuclear and anti-mitochondrial autoantibodies. Twenty cases had received IFN therapy for more than 12 months before the beginning of the study; none of them responded to IFN therapy. Dietary prescriptions included iron intake 7 mg/day or less, energy intake 30 kcal/kg/day, protein intake 1.1-1.2 g/kg/day, and a fat energy fraction of 20%. Nutritional balance was evaluated based on meal records, and instructions was given when necessary. Results The average energy intake before dietary prescription was 2184 kcal (36.7 kcal/kg)/day, and it was significantly reduced to 1655 kcal (28.5 kcal/kg)/day (p < 0.01), and then maintained stable at 30 kcal/kg/day. The average protein intake before dietary prescription was 85.7 g (1.45 g/kg)/day and it was reduced to 1.1-1.2 g/kg/day after the prescription. The average fat intake of 66.5 g (1.1 g/kg)/day and the average fat energy fraction of 27% before the dietary prescription were significantly decreased to 30.8 g (0.52 g/kg)/day; p < 0.01 and 16% (p < 0.001), respectively, after dietary instructions. The fat energy fraction was maintained at a level of 20% or less. Carbohydrate intake did not change remarkably during the observation period, although the carbohydrate energy fraction significantly (p < 0.001) increased. The average iron intake decreased significantly (p < 0.001) from 9.6 (before) to 6.1, 5.2, 5.1, 5.2, and 5.1 mg/day 6, 12, 18, and 24 months after dietary prescription, respectively. Body mass index (BMI) before diet prescription was 23.9 on average; BMI had no significant change throughout the course. The body fat percentage was 24.6% on average before the diet instructions, and it significantly decreased after the diet. The average values of aspartate aminotransferase and ALT before diet prescription were 65 IU/l and 66 IU/l, respectively, and they were significantly reduced to 48 IU/l and 49 IU/l, respectively, after 24 months (p < 0.01). Serum iron levels significantly decreased after 18 (p < 0.01) and 24 (p < 0.05) months, while unsaturated iron binding capacity tended to increase. The average serum ferritin levels were 376, 210, 189, 189, 141 ng/ml before and 6, 12, 18, and 24 months after diet, respectively; there was a significant reduction (p < 0.01) in the values measured before and after the diet instructions. The average levels of hemoglobin, albumin and cholinesterase did not change significantly during the follow-up period. Conclusions Restriction of iron intake is safe and well tolerated for a long period. The results of our present study suggest that decreased dietary intake of iron may constitute an important adjuvant therapy in patients with CH-C. Who loves ya. Tom http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum > Hep-C is not a genetic disease, it's an infectious disease. The acronym > 'HC' refers to the condition called 'hemochromotosis', which is > inherited. It probably shouldn't be used in this forum because it's > easily confused with HCV. I beg to differ. Here on ash-c, HC is our very own Heppiechick! Spidey >>Hep-C is not a genetic disease, it's an infectious disease. The acronym >>'HC' refers to the condition called 'hemochromotosis', which is [quoted text clipped - 4 lines] > > Spidey Very true WS, but that should be changing back to the original name shortly after her 12 month post tx check up. Dwight HC=Heppiechick Group: alt.support.hepatitis-c Date: Tue, May 10, 2005, 8:05pm (CDT+5) From: waterspider@moonshine.net (Waterspider) <elmoemerson@webtv.net> wrote in message news:25856-4280B545-493@storefull-3251.bay.webtv.net... Hep-C is not a genetic disease, it's an infectious disease. The acronym 'HC' refers to the condition called 'hemochromotosis', which is inherited. It probably shouldn't be used in this forum because it's easily confused with HCV. I beg to differ. Here on ash-c, HC is our very own Heppiechick! Spidey ///////// You got that right, Spidey. There's only room around here for one HC, and that's our Heppiechick. Where the hell is she, anyway? :-) Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum >[...] >Objective. >It is important to maintain reduced serum alanine aminotransferase >(ALT) levels in cases with chronic hepatitis C (CH-C) that do not >respond to interferon (IFN) and in those with no indication of IFN >therapy. The objective in itself is faulty. There is little indication that lowered LFT values in itself are beneficial in HCV infection, as shown by cirrhosis developing in patients with persistently normal LFTs. Also, the study did not just examine iron reduction, it examined a reduced calorie diet that led to decreased body fat, and a minor reduction in ALT and AST that was still above normal after 24 months. It did not examine liver health, or general well-being, by any measure other than LFTs. Whether it was the reduced iron or the reduced body fat or just chance that caused the slight improvement in LFTs is unknown because the study had no control group. A faulty study coming to faulty conclusions... Thomas SignatureTo reach me, complete my last name in the address. |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.