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Medical Forum / Diseases and Disorders / Hepatitis / February 2005dosing body weight or viral load?
Is tx dosing the same for every one with hcv or how is it determined. My GI doc is going to use my body size. He told me last week that my Viral load was below midrange, am going to see him tomorrow to go over all testing done in the last few months and to talk over treatment. Just want to keep him honest. I trust him so far but I have also met a lot of freaking idiots in the medical field. Need some feed back. Elmo, thanks for the Anti-D advice recently posted. Sue Hey Sue, Yes by all means the combination therapy using ribavirin 200 mg capsules prescribed number daily usage according to body weight and weekly usage interferon a2b is pegelated which is supposed to dissipate in your system over the course of the week. It is also weight-dosed according to the three general weight catagories. hope this is clear, Cactus Jammies > Is tx dosing the same for every one with hcv or how is it determined. My > GI doc is going to use my body size. He told me last week that my Viral [quoted text clipped - 4 lines] > Elmo, thanks for the Anti-D advice recently posted. > Sue >Is tx dosing the same for every one with hcv or how is it determined. My >GI doc is going to use my body size. He told me last week that my Viral [quoted text clipped - 4 lines] >Elmo, thanks for the Anti-D advice recently posted. >Sue Sue, it is not quite the same. First of all, the ribavirin is weight based for genotype 1 and 4 at 800mg, 1000mg, and 1200mg I can't remember the cutoff weights but it is listed on the pamphlet that is included with the script. For genotype 2 and 3 it is fixed at 800mg but some doctors use the same weight based formula as for geno 1 & 4. If you go with Pegasys (interferon alfa 2a) the dosage is the same for all (180mcg per week) but with Pegintron (interferon alfa 2b) it is weight based at 1mcg per kg per week. Those are the official dosages but some doctors go with a different plan like starting out with smaller dosages and increasing. See www.hepatitisdoctor.com for instance. The doctor their goes with individual plans based on a number of factors and seems to monitor things more closely than most other doctors. But I think doctors like him are pretty rare and most stick to the plan if the patient can stick to the plan. Sometimes people can't tolerate the full dosage of one or both riba/interferon. You will get informational pamphlets for both the riba and interferon with each refill that lists the dosages and the numerous side effects. I recommend reading that because you should be aware of what you are getting into. Run your test results by the group here if you would like some comments. Things of particular interest are HCV genotype, viral load, biopsy staging and grading, LFTs (liver function tests), and CBCs complete blood cell counts. > Is tx dosing the same for every one with hcv or how is it determined. My > GI doc is going to use my body size. He told me last week that my Viral [quoted text clipped - 4 lines] > Elmo, thanks for the Anti-D advice recently posted. > Sue Sue, I can only tell you what happened for me (in the UK). I have genotype 3, initially my hospital was going to put me on pegintron which uses weight based dosing for ribaviarin this would have meant that I had to take 1200mg a day. I asked to switch to Pegasys which under UK guidelines is genotype dosed, this meant that I only have to take 800mg of ribavirin. I believe the same dosing is applied to genotype 2, for all other genotypes both Pegasys and Pegintron are weight based dose for the ribavirin. . Jonathan On Tue, 22 Feb 2005 07:55:00 -0000, "Rasputin" <ras.putin@btinternet.com>, in message ID <cveogl$1j5$1@cpca14.uea.ac.uk>, in the newsgroup alt.support.hepatitis-c wrote: >I can only tell you what happened for me (in the UK). I have genotype 3, >initially my hospital was going to put me on pegintron which uses weight [quoted text clipped - 3 lines] >the same dosing is applied to genotype 2, for all other genotypes both >Pegasys and Pegintron are weight based dose for the ribavirin. . Yes. I treated genotype 2b with pegasys/riba. No weight based dosing as pegasys is an alfainterferon 2a. This stuff can get confusing when new. I had geno 2b and was treated with interferon 2a :-) I'm in the UK too.  SignaturePaul Use the reply by email facility in your newsreader to send email Thanks guys, I am geno 1A and doc has already given me a fancy carrying case filled with Pegasys and copegus info and syringe and pill cases and a tape that teaches to self inject etc. The med pamphlets are included. I will read these again a little more slowly now that I am excepting my disease and not having panic attacks as often! As you all know, this really sucks! I feel fine now and knowing that I am going to make myself sick for such a long time is surreal. I know that you can all relate. Panicing in Pennsylvania :-( Sue > Thanks guys, > I am geno 1A and doc has already given me a fancy carrying case filled > with Pegasys and copegus info and syringe and pill cases and a tape that > teaches to self inject etc. The med pamphlets are included. I will read > these again a little more slowly now that I am excepting my disease and > not having panic attacks as often! Yes, well done. In my opinion it can be useful to take the time and get info about the meds you're taking. > As you all know, this really sucks! I feel fine now and knowing that I am > going to make myself sick for such a long time is surreal. I know that > you can all relate. > Panicing in Pennsylvania :-( > Sue Well Sue, side effects aren't this bad for everybody. Treatment has been manageable for me, until this point (week 18). And so it is, or was, for quite lot of people here. You might even notice a kind of improvement of some of HCV related symptoms. I do wish you good luck. cheers, jeeb. I am trying to go into this as positive as I can. Not very easy to do . I guess I will play it by ear. I don't have a very good tolerance to meds, some of them have hit me like a truck in the past. But you never know. > I am trying to go into this as positive as I can. Not very easy to do . I > guess I will play it by ear. I don't have a very good tolerance to meds, > some of them have hit me like a truck in the past. > But you never know. I too was just as frightened as you are 9 weeks ago when I gave myself the first injection. I had friends lined up to rescue me when all the horrible sides and craziness set in. But guess what? The axe never fell! My only sides are headaches and fatigue. I work 40 hours a week and care for my twin 12 year old sons. I don't do much housework, but honestly never really did. I'd much rather play with my kids and besides that's what they make cleaning people for. Some may say I am one of the lucky ones but a positive attitude goes along way. Try to focus on one day at a time knowing that you are doing everything in your power to rid yourself of this terrible virus. Good luck! Boston Jean > > I am trying to go into this as positive as I can. Not very easy to do > . I > > guess I will play it by ear. I don't have a very good tolerance to > meds, > > some of them have hit me like a truck in the past. > > But you never know. Sue, I also was absolutely petrified before I started treatment. I am 8 weeks in, I am working full time, I swim 1,000 metres every day and weight train 3 times a week. In the main the side effects for me are of an emotional type, I find that weekends are the hardest (either because I have less to keep me occupied or because they follow on from the injection). I suffer some mood swings, from the irrational anger, bursting out crying or occassionally a deep melancholy, I have chosen not to take anti depressants, but I suspect that they would potentially be a help. For now I manage to live with these effects but place a high reliance on my weekly counselling sessions. Hopefully you will have fairly minor side effect too. Good luck Jonathan > You might even notice a kind of improvement of some of HCV related symptoms. The chronic "tennis elbow" I had for 4-5 years went away after a month on the treatment. It hasn't come back either. About the only good thing the treatment did for me. Besides meeting a lot of really nice people! It took about 3 months before the sides wore me down, so the beginning wasn't too bad. Yes it is strange injecting stuff that makes you sick. And knowing you could stop anytime. It's a real test of ones self discipline and patience. Good luck Sue!! SignatureRuss Visit Alaska @ http://www.tannersacre.com > > Thanks guys, > > I am geno 1A and doc has already given me a fancy carrying case filled [quoted text clipped - 22 lines] > cheers, > jeeb. >Thanks guys, >I am geno 1A and doc has already given me a fancy carrying case filled [quoted text clipped - 7 lines] >Panicing in Pennsylvania :-( >Sue Yes, the Pegassist kit, I got one myself when I was starting out. But don't psych yourself out by expecting to be sick throughout treatment. You might think yourself sick. I only had about 24 hours of mild flu-like symptoms in 6 months of treatment. That was with my first shot. The main problem for me was increased fatigue and that wasn't too bad. There are others in this group and elsewhere with similar experiences. Don't think about being sick. Think about elimanating a pesky, dangerous virus. Many people like to do their shots on Friday night so if there are bad effects they won't have them at work. Also, doing the shot before bed may benefit you in sleeping through the worst of it. Good luck Sue. I plan to take my shot on Sunday nights. I need to feel better by the weekends. I sell motorcycle leathers etc. at show and swap meets. It's a lot of hard work but adrenalin gets me through. I am glad to know that it may not effect me as badly as others in this group. I start this Sunday. In article <160df78235a60abd97cf386e6b73e786@localhost.talkaboutsupport.com>, > I plan to take my shot on Sunday nights. I need to feel better by the > weekends. I sell motorcycle leathers etc. at show and swap meets. It's a > lot of hard work but adrenalin gets me through. I am glad to know that it > may not effect me as badly as others in this group. I start this Sunday. I had bad side effects but one thing I learned was that even when I felt bad, I could do a lot (and actually feel better) if I really paced myself. If I pushed too hard even for a little while it would knock me out, but I could go along all day at a steady pace if I needed too. Something you might try if that is a problem for you. Re: dosing body weight or viral load? Group: alt.support.hepatitis-c Date: Tue, Feb 22, 2005, 10:02am (CST+1) From: burningdaylight@private.com (burningdaylight) Thanks guys, I am geno 1A and doc has already given me a fancy carrying case filled with Pegasys and copegus info and syringe and pill cases and a tape that teaches to self inject etc. The med pamphlets are included. I will read these again a little more slowly now that I am excepting my disease and not having panic attacks as often! As you all know, this really sucks! I feel fine now and knowing that I am going to make myself sick for such a long time is surreal. I know that you can all relate. Panicing in Pennsylvania :-( Sue ////////////// No need to panic, Sue. Yeah, we can all relate. That's why I'm telling you not to panic. LOL. Elmo http://community.webtv.net/elmoemerson/DocElmosHepFile http://community.webtv.net/elmoemerson/TheFamilyAlbum |
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