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Medical Forum / Diseases and Disorders / Hepatitis / November 2004

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2 weeks check: ALT levels

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ghibeluno - 24 Nov 2004 08:48 GMT
Hi all,
    had to check after 2 weeks of tx.
I actually gave the blood sample on monday, having had my shot on
saturday night.
Results showed that my red cells count and hemoglobin went just under
the limit and ALT grew from 69 (before starting tx) to 77.

I've actually been surprised by the ALT levels growing.
Does this means I'm not responding? What do you think about? Is or are
there web sites about this?

I'm on week 5 now and I had another test at week 4 (this time I gave the
blood sampple on saturday morning, exactly one week after my 4th shot).
They checked for HCV-RNA levels too, as my baseline viral load was low
(3000 UI/ml).
Results in a couple of weeks.

Hugs,
jeeb
elmoemerson@webtv.net - 24 Nov 2004 14:50 GMT
Don't worry about your ALT going up while on tx, Jeeb.  It does that in
alot of cases.  
Elmo

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
ghibeluno - 24 Nov 2004 15:25 GMT
> Don't worry about your ALT going up while on tx, Jeeb.  It does that in
> alot of cases.  
> Elmo

Thanks Elmo,

    the fact is that actually I've been reading that:
"... If the ALT level decreases quickly in the treatment process, you
have a better chance of responding to treatment ..." (quoting
http://www.hepatitis.va.gov/vahep?page=tp03-01-05-93).

That's the reason why I'm worried.

cheers,
jeeb.
elmoemerson@webtv.net - 24 Nov 2004 16:01 GMT

Re: 2 weeks check: ALT levels  

Group: alt.support.hepatitis-c Date: Wed, Nov 24, 2004, 4:25pm (CST+7)
From: ghibelno@__NOSPAMMEPLEASE__yahoo.it (ghibeluno)
elmoemerson@webtv.net wrote:
Don't worry about your ALT going up while on tx, Jeeb. It does that in
alot of cases.
Elmo
Thanks Elmo,
                the fact is that
actually I've been reading that: "... If the ALT level decreases quickly
in the treatment process, you have a better chance of responding to
treatment ..." (quoting
http://www.hepatitis.va.gov/vahep?page=tp03-01-05-93).
That's the reason why I'm worried.
cheers,
jeeb.  
/////////////
Although the page you're reading was modified a year ago, it was written
nearly 12 years ago.  When that page was written, there were no accurate
methods for measuring viral loads, so they used LFT's as their guage for
measuring whether treatment was working, or not.  The statement you
cited is generally true, but there are exceptions, especially with the
newer treatment regimens.  With some of us, our liver enzymes increase
for a period ot time as a reaction to the interferon.  In this case, it
has nothing to do with the viral load.  A rapid drop in viral load is a
much better indication of successful treatment than is measuring LFT's.  
Like I said, don't sweat it.
Elmo  

http://community.webtv.net/elmoemerson/DocElmosHepFile

http://community.webtv.net/elmoemerson/TheFamilyAlbum
Don - 24 Nov 2004 20:53 GMT
>Hi all,
>    had to check after 2 weeks of tx.
[quoted text clipped - 15 lines]
>Hugs,
>jeeb

My ALT/AST first went down then started climbing.  But the virus is
still undetectable.  As Elmo said it is not uncommon for the LFTs to
climb during tx.  My doctor isn't concerned about it and I'm not as
well.  You have to learn to relax during tx and just go with it.  Good
luck, jeeb.

Don
 
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